Neuroprotective effects of JGK-263 in transgenic SOD1-G93A mice of amyotrophic lateral sclerosis

Journal of the Neurological Sciences

Volumn 340, Issue 1-2, 2014, Pages 112-116

  Ahn, Suk Won ^a   Jeon, Gye Sun ^b   Kim, Myung Jin ^b   Shon, Jee Heun ^b   Kim, Jee Eun ^c   Shin, Je Young ^b   Kim, Sung Min ^b   Kim, Seung Hyun ^d   Ye, In Hae ^e   Lee, Kwang Woo ^b   Hong, Yoon Ho ^f   Sung, Jung Joon ^b  

^a Chung Ang University College of Medicine   (South Korea)

^b Seoul National University Hospital   (South Korea)

^c Seoul Medical Center   (South Korea)

^d Hanyang University College of Medicine   (South Korea)

^e Jeil Pharmaceutical Co Ltd   (South Korea)

^f Seoul National University College of Medicine   (South Korea)

Author keywords

ALS; Amyotrophic lateral sclerosis; Glycogen synthase kinase 3; GSK 3 inhibitor; JGK 263; Transgenic mouse

Indexed keywords

CASPASE 3; CHOLINE ACETYLTRANSFERASE; CYTOCHROME C; GLYCOGEN SYNTHASE KINASE 3BETA; JGK 263; NEUROPROTECTIVE AGENT; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P85; PROTEIN SERINE THREONINE KINASE INHIBITOR; UNCLASSIFIED DRUG; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; POLY(ADP-RIBOSE)POLYMERASE-1, MOUSE; SOD1 G93A PROTEIN; SUPEROXIDE DISMUTASE;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; IN VITRO STUDY; LUMBAR SPINE; MOTONEURON; MOTOR ACTIVITY; MOTOR NERVE; MOUSE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; ROTAROD TEST; SPINAL CORD VENTRAL HORN; SURVIVAL RATE; TRANSGENIC MOUSE; WESTERN BLOTTING; ANALYSIS OF VARIANCE; ANIMAL; ANTAGONISTS AND INHIBITORS; DISEASE MODEL; DRUG EFFECTS; GENETICS; HUMAN; METABOLISM; PATHOLOGY; SINGLE BLIND PROCEDURE; SPINAL CORD; TIME;

AMYOTROPHIC LATERAL SCLEROSIS; ANALYSIS OF VARIANCE; ANIMALS; CASPASE 3; CHOLINE O-ACETYLTRANSFERASE; CYTOCHROMES C; DISEASE MODELS, ANIMAL; GLYCOGEN SYNTHASE KINASE 3; HUMANS; MICE; MICE, TRANSGENIC; MOTOR ACTIVITY; MOTOR NEURONS; NEUROPROTECTIVE AGENTS; PHOSPHATIDYLINOSITOL 3-KINASES; POLY(ADP-RIBOSE) POLYMERASES; SINGLE-BLIND METHOD; SPINAL CORD; SUPEROXIDE DISMUTASE; TIME FACTORS;

EID: 84899975138     PISSN: 0022510X     EISSN: 18785883     Source Type: Journal    
DOI: 10.1016/j.jns.2014.03.008     Document Type: Article

References (20)

