Overcoming antifungal resistance

Drug Discovery Today: Technologies

Volumn 11, Issue 1, 2014, Pages 65-71

  Srinivasan, Anand ^a,b   Lopez Ribot, Jose L ^b   Ramasubramanian, Anand K ^a,b  

^a The University of Texas at San Antonio   (United States)

^b UNIVERSITY OF TEXAS AT SAN ANTONIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOTERICIN B; ANIDULAFUNGIN; ANTIFUNGAL AGENT; CASPOFUNGIN; FLUCONAZOLE; FLUCYTOSINE; ITRACONAZOLE; KETACONAZOLE; KETOCONAZOLE; MICAFUNGIN; MICONAZOLE; NAFTIFINE; NYSTATIN; POLYENE; POSACONAZOLE; TERBINAFINE; UNCLASSIFIED DRUG; VORICONAZOLE;

ANTIFUNGAL RESISTANCE; ARTICLE; BIOFILM; FUNGAL VIRULENCE; GENOMICS; HUMAN; MICROARRAY ANALYSIS; MICROFLUIDICS; MYCOSIS; NONHUMAN; PROTEOMICS; ANTIBIOTIC RESISTANCE; EARLY DIAGNOSIS; MYCOSES;

ANTIFUNGAL AGENTS; DRUG RESISTANCE, MICROBIAL; EARLY DIAGNOSIS; HUMANS; MYCOSES;

EID: 84899989167     PISSN: None     EISSN: 17406749     Source Type: Journal    
DOI: 10.1016/j.ddtec.2014.02.005     Document Type: Review

References (55)

