Chemical inhibition of NAT10 corrects defects of laminopathic cells

Science

Volumn 344, Issue 6183, 2014, Pages 527-532

  Larrieu, Delphine ^a   Britton, Sébastien ^a,d   Demir, Mukerrem ^a   Rodriguez, Raphaël ^b   Jackson, Stephen P ^a,c  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b CNRS   (France)

^c WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^d UNIVERSITÉ DE TOULOUSE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLTRANSFERASE; CHEMICALS AND DRUGS; ENZYME INHIBITOR; LAMIN A; LAMIN C; N ACETYLTRANSFERASE 10; REMODELIN; UNCLASSIFIED DRUG; 4-(4-CYANOPHENYL)-2-(2-CYCLOPENTYLIDENEHYDRAZINYL)THIAZOLE; CHROMATIN; HYDRAZONE DERIVATIVE; NAT10 PROTEIN, HUMAN; NOCODAZOLE; PEPTIDE ALPHA N ACETYLTRANSFERASE E; SMALL INTERFERING RNA; THIAZOLE DERIVATIVE;

CANCER; CELL ORGANELLE; ENZYME ACTIVITY; INHIBITION; MUTATION; PROTEIN;

ARTICLE; CELL TYPE; CLICK CHEMISTRY; CONTROLLED STUDY; ENZYME INHIBITION; HUMAN; HUMAN CELL; LAMINOPATHIC CELL; LAMINOPATHY; LIQUID CHROMATOGRAPHY; MICROTUBULE; NUCLEAR SHAPE; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY; ANTAGONISTS AND INHIBITORS; CELL NUCLEUS; CHEMISTRY; CHROMATIN; DRUG EFFECTS; ENZYMOLOGY; GENETICS; METABOLISM; PROGERIA; PROTEIN TERTIARY STRUCTURE; TUMOR CELL LINE; ULTRASTRUCTURE;

CELL LINE, TUMOR; CELL NUCLEUS; CHROMATIN; ENZYME INHIBITORS; HUMANS; HYDRAZONES; LAMIN TYPE A; MICROTUBULES; N-TERMINAL ACETYLTRANSFERASE E; NOCODAZOLE; PROGERIA; PROTEIN STRUCTURE, TERTIARY; RNA, SMALL INTERFERING; THIAZOLES;

EID: 84900330481     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1252651     Document Type: Article

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