1. A. Okado-Matsumoto, and I. Fridovich Amyotrophic lateral sclerosis: a proposed mechanism Proc Natl Acad Sci U S A 99 2002 9010 9014
2. Y. Doi, T. Yokoyama, T. Tango, K. Takahashi, K. Fujimoto, and I. Nakano Temporal trends and geographic clusters of mortality from amyotrophic lateral sclerosis in Japan 1995-2004 J Neurol Sci 298 2010 78 84
3. F. Fornai, P. Longone, L. Cafaro, O. Kastsiuchenka, M. Ferrucci, and M.L. Manca et al. Lithium delays progression of amyotrophic lateral sclerosis Proc Natl Acad Sci U S A 105 2008 2052 2057
4. K. Yamanaka, S.J. Chun, S. Boillee, N. Fujimori-Tonou, H. Yamashita, and D.H. Gutmann et al. Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis Nat Neurosci 11 2008 251 253
5. Q. Wang, J.L. Johnson, N.Y. Agar, and J.N. Agar Protein aggregation and protein instability govern familial amyotrophic lateral sclerosis patient survival PLoS Biol 6 2008 e170
6. J. Sreedharan, I.P. Blair, V.B. Tripathi, X. Hu, C. Vance, and B. Rogelj et al. TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis Science 319 2008 1668 1672
7. S.H. Koh, Y. Kim, H.Y. Kim, S. Hwang, C.H. Lee, and S.H. Kim Inhibition of glycogen synthase kinase-3 suppresses the onset of symptoms and disease progression of G93A-SOD1 mouse model of ALS Exp Neurol 205 2007 336 346
8. R.V. Bhat, S.L. Budd Haeberlein, and J. Avila Glycogen synthase kinase 3: a drug target for CNS therapies J Neurochem 89 2004 1313 1317
9. S.W. Ahn, J.E. Kim, K.S. Park, W.J. Choi, Y.H. Hong, and S.M. Kim et al. The neuroprotective effect of the GSK-3β inhibitor and influence on the extrinsic apoptosis in the ALS transgenic mice J Neurol Sci 320 2012 1 5
10. G.S. Jeon, J.E. Kim, S.W. Ahn, K.S. Park, Y.H. Hong, and I.H. Ye et al. Effect of JGK-263 as a new glycogen synthase kinase-3β inhibitor on extrinsic apoptosis pathway in motor neuronal cells Biochem Biophys Res Commun 439 2013 309 314
11. M.Y. Noh, K. Chun, B.Y. Kang, H. Kim, J.S. Park, and H.C. Lee et al. Newly developed glycogen synthase kinase-3 (GSK-3) inhibitors protect neuronal cells death in amyloid-beta induced cell model and in a transgenic mouse model of Alzheimer's disease Biochem Biophys Res Commun 435 2013 274 281
12. S.M. Kim, H. Kim, J.S. Lee, K.S. Park, G.S. Jeon, and J. Shon et al. Intermittent hypoxia can aggravate motor neuronal loss and cognitive dysfunction in ALS mice PLoS One 8 2013 e81808
13. M. Pap, and G.M. Cooper Role of translation initiation factor 2B in control of cell survival by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3β signaling pathway Mol Cell Biol 22 2003 578 586
14. P. Watcharasit, G.N. Bijur, L. Song, J. Zhu, X. Chen, and R.S. Jope Glycogen synthase kinase-3beta (GSK3beta) binds to and promotes the actions of p53 J Biol Chem 278 2003 48872 48879
15. M. Peviani, C. Cheroni, F. Troglio, M. Quarto, G. Pelicci, and C. Bendotti Lack of changes in the PI3K/AKT survival pathway in the spinal cord motor neurons of a mouse model of familial amyotrophic lateral sclerosis Mol Cell Neurosci 34 2007 592 602
16. X. Wu, T. Kihara, A. Akaike, T. Niidome, and H. Sugimoto PI3K/Akt/mTOR signaling regulates glutamate transporter 1 in astrocytes Biochem Biophys Res Commun 393 2010 514 518
17. Q. Wang, Y. Zhou, X. Wang, and B.M. Evers Glycogen synthase kinase-3 is a negative regulator of extracellular signal-regulated kinase Oncogene 25 2006 43 50
18. E. Beurel, and R.S. Jope The paradoxical pro- and anti-apoptotic actions of GSK3 in the intrinsic and extrinsic apoptosis signaling pathways Prog Neurobiol 79 2006 173 189
19. I.G. Kirkinezos, S.R. Bacman, D. Hernandez, J. Oca-Cossio, L.J. Arias, and M.A. Perez-Pinzon et al. Cytochrome c association with the inner mitochondrial membrane is impaired in the CNS of G93A-SOD1 mice J Neurosci 25 2005 164 172
20. J.E. Forde, and T.C. Dale Glycogen synthase kinase 3: a key regulator of cellular fate Cell Mol Life Sci 64 2007 1930 1944