Current status of human hepatocyte transplantation and its potential for Wilson's disease

Annals of the New York Academy of Sciences

Volumn 1315, Issue 1, 2014, Pages 50-55

  Filippi, Celine ^a,b   Dhawan, Anil ^b,c  

^a GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c KING S COLLEGE HOSPITAL   (United Kingdom)

Author keywords

Acute liver failure; Hepatocyte; Transplantation; Wilson's disease

Indexed keywords

ALGINIC ACID; BALANCED SALT SOLUTION; COLLAGENASE; COPPER; CRYOPROTECTIVE AGENT; EGTAZIC ACID; INTERLEUKIN 2 RECEPTOR ANTIBODY; MONOCLONAL ANTIBODY; PENICILLAMINE; POLYSACCHARIDE; STEROID; TACROLIMUS; TRIENTINE; UNIVERSITY OF WISCONSIN SOLUTION; ZINC DERIVATIVE;

ACUTE LIVER FAILURE; ANIMAL MODEL; ARTICLE; BIOCOMPATIBILITY; CELL ENCAPSULATION; CELL FUNCTION; CELL ISOLATION; CELL POPULATION; CELL SURVIVAL; CELL SUSPENSION; CELL VIABILITY; CLINICAL EFFECTIVENESS; CRIGLER NAJJAR SYNDROME; CRYOPRESERVATION; DESMOSOME; DISEASE COURSE; EXTRACELLULAR MATRIX; GOOD MANUFACTURING PRACTICE; HEPATOCYTE TRANSPLANTATION; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; INNATE IMMUNITY; LIVER TRANSPLANTATION; MESENCHYMAL STEM CELL; NONHUMAN; ONCOTIC PRESSURE; OXIDATIVE PHOSPHORYLATION; WILSON DISEASE;

ACUTE LIVER FAILURE; HEPATOCYTE; TRANSPLANTATION; WILSON'S DISEASE;

ANIMALS; CELL SEPARATION; CELL SURVIVAL; HEPATOCYTES; HEPATOLENTICULAR DEGENERATION; HUMANS; IMMUNOSUPPRESSION; LIVER FAILURE, ACUTE;

EID: 84900009102     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/nyas.12386     Document Type: Article

References (38)

