-
1
-
-
80053321997
-
Mechanisms of integrin activation and trafficking
-
Margadant, C. et al. (2011) Mechanisms of integrin activation and trafficking. Curr. Opin. Cell Biol., 23, 607-614.
-
(2011)
Curr. Opin. Cell Biol
, vol.23
, pp. 607-614
-
-
Margadant, C.1
-
2
-
-
0033152940
-
Integrins: alternative splicing as a mechanism to regulate ligand binding and integrin signaling events
-
de Melker, A.A. et al. (1999) Integrins: alternative splicing as a mechanism to regulate ligand binding and integrin signaling events. Bioessays, 21, 499-509.
-
(1999)
Bioessays
, vol.21
, pp. 499-509
-
-
de Melker, A.A.1
-
3
-
-
0037145037
-
Integrins: bidirectional, allosteric signaling machines
-
Hynes, R.O. (2002) Integrins: bidirectional, allosteric signaling machines. Cell, 110, 673-687.
-
(2002)
Cell
, vol.110
, pp. 673-687
-
-
Hynes, R.O.1
-
4
-
-
0037321788
-
A structural view of integrin activation and signaling
-
Giancotti, F.G. (2003) A structural view of integrin activation and signaling. Dev. Cell, 4, 149-151.
-
(2003)
Dev. Cell
, vol.4
, pp. 149-151
-
-
Giancotti, F.G.1
-
5
-
-
84855792427
-
Cancer statistics, 2012
-
Siegel, R. et al. (2012) Cancer statistics, 2012. CA Cancer J. Clin., 62, 10-29.
-
(2012)
CA Cancer J. Clin
, vol.62
, pp. 10-29
-
-
Siegel, R.1
-
6
-
-
5044238876
-
Integrin signalling during tumour progression
-
Guo, W. et al. (2004) Integrin signalling during tumour progression. Nat. Rev. Mol. Cell Biol., 5, 816-826.
-
(2004)
Nat. Rev. Mol. Cell Biol
, vol.5
, pp. 816-826
-
-
Guo, W.1
-
8
-
-
68149163950
-
Integrin-linked kinase: a multi-functional regulator modulating extracellular pressure-stimulated cancer cell adhesion through focal adhesion kinase and AKT
-
Wang, S. et al. (2009) Integrin-linked kinase: a multi-functional regulator modulating extracellular pressure-stimulated cancer cell adhesion through focal adhesion kinase and AKT. Cell. Oncol., 31, 273-289.
-
(2009)
Cell. Oncol
, vol.31
, pp. 273-289
-
-
Wang, S.1
-
9
-
-
0035019920
-
Towards a mechanistic understanding of tumor invasion-lessons from the alpha6beta 4 integrin
-
Mercurio, A.M. et al. (2001) Towards a mechanistic understanding of tumor invasion-lessons from the alpha6beta 4 integrin. Semin. Cancer Biol., 11, 129-141.
-
(2001)
Semin. Cancer Biol
, vol.11
, pp. 129-141
-
-
Mercurio, A.M.1
-
10
-
-
0026554712
-
The integrin alpha 6 beta 4 is a laminin receptor
-
Lee, E.C. et al. (1992) The integrin alpha 6 beta 4 is a laminin receptor. J. Cell Biol., 117, 671-678.
-
(1992)
J. Cell Biol
, vol.117
, pp. 671-678
-
-
Lee, E.C.1
-
11
-
-
0033569721
-
Expression of functionally distinct variants of the beta(4)A integrin subunit in relation to the differentiation state in human intestinal cells
-
Basora, N. et al. (1999) Expression of functionally distinct variants of the beta(4)A integrin subunit in relation to the differentiation state in human intestinal cells. J. Biol. Chem., 274, 29819-29825.
-
(1999)
J. Biol. Chem
, vol.274
, pp. 29819-29825
-
-
Basora, N.1
-
12
-
-
68249162061
-
Integrin alpha6Bbeta4 inhibits colon cancer cell proliferation and c-Myc activity
-
Dydensborg, A.B. et al. (2009) Integrin alpha6Bbeta4 inhibits colon cancer cell proliferation and c-Myc activity. BMC Cancer, 9, 223.
