Factors affecting hepatocyte isolation, engraftment, and replication in an in vivo model

Liver Transplantation

Volumn 16, Issue 8, 2010, Pages 974-982

  Kawahara, Toshiyasu ^a   Toso, Christian ^a   Douglas, Donna N ^a   Nourbakhsh, Mahra ^a   Lewis, Jamie T ^a   Tyrrell, David Lorne ^b,c   Lund, Garry A ^b   Churchill, Thomas A ^c   Kneteman, Norman M ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b KMT Hepatech Inc   (Canada)

^c UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; PROUROKINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ISOLATION; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DISEASE SEVERITY; ENGRAFTMENT; HEPATOCYTE TRANSPLANTATION; HUMAN; HUMAN TISSUE; IN VIVO STUDY; LIVER CELL; LIVER ISCHEMIA; MOUSE; NONHUMAN; ORGAN DONOR; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; RISK FACTOR; TREATMENT OUTCOME;

AGE FACTORS; AGED; ALBUMINS; ANIMALS; DISEASE MODELS, ANIMAL; HEPATOCYTES; HUMANS; ISCHEMIA; MICE; MICE, SCID; MIDDLE AGED; MULTIVARIATE ANALYSIS; PROMOTER REGIONS, GENETIC; REGENERATION; UROKINASE-TYPE PLASMINOGEN ACTIVATOR;

EID: 77955670666     PISSN: 15276465     EISSN: 15276473     Source Type: Journal    
DOI: 10.1002/lt.22099     Document Type: Article

References (23)

1. Fisher RA, Stephen CS. Human hepatocyte transplantation: worldwide results. Transplantation 2006;82:441-449.
2. Fox IJ, Chowdhury JR, Kaufman SS, Goertzen TC, Chowdhury NR, Warkentin PI, et al. Treatment of the Crigler-Najjar syndrome type I with hepatocyte transplantation. N Engl J Med 1998;338:1422-1427.
3. Bilir BM, Guinette D, Karrer F, Kumpe DA, Krysl J, Stephens J, et al. Hepatocyte transplantation in acute liver failure. Liver Transpl 2000;6:32-40. (Pubitemid 30123365)
4. Rayhill S, Wu Y, Katz D, Voigt M, Labrecque D, Kirby P, et al. Older donor livers show early severe histological activity, fibrosis, and graft failure after liver transplantation for hepatitis C. Transplantation 2007;84:331-339. (Pubitemid 47258320)
5. Khapra A, Agarwal K, Fiel MI, Kontorinis N, Hossain S, Emre S, et al. Impact of donor age on survival and fibrosis progression in patients with hepatitis C undergoing liver transplantation using HCV+ allografts. Liver Transpl 2006;12:1496-1503. (Pubitemid 44594280)
6. Shultz LD, Ishikawa F, Greiner DL. Humanized mice in translational biomedical research. Nat Rev Immunol 2007;7:118-130. (Pubitemid 46174859)
7. Heckel JL, Sandgren EP, Degen JL, Palmiter RD, Brinster RL. Neonatal bleeding in transgenic mice expressing urokinase-type plasminogen activator. Cell 1990;62:447-456. (Pubitemid 20263215)
8. Sandgren EP, Palmiter RD, Heckel JL, Daugherty CC, Brinster RL, Degen JL. Complete hepatic regeneration after somatic deletion of an albumin-plasminogen activator transgene. Cell 1991;66:245-256.
9. Mercer DF, Schiller DE, Elliott JF, Douglas DN, Hao C, Rinfret A, et al. Hepatitis C virus replication in mice with chimeric human livers. Nat Med 2001;7:927-933. (Pubitemid 32756430)
10. Kneteman NM, Mercer DF. Mice with chimeric human livers: who says supermodels have to be tall? Hepatology 2005;41:703-706.
11. Sacci JB Jr, Alam U, Douglas D, Lewis J, Tyrrell DL, Azad AF, et al. Plasmodium falciparum infection and exoerythrocytic development in mice with chimeric human livers. Int J Parasitol 2006;36:353-360. (Pubitemid 43376117)
12. Morosan S, Hez-Deroubaix S, Lunel F, Renia L, Giannini C, Rooijen NV, et al. Liver-stage development of plasmodium falciparum, in a humanized mouse model. J Infect Dis 2006;193:996-1004.
13. Kneteman NM, Weiner AJ, O'Connell J, Collett M, Gao T, Aukerman L, et al. Anti-HCV therapies in chimeric scid-Alb/uPA mice parallel outcomes in human clinical application. Hepatology 2006;43:1346-1353. (Pubitemid 43980114)
14. Baccarani U, Sanna A, Cariani A, Sainz-Barriga M, Adani GL, Zambito AM, et al. Isolation of human hepatocytes from livers rejected for liver transplantation on a national basis: results of a 2-year experience. Liver Transpl 2003;9:506-512. (Pubitemid 36621721)
15. Busuttil RW, Tanaka K. The utility of marginal donors in liver transplantation. Liver Transpl 2003;9:651-663. (Pubitemid 36874450)
16. Gruttadauria S, Vizzini G, Biondo D, Mandala L, Volpes R, Palazzo U, et al. Critical use of extended criteria donor liver grafts in adult-to-adult whole liver transplantation: a single-center experience. Liver Transpl 2008;14:220-227. (Pubitemid 351267280)
17. Reddy S, Zilvetti M, Brockmann J, McLaren A, Friend P. Liver transplantation from non-heart-beating donors: Current status and future prospects. Liver Transpl 2004;10:1223-1232. (Pubitemid 39406075)
18. Ercolani G, Luca G, Matteo G, Massimo R, Matteo DG, Giovanni C, et al. Histological recurrent hepatitis C after liver transplantation: Outcome and role of retransplantation. Liver Transpl 2006;12:1104-1111. (Pubitemid 44063785)
19. Ciccorossi P, Maina AM, Oliveri F, Petruccelli S, Leandro G, Colombatto P, et al. Viral load 1 week after liver transplantation, donor age and rejections correlate with the outcome of recurrent hepatitis C. Liver Int 2007;27:612-619. (Pubitemid 47097310)
20. Ikeda T, Yanaga K, Kishikawa K, Kakizoe S, Shimada M, Sugimachi K. Ischemic injury in liver transplantation: difference in injury sites between warm and cold ischemia in rats. Hepatology 1992;16:454-461.
21. Hughes RD, Mitry RR, Dhawan A, Lehec SC, Girlanda R, Rela M, et al. Isolation of hepatocytes from livers from non-heart-beating donors for cell transplantation. Liver Transpl 2006;12:713-717.
22. Mitry R, Hughes R, Aw M, Terry C, Mieli-Vergani G, Girlanda R, et al. Human hepatocyte isolation and relationship of cell viability to early graft function. Cell Transplant 2003;12:69-74. (Pubitemid 36397317)
23. Richert L, Alexandre E, Lloyd T, Orr S, Viollon-Abadie C, Patel R, et al. Tissue collection, transport and isolation procedures required to optimize human hepatocyte isolation from waste liver surgical resections. A multilaboratory study. Liver Int 2004;24:371-378. (Pubitemid 39162077)