1. Ala, A., A.P. Walker, K. Ashkan, et al. 2007. Wilson's disease. Lancet 369: 397-408.
2. Dhawan, A., R. Taylor, P. Cheeseman, et al. 2005. Wilson's disease in children: 37-year experience and revised King's score for liver transplantation. Liver. Transplant. 11: 441-448.
3. Dhawan, A. 2012. Acute liver failure in children and adolescents. Clin. Res. Hepatol. Gastroenterol. 36: 278-283.
4. Puppi, J., N. Tan, R.R. Mitry, et al. 2008. Hepatocyte transplantation followed by auxiliary liver transplantation-a novel treatment for ornithine transcarbamylase deficiency. Am. J. Transplant. 8: 452-457.
5. Berry, M.N. & D.S. Friend. 1969. High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study. J. Cell. Biol. 43: 506-520.
6. Seglen, P.O. 1976. Preparation of isolated rat liver cells. Methods Cell. Biol. 13: 29-83.
7. Strom, S., K. Dorko, M. Thompson, et al. 1998. In Îlots de Langerhans et hépatocytes: vers une utilisation therapeutique. D. Franco, K. Boudjema & B. Varet, Eds.: 195-205. Les Editions INSERM: Paris.
8. Mitry, R.R., R.D. Hughes, M.M. Aw, et al. 2003. Human hepatocyte isolation and relationship of cell viability to early graft function. Cell. Transplant. 12: 69-74.
9. Hughes, R.D., R.R. Mitry, A. Dhawan, et al. 2006. Isolation of hepatocytes from livers from non-heart-beating donors for cell transplantation. Liver. Transplant. 12: 713-717.
10. Meyburg, J., A.M. Das, F. Hoerster, et al. 2009. One liver for four children: first clinical series of liver cell transplantation for severe neonatal urea cycle defects. Transplantation 87: 636-641.
11. Fox, I.J., J.R. Chowdhury, S.S. Kaufman, et al. 1998. Treatment of the Crigler-Najjar syndrome type I with hepatocyte transplantation. N. Engl. J. Med. 338: 1422-1426.
12. Terry, C., R.R. Mitry, S.C. Lehec, et al. 2005. The effects of cryopreservation on human hepatocytes obtained from different sources of liver tissue. Cell. Transplant. 14: 585-594.
13. Terry, C., A. Dhawan, R.R. Mitry & R.D. Hughes. 2006. Cryopreservation of isolated human hepatocytes for transplantation: state of the art. Cryobiology 53: 149-159.
14. Terry, C., A. Dhawan, R.R. Mitry, et al. 2010. Optimization of the cryopreservation and thawing protocol for human hepatocytes for use in cell transplantation. Liver. Transplant. 16: 229-237.
15. Stéphenne, X., M. Najimi, F. Smets, et al. 2005. Cryopreserved liver cell transplantation controls ornithine transcarbamylase deficient patient while awaiting liver transplantation. Am. J. Transplant. 5: 2058-2061.
16. Balan, V., K. Ruppert, A. Demetris, et al. 2008. Long-term outcome of human leukocyte antigen mismatching in liver transplantation: results of the National Institute of Diabetes and Digestive and Kidney Diseases Liver Transplantation Database. Hepatology 48: 878-888.
17. Fisher, R.A., D. Bu, M. Thompson, et al. 2004. Optimization of conditions for clinical human hepatocyte infusion. Cell Transplant. 13: 677-689.
18. Joseph, B., H. Malhi, K.K. Bhargava, et al. 2002. Kupffer cells participate in early clearance of syngeneic hepatocytes transplanted in the rat liver. Gastroenterology 123: 1677-1685.
19. Allen, K.J., N.A. Mifsud, R. Williamson, et al. 2008. Cell-mediated rejection results in allograft loss after liver cell transplantation. Liver Transplant. 14: 688-694.
20. Stéphenne, X., M. Najimi, C. Sibille, et al. 2006. Sustained engraftment and tissue enzyme activity after liver cell transplantation for argininosuccinate lyase deficiency. Gastroenterology 130: 1317-1323.
21. Fox, I.J. & J.R. Chowdhury. 2004. Hepatocyte transplantation. Am. J. Transplantation 4: 7-13.
22. Dhawan, A., R.R. Mitry, R.D. Hughes, et al. 2004. Hepatocyte transplantation for inherited factor VII deficiency. Transplantation 78: 1812-1814.
23. Muraca, M., G. Gerunda, D. Neri, et al. 2002. Hepatocyte transplantation as a treatment for glycogen storage disease type 1a. Lancet 359: 317-318.
24. Bohnen, N.I., M. Charron, J. Reyes, et al. 2000. Use of indium-111-labeled hepatocytes to determine the biodistribution of transplanted hepatocytes through portal vein infusion. Clin. Nucl. Med. 25: 447-450.
25. Dhawan, A., J. Puppi, R.D. Hughes & R.R. Mitry. 2010. Human hepatocyte transplantation: current experience and future challenges. Nat. Rev. Gastroenterol. Hepatol. 7: 288-298.
26. Gupta, S., P. Rajvanshi, R. Sokhi, et al. 1999. Entry and integration of transplanted hepatocytes in rat liver plates occur by disruption of hepatic sinusoidal endothelium. Hepatology 29: 509-519.
27. Malhi, H., B. Joseph, M.L. Schilsky & S. Gupta. 2008. Development of cell therapy strategies to overcome copper toxicity in the LEC rat model of Wilson disease. Regen. Med. 3: 165-173.
28. Hughes, R.D., R.R. Mitry & A. Dhawan. 2012. Current status of hepatocyte transplantation. Transplantation 93: 342-347.
29. Philippeos, C., A. Dhawan, R.D. Hughes, et al. 2010. Effects of ascitic fluid on alginate-encapsulated human hepatocytes in vitro. Hepatology 52: 1106A.
30. Zimmermann, H., S.G. Shirley & U. Zimmermann. 2007. Alginate-based encapsulation of cells: past, present, and future. Curr. Diab. Rep. 7: 314-320.
31. De Vos, P., B. De Haan, J. Pater & R. Van Schilfgaarde. 1996. Association between capsule diameter, adequacy of encapsulation, and survival of microencapsulated rat islet allografts. Transplantation 62: 893-899.
32. Dhawan, A. 2013. Human Hepatocyte Transplantation. CellR4. 1: 50.
33. Fisher, R.A. & S.C. Strom. 2006. Human hepatocyte transplantation: worldwide results. Transplantation 82: 441-449.
34. Dhawan, A., R.R. Mitry & R.D. Hughes. 2006. Hepatocyte transplantation for liver-based metabolic disorders. J. Inherit. Metab. Dis. 29: 431-435.
35. Darwish, A.A., E. Sokal, X. Stephenne, et al. 2004. Permanent access to the portal system for cellular transplantation using an implantable port device. Liver Transplant. 10: 1213-1215.
36. Ambrosino, G., S. Varotto, S.C. Strom, et al. 2005. Isolated hepatocyte transplantation for Crigler-Najjar syndrome type 1. Cell Transplant. 14: 151-157.
37. Lysy, P.A., M. Najimi, X. Stephenne, et al. 2008. Liver cell transplantation for Crigler-Najjar syndrome type I: update and perspectives. World. J. Gastroenterol. 14: 3464-3470.
38. Grossman, M., D.J. Rader, D.W. Muller, et al. 1995. A pilot study of ex vivo gene therapy for homozygous familial hypercholesterolaemia. Nat. Med. 1: 1148-1154.