The effect of trauma-focused therapy on the altered T cell distribution in individuals with PTSD: Evidence from a randomized controlled trial

Journal of Psychiatric Research

Volumn 54, Issue 1, 2014, Pages 1-10

  Morath, Julia ^a   Gola, Hannah ^b   Sommershof, Annette ^a   Hamuni, Gilava ^b   Kolassa, Stephan ^c   Catani, Claudia ^d   Adenauer, Hannah ^a   Ruf Leuschner, Martina ^a   Schauer, Maggie ^a   Elbert, Thomas ^a   Groettrup, Marcus ^a,e   Kolassa, Iris Tatjana ^a,b  

^a UNIVERSITY OF KONSTANZ   (Germany)

^b UNIVERSITY OF ULM   (Germany)

^c SAP AG   (Switzerland)

^d BIELEFELD UNIVERSITY   (Germany)

^e UNIVERSITY OF KONSTANZ   (Switzerland)

Author keywords

Narrative exposure therapy (NET); Posttraumatic stress disorder (PTSD); Psychotherapy; Regulatory T cells; T lymphocytes

Indexed keywords

CD45RA ANTIGEN; CHEMOKINE RECEPTOR CCR7; LEUKOCYTE ANTIGEN;

ADOLESCENT; ADULT; ARTICLE; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; CONTROLLED STUDY; EVIDENCE BASED PRACTICE; FEMALE; FOLLOW UP; GENERAL CONDITION IMPROVEMENT; HOSPITAL ADMISSION; HUMAN; IMMUNE RESPONSE; MALE; MEMORY T LYMPHOCYTE; NARRATIVE EXPOSURE THERAPY; NARRATIVE THERAPY; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REGULATORY T LYMPHOCYTE; BEHAVIOR THERAPY; IMMUNOLOGY; MIDDLE AGED; NONPARAMETRIC TEST; PATHOLOGY; PHENOTYPE; PROCEDURES; PSYCHOLOGY; STRESS DISORDERS, POST-TRAUMATIC; T LYMPHOCYTE; TREATMENT OUTCOME; YOUNG ADULT;

ADOLESCENT; ADULT; ANTIGENS, CD; FEMALE; FOLLOW-UP STUDIES; HUMANS; IMPLOSIVE THERAPY; MALE; MIDDLE AGED; PHENOTYPE; STATISTICS, NONPARAMETRIC; STRESS DISORDERS, POST-TRAUMATIC; T-LYMPHOCYTES; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84899956233     PISSN: 00223956     EISSN: 18791379     Source Type: Journal    
DOI: 10.1016/j.jpsychires.2014.03.016     Document Type: Article

References (64)

