Persistent effects of delayed treatment with nefiracetam on the water maze task in rats with sustained cerebral ischemia

Journal of Pharmacology and Experimental Therapeutics

Volumn 304, Issue 2, 2003, Pages 513-523

  Takeo, Satoshi ^a   Fukatsu, Tomoko ^a   Miyake Takagi, Keiko ^a   Takagi, Norio ^a   Niimura, Makiko ^a   Nagakura, Akira ^a   Ando, Tsuyoshi ^a   Tanonaka, Kouichi ^a  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

NEFIRACETAM;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN CORTEX; BRAIN ISCHEMIA; BRAIN MEMBRANE; CONTROLLED STUDY; DRUG EFFECT; ENZYME SUBUNIT; HIPPOCAMPUS; INTERNAL CAROTID ARTERY; MAZE TEST; MOTOR PERFORMANCE; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; SPATIAL MEMORY;

ANIMALS; BRAIN; BRAIN ISCHEMIA; CYCLIC AMP-DEPENDENT PROTEIN KINASES; MALE; MAZE LEARNING; MEMORY DISORDERS; PYRROLIDINONES; RATS; RATS, WISTAR;

EID: 0037309603     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.102.043653     Document Type: Article

References (32)

1. Abel T, Nguyen PV, Barad M, Deuel TAS, Kandel ER, and Bourtchouladze R (1997) Genetic demonstration of a role for PKA in the late phase of LTD and hippocampus-based long-term memory. Cell 88:615-626.
2. Bernabeu R, Bevilaqua L, Ardenghi P, Bromberg E, Schmitz P, Bianchin M, Izquierdo I, and Medina JH (1997) Involvement of hippocampal cAMP/cAMP-dependent protein kinase signaling pathways in a late memory consolidation phase of aversively motivated learning in rats. Proc Natl Acad Sci USA 94:7041-7046.
3. Bourtchuladze R, Frenguelli B, Blendy J, Cioffi D, Schutz G, and Silva AJ (1994) Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein. Cell 79:59-68.
4. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
5. Cammarota M, Bevilaqua LRM, Ardenghi P, Paratcha G, Levi deStein M, Izquierdo I, and Medina JH (2000) Learning-associated activation of nuclear MAPK, CREB and Elk-1, along with Fox production, in the rat hippocampus after a one-trial avoidance learning: abolition by NMDA receptor blockade. Mol Brain Res 76:36-46.
6. Chute DL, Villiger JW, and Kirton NF (1981) Testing cyclic AMP mediation of memory: reversal of alpha-methyl-p-tyrosine-induced amnesia. Psychopharmacology 74:129-131.
7. DiMattia BC and Kesner RP (1988) Spatial cognitive maps; differential role of parietal cortex and hippocampal formation. Behav Neurosci 102:471-480.
8. Doyle E, Regan CM, and Shiotani T (1993) nefiracetam (DM-9384) preserves hippocampal neural cell adhesion molecule-mediated memory consolidation processes during scopolamine-disruption of passive avoidance training in the rat. J Neurochem 61:266-272.
9. Guillou JL, Micheau J, and Jaffard R (1998) The opposite effects of cysteamine on the acquisition of two different tasks in mice are associated with bidirectional testinginduced changes in hippocampal adenylyl cyclase activity. Behav Neurosci 112:900-908.
10. Guillou JL, Rose GM, and Cooper DM (1999) Differential activation of adenylyl cyclases by spatial and procedural learning. J. Neurosci 19:6183-6190.
11. Guzowski JF and MeGaugh JL (1997) Antisense oligodeoxynucleotide-mediated disruption of hippocampal cAMP response element binding protein levels impaired consolidation of memory for water maze training. Proc Natl Acad Sci USA 94:2693-2698.
12. Hara C and Ogawa N (1990) Characteristic of learning deficit induced by ibotenic acid lesion of the frontal cortex related with the nucleus basalis of Meynert in rats, in Basic, Clinical and Therapeutic Aspects of Alzheimer's and Parkinson's Diseases (Nagatsu T, Fisher A, and Yoshida M eds), vol 1, pp 735-738, Plenum Press, New York