1. D.L. Hawksworth The magnitude of fungal diversity: the 1.5 million species estimate revisited Mycol Res 105 2001 1422 1432
2. K.J. Kwon-Chung, and J.E. Bennett Medical mycology Rev Inst Med Trop São Paulo 34 1992 504-504
3. M. Knoke, and G. Schwesinger One hundred years ago: the history of cryptococcosis in Greifswald. Medical mycology in the nineteenth century Mycoses 37 7-8 1994 229 233
4. T.J. Walsh, and A.H. Groll Emerging fungal pathogens: evolving challenges to immunocompromised patients for the twenty-first century Transplant Infect Dis 1 4 1999 247 261
5. S. Ascioglu, J.H. Rex, B. de Pauw, J.E. Bennett, J. Bille, and F. Crokaert et al. Defining opportunistic invasive fungal infections in immunocompromised patients with cancer and hematopoietic stem cell transplants: an international consensus Clin Infect Dis 34 1 2002 7 14
6. G.D. Brown, D.W. Denning, N.A. Gow, S.M. Levitz, M.G. Netea, and T.C. White Hidden killers: human fungal infections Sci Transl Med 4 165 2012 165rv113
7. M.M. McNeil, S.L. Nash, R.A. Hajjeh, M.A. Phelan, L.A. Conn, and B.D. Plikaytis et al. Trends in mortality due to invasive mycotic diseases in the United States, 1980-1997 Clin Infect Dis 33 5 2001 641 647
8. S. Fanning, and A.P. Mitchell Fungal biofilms PLoS Pathog 8 4 2012 e1002585
9. L. Ostrosky-Zeichner, K.A. Marr, J.H. Rex, and S.H. Cohen Amphotericin B: time for a new 'gold standard' Clin Infect Dis 37 3 2003 415 425
10. F.C. Odds, A.J. Brown, and N.A. Gow Antifungal agents: mechanisms of action Trends Microbiol 11 6 2003 272 279
11. J.M. Balkovec, D.L. Hughes, P.S. Masurekar, C.A. Sable, R.E. Schwartz, and S.B. Singh Discovery and development of first in class antifungal caspofungin (CANCIDAS[registered sign]) - a case study Nat Prod Rep 2014
12. A. Srinivasan, K.P. Leung, J.L. Lopez-Ribot, and A.K. Ramasubramanian High-throughput nano-biofilm microarray for antifungal drug discovery mBio 4 4 2013
13. P. Uppuluri, A.K. Chaturvedi, A. Srinivasan, M. Banerjee, A.K. Ramasubramaniam, and J.R. Kohler et al. Dispersion as an important step in the Candida albicans biofilm developmental cycle PLoS Pathog 6 3 2010 e1000828
14. P.G. Pappas, Alexander B.D., Andes D.R., Hadley S., Kauffman C.A., and Freifeld A. et al. Invasive fungal infections among organ transplant recipients: results of the Transplant-Associated Infection Surveillance Network (TRANSNET) Clin Infect Dis 50 8 2010 1101 1111
15. J.A. Vazquez, M.H. Miceli, and G. Alangaden Invasive fungal infections in transplant recipients Ther Adv Infect Dis 1 3 2013 85 105
16. S. Perea, J.L. Lopez-Ribot, W.R. Kirkpatrick, R.K. McAtee, R.A. Santillan, and M. Martinez et al. Prevalence of molecular mechanisms of resistance to azole antifungal agents in Candida albicans strains displaying high-level fluconazole resistance isolated from human immunodeficiency virus-infected patients Antimicrob Agents Chemother 45 10 2001 2676 2684
17. J.H. Rex, C.R. Cooper Jr, W.G. Merz, J.N. Galgiani, and E.J. Anaissie Detection of amphotericin B-resistant Candida isolates in a broth-based system Antimicrob Agents Chemother 39 4 1995 906 909
18. B. Collin, C.J. Clancy, and M.H. Nguyen Antifungal resistance in non-albicans Candida species Drug Resist Updates 2 1 1999 9 14
19. E.I. Boutati, and E.J. Anaissie Fusarium, a significant emerging pathogen in patients with hematologic malignancy: ten years' experience at a cancer center and implications for management Blood 90 3 1997 999 1008
20. P.C. Iwen, M.E. Rupp, A.N. Langnas, E.C. Reed, and S.H. Hinrichs Invasive pulmonary aspergillosis due to Aspergillus terreus: 12-year experience and review of the literature Clin Infect Dis 26 5 1998 1092 1097
21. J. Berenguer, J.L. Rodriguez-Tudela, C. Richard, M. Alvarez, M.A. Sanz, and L. Gaztelurrutia et al. Deep infections caused by Scedosporium prolificans. A report on 16 cases in Spain and a review of the literature. Scedosporium prolificans Spanish Study Group Medicine 76 4 1997 256 265
22. D.S. Perlin Current perspectives on echinocandin class drugs Future Microbiol 6 4 2011 441 457
23. D.R. Hospenthal, and J.E. Bennett Flucytosine monotherapy for cryptococcosis Clin Infect Dis 27 2 1998 260 264
24. G. Ramage, R. Rajendran, L. Sherry, and C. Williams Fungal biofilm resistance Int J Microbiol 2012 2012 528521
25. L. Mathe, and P. Van Dijck Recent insights into Candida albicans biofilm resistance mechanisms Curr Genet 59 4 2013 251 264
26. D. Sanglard, and F.C. Odds Resistance of Candida species to antifungal agents: molecular mechanisms and clinical consequences Lancet Infect Dis 2 2 2002 73 85
27. L. Ostrosky-Zeichner Invasive mycoses: diagnostic challenges Am J Med 125 1 Suppl 2012 S14 S24
28. W.W. Hope, T.J. Walsh, and D.W. Denning Laboratory diagnosis of invasive aspergillosis Lancet Infect Dis 5 10 2005 609 622
29. C. Althoff Souza, N.L. Muller, E. Marchiori, D.L. Escuissato, and T. Franquet Pulmonary invasive aspergillosis and candidiasis in immunocompromised patients: a comparative study of the high-resolution CT findings J Thoracic Imaging 21 3 2006 184 189
