R992C (p.R1192C) Substitution in Collagen II Alters the Structure of Mutant Molecules and Induces the Unfolded Protein Response

Journal of Molecular Biology

Volumn 390, Issue 2, 2009, Pages 306-318

  Chung, Hye Jin ^a   Jensen, Deborah A ^a   Gawron, Katarzyna ^a   Steplewski, Andrzej ^a   Fertala, Andrzej ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

apoptosis; collagen II mutations; ER stress; extracellular matrix; unfolded protein response

Indexed keywords

ARGININE; COLLAGEN TYPE 2; CYSTEINE; DISULFIDE; GREEN FLUORESCENT PROTEIN; IMMUNOGLOBULIN BINDING FACTOR; PROCOLLAGEN LYSINE 2 OXOGLUTARATE 5 DIOXYGENASE; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; PROTEIN DISULFIDE ISOMERASE;

AMINO ACID SUBSTITUTION; APOPTOSIS; ARTICLE; COMPUTER MODEL; CONTROLLED STUDY; DISULFIDE BOND; ELECTROPHORETIC MOBILITY; ENDOPLASMIC RETICULUM STRESS; EXTRACELLULAR SPACE; GENE MUTATION; HOST CELL; HUMAN; HUMAN CELL; MOLECULAR MECHANICS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN LOCALIZATION; PROTEIN SECRETION; PROTEIN STRUCTURE; SPONDYLOEPIPHYSEAL DYSPLASIA; THERMOSTABILITY;

EID: 67349245447     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2009.05.004     Document Type: Article

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