Baicalin inhibits hypoxia-induced pulmonary artery smooth muscle cell proliferation via the AKT/HIF-1α/p27-associated pathway

International Journal of Molecular Sciences

Volumn 15, Issue 5, 2014, Pages 8153-8168

  Zhang, Lin ^a   Pu, Zhichen ^b   Wang, Junsong ^c   Zhang, Zhifeng ^a   Hu, Dongmei ^a   Wang, Junjie ^a  

^a DALIAN MEDICAL UNIVERSITY   (China)

^b WANNAN MEDICAL COLLEGE   (China)

^c DALIAN UNIVERSITY   (China)

Author keywords

Baicalin; Proliferation; Pulmonary artery smooth muscle cells; Pulmonary hypertension

Indexed keywords

BAICALIN; BETA ACTIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA; OXYGEN; PROTEIN KINASE B; PROTEIN P21; PROTEIN P27; FLAVONOID;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER GROWTH; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; FEMALE; HEART RIGHT VENTRICLE PRESSURE; HEART VENTRICLE HYPERTROPHY; HYPOXIA; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PULMONARY ARTERY; PULMONARY HYPERTENSION; RAT; SMOOTH MUSCLE FIBER; SYSTOLIC BLOOD PRESSURE; WESTERN BLOTTING; ANIMAL; ANOXIA; CELL CULTURE; CHEMISTRY; COMPLICATION; CYTOLOGY; DRUG EFFECTS; HYPERTENSION, PULMONARY; ISOLATION AND PURIFICATION; LUNG; METABOLISM; PATHOLOGY; SCUTELLARIA BAICALENSIS; SIGNAL TRANSDUCTION; VASCULAR SMOOTH MUSCLE; VASCULARIZATION; WISTAR RAT;

ANIMALS; ANOXIA; CELL PROLIFERATION; CELLS, CULTURED; FEMALE; FLAVONOIDS; HYPERTENSION, PULMONARY; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LUNG; MALE; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PROTO-ONCOGENE PROTEINS C-AKT; PULMONARY ARTERY; RATS; RATS, WISTAR; SCUTELLARIA BAICALENSIS; SIGNAL TRANSDUCTION;

EID: 84900037563     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms15058153     Document Type: Article

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