13. Hodges H (1996) Maze procedures: the radial-arm and water maze compared. Cogn Brain Res 3:167-181.
14. Imanishi T, Sawa A, Ichimaru Y, Miyashiro M, Kato S, Yamamoto T, and Ueki S (1997) Ameliorating effects of rolipram on experimentally induced impairments of learning and memory in rodents. Eur J Pharmacol 321:273-278.
15. Kirino T (1982) Delayed neuronal death in the gerbil hippocampus following ischemia. Brain Res 39:57-69.
16. Lyden PD, Zivin JA, Chabolla DR, Jacobs MA, and Gage FH (1992) Quantitative effects of cerebral infarction on spatial learning in rats. Exp Neurol 116:122-132.
17. Miyake K, Takeo S, and Kajihara H (1993) Sustained decrease in brain regional blood flow after microsphere embolism in rats. Stroke 24:415-420.
18. Modo M, Stroemer RP, Tang E, Veizovic T, Sowniski P, and Hodges H (2000) Neurological sequelae and long-term behevioural assessment of rats with transient middle cerebral artery occlusion. J Neurosci Methods 194:99-109.
19. Nabeshima T, Tohyama K, and Kameyama T (1990) Effects of DM-9384, a pyrrolidone derivative, on alcohol- and chlordiazepoxide-induced amnesia in mice. Pharmacol Biochem Behav 36:233-236.
20. Nabeshima T, Tohyama K, Murase K, Ishihara S, Kameyama T, Yamasaki T, Hatanaka S, Kojima H, Sakurai T, Takasu Y, et al. (1991) Effects of DM-9384, a cyclic derivative, on alcohol- and chlordiazepoxide-induced amnesia in mice. J Pharmacol Exp Ther 257:271-275.
21. Nagakura A, Miyake-Takagi K, Takagi N, and Takeo S (2002a) Impairment of adenylyl cyclase and of spatial memory function after microsphere embolism in rats. J Neurosci Res 68:363-372.
22. Nagakura A, Niimura M, and Takeo S (2002c) Effects of phosphodiesterase IV inhibitor rolipram on microsphere embolism-induced defects in memory function and cerebral cyclic AMP signal transduction system in rats. Br J Pharmacol 135:1783-1793.
23. Nagakura A, Takagi N, and Takeo S (2002b) Impairment of cerebral cAMP-mediated signal transduction system and of spatial memory function after microsphere embolism in rats. Neuroscience 113:519-528.
24. Naritomi H (1991) Experimental basis of multi-infarct dementia: memory impairments in rodent models of ischemia. Alzheimer Dis Assoc Disord 5:103-111.
25. Save E, Poucet B, Foreman N and Buhot MC (1992) Object exploration and reactions to spatial and nonspatial changes in hooded rats following damage to parietal cortex or hippocampal formation. Behav Neurosci 106:447-456.
26. Smith ML, Auer RN, and Siesjo BK (1984) The density and distribution of ischemic brain injury in the rat following 2-10 min of forebrain ischemia. Acta Neuropathol 64:319-332.
27. Takagi N, Miyake K, Taguchi T, Tamada H, Takagi K, Sugita N, and Takeo S (1997) Failure in learning task and loss of cortical cholinergic fibers in microsphere-embolized rats. Exp Brain Res 114:279-287.
28. Takeo S, Taguchi T Tanonaka K, Miyake K, Horiguchi T, Takagi N, and Fujimori K (1992) Sustained damage to energy metabolism of brain regions after microsphere embolism in rats. Stroke 23:62-68.
29. Yamada K and Nabeshima T (1996) Nefiracetam (DM-9384): a novel anti-amnesic drug. CNS Drugs Rev 2 (1996) 322-342.
30. Yonemori F, Yamaguchi T, Yamada H, and Tamura A (1999) Spatial cognitive performance after chronic focal cerebral ischemia in rats. J Cereb Blood Flow Metab 19:483-494.
31. Yamamoto M, Ozawa H, Saito T, Frolich L, Riederer P, and Takahata N (1996) Reduced immunoreactivity of adenylyl cyclase in dementia of the Alzheimer type. Neuroreport 7:2965-2970.
32. Zhao WQ, Polya GM, Wang BH, Gibbs ME, Sedman GL, and Ng KT (1995) Inhibitors of cAMP-dependent protein kinase impair long-term memory formation in day-old chicks. Neurobiol Learn Mem 64:106-118.