Function-regulating pharmacophores in a sulfonamide class of glucocorticoid receptor agonists

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 24, 2013, Pages 6640-6644

  Kuzmich, Daniel ^a   Bentzien, Jörg ^a   Betageri, Raj ^a   Disalvo, Darren ^a   Fadra Khan, Tazmeen ^a   Harcken, Christian ^a   Kukulka, Alison ^a   Nabozny, Gerald ^a   Nelson, Richard ^a   Pack, Edward ^a   Souza, Donald ^a   Thomson, David ^a  

^a BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

Author keywords

Arylsulfonamide; Collagen induced arthritis; Glucocorticoid receptor; Glucocorticoids; Inflammation; Mineralocorticoid receptor; Nuclear hormone receptor; Progesterone receptor

Indexed keywords

GLUCOCORTICOID RECEPTOR; SULFONAMIDE;

ARTICLE; CONTROLLED STUDY; IC 50; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; MOLECULAR MODEL; PHARMACOPHORE; STRUCTURE ACTIVITY RELATION;

ARYLSULFONAMIDE; COLLAGEN INDUCED ARTHRITIS; GLUCOCORTICOID RECEPTOR; GLUCOCORTICOIDS; INFLAMMATION; MINERALOCORTICOID RECEPTOR; NUCLEAR HORMONE RECEPTOR; PROGESTERONE RECEPTOR;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ARTHRITIS; BINDING SITES; MICE; MOLECULAR DOCKING SIMULATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, GLUCOCORTICOID; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; TRYPTAMINES;

EID: 84888874682     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.10.052     Document Type: Article

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