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Volumn 22, Issue 5, 2014, Pages 1287-1295

Effects of a novel MC4R agonist on maintenance of reduced body weight in diet-induced obese mice

Author keywords

[No Author keywords available]

Indexed keywords

AZD 2820; GLUCOSE; INSULIN; LEPTIN; MELANOCORTIN RECEPTOR AGONIST; UNCLASSIFIED DRUG; GLUCOSE BLOOD LEVEL; HORMONE; MC4R PROTEIN, MOUSE; MELANOCORTIN 4 RECEPTOR;

EID: 84899961471     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1002/oby.20678     Document Type: Article
Times cited : (11)

References (34)
  • 1
    • 0033162787 scopus 로고    scopus 로고
    • Behavioral strategies of individuals who have maintained long-term weight losses
    • McGuire MT, Wing RR, Klem ML, Hill JO,. Behavioral strategies of individuals who have maintained long-term weight losses. Obes Res 1999; 7: 334-341.
    • (1999) Obes Res , vol.7 , pp. 334-341
    • McGuire, M.T.1    Wing, R.R.2    Klem, M.L.3    Hill, J.O.4
  • 2
    • 0028959193 scopus 로고
    • Changes in energy expenditure resulting from altered body weight
    • Leibel RL, Rosenbaum M, Hirsch J,. Changes in energy expenditure resulting from altered body weight. N Engl J Med 1995; 332: 621-628.
    • (1995) N Engl J Med , vol.332 , pp. 621-628
    • Leibel, R.L.1    Rosenbaum, M.2    Hirsch, J.3
  • 3
    • 79958807282 scopus 로고    scopus 로고
    • Effects of chronic weight perturbation on energy homeostasis and brain structure in mice
    • Ravussin Y, Gutman R, Diano S, et al. Effects of chronic weight perturbation on energy homeostasis and brain structure in mice. Am J Physiol Regul Integr Comp Physiol 2011; 300: R1352-R1362.
    • (2011) Am J Physiol Regul Integr Comp Physiol , vol.300
    • Ravussin, Y.1    Gutman, R.2    Diano, S.3
  • 4
    • 0038650880 scopus 로고    scopus 로고
    • Effects of experimental weight perturbation on skeletal muscle work efficiency in human subjects
    • Rosenbaum M, Vandenborne K, Goldsmith R, et al. Effects of experimental weight perturbation on skeletal muscle work efficiency in human subjects. Am J Physiol Regul Integr Comp Physiol 2003; 285: R183-R192.
    • (2003) Am J Physiol Regul Integr Comp Physiol , vol.285
    • Rosenbaum, M.1    Vandenborne, K.2    Goldsmith, R.3
  • 6
    • 46749099010 scopus 로고    scopus 로고
    • Leptin reverses weight loss-induced changes in regional neural activity responses to visual food stimuli
    • Rosenbaum M, Sy M, Pavlovich K, Leibel RL, Hirsch J,. Leptin reverses weight loss-induced changes in regional neural activity responses to visual food stimuli. J Clin Invest 2008; 118: 2583-2591.
    • (2008) J Clin Invest , vol.118 , pp. 2583-2591
    • Rosenbaum, M.1    Sy, M.2    Pavlovich, K.3    Leibel, R.L.4    Hirsch, J.5
  • 7
    • 84875288613 scopus 로고    scopus 로고
    • Effects of reduced weight maintenance and leptin repletion on functional connectivity of the hypothalamus in obese humans
    • Hinkle W, Cordell M, Leibel R, Rosenbaum M, Hirsch J,. Effects of reduced weight maintenance and leptin repletion on functional connectivity of the hypothalamus in obese humans. PLoS One 2013; 8: e59114.
    • (2013) PLoS One , vol.8
    • Hinkle, W.1    Cordell, M.2    Leibel, R.3    Rosenbaum, M.4    Hirsch, J.5
  • 8
    • 31044444463 scopus 로고    scopus 로고
    • Low-dose leptin reverses skeletal muscle, autonomic, and neuroendocrine adaptations to maintenance of reduced weight
    • Rosenbaum M, Goldsmith R, Bloomfield D, et al. Low-dose leptin reverses skeletal muscle, autonomic, and neuroendocrine adaptations to maintenance of reduced weight. J Clin Invest 2005; 115: 3579-3586.
    • (2005) J Clin Invest , vol.115 , pp. 3579-3586
    • Rosenbaum, M.1    Goldsmith, R.2    Bloomfield, D.3
  • 9
    • 84856399476 scopus 로고    scopus 로고
    • Leptin reverses declines in satiation in weight-reduced obese humans
    • Kissileff HR, Thornton JC, Torres MI, et al. Leptin reverses declines in satiation in weight-reduced obese humans. Am J Clin Nutr 2012; 95: 309-317.
    • (2012) Am J Clin Nutr , vol.95 , pp. 309-317
    • Kissileff, H.R.1    Thornton, J.C.2    Torres, M.I.3
  • 10
    • 22144457639 scopus 로고    scopus 로고
    • Microanalysis of eating behavior of three leptin deficient adults treated with leptin therapy