-
(2009)
BMC Cancer
, vol.9
, pp. 223
-
-
Dydensborg, A.B.1
-
13
-
-
27144444995
-
Upregulation of a functional form of the beta4 integrin subunit in colorectal cancers correlates with c-Myc expression
-
Ni, H. et al. (2005) Upregulation of a functional form of the beta4 integrin subunit in colorectal cancers correlates with c-Myc expression. Oncogene, 24, 6820-6829.
-
(2005)
Oncogene
, vol.24
, pp. 6820-6829
-
-
Ni, H.1
-
14
-
-
0028170394
-
Integrin beta-4 expression in colorectal-cancer
-
Falcioni, R. et al. (1994) Integrin beta-4 expression in colorectal-cancer. Int. J. Oncol., 5, 573-578.
-
(1994)
Int. J. Oncol
, vol.5
, pp. 573-578
-
-
Falcioni, R.1
-
15
-
-
0029661897
-
A function for the integrin alpha6beta4 in the invasive properties of colorectal carcinoma cells
-
Chao, C. et al. (1996) A function for the integrin alpha6beta4 in the invasive properties of colorectal carcinoma cells. Cancer Res., 56, 4811-4819.
-
(1996)
Cancer Res
, vol.56
, pp. 4811-4819
-
-
Chao, C.1
-
16
-
-
0034951677
-
Identification of insulin receptor substrate 1 (IRS-1) and IRS-2 as signaling intermediates in the alpha6beta4 integrin-dependent activation of phosphoinositide 3-OH kinase and promotion of invasion
-
Shaw, L.M. (2001) Identification of insulin receptor substrate 1 (IRS-1) and IRS-2 as signaling intermediates in the alpha6beta4 integrin-dependent activation of phosphoinositide 3-OH kinase and promotion of invasion. Mol. Cell. Biol., 21, 5082-5093.
-
(2001)
Mol. Cell. Biol
, vol.21
, pp. 5082-5093
-
-
Shaw, L.M.1
-
17
-
-
1242272855
-
Autocrine signaling in carcinoma: VEGF and the alpha6beta4 integrin
-
Mercurio, A.M. et al. (2004) Autocrine signaling in carcinoma: VEGF and the alpha6beta4 integrin. Semin. Cancer Biol., 14, 115-122.
-
(2004)
Semin. Cancer Biol
, vol.14
, pp. 115-122
-
-
Mercurio, A.M.1
-
18
-
-
0035847016
-
Tyrosine phosphorylation of the beta 4 integrin cytoplasmic domain mediates Shc signaling to extracellular signal-regulated kinase and antagonizes formation of hemidesmosomes
-
Dans, M. et al. (2001) Tyrosine phosphorylation of the beta 4 integrin cytoplasmic domain mediates Shc signaling to extracellular signal-regulated kinase and antagonizes formation of hemidesmosomes. J. Biol. Chem., 276, 1494-1502.
-
(2001)
J. Biol. Chem
, vol.276
, pp. 1494-1502
-
-
Dans, M.1
-
19
-
-
59449086789
-
Integrin alpha6beta4 controls the expression of genes associated with cell motility, invasion, and metastasis, including S100A4/metastasin
-
Chen, M. et al. (2009) Integrin alpha6beta4 controls the expression of genes associated with cell motility, invasion, and metastasis, including S100A4/metastasin. J. Biol. Chem., 284, 1484-1494.
-
(2009)
J. Biol. Chem
, vol.284
, pp. 1484-1494
-
-
Chen, M.1
-
20
-
-
79960131390
-
Integrin subunits alpha5 and alpha6 regulate cell cycle by modulating the chk1 and Rb/E2F pathways to affect breast cancer metastasis
-
Wang, Y. et al. (2011) Integrin subunits alpha5 and alpha6 regulate cell cycle by modulating the chk1 and Rb/E2F pathways to affect breast cancer metastasis. Mol. Cancer, 10, 84.
