2-(4-Methoxyphenyl)ethyl-2-acetamido-2-deoxy-β-d-pyranoside confers neuroprotection in cell and animal models of ischemic stroke through calpain1/PKA/CREB-mediated induction of neuronal glucose transporter 3

Toxicology and Applied Pharmacology

Volumn 277, Issue 3, 2014, Pages 259-269

  Yu, Shu ^a   Cheng, Qiong ^a   Li, Lu ^a   Liu, Mei ^a   Yang, Yumin ^a   Ding, Fei ^a  

^a NANTONG UNIVERSITY   (China)

Author keywords

2 (4 Methoxyphenyl)ethyl 2 acetamido 2 deoxy d pyranoside; CREB; Ischemic stroke models; Neuronal glucose transporter 3; Neuroprotection; PKA

Indexed keywords

2 (4 METHOXYPHENYL)ETHYL 2 ACETAMIDO 2 DEOXY BETA DEXTRO PYRANOSIDE; CALPAIN 1; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GLUCOSE; GLUCOSE TRANSPORTER 3; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; OXYGEN; PYRANOSIDE; SALIDROSIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN ISCHEMIA; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; EMBRYO; GLUCOSE TRANSPORT; HIPPOCAMPAL NEURONAL CULTURE; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NONHUMAN; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; RAT;

ANIMALIA; RATTUS;

2-(4-METHOXYPHENYL)ETHYL-2-ACETAMIDO-2-DEOXY-Β-D-PYRANOSIDE; CREB; ISCHEMIC STROKE MODELS; NEURONAL GLUCOSE TRANSPORTER 3; NEUROPROTECTION; PKA;

ACETYLGLUCOSAMINE; ANIMALS; BRAIN ISCHEMIA; CALPAIN; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; CYCLIC AMP-DEPENDENT PROTEIN KINASES; GENE EXPRESSION REGULATION; GLUCOSE TRANSPORTER TYPE 3; HIPPOCAMPUS; MICE; MOLECULAR STRUCTURE; NEURONS; NEUROPROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; STROKE;

EID: 84899919929     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2014.03.025     Document Type: Article

References (44)

