Sociodemographic characteristics, clinical factors, and genetic polymorphisms associated with Alzheimer's disease

International Journal of Geriatric Psychiatry

Volumn 28, Issue 6, 2013, Pages 640-646

  Bicalho, Maria Aparecida Camargos ^a,c   Pimenta, Fausto Aloísio ^b   Bastos Rodrigues, Luciana ^a   De Oliveira Hansen, Érika ^a   Neves, Samara Canguçu ^a   Melo, Marina ^a   Rosa, Daniela Valadão ^a   De Souza, Renan Pedra ^a   De Miranda, Débora Marques ^a   De Moraes, Edgar Nunes ^a   Romano Silva, Marco Aurélio ^a   Marco, Luiz De ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^b FEDERAL UNIVERSITY OF OURO PRETO   (Brazil)

^c FUNDAÇÃO HOSPITALAR DO ESTADO DE MINAS GERAIS   (Brazil)

Author keywords

age at onset of disease; Alzheimer's disease; depression; polymorphisms

Indexed keywords

APOLIPOPROTEIN E; BRAIN DERIVED NEUROTROPHIC FACTOR; CATECHOL METHYLTRANSFERASE; SEROTONIN TRANSPORTER;

AGED; ALLELE; ALZHEIMER DISEASE; BRAZIL; CLINICAL FEATURE; CONTROLLED STUDY; DEMOGRAPHY; DEPRESSION; DISEASE ASSOCIATION; DNA POLYMORPHISM; EDUCATIONAL STATUS; FEMALE; FUNCTIONAL GENOMICS; GENETIC ASSOCIATION; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICAL HISTORY; ONSET AGE; REVIEW; RISK FACTOR; SOCIAL ASPECT; VASCULAR DISEASE;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; ANALYSIS OF VARIANCE; APOLIPOPROTEIN E3; APOLIPOPROTEIN E4; BRAZIL; DEPRESSION; EDUCATIONAL STATUS; FEMALE; GENE-ENVIRONMENT INTERACTION; GENOTYPE; HEALTH STATUS; HUMANS; MALE; POLYMORPHISM, GENETIC; RISK FACTORS;

EID: 84877577358     PISSN: 08856230     EISSN: 10991166     Source Type: Journal    
DOI: 10.1002/gps.3875     Document Type: Review

References (48)