-
(2011)
Mol. Cancer
, vol.10
, pp. 84
-
-
Wang, Y.1
-
21
-
-
77956245743
-
Integrin alpha 6 regulates glioblastoma stem cells
-
Lathia, J.D. et al. (2010) Integrin alpha 6 regulates glioblastoma stem cells. Cell Stem Cell, 6, 421-432.
-
(2010)
Cell Stem Cell
, vol.6
, pp. 421-432
-
-
Lathia, J.D.1
-
22
-
-
84868319447
-
A complex of a6 integrin and E-cadherin drives liver metastasis of colorectal cancer cells through hepatic angiopoietin-like 6
-
Marchiò, S. et al. (2012) A complex of a6 integrin and E-cadherin drives liver metastasis of colorectal cancer cells through hepatic angiopoietin-like 6. EMBO Mol. Med., 4, 1156-1175.
-
(2012)
EMBO Mol. Med
, vol.4
, pp. 1156-1175
-
-
Marchiò, S.1
-
23
-
-
83355166913
-
Integrin a6(high) cell population functions as an initiator in tumorigenesis and relapse of human liposarcoma
-
Wang, L. et al. (2011) Integrin a6(high) cell population functions as an initiator in tumorigenesis and relapse of human liposarcoma. Mol. Cancer Ther., 10, 2276-2286.
-
(2011)
Mol. Cancer Ther
, vol.10
, pp. 2276-2286
-
-
Wang, L.1
-
24
-
-
72949119124
-
Integrins in cancer: biological implications and therapeutic opportunities
-
Desgrosellier, J.S. et al. (2010) Integrins in cancer: biological implications and therapeutic opportunities. Nat. Rev. Cancer, 10, 9-22.
-
(2010)
Nat. Rev. Cancer
, vol.10
, pp. 9-22
-
-
Desgrosellier, J.S.1
-
25
-
-
0028813315
-
High expression level of alpha 6 integrin in human breast carcinoma is correlated with reduced survival
-
Friedrichs, K. et al. (1995) High expression level of alpha 6 integrin in human breast carcinoma is correlated with reduced survival. Cancer Res., 55, 901-906.
-
(1995)
Cancer Res
, vol.55
, pp. 901-906
-
-
Friedrichs, K.1
-
26
-
-
0027537324
-
Biochemical characterization and tissue distribution of the A and B variants of the integrin alpha 6 subunit
-
Hogervorst, F. et al. (1993) Biochemical characterization and tissue distribution of the A and B variants of the integrin alpha 6 subunit. J. Cell Biol., 121, 179-191.
-
(1993)
J. Cell Biol
, vol.121
, pp. 179-191
-
-
Hogervorst, F.1
-
27
-
-
0035965293
-
PDZ interaction sites in integrin alpha subunits. T14853, TIP/GIPC binds to a type I recognition sequence in alpha 6A/alpha 5 and a novel sequence in alpha 6B
-
Tani, T.T. et al. (2001) PDZ interaction sites in integrin alpha subunits. T14853, TIP/GIPC binds to a type I recognition sequence in alpha 6A/alpha 5 and a novel sequence in alpha 6B. J. Biol. Chem., 276, 36535-36542.
-
(2001)
J. Biol. Chem
, vol.276
, pp. 36535-36542
-
-
Tani, T.T.1
-
28
-
-
0033021943
-
Identification of novel interaction partners for the conserved membrane proximal region of alpha-integrin cytoplasmic domains
-
Wixler, V. et al. (1999) Identification of novel interaction partners for the conserved membrane proximal region of alpha-integrin cytoplasmic domains. FEBS Lett., 445, 351-355.
-
(1999)
FEBS Lett
, vol.445
, pp. 351-355
-
-
Wixler, V.1
-
29
-
-
0028970786
-
The alpha 6A beta 1 and alpha 6B beta 1 integrin variants signal differences in the tyrosine phosphorylation of paxillin and other proteins
-
Shaw, L.M. et al. (1995) The alpha 6A beta 1 and alpha 6B beta 1 integrin variants signal differences in the tyrosine phosphorylation of paxillin and other proteins. J. Biol. Chem., 270, 23648-23652.