1. Altemus M., Dhabhar F.S., Yang R. Immune function in PTSD. Annals of the New York Academy of Sciences 2006, 1071:167-183.
2. Antoni M.H., Carrico A.W., Durán R.E., Spitzer S., Penedo F., Ironson G., et al. Randomized clinical trial of cognitive behavioral stress management on human immunodeficiency virus viral load in gay men treated with highly active antiretroviral therapy. Psychosomatic Medicine 2006, 68:143-151.
3. Bennett C., Christie J., Ramsdell F., ME B., Ferguson P., Whitesell L., et al. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nature Genetics 2001, 27:20-21.
4. Blake D.D., Weathers F.W., Nagy L.M., Kaloupek D.G., Gusman F.D., Charney D.S., et al. The development of a clinician-administered PTSD scale. Journal of Traumatic Stress 1995, 8:75-90.
5. Bohus M., Dyer A.S., Priebe K., Krüger A., Kleindienst N., Schmahl C., et al. Dialectical behaviour therapy for post-traumatic stress disorder after childhood sexual abuse in patients with and without borderline personality disorder: a randomised controlled trial. Psychotherapy and Psychosomatics 2013, 82:221-233.
6. Boscarino J. Posttraumatic stress disorder and physical illness: results from clinical and epidemiologic studies. Annals of the New York Academy of Sciences 2004, 1032:141-153.
7. Boscarino J., Chang J. Higher abnormal leukocyte and lymphocyte counts 20 years after exposure to severe stress: research and clinical implications. Psychosomatic Medicine 1999, 61:378-386.
8. Boscarino J., Forsberg C.W., Goldberg J. A twin study of the association between PTSD symptoms and rheumatoid arthritis. Psychosomatic Medicine 2010, 72:481-486.
9. Bosch J.A., Fischer J.E., Fischer J.C. Psychologically adverse work conditions are associated with CD8+ T cell differentiation indicative of immunesenescence. Brain, Behavior, and Immunity 2009, 23:527-534.
10. Buckner J. Mechanisms of impaired regulation by CD4+ CD25+ FOXP3+ regulatory T cells in human autoimmune diseases. Nature Reviews in Immunology 2010, 10:849-859.
11. Burnham K.P., Anderson D.R. Model selection and multi-model inference: a practical information - theoretic approach 2002, Springer.
12. Carlson L.E. Mindfulness-based interventions for physical conditions: a narrative review evaluating levels of evidence. ISRN Psychiatry 2012, 2012:1-21.
13. Carrico A.W., Antoni M.H., Pereira D.B., Fletcher M.A., Klimas N., Lechner S.C., et al. Cognitive behavioral stress management effects on mood, social support, and a marker of antiviral immunity are maintained up to 1 year in HIV-infected gay men. International Journal of Behavioral Medicine 2005, 12:218-226.
14. Cloitre M. Effective psychotherapies for posttraumatic stress disorder: a review and critique. CNS Spectrums 2009, 14:32-43.
15. Cools N., Ponsaerts P., Van Tendeloo V.F.I., Berneman Z.N. Regulatory t cells and human disease. Clinical and Developmental Immunology 2007, 89195.
16. Costantino C.M., Baecher-Allan C.M., Hafler D.A. Human regulatory T cells and autoimmunity. European Journal of Immunology 2008, 38:921-924.
17. Creswell J.D., Myers H.F., Cole S.W., Irwin M.R. Mindfulness meditation training effects on CD4+ T lymphocytes in HIV-1 infected adults: a small randomized controlled trial. Brain Behavior, and Immunity 2009, 23:184-188.
18. van Dam D., Ehring T., Vedel E., Emmelkamp P.M. Trauma-focused treatment for posttraumatic stress disorder combined with CBT for severe substance use disorder: a randomized controlled trial. BMC Psychiatry 2013, 13:172-185.
19. Dorshkind K., Montecino-Rodriguez E., Signer R.a J. The ageing immune system: is it ever too old to become young again?. Nature Reviews. Immunology 2009, 9:57-62.
20. Ehlers A., Bisson J., Clark D.M., Creamer M., Pilling S., Richards D., et al. Do all psychological treatments really work the same in posttraumatic stress disorder?. Clinical Psychology Review 2010, 30:269-276.
21. Epel E.S., Blackburn E.H., Lin J., Dhabhar F.S., Adler N.E., Morrow J.D., et al. Accelerated telomere shortening in response to life stress. Proceedings of the National Academy of Sciences of the United States of America 2004, 101:17312-17315.
22. Ertl V., Pfeiffer A., Schauer E., Elbert T., Neuner F. Community-implemented trauma therapy for former child soldiers in Northern Uganda: a randomized controlled trial. JAMA: The Journal of the American Medical Association 2011, 306:503-512.
