Effects of pomegranate juice consumption on inflammatory markers in patients with type 2 diabetes: A randomized, placebo-controlled trial

Journal of Research in Medical Sciences

Volumn 19, Issue 3, 2014, Pages 215-220

  Sohrab, Golbon ^a   Nasrollahzadeh, Javad ^a   Zand, Hamid ^b   Amiri, Zohreh ^b   Tohidi, Maryam ^c   Kimiagar, Masoud ^a  

^a Department of Clinical Nutrition and Dietetics ^*  (Iran)

^b SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Diabetes mellitus; Inflammation; Pomegranate

Indexed keywords

ALBUMIN; BIOLOGICAL MARKER; C REACTIVE PROTEIN; GLUCOSE; INSULIN; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BLOOD ANALYSIS; BODY MASS; CLINICAL ASSESSMENT; CLINICAL PROTOCOL; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FOLLOW UP; HUMAN; INFLAMMATION; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PATIENT COMPLIANCE; POMEGRANATE JUICE; QUANTITATIVE ANALYSIS; RANDOMIZED CONTROLLED TRIAL; TREATMENT RESPONSE;

EID: 84900303809     PISSN: 17351995     EISSN: 17357136     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Calle MC, Fernandez ML. Inflammation and type 2 diabetes. Diabetes Metab 2012;38:183-91.
2. Puglisi M, Fernandez ML. Modulation of C-reactive protein, tumor necrosis factor-alpha and adiponectin by diet, exercise and weight loss. J Nutr 2008;138:2293-6.
3. Shema-Didi L, Sela S, Ore L, Shapiro G, Geron R, Moshe G, et al. One year of pomegranate juice intake decreases oxidative stress, inflammation, and incidence of infections in hemodialysis patients: A randomized placebo-controlled trial. Free Radic Biol Med 2012;53:297-304.
4. Gil MI, Tomas-Barberan FA, Hess-Pierce B, Holcroft DM, Kader AA. Antioxidant Activity of Pomegranate Juice and Its Relationship with Phenolic Composition and Processing. J Agric Food Chem 2000;48:4581-9.
5. Seeram NP, Aviram M, Zhang Y, Henning SM, Feng L, Dreher M, et al. Comparison of antioxidant potency of commonly consumed Polyphenol-Rich beverages in the United States. J Agric Food Chem 2008;56:1415-22.
6. Aviram M, Rosenblat M, Gaitini D, Nitecki S, Hoffman A, Dornfeld L, et al. Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotidintimamedia thickness, blood pressure and LDL oxidation. Clin Nutr 2004;23:423-33.
7. Rosenblat M, Hayek T, Aviram M. Anti-oxidative effects of pomegranate juice (PJ) consumption by diabetic patients on serum and on macrophages. Atherosclerosis 2006;187:363-71.
8. Esmaillzadeh A, Tahbaz F, Gaieni I, Alavi-Majd H, Azadbakht L. Concentrated pomegranate juice improves lipid profiles in diabetic patients with hyperlipidemia. J Med Food 2004;7:305-8.
9. Adams LS, Seeram NP, Aggarwal BB, Takada Y, Sand D, Heber D. Pomegranate juice, total pomegranate ellagitannins, and punicalagin suppress inflammatory cell signaling in colon cancer cells. J Agric Food Chem 2006;54:980-5.
10. Rasheed Z, Akhtar N, Anbazhagan AN, Ramamurthy S, Shukla M, Haqqi TM. Polyphenol-rich pomegranate fruit extract (POMx) suppresses PMACI-induced expression of pro-inflammatory cytokines by inhibiting the activation of MAP Kinases and NFkappaB in human KU812 cells. J Inflamm (Lond) 2009;6:1.
11. Bray HG, Thorpe WV. Analysis of phenolic compounds of interest in metabolism. Methods Biochem Anal 1954;1:27-52.
12. Hajimahmoodi M, Oveisi MR, Sadeghi N, Jannat B, Hadjibabaie M, Farahani E, et al. Antioxidant properties of peel and pulp hydro extract in ten Persian pomegranate cultivars. Pak J Biol Sci 2008;11:1600-4.
13. Cano A, Hernández-Ruiz J, García-Cánovas F, Acosta M, Arnao MB. An end-point method for estimation of the total antioxidant activity in plant material. Phytochem Anal 1998;9:196-202.
14. Noori N, Tabibi H, Hosseinpanah F, Hedayati M, Nafar M. Effects of combined administration of Lipoic Acid and Pyridoxine on serum systemic and vascular inflammatory factors in patients with diabetic nephropathy. Iran J Endocrinol Metab 2010;12:99-110.
15. Rosenblat M, Hayek T, Aviram M. Anti-oxidative effects of pomegranate juice (PJ) consumption by diabetic patients on serum and on macrophages. Atherosclerosis 2006;187:363-71.
16. Rock W, Rosenblat M, Miller-Lotan R, Levy AP, Elias M, Aviram M. Consumption of wonderful variety pomegranate juice and extract by diabetic patients increases paraoxonase 1 association with highdensity lipoprotein and stimulates its catalytic activities. J Agric Food Chem 2008;56:8704-13.
17. Parsaeyan N, Mozaffari-Khosravi H, Mozayan MR. Effect of pomegranate juice on paraoxonase enzyme activity in patients with type 2 diabetes. J Diabetes Metab Disord 2012;11:11.
18. Asgary S, Sahebkar A, Afshani MR, Keshvari M, Haghjooy Javanmard S, Rafieian-Kopaei M. Clinical evaluation of blood pressure lowering endothelial function improving, hypolipidemic and anti-inflammatory effects of Pomegranatejuice in hypertensive subjects. Phytother Res 2013 Mar 21 [In Press].
19. Boussetta T, Raad H, Lettéron P, Gougerot-Pocidalo MA, Marie JC, Driss F, et al. Punicic acid a conjugated linolenic acid inhibits TNF alpha-induced neutrophil hyperactivation and protects from experimental colon inflammation in rats. PLoS One 2009;4:e6458.
20. Lotito SB, Zhang WJ, Yang CS, Crozier A, Frei B. Metabolic conversion of dietary flavonoids alters their anti-inflammatory and antioxidant properties. Free Radic Biol Med 2011;51:454-63.
21. Zhao SP, Xu TD. Elevated tumor necrosis factor alpha of blood mononuclear cells in patients with congestive heart failure. Int J Cardiol 1999;71:257-61.
22. Tracy K, Cerami A. Tumor necrosis factor, other cytokines and disease. Annu Rev Cell Biol 1993;9:317-43.
23. Yoon JH, Baek SJ. Molecular targets of dietary polyphenols with anti-inflammatory properties. Yonsei Med J 2005;46:585-96.
24. Lotito S, Frei B. Consumption of flavonoid-rich food and increased plasma antioxidant capacity in humans: Cause, consequence, or epiphenomenon? Free Radic Biol Med 2006;41:1727-46.
25. Schmitt CA, Dirsch VM. Modulation of endothelial nitric oxide by plant-derived products. Nitric Oxide 2009;21:77-91.
26. Ignarro L, Byrns R, Sumi D, Nigris F, Napoli C. Pomegranate juice protects nitric oxide against oxidative destruction and enhances the biological actions of nitricoxide. Nitric Oxide 2006;15:93-102.