Kinetic modeling of the monoamine oxidase B radioligand [ 11C]SL25.1188 in human brain with high-resolution positron emission tomography

Journal of Cerebral Blood Flow and Metabolism

Volumn 34, Issue 5, 2014, Pages 883-889

  Rusjan, Pablo M ^a   Wilson, Alan A ^a,b   Miler, Laura ^a   Fan, Ian ^a   Mizrahi, Romina ^a,b   Houle, Sylvain ^a,b   Vasdev, Neil ^c   Meyer, Jeffrey H ^a,b  

^a CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

human; MAO B; modeling; PET; reversible radioligand; 11C SL25.1188

Indexed keywords

5 METHOXYMETHYL 3 [6 (4,4,4 TRIFLUOROBUTOXY) BENZO[DEXTRO]ISOXAZOL 3YL] OXAZOLIDIN 2 C 11; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; RADIOLIGAND; UNCLASSIFIED DRUG;

ADULT; ANIMAL EXPERIMENT; ANTERIOR CINGULATE; ARTICLE; BLOOD ANALYSIS; BLOOD SAMPLING; BRAIN; CAUDATE NUCLEUS; CEREBELLUM CORTEX; CLINICAL ARTICLE; COMPARTMENT MODEL; DISTRIBUTION VOLUME; DRUG BINDING; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG METABOLISM; DRUG STABILITY; DRUG UPTAKE; FEMALE; HUMAN; MALE; NONHUMAN; NORMAL HUMAN; PET SCANNER; PHARMACOKINETICS; PONS; POSITRON EMISSION TOMOGRAPHY; PREFRONTAL CORTEX; PRIORITY JOURNAL; PUTAMEN; RADIOACTIVITY; RAT; REPRODUCIBILITY; TEMPORAL CORTEX; TEST RETEST RELIABILITY; THALAMUS;

ADULT; ANIMALS; BRAIN; CARBON RADIOISOTOPES; FEMALE; HUMANS; KINETICS; MALE; MIDDLE AGED; MONOAMINE OXIDASE; OXAZOLIDINONES; POSITRON-EMISSION TOMOGRAPHY; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; YOUNG ADULT;

EID: 84899940222     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2014.34     Document Type: Article

References (39)

