Design and synthesis of highly potent HIV-1 protease inhibitors with novel isosorbide-derived P2 ligands

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 11, 2014, Pages 2465-2468

  Qiu, Xin ^a   Zhao, Guo Dong ^a   Tang, Long Qiang ^a   Liu, Zhao Peng ^a  

^a SHANDONG UNIVERSITY   (China)

Author keywords

Design; Drug resistant; HIV 1 protease inhibitors; Isosorbides; P2 ligand; Synthesis

Indexed keywords

HUMAN IMMUNODEFICIENCY VIRUS PROTEINASE INHIBITOR; INDINAVIR; ISOSORBIDE DERIVATIVE; HUMAN IMMUNODEFICIENCY VIRUS PROTEINASE; ISOSORBIDE; LIGAND;

ARTICLE; BIOLOGICAL ACTIVITY; CATALYSIS; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; HUMAN IMMUNODEFICIENCY VIRUS 1; HYDROGEN BOND; HYDROGENATION; IC 50; LIGAND BINDING; MOLECULAR DOCKING; STEREOCHEMISTRY; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; DOSE RESPONSE; DRUG EFFECTS; ENZYMOLOGY; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

HUMAN IMMUNODEFICIENCY VIRUS 1;

DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; HIV PROTEASE; HIV PROTEASE INHIBITORS; HIV-1; ISOSORBIDE; LIGANDS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84899977772     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.04.008     Document Type: Article

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