1. Albani D, Prato F, Tettamanti M, et al,. 2009. The serotonin transporter promoter polymorphic region is not a risk factor for Alzheimer's disease related behavioral disturbances. J Alzheimers Dis 18 (1): 125-130.
2. Alzheimer's Disease International. World Alzheimer Report. 2010. The Global Economic Impact of Dementia. King's College: London, United Kingdom; 2010.
3. Amorim P,. 2000. MINI International Neuropsychiatric Interview (MINI): validation of a short structured diagnostic psychiatric interview. Rev Bras Psiquiatr 22 (3): 106-115.
4. Bastos-Rodrigues L, Pimenta JR, Pena SD,. 2006. The genetic structure of human populations studied through short insertion-deletion polymorphisms. Ann Hum Genet 70 (Pt 5): 1-8.
5. Bertram L, Lill CM, Tanzi RE,. 2010. The genetics of Alzheimer disease: back to the future. Neuron 68 (2): 270-281.
6. Borroni B, Grassi M, Agosti C, et al,. 2006. Genetic correlates of behavioral endophenotypes in Alzheimer disease: role of COMT, 5-HTTLPR and ApOE polymorphisms. Neurobiol Aging 27 (11): 1595-1603.
7. Borroni B, Grassi M, Costanzi C, et al,. 2007. Haplotypes in cathechol-O-methyltransferase gene confer increased risk for psychosis in Alzheimer disease. Neurobiol Aging 28 (8): 1231-1238.
8. Cobb JL, Wolf PA, Au R, White R, D'Agostino RB,. 1995. The effect of education on the incidence of dementia and Alzheimer's disease in the Framingham study. Neurology 45 (9): 1707-1712.
9. Corder EH, Saunders AM, Strittmatter WJ, et al,. 1993. Gene dose of Apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 261 (5123): 921-923.
10. Corder EH, Saunders AM, Risch, NJ, et al,. 1994. Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease. Nat Genet 7 (2): 180-184.
11. Cummings JL, Mega M, Gray K, Rosenberg-Thompson S, Carusi DA, Gornbein J,. 1994. Neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia. Neurology 44 (12): 2308-2323.
12. Egan MF, Kojima M, Callicott JH, et al,. 2003. The BDNF Val66Met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 112 (2): 257-269.
13. Feulner TM, Laws SM, Friedrich P, et al,. 2009. Examination of the current top candidate genes for AD in a genome-wide association study. Mol Psychiatry 6 (7): 1-11.
14. Folstein MF, Folstein SE, McHugh PR,. 1975. "Mini-mental state". A practical method for grading the cognitive status of patients for the clinician. J Psychiatr Rev 12 (3): 189-195.
15. Fratiglioni L, Wang HX,. 2007. Brain reserve hypothesis in dementia. J Alzheimers Dis 12 (1): 11-22.
16. Griffith DM, Griffith PA,. 2008. Commentary on "Perspective on race and ethnicity in Alzheimer's disease research". Alzheimers Dement 4 (4): 239-241.
17. Grünblatt E, Zehetmayer S, Bartl J, et al,. 2009. Genetic risk factors and markers for Alzheimer's disease and/or depression in the VITA study. J Psychiatr Res 43 (3): 298-308.
18. Grupe A, Abraham R, Li Y, et al,. 2007. Evidence for novel susceptibility genes for late-onset Alzheimer's disease from a genome-wide association study of putative functional variants. Hum Mol Genet 16 (8): 865-873.
19. Huang R, Huang J, Cathcart H, Smith S, Poduslo SE,. 2007. Genetic variants in brain-derived neurotrophic factor associated with Alzheimer's disease. J Med Genet 44 (2): e66.
20. Katz S, Ford AB, Moskowitz RW, Jackson BA, Jaffe MW,. 1963. Studies of illness in the aged. The index of ADL: a standardized measure of biological and psychosocial function. J Am Med Assoc 185: 914-919.
21. Kivipelto M, Ngandu T, Laatikainen T, et al,. 2006. Risk score for the prediction of dementia risk in 20 years among middle aged people: a longitudinal, population based study. Lancet Neurol 5 (9): 735-741.
22. Lahiri DK, Nurnberger JI Jr., 1991. A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies. Nucleic Acids Res 19 (19): 5444.
23. Launer LJ, Andersen K, Dewey ME, et al,. 1999. Rates and risk factors for dementia and Alzheimer's disease: results from EURODEM pooled analysis. EURODEM Incidence Research Group and Work Groups. European Studies of Dementia. Neurology 52 (1): 78-84.