    • Williamson DA, Ravussin E, Wong ML, et al. Microanalysis of eating behavior of three leptin deficient adults treated with leptin therapy. Appetite 2005; 45: 75-80.
    • (2005) Appetite , vol.45 , pp. 75-80
    • Williamson, D.A.1    Ravussin, E.2    Wong, M.L.3
  • 11
    • 36749097922 scopus 로고    scopus 로고
    • Leptin replacement alters brain response to food cues in genetically leptin-deficient adults
    • Baicy K, London ED, Monterosso J, et al. Leptin replacement alters brain response to food cues in genetically leptin-deficient adults. Proc Natl Acad Sci U S A 2007; 104: 18276-18279.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 18276-18279
    • Baicy, K.1    London, E.D.2    Monterosso, J.3
  • 12
    • 85011486581 scopus 로고    scopus 로고
    • A leptin dose-response study in obese (ob/ob) and lean (+/?) mice
    • Harris RB, Zhou J, Redmann SM, Jr. , et al. A leptin dose-response study in obese (ob/ob) and lean (+/?) mice. Endocrinology 1998; 139: 8-19.
    • (1998) Endocrinology , vol.139 , pp. 8-19
    • Harris, R.B.1    Zhou, J.2    Redmann Jr., S.M.3
  • 13
    • 0032747280 scopus 로고    scopus 로고
    • Recombinant leptin for weight loss in obese and lean adults: A randomized, controlled, dose-escalation trial
    • Heymsfield SB, Greenberg AS, Fujioka K, et al. Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial. JAMA 1999; 282: 1568-1575.
    • (1999) JAMA , vol.282 , pp. 1568-1575
    • Heymsfield, S.B.1    Greenberg, A.S.2    Fujioka, K.3
  • 15
    • 0027227288 scopus 로고
    • Molecular cloning, expression, and gene localization of a fourth melanocortin receptor
    • Gantz I, Miwa H, Konda Y, et al. Molecular cloning, expression, and gene localization of a fourth melanocortin receptor. J Biol Chem 1993; 268: 15174-15179.
    • (1993) J Biol Chem , vol.268 , pp. 15174-15179
    • Gantz, I.1    Miwa, H.2    Konda, Y.3
  • 16
    • 0041624549 scopus 로고    scopus 로고
    • Transgenic mice expressing green fluorescent protein under the control of the melanocortin-4 receptor promoter
    • Liu H, Kishi T, Roseberry AG, et al. Transgenic mice expressing green fluorescent protein under the control of the melanocortin-4 receptor promoter. J Neurosci 2003; 23: 7143-7154.
    • (2003) J Neurosci , vol.23 , pp. 7143-7154
    • Liu, H.1    Kishi, T.2    Roseberry, A.G.3
  • 17
    • 84867136887 scopus 로고    scopus 로고
    • Melanocortin-4 receptor expression in different classes of spinal and vagal primary afferent neurons in the mouse
    • Gautron L, Lee CE, Lee S, Elmquist JK,. Melanocortin-4 receptor expression in different classes of spinal and vagal primary afferent neurons in the mouse. J Comp Neurol 2012; 520: 3933-3948.
    • (2012) J Comp Neurol , vol.520 , pp. 3933-3948
    • Gautron, L.1    Lee, C.E.2    Lee, S.3    Elmquist, J.K.4
  • 18
    • 74049115069 scopus 로고    scopus 로고
    • Melanocortin-4 receptor expression in a vago-vagal circuitry involved in postprandial functions
    • Gautron L, Lee C, Funahashi H, Friedman J, Lee S, Elmquist J,. Melanocortin-4 receptor expression in a vago-vagal circuitry involved in postprandial functions. J Comp Neurol 2010; 518: 6-24.
    • (2010) J Comp Neurol , vol.518 , pp. 6-24
    • Gautron, L.1    Lee, C.2    Funahashi, H.3    Friedman, J.4    Lee, S.5    Elmquist, J.6
  • 21
    • 0036312394 scopus 로고    scopus 로고
    • Effects of acute and chronic administration of the melanocortin agonist MTII in mice with diet-induced obesity
    • Pierroz DD, Ziotopoulou M, Ungsunan L, Moschos S, Flier JS, Mantzoros CS,. Effects of acute and chronic administration of the melanocortin agonist MTII in mice with diet-induced obesity. Diabetes 2002; 51: 1337-1345.
    • (2002) Diabetes , vol.51 , pp. 1337-1345
    • Pierroz, D.D.1    Ziotopoulou, M.2    Ungsunan, L.3    Moschos, S.4    Flier, J.S.5    Mantzoros, C.S.6
  • 22
    • 0036515969 scopus 로고    scopus 로고
    • Chronic application of MTII in a rat model of obesity results in sustained weight loss
    • Hamilton BS, Doods HN,. Chronic application of MTII in a rat model of obesity results in sustained weight loss. Obes Res 2002; 10: 182-187.
    • (2002) Obes Res , vol.10 , pp. 182-187
    • Hamilton, B.S.1    Doods, H.N.2
  • 23