1. Bae O.N., Serfozo K., Baek S.H., Lee K.Y., Dorrance A., Rumbeiha W., Fitzgerald S.D., Farooq M.U., Naravelta B., Bhatt A., Majid A. Safety and efficacy evaluation of carnosine, an endogenous neuroprotective agent for ischemic stroke. Stroke 2013, 44:205-212.
2. Bernabeu R., Bevilaqua L., Ardenghi P., Bromberg E., Schmitz P., Bianchin M., Izquierdo I., Medina J.H. Involvement of hippocampal cAMP/cAMP-dependent protein kinase signaling pathways in a late memory consolidation phase of aversively motivated learning in rats. Proc. Natl. Acad. Sci. U. S. A. 1997, 94:7041-7046.
3. Brewer G.J., Torricelli J.R., Evege E.K., Price P.J. Optimized survival of hippocampal neurons in B27-supplemented Neurobasal, a new serum-free medium combination. J. Neurosci. Res. 1993, 35:567-576.
4. Broughton B.R., Reutens D.C., Sobey C.G. Apoptotic mechanisms after cerebral ischemia. Stroke 2009, 40:e331-e339.
5. Cammarota M., Bevilaqua L.R., Ardenghi P., Paratcha G., Levi de Stein M., Izquierdo I., Medina J.H. Learning-associated activation of nuclear MAPK, CREB and Elk-1, along with Fos production, in the rat hippocampus after a one-trial avoidance learning: abolition by NMDA receptor blockade. Brain Res. Mol. Brain Res. 2000, 76:36-46.
6. Cao L.L., Du G.H., Wang M.W. The effect of Sal on cell damage induced by glutamate and intracellular free calcium in PC12 cells. J. Asian Nat. Prod. Res. 2006, 8:159-165.
7. Chen J., Li Y., Wang L., Zhang Z., Lu D., Lu M., Chopp M. Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats. Stroke 2001, 32:1005-1011.
8. Chen X., Liu J., Gu X., Ding F. Salidroside attenuates glutamate-induced apoptotic cell death in primary cultured hippocampal neurons of rats. Brain Res. 2008, 1238:189-198.
9. Chen X., Zhang Q., Cheng Q., Ding F. Protective effect of Sal against H2O2-induced cell apoptosis in primary culture of rat hippocampal neurons. Mol. Cell. Biochem. 2009, 332:85-93.
10. Cline H.T., Tsien R.W. Glutamate-induced increases in intracellular Ca2+ in cultured frog tectal cells mediated by direct activation of NMDA receptor channels. Neuron 1991, 6:259-267.
11. Emery A.C., Eiden L.E. Signaling through the neuropeptide GPCR PAC(1) induces neuritogenesis via a single linear cAMP- and ERK-dependent pathway using a novel cAMP sensor. FASEB J. 2012, 26:3199-3211.
12. Ghosh A., Greenberg M.E. Calcium signaling in neurons: molecular mechanisms and cellular consequences. Science 1995, 268:239-247.
13. Goll D.E., Thompson V.F., Li H., Wei W., Cong J. The calpain system. Physiol. Rev. 2003, 83:731-801.
14. Gubern C., Hurtado O., Rodríguez R., Morales J., Romera V., Moro M., Lizasoain I., Serena J., Mallolas J. Validation of housekeeping genes for quantitative real-time PCR in in-vivo and in-vitro models of cerebral ischaemia. BMC Mol. Biol. 2009, 10:57.
15. Guo X., Geng M., Du G. Glucose transporter 1, distribution in the brain and in neural disorders: its relationship with transport of neuroactive drugs through the blood-brain barrier. Biochem. Genet. 2005, 43:175-187.
16. Guo Y., Zhao Y., Zheng C., Meng Y., Yang Y. Synthesis, biological activity of Sal and its analogues. Chem. Pharm. Bull. 2010, 58:1627-1629.
17. Hwang S.Y., Shin J.H., Hwang J.S., Kim S.Y., Shin J.A., Oh E.S., Oh S., Kim J.B., Lee J.K., Han I.O. Glucosamine exerts a neuroprotective effect via suppression of inflammation in rat brain ischemia/reperfusion injury. Glia 2010, 58:1881-1892.
18. Jin N., Qian W., Yin X., Zhang L., Iqbal K., Grundke-Iqbal I., Gong C.X., Liu F. CREB regulates the expression of neuronal glucose transporter 3: a possible mechanism related to impaired brain glucose uptake in Alzheimer's disease. Nucleic Acids Res. 2013, 41:3240-3256.
19. Joshi C.N., Jain S.K., Murthy P.S. An optimized triphenyltetrazolium chloride method for identification of cerebral infarcts. Brain Res. Brain Res. Protoc. 2004, 13:11-17.
20. Kisilevsky R., Szarek W.A. Novel glycosaminoglycan precursors as anti-amyloid agents part II. J. Mol. Neurosci. 2002, 19:45-50.
21. Liang Z., Liu F., Grundke-Iqbal I., Iqbal K., Gong C.X. Down-regulation of cAMP-dependent protein kinase by over-activated calpain in Alzheimer disease brain. J. Neurochem. 2007, 103:2462-2470.
22. Martinive P., Defresne F., Bouzin C., Saliez J., Lair F., Gregoire V., Michiels C., Dessy C., Feron O. Preconditioning of the tumor vasculature and tumor cells by intermittent hypoxia: implications for anticancer therapies. Cancer Res. 2006, 66:11736-11744.