1. Youdim MB, Edmondson D, Tipton KF. The therapeutic potential of monoamine oxidase inhibitors. Nat Rev Neurosci 2006; 7: 295-309.
2. Saura J, Bleuel Z, Ulrich J, Mendelowitsch A, Chen K, Shih JC et al. Molecular neuroanatomy of human monoamine oxidases A and B revealed by quantitative enzyme radioautography and in situ hybridization histochemistry. Neuroscience 1996; 70: 755-774.
3. Saura J, Kettler R, Da Prada M, Richards JG. Quantitative enzyme radioautography with 3H-Ro 41-1049 and 3H-Ro 19-6327 in vitro: localization and abundance of MAO-A and MAO-B in rat CNS, peripheral organs, and human brain. J Neurosci 1992; 12: 1977-1999.
4. Jossan SS, Gillberg PG, Gottfries CG, Karlsson I, Oreland L. Monoamine oxidase B in brains from patients with Alzheimer's disease: a biochemical and autoradiographical study. Neuroscience 1991; 45: 1-12.
5. Mann JJ, Kaplan RD, Bird ED. Elevated postmortem monoamine oxidase B activity in the caudate nucleus in Huntington's disease compared to schizophrenics and controls. J Neural Transm 1986; 65: 277-283.
6. Fowler JS, Volkow ND, Wang GJ, Pappas N, Logan J, MacGregor R et al. Inhibition of monoamine oxidase B in the brains of smokers. Nature 1996; 379: 733-736.
7. Fowler JS, MacGregor RR, Wolf AP, Arnett CD, Dewey SL, Schlyer D et al. Mapping human brain monoamine oxidase A and B with 11C-labeled suicide inactivators and PET. Science 1987; 235: 481-485.
8. Fowler JS, Wolf AP, MacGregor RR, Dewey SL, Logan J, Schlyer DJ et al. Mechanistic positron emission tomography studies: demonstration of a deuterium isotope effect in the monoamine oxidase-catalyzed binding of [11C]Ldeprenyl in living baboon brain. J Neurochem 1988; 51: 1524-1534.
9. Azzaro AJ, Ziemniak J, Kemper E, Campbell BJ, VanDenBerg C. Pharmacokinetics and absolute bioavailability of selegiline following treatment of healthy subjects with the selegiline transdermal system (6 mg/24 h): a comparison with oral selegiline capsules. J Clin Pharmacol 2007; 47: 1256-1267.
10. Fowler JS, Volkow ND, Logan J, Schlyer DJ, MacGregor RR, Wang GJ et al. Monoamine oxidase B (MAO B) inhibitor therapy in Parkinson's disease: the degree and reversibility of human brain MAO B inhibition by Ro 19 6327. Neurology 1993; 43: 1984-1992.
11. Logan J, Fowler JS, Volkow ND, Wang GJ, MacGregor RR, Shea C. Reproducibility of repeated measures of deuterium substituted [11C]L-deprenyl ([11C]L-deprenyl-D2) binding in the human brain. Nucl Med Biol 2000; 27: 43-49.
12. Bramoullé Y, Puech F, Saba W, Valette H, Bottlaender M, George P et al. Radiosynthesis of (S)-5-methoxymethyl-3-[6-(4,4,4-trifluorobutoxy) benzo[d]isoxazol-3-yl] oxazolidin-2-[11C]one ([11C]SL25.1188), a novel radioligand for imaging monoamine oxidase-B with PET. J Labelled Comp Radiopharm 2008; 51: 153-158.
13. Saba W, Valette H, Peyronneau MA, Bramoulle Y, Coulon C, Curet O et al. [(11)C]SL25.1188, a new reversible radioligand to study the monoamine oxidase type B with PET: preclinical characterisation in nonhuman primate. Synapse 2010; 64: 61-69.
14. Rotstein BH, Liang SH, Holland JP, Collier TL, Hooker JM, Wilson AA et al. 11CO2 fixation: a renaissance in PET radiochemistry. Chem Commun 2013; 49: 5621-5629.
15. Vasdev N, Sadovski O, Garcia A, Dollé F, Meyer JH, Houle S et al. Radiosynthesis of [11C]SL25.1188 via [11C]CO2 fixation for imaging monoamine oxidase B. J Labelled Comp Radiopharm 2011; 54: 678-680.
16. Wilson AA, Garcia A, Parkes J, McCormick P, Stephenson KA, Houle S et al. Radiosynthesis and initial evaluation of [18F]-FEPPA for PET imaging of peripheral benzodiazepine receptors. Nucl Med Biol 2008; 35: 305-314.
17. Hong IK, Chung ST, Kim HK, Kim YB, Son YD, Cho ZH. Ultra fast symmetry and SIMD-based projection-backprojection (SSP) algorithm for 3-D PET image reconstruction. IEEE Trans Med Imaging 2007; 26: 789-803.