-
(1995)
J. Biol. Chem
, vol.270
, pp. 23648-23652
-
-
Shaw, L.M.1
-
30
-
-
0032489532
-
Regulation of mitogen-activated protein kinase activation by the cytoplasmic domain of the alpha6 integrin subunit
-
Wei, J. et al. (1998) Regulation of mitogen-activated protein kinase activation by the cytoplasmic domain of the alpha6 integrin subunit. J. Biol. Chem., 273, 5903-5907.
-
(1998)
J. Biol. Chem
, vol.273
, pp. 5903-5907
-
-
Wei, J.1
-
31
-
-
64649105830
-
Differential expression of the integrins alpha6Abeta4 and alpha6Bbeta4 along the crypt-villus axis in the human small intestine
-
Dydensborg, A.B. et al. (2009) Differential expression of the integrins alpha6Abeta4 and alpha6Bbeta4 along the crypt-villus axis in the human small intestine. Histochem. Cell Biol., 131, 531-536.
-
(2009)
Histochem. Cell Biol
, vol.131
, pp. 531-536
-
-
Dydensborg, A.B.1
-
32
-
-
84864884496
-
Autophagy is active in normal colon mucosa
-
Groulx, J.F. et al. (2012) Autophagy is active in normal colon mucosa. Autophagy, 8, 893-902.
-
(2012)
Autophagy
, vol.8
, pp. 893-902
-
-
Groulx, J.F.1
-
33
-
-
33645837045
-
Normalizing genes for quantitative RT-PCR in differentiating human intestinal epithelial cells and adenocarcinomas of the colon
-
Dydensborg, A.B. et al. (2006) Normalizing genes for quantitative RT-PCR in differentiating human intestinal epithelial cells and adenocarcinomas of the colon. Am. J. Physiol. Gastrointest. Liver Physiol., 290, G1067-G1074.
-
(2006)
Am. J. Physiol. Gastrointest. Liver Physiol
, vol.290
, pp. G1067-G1074
-
-
Dydensborg, A.B.1
-
34
-
-
17344392308
-
A new mathematical model for relative quantification in real-time RT-PCR
-
Pfaffl, M.W. (2001) A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res., 29, e45.
-
(2001)
Nucleic Acids Res
, vol.29
-
-
Pfaffl, M.W.1
-
35
-
-
33845373278
-
Colorectal cancer and genetic alterations in the Wnt pathway
-
Segditsas, S. et al. (2006) Colorectal cancer and genetic alterations in the Wnt pathway. Oncogene, 25, 7531-7537.
-
(2006)
Oncogene
, vol.25
, pp. 7531-7537
-
-
Segditsas, S.1
-
36
-
-
33847214547
-
The intestinal Wnt/TCF signature
-
Van der Flier, L.G. et al. (2007) The intestinal Wnt/TCF signature. Gastroenterology, 132, 628-632.
-
(2007)
Gastroenterology
, vol.132
, pp. 628-632
-
-
Van der Flier, L.G.1
-
37
-
-
35548974423
-
Identification of stem cells in small intestine and colon by marker gene Lgr5
-
Barker, N. et al. (2007) Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature, 449, 1003-1007.
-
(2007)
Nature
, vol.449
, pp. 1003-1007
-
-
Barker, N.1
-
38
-
-
34247171828
-
GSK3 beta mediates suppression of cyclin D2 expression by tumor suppressor PTEN
-
Huang, W. et al. (2007) GSK3 beta mediates suppression of cyclin D2 expression by tumor suppressor PTEN. Oncogene, 26, 2471-2482.
-
(2007)
Oncogene
, vol.26
, pp. 2471-2482
-
-
Huang, W.1
-
39
-
-
77951888466
-
Dishevelled: the hub of Wnt signaling
-
Gao, C. et al. (2010) Dishevelled: the hub of Wnt signaling. Cell. Signal., 22, 717-727.
-
(2010)
Cell. Signal
, vol.22
, pp. 717-727
-
-
Gao, C.1
-
40
-
-
84870341344
-
Splice isoforms as therapeutic targets for colorectal cancer
-
Miura, K. et al. (2012) Splice isoforms as therapeutic targets for colorectal cancer. Carcinogenesis, 33, 2311-2319.
