A new combination approach of CI jet and QESD to formulate pH-susceptible amorphous solid dispersions

International Journal of Pharmaceutics

Volumn 466, Issue 1-2, 2014, Pages 368-374

  Kumar, Sumit ^a   Linehan, Brian ^b   Tseng, Yin Chao ^b  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

Author keywords

Amorphous; DoE; pH susceptible; Solid dispersion; Solubility enhancement

Indexed keywords

ACETONE; BI 906; DICHLOROMETHANE; DRUG; DRUG SOLVENT; HYDROXYPROPYLMETHYLCELLULOSE; HYDROXYPROPYLMETHYLCELLULOSE PHTHALATE; SODIUM DIHYDROGEN PHOSPHATE; STABILIZING AGENT; UNCLASSIFIED DRUG; WATER; METHYLCELLULOSE; SOLVENT;

AMORPHOUS SOLID DISPERSION; ARTICLE; CONFINED IMPINGING JET; CRYSTALLIZATION; DRUG DELIVERY SYSTEM; DRUG DESIGN PROGRAM; DRUG FORMULATION; DRUG RELEASE; DRUG SOLUBILITY; ENCAPSULATION; FLOW RATE; IN VITRO STUDY; MICROSCOPY; PARTICLE SIZE; PH; PHARMACEUTICAL ENGINEERING; PRIORITY JOURNAL; QUASI EMULSION SOLVENT DIFFUSION; SOLID STATE; X RAY POWDER DIFFRACTION; ANALOGS AND DERIVATIVES; CHEMISTRY; DEVICES; DIFFUSION; MEDICINAL CHEMISTRY; PHARMACEUTICS; PROCEDURES;

ACETONE; CHEMISTRY, PHARMACEUTICAL; DIFFUSION; HYDROGEN-ION CONCENTRATION; METHYLCELLULOSE; METHYLENE CHLORIDE; PHARMACEUTICAL PREPARATIONS; SOLVENTS; TECHNOLOGY, PHARMACEUTICAL;

EID: 84899974291     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.03.042     Document Type: Article

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