18. Comtat C, Bataille F, Michel C, Jones JP, Sibomana M, Janeiro L et al. OSEM-3D reconstruction strategies for the ECAT HRRT. IEEE Nucl Sci Symp Conf Rec 2004; 6: 3492-3496.
19. Lammertsma AA, Bench CJ, Price GW, Cremer JE, Luthra SK, Turton D et al. Measurement of cerebral monoamine oxidase B activity using L-[11C]deprenyl and dynamic positron emission tomography. J Cereb Blood Flow Metab 1991; 11: 545-556.
20. Gandelman MS, Baldwin RM, Zoghbi SS, Zea-Ponce Y, Innis RB. Evaluation of ultrafiltration for the free-fraction determination of single photon emission computed tomography (SPECT) radiotracers: beta-CIT, IBF, and iomazenil. J Pharm Sci 1994; 83: 1014-1019.
21. Hilton J, Yokoi F, Dannals RF, Ravert HT, Szabo Z, Wong DF. Column-switching HPLC for the analysis of plasma in PET imaging studies. Nucl Med Biol 2000; 27: 627-630.
22. Rusjan P, Mamo D, Ginovart N, Hussey D, Vitcu I, Yasuno F et al. An automated method for the extraction of regional data from PET images. Psychiatry Res 2006; 147: 79-89.
23. Studholme C, Hill DLG, Hawkes DJ. An overlap invariant entropy measure of 3D medical image alignment. Pattern Recogn 1999; 32: 71-86.
24. Innis RB, Carson R. Consensus nomenclature: its time has come. Eur J Nucl Med Mol Imaging 2007; 34: 1239.
25. Logan J, Fowler JS, Volkow ND, Wolf AP, Dewey SL, Schlyer DJ et al. Graphical analysis of reversible radioligand binding from time-activity measurements applied to [N-11C-methyl]-(-)-cocaine PET studies in human subjects. J Cereb Blood Flow Metab 1990; 10: 740-747.
26. Varga J, Szabo Z. Modified regression model for the Logan plot. J Cereb Blood Flow Metab 2002; 22: 240-244.
27. Mintun MA, Raichle ME, Kilbourn MR, Wooten GF, Welch MJ. A quantitative model for the in vivo assessment of drug binding sites with positron emission tomography. Ann Neurol 1984; 15: 217-227.
28. 15O autoradiography and positron emission tomography, with respect to the dispersion of the input function. J Cereb Blood Flow Metab 1986; 6: 536-545.
29. Kanno I, Lammertsma AA, Heather JD, Gibbs JM, Rhodes CG, Clark JC et al. Measurement of cerebral blood flow using bolus inhalation of C15O2 and positron emission tomography: description of the method and its comparison with the C15O2 continuous inhalation method. J Cereb Blood Flow Metab 1984; 4: 224-234.
30. Carasso A. Linear and nonlinear image deblurring: a documented study. SIAM J Numer Anal 1999; 36: 1659-1689.
31. 15O-labelled carbon dioxide or water, carbon monoxide and oxygen: a multicentre study in Japan. Eur J Nucl Med Mol Imaging 2004; 31: 635-643.
32. Lammertsma AA. Compartmental modeling in emission tomography. In: Handbook of Particle Detection and Imaging. Springer: Berlin Heidelberg, 2012, pp 1065-1081.
33. Akaike H. A new look at the statistical model identification. IEEE Trans Automat Contr 1974; 19: 716-723.
34. Micro Math. Micro Math Scientist Handbook Rev. 7EEF. Micromath: Salt Lake City, 1995.
35. Tong J, Meyer JH, Furukawa Y, Boileau I, Chang LJ, Wilson AA et al. Distribution of monoamine oxidase proteins in human brain: implications for brain imaging studies. J Cereb Blood Flow Metab 33: 863-871.
36. Rusjan P, Meyer J, Bloomfield P, Houle S. Parametric modeling of [11C]harmine acquired on the HRRT PET. J Nucl Med 2009; 50: 1417.
37. Boellaard R, van Lingen A, van Balen SC, Hoving BG, Lammertsma AA. Characteristics of a new fully programmable blood sampling device for monitoring blood radioactivity during PET. Eur J Nucl Med 2001; 28: 81-89.
38. Guo Q, Brady M, Gunn RN. A biomathematical modeling approach to central nervous system radioligand discovery and development. J Nucl Med 2009; 50: 1715-1723.
39. Farde L, Eriksson L, Blomquist G, Halldin C. Kinetic analysis of central [11C]raclopride binding to D2-dopamine receptors studied by PET-a comparison to the equilibrium analysis. J Cereb Blood Flow Metab 1989; 9: 696-708.