Diverse effects of type II collagen on osteogenic and adipogenic differentiation of mesenchymal stem cells

Journal of Cellular Physiology

Volumn 227, Issue 6, 2012, Pages 2412-2420

  Chiu, Li Hsuan ^a   Yeh, Tien Shun ^b   Huang, Huei Mei ^a   Leu, Sy Jye ^a,c   Yang, Charng Bin ^d   Tsai, Yu Hui ^a,c  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^d Taipei County Hospital   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; BLOCKING ANTIBODY; CALCIUM; COLLAGEN TYPE 2; ENZYME INHIBITOR; FOCAL ADHESION KINASE; INTEGRIN; INTEGRIN BINDING PEPTIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; OSTEOCALCIN; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 1; VERY LATE ACTIVATION ANTIGEN 2;

ADIPOGENESIS; AGED; ARTICLE; BONE DEVELOPMENT; BONE MARROW BIOPSY; BONE MINERALIZATION; CELL ADHESION; CELL DIFFERENTIATION; CELL STRUCTURE; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; MESENCHYMAL STEM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

ADIPOGENESIS; AGED; ALKALINE PHOSPHATASE; BIOLOGICAL MARKERS; CALCIUM; CELL ADHESION; CELL SHAPE; CELLS, CULTURED; COLLAGEN TYPE II; CORE BINDING FACTOR ALPHA 1 SUBUNIT; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FOCAL ADHESION KINASE 1; HUMANS; INTEGRIN ALPHA1BETA1; INTEGRIN ALPHA2BETA1; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MESENCHYMAL STROMAL CELLS; OSTEOCALCIN; OSTEOGENESIS; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; RNA, MESSENGER; SIGNAL TRANSDUCTION; TIME FACTORS; UP-REGULATION;

EID: 84863170584     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.22976     Document Type: Article

References (34)