24. Li Y, Rowland C, Tacey K, et al,. 2005. The BDNF Val66Met polymorphism is not associated with late onset Alzheimer's disease in three case-control samples. Mol Psychiatry 10 (9): 809-810.
25. Luchsinger JA, Reitz C, Honig LS, et al,. 2005. Aggregation of vascular risk factors and risk of incident Alzheimer disease. Neurology 65 (4): 545-551.
26. Martínez MF, Martin XE, Alcelay LG, et al,. 2009. The COMT Val158Met polymorphism as an associated risk factor for Alzheimer disease and mild cognitive impairment in APOE 4 carriers. BMC Neurosci 10: 25-134.
27. Matsushita S, Arai H, Matsui T, et al,. 2005. Brain-derived neurotrophic factor gene polymorphisms and Alzheimer's disease. J Neural Transm 112 (5): 703-711.
28. McDowell I,. 2001. Alzheimer's disease: insights from epidemiology. Aging 13: 143-162.
29. McKhann G, Drachman D, Folstein M, et al,. 1984. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease. Neurology 34 (7): 939-944.
30. Morris JC,. 1993. The Clinical Dementia Rating (CDR): current version and scoring rules. Neurology 43 (11): 2412-2414.
31. Morris JC, Mohs RC, Hughes JP, et al,. 1989. The Consortium to Establish a Registry for Alzheimer's Disease. Neurology 39 (9): 1159-1165.
32. Murer MG, Yan Q, Raisman-Vozari R,. 2001. Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinsons disease. Prog Neurobiol 63 (1): 71-124.
33. Ownby R L, Crocco E, Acevedo A, John V, Loewenstein D,. 2006. Depression and risk for Alzheimer disease: systematic review, meta-analysis, and metaregression analysis. Arch Gen Psychiatry 63 (5): 530-538.
34. Pfeffer RI, Kurosaki TT, Harrah CH Jr, Chance JM, Filos S,. 1982. Measurement of functional activities on older adults in the community. J Gerontol 37 (3): 323-329.
35. Pritchard JK, Stephens M, Donnelly P,. 2000. Inference of population structure using multilocus genotype data. Genetics 155 (2): 945-959.
36. Reitz C, Tang MX, Schupf N, et al,. 2010. A summary risk score for the prediction of Alzheimer disease in elderly persons. Arch Neurol 67 (7): 835-841.
37. Roe CM, Xiong C, Miller JP, Morris JC,. 2007. Education and Alzheimer disease without dementia: support for the cognitive reserve hypothesis. Neurology 68 (3): 223-228.
38. Rosen WG, Terry RD, Fuld PA, Katzman R, Peck A,. 1980. Pathological verification of ischemic score in differentiation of dementias. Ann Neurol 7 (5): 486-488.
39. Saczynski JS, Beiser A, Seshadri S, et al,. 2010. Depressive symptoms and risk of dementia: The Framingham Heart Study. Neurology 75 (1): 35-41.
40. Scazufca M, Menezes PR, Araya R, et al,. 2008. Risk factor across the life course and dementia in a Brazilian population: results from the Sao Paulo Ageing & Health Study (SPAH). Int J Epidemiol 37 (4): 879-890.
41. Schweitzer I, Tuckwell V, O'Brien J, Ames D,. 2002. Is late onset depression a prodrome to dementia? Int J Geriatr Psychiatry 17 (11): 997-1005.
42. Serretti A, Olgiati P, De Ronchi D,. 2007. Genetics of Alzheimer's disease. A rapidly evolving field. J Alzheimers Dis 12 (12): 73-92.
43. Sweet RA, Pollock BG, Sukonick DL, et al,. 2001. The 5-HTTLPR polymorphism confers liability to a combined phenotype of psychotic and aggressive behavior in Alzheimer disease. Int Psychogeriatr 13 (4): 401-409.
44. Tsai SJ, Hong CJ, Liu HC, et al,. 2004. Association analysis of brain-derived neurotrophic factor Val66Met polymorphisms with Alzheimer's disease and age of onset. Neuropsychobiology 49 (1): 10-12.
45. Tsopelas C, Stewart R, Savva GM, et al,. 2011. Neuropathological correlates of late-life depression in older people. Br J Psychiatry 198 (2): 109-114.
46. Weber JL, David D, Heil J, et al,. 2002. Human diallelic insertion/deletion polymorphisms. Am J Human Genet 71 (4): 854-862.
47. Xu C, Wang Z, Fan M, et al,. 2010. Effects of BDNF Val66Met polymorphism on brain metabolism in Alzheimer's disease. Neuroreport 21 (12): 802-807.
48. Yoshitake T, Kiyohara Y, Kato I, et al,. 1995. Incidence and risk factors of vascular dementia and Alzheimer's disease in a defined elderly Japanese population: the Hisayama study. Neurology 45 (6): 1161-1168.