23. Fagnoni F.F., Vescovini R., Passeri G., Bologna G., Pedrazzoni M., Lavagetto G., et al. Shortage of circulating naive CD8(+) T cells provides new insights on immunodeficiency in aging. Blood 2000, 95:2860-2868.
24. Felitti V.J., Anda R.F., Nordenberg D., Williamson D.F., Spitz A.M., Edwards V., Koss M.P., Marks J.S. Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults. The Adverse Childhood Experiences (ACE) Study. American Journal of Preventive Medicine 1998, 14:245-258.
25. Hamann D., Roos M.T.L., van Lier R.A.W. Faces and phases of human CD8+ T-cell development. Immunology Today 1999, 20:177-180.
26. Hamilton M. A rating scale for depression. Journal of Neurology, Neurosurgery, and Psychiatry 1960, 23:56-62.
27. Hamuni H, Gola H, Sommershof A, Kolassa S, Elbert T, Groettrup M, Kolassa I-T. No reduction of naive and regulatory T cells following examination stress, submitted for publication.
28. Hedges L.V. Distribution theory for glass's estimator of effect size and related estimators. Journal of Educational and Behavioral Statistics 1981, 6:107-128.
29. Hensel-Dittmann D., Schauer M., Ruf M., Catani C., Odenwald M., Elbert T., et al. Treatment of traumatized victims of war and torture: a randomized controlled comparison of narrative exposure therapy and stress inoculation training. Psychotherapy and Psychosomatics 2011, 80:345-352.
30. Himmerich H., Milenović S., Fulda S., Plümäkers B., Sheldrick A.J., Michel T.M., et al. Regulatory T cells increased while IL-1beta decreased during antidepressant therapy. Journal of Psychiatric Research 2010, 44:1052-1057.
31. Hong M.S., Dan J.M., Choi J.-Y., Kang I. Age-associated changes in the frequency of naïve, memory and effector CD8+ T cells. Mechanisms of Ageing and Development 2004, 125:615-618.
32. Hosaka T., Tokuda Y., Sugiyama Y., Hirai K., Okuyama T. Effects of a structured psychiatric intervention on immune function of cancer patients. The Tokai Journal of Experimental and Clinical Medicine 2000, 25:183-188.
33. Ironson G., Wynings C., Schneiderman N., Baum a, Rodriguez M., Greenwood D., et al. Posttraumatic stress symptoms, intrusive thoughts, loss, and immune function after Hurricane Andrew. Psychosomatic Medicine 1997, 59:128-141.
34. Von Känel R., Hepp U., Kraemer B., Traber R., Keel M., Mica L., et al. Evidence for low-grade systemic proinflammatory activity in patients with posttraumatic stress disorder. Journal of Psychiatric Research 2007, 41:744-752.
35. Kawamura N., Kim Y., Asukai N. Suppression of cellular immunity in men with a past history of posttraumatic stress disorder. The American Journal of Psychiatry 2001, 158:484-486.
36. Kiecolt-Glaser J.K., Preacher K.J., Maccallum R.C., Atkinson C., Malarkey W.B., Glaser R. Chronic stress and age-related increases in the proinflammatory cytokine IL-6. PNAS 2003, 100:9090-9095.
37. Kleim B., Grey N., Wild J., Nussbeck F.W., Stott R., Hackmann A., et al. Cognitive change predicts symptom reduction with cognitive therapy for posttraumatic stress disorder. Journal of Consulting and Clinical Psychology 2012, 81:383-393.
38. Kolassa I.T., Ertl V., Eckart C., Kolassa S., Onyut L.P., Elbert T. Spontaneous remission from PTSD depends on the number of traumatic event types experienced. Psychological Trauma: Theory, Research, Practice, and Policy 2010, 2:169-174.
39. Laudenslager M.L., Aasal R., Adler L., Berger C.L., Montgomery P.T., Sandberg E., et al. Elevated cytotoxicity in combat veterans with long-term post-traumatic stress disorder: preliminary observations. Brain, Behavior, and Immunity 1998, 12:74-79.
40. Morath J, Moreno-Villanueva M, Hamuni G, Kolassa S, Ruf-Leuschner M, Schauer M, et al. Effects of psychotherapy on DNA strand break accumulation originating from traumatic stress. Psychotherapy and Psychosomatics; 2014 (in press).
41. Neuner F., Elbert T. The mental health disaster in conflict settings: can scientific research help?. BMC Public Health 2007, 7:275.
42. Neuner F., Onyut P.L., Ertl V., Odenwald M., Schauer E., Elbert T. Treatment of posttraumatic stress disorder by trained lay counselors in an African refugee settlement: a randomized controlled trial. Journal of Consulting and Clinical Psychology 2008, 76:686-694.
43. Neuner F., Schauer M., Karunakara U., Klaschik C., Robert C., Elbert T. Psychological trauma and evidence for enhanced vulnerability for posttraumatic stress disorder through previous trauma among West Nile refugees. BMC Psychiatry 2004, 4:34.
