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Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 11, 2014, Pages 2493-2496

Discovery of BRD4 bromodomain inhibitors by fragment-based high-throughput docking

(5) Zhao, Hongtao a Gartenmann, Lisa a Dong, Jing a Spiliotopoulos, Dimitrios a Caflisch, Amedeo a

a UNIVERSITY OF ZURICH (Switzerland)

Author keywords

Diazepam; Epigenetics; Fragment based drug discovery; Molecular dynamics; Virtual screening

Indexed keywords

BENZODIAZEPINE; BROMODOMAIN 4 INHIBITOR; DIAZEPAM; LIGAND; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; BRD4 PROTEIN, HUMAN; MOLECULAR LIBRARY; NUCLEAR PROTEIN; TRANSCRIPTION FACTOR;

ARTICLE; ATOM; COMPUTER MODEL; FRAGMENT BASED HIGH THROUGHPUT DOCKING; HIGH THROUGHPUT SCREENING; IN VITRO STUDY; MOLECULAR DOCKING; MOLECULE; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG DEVELOPMENT; HUMAN; MOLECULAR LIBRARY; PHARMACOLOGY; STRUCTURE ACTIVITY RELATION;

DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NUCLEAR PROTEINS; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTION FACTORS;

EID: 84899934825 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2014.04.017 Document Type: Article

Times cited : (57)

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