    • 70349299827 scopus 로고    scopus 로고
    • Obese reversal by a chronic energy restricted diet leaves an increased Arc NPY/AgRP, but no alteration in POMC/CART, mRNA expression in diet-induced obese mice
    • Yu Y, Deng C, Huang XF,. Obese reversal by a chronic energy restricted diet leaves an increased Arc NPY/AgRP, but no alteration in POMC/CART, mRNA expression in diet-induced obese mice. Behav Brain Res 2009; 205: 50-56.
    • (2009) Behav Brain Res , vol.205 , pp. 50-56
    • Yu, Y.1    Deng, C.2    Huang, X.F.3
  • 24
    • 0032130554 scopus 로고    scopus 로고
    • Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons
    • Hahn TM, Breininger JF, Baskin DG, Schwartz MW,. Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons. Nat Neurosci 1998; 1: 271-272.
    • (1998) Nat Neurosci , vol.1 , pp. 271-272
    • Hahn, T.M.1    Breininger, J.F.2    Baskin, D.G.3    Schwartz, M.W.4
  • 25
    • 60849087959 scopus 로고    scopus 로고
    • Central and peripheral effects of chronic food restriction and weight restoration in the rat
    • Kinzig KP, Hargrave SL, Tao EE,. Central and peripheral effects of chronic food restriction and weight restoration in the rat. Am J Physiol Endocrinol Metab 2009; 296: E282-E290.
    • (2009) Am J Physiol Endocrinol Metab , vol.296
    • Kinzig, K.P.1    Hargrave, S.L.2    Tao, E.E.3
  • 27
    • 84899898191 scopus 로고    scopus 로고
    • Melanocortin receptor-specific peptides. U.P. Office 2013;8,455,617B2
    • Melanocortin receptor-specific peptides. U.P. Office 2013;8,455,617B2.
  • 28
    • 79958806992 scopus 로고    scopus 로고
    • Reproducibility and accuracy of body composition assessments in mice by dual energy x-ray absorptiometry and time domain nuclear magnetic resonance
    • Halldorsdottir S, Carmody J, Boozer CN, Leduc CA, Leibel RL,. Reproducibility and accuracy of body composition assessments in mice by dual energy x-ray absorptiometry and time domain nuclear magnetic resonance. Int J Body Compos Res 2009; 7: 147-154.
    • (2009) Int J Body Compos Res , vol.7 , pp. 147-154
    • Halldorsdottir, S.1    Carmody, J.2    Boozer, C.N.3    Leduc, C.A.4    Leibel, R.L.5
  • 29
    • 11244325044 scopus 로고    scopus 로고
    • Peripherally administered [Nle4,D-Phe7]-alpha-melanocyte stimulating hormone increases resting metabolic rate, while peripheral agouti-related protein has no effect, in wild type C57BL/6 and ob/ob mice
    • Hoggard N, Rayner DV, Johnston SL, Speakman JR,. Peripherally administered [Nle4,D-Phe7]-alpha-melanocyte stimulating hormone increases resting metabolic rate, while peripheral agouti-related protein has no effect, in wild type C57BL/6 and ob/ob mice. J Mol Endocrinol 2004; 33: 693-703.
    • (2004) J Mol Endocrinol , vol.33 , pp. 693-703
    • Hoggard, N.1    Rayner, D.V.2    Johnston, S.L.3    Speakman, J.R.4
  • 30
    • 0000304384 scopus 로고    scopus 로고
    • Role of the melanocortin-4 receptor in metabolic rate and food intake in mice
    • Chen AS, Metzger JM, Trumbauer ME, et al. Role of the melanocortin-4 receptor in metabolic rate and food intake in mice. Transgenic Res 2000; 9: 145-154.
    • (2000) Transgenic Res , vol.9 , pp. 145-154
    • Chen, A.S.1    Metzger, J.M.2    Trumbauer, M.E.3
  • 32
    • 84873053314 scopus 로고    scopus 로고
    • Chronic treatment with a melanocortin-4 receptor agonist causes weight loss, reduces insulin resistance, and improves cardiovascular function in diet-induced obese rhesus macaques
    • Kievit P, Halem H, Marks DL, et al. Chronic treatment with a melanocortin-4 receptor agonist causes weight loss, reduces insulin resistance, and improves cardiovascular function in diet-induced obese rhesus macaques. Diabetes 2013; 62: 490-497.
    • (2013) Diabetes , vol.62 , pp. 490-497
    • Kievit, P.1    Halem, H.2    Marks, D.L.3
  • 33
    • 23844458359 scopus 로고    scopus 로고
    • The effect of the melanocortin agonist, MT-II, on the defended level of body adiposity
    • Seeley RJ, Burklow ML, Wilmer KA, et al. The effect of the melanocortin agonist, MT-II, on the defended level of body adiposity. Endocrinology 2005; 146: 3732-3738.
    • (2005) Endocrinology , vol.146 , pp. 3732-3738
    • Seeley, R.J.1    Burklow, M.L.2    Wilmer, K.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.