23. Meng Y., Guo Y., Ling Y., Zhao Y., Zhang Q., Zhou X., Ding F., Yang Y. Synthesis and protective effects of aralkyl alcoholic 2-acetamido-2-deoxy-beta-D-pyranosides on hypoglycemia and serum limitation induced apoptosis in PC12 cell. Bioorg. Med. Chem. 2011, 19:5577-5584.
24. Obrenovitch T.P. Molecular physiology of preconditioning-induced brain tolerance to ischemia. Physiol. Rev. 2008, 88:211-247.
25. Qiu S., Jebelli A.K., Ashe J.H., Curras-Collazo M.C. Domoic acid induces a long-lasting enhancement of CA1 field responses and impairs tetanus-induced long-term potentiation in rat hippocampal slices. Toxicol. Sci. 2009, 111:140-150.
26. Rajakumar A., Thamotharan S., Raychaudhuri N., Menon R.K., Devaskar S.U. Trans-activators regulating neuronal glucose transporter isoform-3 gene expression in mammalian neurons. J. Biol. Chem. 2004, 279:26768-26779.
27. Reddy A.B., Srivastava S.K., Ramana K.V. Aldose reductase inhibition prevents lipopolysaccharide-induced glucose uptake and glucose transporter 3 expression in RAW264.7 macrophages. Int. J. Biochem. Cell Biol. 2010, 42:1039-1045.
28. Riccio A., Ahn S., Davenport C.M., Blendy J.A., Ginty D.D. Mediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neurons. Science 1999, 286:2358-2361.
29. Satoh J.-i., Tabunoki H., Arima K. Molecular network analysis suggests aberrant CREB-mediated gene regulation in the Alzheimer disease hippocampus. Dis. Markers 2009, 27:239-252.
30. Saunders N.R., Ek C.J., Habgood M.D., Dziegielewska K.M. Barriers in the brain: a renaissance?. Trends Neurosci. 2008, 31:279-286.
31. Sheikh A.Y., Chun H.J., Glassford A.J., Kundu R.K., Kutschka I., Ardigo D., Hendry S.L., Wagner R.A., Chen M.M., Ali Z.A., Yue P., Huynh D.T., Connolly A.J., Pelletier M.P., Tsao P.S., Robbins R.C., Quertermous T. In vivo genetic profiling and cellular localization of apelin reveals a hypoxia-sensitive, endothelial-centered pathway activated in ischemic heart failure. Am. J. Physiol. Heart Circ. Physiol. 2008, 294:H88-H98.
32. Shen H., Yuan Y., Ding F., Hu N., Liu J., Gu X. Achyranthes bidentata polypeptides confer neuroprotection through inhibition of reactive oxygen species production, Bax expression, and mitochondrial dysfunction induced by overstimulation of N-methyl-D-aspartate receptors. J. Neurosci. Res. 2010, 88:669-676.
33. Simpson I.A., Dwyer D., Malide D., Moley K.H., Travis A., Vannucci S.J. The facilitative glucose transporter GLUT3: 20years of distinction. Am. J. Physiol. Endocrinol. Metab. 2008, 295:E242-E253.
34. Szydlowska K., Tymianski M. Calcium, ischemia and excitotoxicity. Cell Calcium 2010, 47:122-129.
35. Takeo S., Fukatsu T., Miyake-Takagi K., Takagi N., Niimura M., Nagakura A., Ando T., Tanonaka K. Persistent effects of delayed treatment with nefiracetam on the water maze task in rats with sustained cerebral ischemia. J. Pharmacol. Exp. Ther. 2003, 304:513-523.
36. Tanaka K., Nogawa S., Nagata E., Suzuki S., Dembo T., Kosakai A., Fukuuchi Y. Temporal profile of CREB phosphorylation after focal ischemia in rat brain. Neuroreport 1999, 10:2245-2250.
37. Taylor R.C., Cullen S.P., Martin S.J. Apoptosis: controlled demolition at the cellular level. Nat. Rev. Mol. Cell Biol. 2008, 9:231-241.
38. Vannucci S.J., Maher F., Simpson I.A. Glucose transporter proteins in brain: delivery of glucose to neurons and glia. Glia 1997, 21:2-21.
39. Walker W.H., Sanborn B.M., Habener J.F. An isoform of transcription factor CREM expressed during spermatogenesis lacks the phosphorylation domain and represses cAMP-induced transcription. Proc. Natl. Acad. Sci. U. S. A. 1994, 91:12423-12427.
40. Yamamoto K.K., Gonzalez G.A., Biggs W.H., Montminy M.R. Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB. Nature 1988, 334:494-498.
41. Yu S., Liu M., Gu X., Ding F. Neuroprotective effects of Sal in the PC12 cell model exposed to hypoglycemia and serum limitation. Cell. Mol. Neurobiol. 2008, 28:1067-1078.
42. Zhang L., Yu H., Sun Y., Lin X., Chen B., Tan C., Cao G., Wang Z. Protective effects of Sal on hydrogen peroxide-induced apoptosis in SH-SY5Y human neuroblastoma cells. Eur. J. Pharmacol. 2007, 564:18-25.
43. Zhang Y., Su P., Liang P., Liu T., Liu X., Liu X.Y., Zhang B., Han T., Zhu Y.B., Yin D.M., Li J., Zhou Z., Wang K.W., Wang Y. The DREAM protein negatively regulates the NMDA receptor through interaction with the NR1 subunit. J. Neurosci. 2010, 30:7575-7586.
44. Zhang S., Chen X., Yang Y., Zhou X., Liu J., Ding F. Neuroprotection against cobalt chloride-induced cell apoptosis of primary cultured cortical neurons by Sal. Mol. Cell. Biochem. 2011, 354:161-170.