44. Neuner F., Schauer M., Klaschik C., Karunakara U., Elbert T. A comparison of narrative exposure therapy, supportive counseling, and psychoeducation for treating posttraumatic stress disorder in an African refugee settlement. Journal of Consulting and Clinical Psychology 2004, 72:579-587.
45. Pace T.W.W., Heim C.M. A short review on the psychoneuroimmunology of posttraumatic stress disorder: from risk factors to medical comorbidities. Brain Behavior, and Immunity 2011, 25:6-13.
46. Petrie Keith J., Fontanilla I., Thomas M.G., Booth R.J., Pennebaker J.W. Effect of written emotional expression on immune function in patients with human immunodeficiency virus infection: a randomized trial. Psychosomatic Medicine 2004, 66:272-275.
47. Rief W., Hiller W. A new approach to the assessment of the treatment effects of somatoform disorders. Psychosomatics 2003, 44:492-498.
48. Robjant K., Fazel M. The emerging evidence for narrative exposure therapy: a review. Clinical Psychology Review 2010, 30:1030-1039.
49. Sallusto F., Lenig D., Förster R., Lipp M., Lanzavecchia A. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 1999, 401:708-712.
50. Sareen J., Cox B.J., Stein M.B., Afifi T.O., Fleet C., Asmundson G.J.G. Physical and mental comorbidity, disability, and suicidal behavior associated with posttraumatic stress disorder in a large community sample. Psychosomatic Medicine 2007, 69:242-248.
51. Schauer M, Neuner F, Elbert T. Narrative exposure therapy: a short-term treatment for traumatic stress disorders. 2nd revised. Cambridge/Göttingen: Hogrefe & Huber Publishers, 2011a.
52. Schauer M., Neuner F., Elbert T. Vivo event checklist for war, detention, and torture experiences. Narrative exposure therapy: a short-term treatment for traumatic stress disorders 2011, 77-79. Hogrefe & Huber Publishers, Cambridge/Göttingen. 2nd revised.
53. Seidler G.H., Wagner F.E. Comparing the efficacy of EMDR and trauma-focused cognitive-behavioral therapy in the treatment of PTSD: a meta-analytic study. Psychological Medicine 2006, 36:1515-1522.
54. Sheehan D.V., Lecrubier Y., Sheehan K.H., Amorim P., Janavs J., Weiller E., et al. The Mini-International Neuropsychiatric Interview (MINI): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. Journal of Clinical Psychiatry 1998, 59:22-33.
55. Shen S.S., Kim J.S., Weksler M.E. Effect of age on thymic development, T cell immunity, and helper T cell function. Reviews of Physiology, Biochemistry and Pharmacology 1999, 139:123-139.
56. Sherman B.F., Bonanno G a., Wiener L.S., Battles H.B. When children tell their friends they have AIDS: possible consequences for psychological well-being and disease progression. Psychosomatic Medicine 2000, 62:238-247.
57. Sommershof A., Aichinger H., Engler H., Adenauer H., Catani C., Boneberg E.-M., et al. Substantial reduction of naïve and regulatory T cells following traumatic stress. Brain, Behavior, and Immunity 2009, 23:1117-1124.
58. Spitzer C., Barnow S., Völzke H., Wallaschofski H., John U., Freyberger H.J., et al. Association of posttraumatic stress disorder with low-grade elevation of C-reactive protein: evidence from the general population. Journal of Psychiatric Research 2010, 44:15-21.
59. Teicher M.H., Anderson C.M., Polcari A. Childhood maltreatment is associated with reduced volume in the hippocampal subfields CA3, dentate gyrus, and subiculum. Proceedings of the National Academy of Sciences of the United States of America 2012, 109:563-572.
60. Vidović A., Vilibić M., Sabioncello A., Gotovac K., Rabatić S., Folnegović-Smalc V., et al. Circulating lymphocyte subsets, natural killer cell cytotoxicity, and components of hypothalamic-pituitary-adrenal axis in Croatian war veterans with posttraumatic stress disorder: cross-sectional study. Croatian Medical Journal 2007, 48:198-206.
61. Vignali D.A.A., Collison L.W., Workman C.J. How regulatory T cells work. Nature Review Immunology 2008, 8:523-532.
62. Weisberg R.B., Bruce S.E., Machan J.T., Kessler R.C., Culpepper L., Keller M.B. Nonpsychiatric illness among primary care patients with trauma histories and posttraumatic stress disorder. Psychiatric Services 2002, 53:848-854.
63. Wildin R., Smyk-Pearson S., Filipovich A. Clinical and molecular features of the immunodysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndrome. Journal of Medical Genetics 2002, 39:537-545.
64. Wilson S.N., van der Kolk B., Burbridge J., Fisler R., Kradin R. Phenotype of blood lymphocytes in PTSD suggests chronic immune activation. Psychosomatics 1999, 40:222-225.