30. J. Berenguer, M. Buck, F. Witebsky, F. Stock, P.A. Pizzo, and T.J. Walsh Lysis-centrifugation blood cultures in the detection of tissue-proven invasive candidiasis. Disseminated versus single-organ infection Diag Microbiol Infect Dis 17 2 1993 103 109
31. J.R. Perfect, G.M. Cox, J.Y. Lee, C.A. Kauffman, L. de Repentigny, and S.W. Chapman et al. The impact of culture isolation of Aspergillus species: a hospital-based survey of aspergillosis Clin Infect Dis 33 11 2001 1824 1833
32. R. Sherif, and B.H. Segal Pulmonary aspergillosis: clinical presentation, diagnostic tests, management and complications Curr Opin Pulmon Med 16 3 2010 242 250
33. K.W. Garey, M. Rege, M.P. Pai, D.E. Mingo, K.J. Suda, and R.S. Turpin et al. Time to initiation of fluconazole therapy impacts mortality in patients with candidemia: a multi-institutional study Clin Infect Dis 43 1 2006 25 31
34. N. Akamatsu, Y. Sugawara, J. Kaneko, S. Tamura, and M. Makuuchi Preemptive treatment of fungal infection based on plasma (1→3)beta-d-glucan levels after liver transplantation Infection 35 5 2007 346 351
35. N.L. Wengenack, and M.J. Binnicker Fungal molecular diagnostics Clin Chest Med 30 2 2009 391 408 viii
36. A. Philip, Z. Odabasi, G. Matiuzzi, V.L. Paetznick, S.W. Tan, and J. Warmington et al. Syscan3, a kit for detection of anti-Candida antibodies for diagnosis of invasive candidiasis J Clin Microbiol 43 9 2005 4834 4835
37. L. Lehtonen, V.J. Anttila, T. Ruutu, J. Salonen, J. Nikoskelainen, and E. Eerola et al. Diagnosis of disseminated candidiasis by measurement of urine d-arabinitol/l-arabinitol ratio J Clin Microbiol 34 9 1996 2175 2179
38. V. Verdaguer, T.J. Walsh, W. Hope, and K.J. Cortez Galactomannan antigen detection in the diagnosis of invasive aspergillosis Expert Rev Mol Diag 7 1 2007 21 32
39. C.G. Pierce, P. Uppuluri, A.R. Tristan, F.L. Wormley Jr., E. Mowat, and G. Ramage et al. A simple and reproducible 96-well plate-based method for the formation of fungal biofilms and its application to antifungal susceptibility testing Nat Protoc 3 9 2008 1494 1500
40. A. Srinivasan, J.L. Lopez-Ribot, and A.K. Ramasubramanian Candida albicans biofilm chip (CaBChip) for high-throughput antifungal drug screening: Development of a high-throughput Candida albicans biofilm chip J Vis Exp 6 65 2012 e3845
41. A. Srinivasan, P. Uppuluri, J.L. Lopez-Ribot, and A.K. Ramasubramanian Development of a high-throughput Candida albicans biofilm chip PLoS ONE 6 4 2011 e19036
42. N. Robbins, P. Uppuluri, J. Nett, R. Rajendran, G. Ramage, and J.L. Lopez-Ribot et al. Hsp90 governs dispersion and drug resistance of fungal biofilms PLoS Pathog 7 9 2011 e1002257
43. P. Uppuluri, J. Nett, J. Heitman, and D. Andes Synergistic effect of calcineurin inhibitors and fluconazole against Candida albicans biofilms Antimicrob Agents Chemother 52 3 2008 1127 1132
44. J. Oh, E. Fung, U. Schlecht, R.W. Davis, G. Giaever, and R.P. St Onge et al. Gene annotation and drug target discovery in Candida albicans with a tagged transposon mutant collection PLoS Pathog 6 10 2010 e1001140
45. R. Pukkila-Worley, E. Holson, F. Wagner, and E. Mylonakis Antifungal drug discovery through the study of invertebrate model hosts Curr Med Chem 16 13 2009 1588 1595
46. C.G. Pierce, and J.L. Lopez-Ribot Candidiasis drug discovery and development: new approaches targeting virulence for discovering and identifying new drugs Expert Opin Drug Discov 8 9 2013 1117 1126
47. B.G. Hall Predicting the evolution of antibiotic resistance genes Nat Rev Microbiol 2 5 2004 430 435
48. R.W. Holz The effects of the polyene antibiotics nystatin and amphotericin B on thin lipid membranes Ann N Y Acad Sci 235 1 1974 469 479
49. S.L. Kelly, D.C. Lamb, M. Taylor, A.J. Corran, B.C. Baldwin, and W.G. Powderly Resistance to amphotericin B associated with defective sterol delta 8,7 isomerase in a Cryptococcus neoformans strain from an AIDS patient FEMS Microbiol Lett 122 1-2 1994 39 42
50. G. Chamilos, and D.P. Kontoyiannis Update on antifungal drug resistance mechanisms of Aspergillus fumigatus Drug Resist Updates 8 6 2005 344 358
51. D. Sanglard, F. Ischer, L. Koymans, and J. Bille Amino acid substitutions in the cytochrome P-450 lanosterol 14α-demethylase (CYP51A1) from azole-resistant Candida albicans clinical isolates contribute to resistance to azole antifungal agents Antimicrob Agents Chemother 42 2 1998 241 253
52. J.L. Lopez-Ribot, R.K. McAtee, L.N. Lee, W.R. Kirkpatrick, T.C. White, and D. Sanglard et al. Distinct patterns of gene expression associated with development of fluconazole resistance in serial candida albicans isolates from human immunodeficiency virus-infected patients with oropharyngeal candidiasis Antimicrob Agents Chemother 42 11 1998 2932 2937
53. A. Lupetti, R. Danesi, M. Campa, M. Del Tacca, and S. Kelly et al. Molecular basis of resistance to azole antifungals Trends Mol Med 8 2 2002 76 81
54. D.S. Perlin Resistance to echinocandin-class antifungal drugs Drug Resist Updates 10 3 2007 121 130
55. N.S. Ryder, and I. Leitner Synergistic interaction of terbinafine with triazoles or amphotericin B against Aspergillus species Med Mycol 39 1 2001 91 95