-
(2012)
Carcinogenesis
, vol.33
, pp. 2311-2319
-
-
Miura, K.1
-
41
-
-
36849013105
-
Alpha-6 integrin is necessary for the tumourigenicity of a stem cell-like subpopulation within the MCF7 breast cancer cell line
-
Cariati, M. et al. (2008) Alpha-6 integrin is necessary for the tumourigenicity of a stem cell-like subpopulation within the MCF7 breast cancer cell line. Int. J. Cancer, 122, 298-304.
-
(2008)
Int. J. Cancer
, vol.122
, pp. 298-304
-
-
Cariati, M.1
-
42
-
-
84862091378
-
Mss4 protein is a regulator of stress response and apoptosis
-
Walter, B.M. et al. (2012) Mss4 protein is a regulator of stress response and apoptosis. Cell Death Dis., 3, e297.
-
(2012)
Cell Death Dis
, vol.3
-
-
Walter, B.M.1
-
43
-
-
0029741917
-
BIN1 is a novel MYC-interacting protein with features of a tumour suppressor
-
Sakamuro, D. et al. (1996) BIN1 is a novel MYC-interacting protein with features of a tumour suppressor. Nat. Genet., 14, 69-77.
-
(1996)
Nat. Genet
, vol.14
, pp. 69-77
-
-
Sakamuro, D.1
-
44
-
-
67449138838
-
Targeting GIPC/synectin in pancreatic cancer inhibits tumor growth
-
Muders, M.H. et al. (2009) Targeting GIPC/synectin in pancreatic cancer inhibits tumor growth. Clin. Cancer Res., 15, 4095-4103.
-
(2009)
Clin. Cancer Res
, vol.15
, pp. 4095-4103
-
-
Muders, M.H.1
-
45
-
-
67651159312
-
Stem cells, self-renewal, and differentiation in the intestinal epithelium
-
van der Flier, L.G. et al. (2009) Stem cells, self-renewal, and differentiation in the intestinal epithelium. Annu. Rev. Physiol., 71, 241-260.
-
(2009)
Annu. Rev. Physiol
, vol.71
, pp. 241-260
-
-
van der Flier, L.G.1
-
46
-
-
0034724186
-
APC mutations in sporadic colorectal tumors: a mutational "hotspot" and interdependence of the "two hits"
-
Rowan, A.J. et al. (2000) APC mutations in sporadic colorectal tumors: a mutational "hotspot" and interdependence of the "two hits". Proc. Natl Acad. Sci. USA, 97, 3352-3357.
-
(2000)
Proc. Natl Acad. Sci. USA
, vol.97
, pp. 3352-3357
-
-
Rowan, A.J.1
-
47
-
-
0030975671
-
Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/-colon carcinoma
-
Korinek, V. et al. (1997) Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/-colon carcinoma. Science, 275, 1784-1787.
-
(1997)
Science
, vol.275
, pp. 1784-1787
-
-
Korinek, V.1
-
48
-
-
33745809820
-
Adenomatous polyposis coli (APC) differentially regulates beta-catenin phosphorylation and ubiquitination in colon cancer cells
-
Yang, J. et al. (2006) Adenomatous polyposis coli (APC) differentially regulates beta-catenin phosphorylation and ubiquitination in colon cancer cells. J. Biol. Chem., 281, 17751-17757.
-
(2006)
J. Biol. Chem
, vol.281
, pp. 17751-17757
-
-
Yang, J.1
-
49
-
-
77955172368
-
Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation
-
Gao, C. et al. (2010) Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation. Nat. Cell Biol., 12, 781-790.
-
(2010)
Nat. Cell Biol
, vol.12
, pp. 781-790
-
-
Gao, C.1
-
50
-
-
33749501476
-
Prickle-1 negatively regulates Wnt/beta-catenin pathway by promoting Dishevelled ubiquitination/degradation in liver cancer
-
Chan, D.W. et al. (2006) Prickle-1 negatively regulates Wnt/beta-catenin pathway by promoting Dishevelled ubiquitination/degradation in liver cancer. Gastroenterology, 131, 1218-1227.
-
(2006)
Gastroenterology
, vol.131
, pp. 1218-1227
-
-
Chan, D.W.1
|