1. Cary LA, Han DC, Polte TR, Hanks SK, Guan JL. 1998. Identification of p130Cas as a mediator of focal adhesion kinase-promoted cell migration. J Cell Biol 140: 211-221.
2. Chen CW, Tsai YH, Deng WP, Shih SN, Fang CL, Burch JG, Chen WH, Lai WF. 2005. Type I and II collagen regulation of chondrogenic differentiation by mesenchymal progenitor cells. J Orthop Res 23: 446-453.
3. Dickhut A, Pelttari K, Janicki P, Wagner W, Eckstein V, Egermann M, Richter W. 2009. Calcification or dedifferentiation: Requirement to lock mesenchymal stem cells in a desired differentiation stage. J Cell Physiol 219: 219-226.
4. Einhorn TA. 1998. The cell and molecular biology of fracture healing. Clin Orthop Relat Res 355 Suppl: S7-S21.
5. Fu L, Tang T, Miao Y, Zhang S, Qu Z, Dai K. 2008. Stimulation of osteogenic differentiation and inhibition of adipogenic differentiation in bone marrow stromal cells by alendronate via ERK and JNK activation. Bone 43: 40-47.
6. Giancotti FG, Ruoslahti E. 1999. Integrin signaling. Science 285: 1028-1032.
7. Gronthos S, Simmons PJ, Graves SE, Robey PG. 2001. Integrin-mediated interactions between human bone marrow stromal precursor cells and the extracellular matrix. Bone 28: 174-181.
8. Jaiswal RK, Jaiswal N, Bruder SP, Mbalaviele G, Marshak DR, Pittenger MF. 2000. Adult human mesenchymal stem cell differentiation to the osteogenic or adipogenic lineage is regulated by mitogen-activated protein kinase. J Biol Chem 275: 9645-9652.
9. Jikko A, Harris SE, Chen D, Mendrick DL, Damsky CH. 1999. Collagen integrin receptors regulate early osteoblast differentiation induced by BMP-2. J Bone Miner Res 14: 1075-1083.
10. Kajkenova O, Lecka-Czernik B, Gubrij I, Hauser SP, Takahashi K, Parfitt AM, Jilka RL, Manolagas SC, Lipschitz DA. 1997. Increased adipogenesis and myelopoiesis in the bone marrow of SAMP6, a murine model of defective osteoblastogenesis and low turnover osteopenia. J Bone Miner Res 12: 1772-1779.
11. Kirsch T, von der Mark K. 1991. Isolation of human type X collagen and immunolocalization in fetal human cartilage. Eur J Biochem 196: 575-580.
12. Klees RF, Salasznyk RM, Kingsley K, Williams WA, Boskey A, Plopper GE. 2005. Laminin-5 induces osteogenic gene expression in human mesenchymal stem cells through an ERK-dependent pathway. Mol Biol Cell 16: 881-890.
13. Knight CG, Morton LF, Peachey AR, Tuckwell DS, Farndale RW, Barnes MJ. 2000. The collagen-binding A-domains of integrins alpha(1)beta(1) and alpha(2)beta(1) recognize the same specific amino acid sequence, GFOGER, in native (triple-helical) collagens. J Biol Chem 275: 35-40.
14. Kronenberg HM. 2003. Developmental regulation of the growth plate. Nature 423: 332-336.
15. Li SW, Prockop DJ, Helminen H, Fassler R, Lapveteläinen T, Kiraly K, Peltarri A, Arokoski J, Lui H, Arita M, Khillan JS. 1995. Transgenic mice with targeted inactivation of the Col2 alpha 1 gene for collagen II develop a skeleton with membranous and periosteal bone but no endochondral bone. Genes Dev 9: 2821-2830.
16. Mizuno M, Kuboki Y. 2001. Osteoblast-related gene expression of bone marrow cells during the osteoblastic differentiation induced by type I collagen. J Biochem 129: 133-138.
17. Ornitz DM, Marie PJ. 2002. FGF signaling pathways in endochondral and intramembranous bone development and human genetic disease. Genes Dev 16: 1446-1465.
18. Pelttari K, Winter A, Steck E, Goetzke K, Hennig T, Ochs BG, Aigner T, Richter W. 2006. Premature induction of hypertrophy during in vitro chondrogenesis of human mesenchymal stem cells correlates with calcification and vascular invasion after ectopic transplantation in SCID mice. Arthritis Rheum 54: 3254-3266.
19. Ruest PJ, Roy S, Shi E, Mernaugh RL, Hanks SK. 2000. Phosphospecific antibodies reveal focal adhesion kinase activation loop phosphorylation in nascent and mature focal adhesions and requirement for the autophosphorylation site. Cell Growth Differ 11: 41-48.
20. Salasznyk RM, Klees RF, Hughlock MK, Plopper GE. 2004a. ERK signaling pathways regulate the osteogenic differentiation of human mesenchymal stem cells on collagen I and vitronectin. Cell Commun Adhes 11: 137-153.
21. Salasznyk RM, Williams WA, Boskey A, Batorsky A, Plopper GE. 2004b. Adhesion to vitronectin and collagen I promotes osteogenic differentiation of human mesenchymal stem cells. J Biomed Biotechnol 2004: 24-34.
22. Schaller MD. 2001. Biochemical signals and biological responses elicited by the focal adhesion kinase. Biochim Biophys Acta 1540: 1-21.
23. Schaller MD, Hildebrand JD, Shannon JD, Fox JW, Vines RR, Parsons JT. 1994. Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src. Mol Cell Biol 14: 1680-1688.
24. Schlaepfer DD, Broome MA, Hunter T. 1997. Fibronectin-stimulated signaling from a focal adhesion kinase-c-Src complex: Involvement of the Grb2, p130cas, and Nck adaptor proteins. Mol Cell Biol 17: 1702-1713.
25. Schneider GB, Zaharias R, Stanford C. 2001. Osteoblast integrin adhesion and signaling regulate mineralization. J Dent Res 80: 1540-1544.
26. Spranger J, Winterpacht A, Zabel B. 1994. The type II collagenopathies: A spectrum of chondrodysplasias. Eur J Pediatr 153: 56-65.
27. Tachibana K, Urano T, Fujita H, Ohashi Y, Kamiguchi K, Iwata S, Hirai H, Morimoto C. 1997. Tyrosine phosphorylation of Crk-associated substrates by focal adhesion kinase. A putative mechanism for the integrin-mediated tyrosine phosphorylation of Crk-associated substrates. J Biol Chem 272: 29083-29090.
28. Takeuchi Y, Suzawa M, Kikuchi T, Nishida E, Fujita T, Matsumoto T. 1997. Differentiation and transforming growth factor-beta receptor down-regulation by collagen-alpha2beta1 integrin interaction is mediated by focal adhesion kinase and its downstream signals in murine osteoblastic cells. J Biol Chem 272: 29309-29316.
29. Tuckwell DS, Ayad S, Grant ME, Takigawa M, Humphries MJ. 1994. Conformation dependence of integrin-type II collagen binding. Inability of collagen peptides to support alpha 2 beta 1 binding, and mediation of adhesion to denatured collagen by a novel alpha 5 beta 1-fibronectin bridge. J Cell Sci 107: 993-1005.
30. Vandenberg P, Khillan JS, Prockop DJ, Helminen H, Kontusaari S, Ala-Kokko L. 1991. Expression of a partially deleted gene of human type II procollagen (COL2A1) in transgenic mice produces a chondrodysplasia. Proc Natl Acad Sci USA 88: 7640-7644.
31. von der Mark K, von der Mark H. 1977. The role of three genetically distinct collagen types in endochondral ossification and calcification of cartilage. J Bone Joint Surg Br 59-B: 458-464.
32. Winterpacht A, Hilbert M, Schwarze U, Mundlos S, Spranger J, Zabel BU. 1993. Kniest and Stickler dysplasia phenotypes caused by collagen type II gene (COL2A1) defect. Nat Genet 3: 323-326.
33. Xiao G, Wang D, Benson MD, Karsenty G, Franceschi RT. 1998. Role of the alpha2-integrin in osteoblast-specific gene expression and activation of the Osf2 transcription factor. J Biol Chem 273: 32988-32994.
34. Xu Y, Gurusiddappa S, Rich RL, Owens RT, Keene DR, Mayne R, Hook A, Hook M. 2000. Multiple binding sites in collagen type I for the integrins alpha1beta1 and alpha2beta1. J Biol Chem 275: 38981-38989.