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Volumn 22, Issue 11, 2014, Pages 2947-2954
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Synthesis, biological evaluation, and molecular docking studies of novel 2-styryl-5-nitroimidazole derivatives containing 1,4-benzodioxan moiety as FAK inhibitors with anticancer activity
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Author keywords
2 Styryl 5 nitroimidazole derivatives; Focal adhesion kinase; Molecular docking; Structure activity relationship
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Indexed keywords
2 (5 NITRO 2 STYRYL 1H IMIDAZOL 1 YL)ETHYL 2,3 DIHYDROBENZO[B][1,4]DIOXINE 5 CARBOXYLATE;
2 STYRYL 5 NITROIMIDAZOLE DERIVATIVE;
2 [2 (2 BROMOSTYRYL) 5 NITRO 1H IMIDAZOL 1 YL]ETHYL 2,3 DIHYDROBENZO[B][1,4]DIOXINE 5 CARBOXYLATE;
2 [2 (2 CHLORO 6 FLUOROSTYRYL) 5 NITRO 1H IMIDAZOL 1 YL]ETHYL 2,3 DIHYDROBENZO[B][1,4]DIOXINE 5 CARBOXYLATE;
2 [2 (2 CHLOROSTYRYL) 5 NITRO 1H IMIDAZOL 1 YL]ETHYL 2,3 DIHYDROBENZO[B][1,4]DIOXINE 5 CARBOXYLATE;
2 [2 (2 FLUOROSTYRYL) 5 NITRO 1H IMIDAZOL 1 YL]ETHYL 2,3 DIHYDROBENZO[B][1,4]DIOXINE 5 CARBOXYLATE;
2 [2 (2 METHOXYSTYRYL) 5 NITRO 1H IMIDAZOL 1 YL]ETHYL 2,3 DIHYDROBENZO[B][1,4]DIOXINE 5 CARBOXYLATE;
2 [2 (2 METHYLSTYRYL) 5 NITRO 1H IMIDAZOL 1 YL]ETHYL 2,3 DIHYDROBENZO[B][1,4]DIOXINE 5 CARBOXYLATE;
2 [2 (3 BROMOSTYRYL) 5 NITRO 1H IMIDAZOL 1 YL]ETHYL 2,3 DIHYDROBENZO[B][1,4]DIOXINE 5 CARBOXYLATE;
2 [2 (3 CHLOROSTYRYL) 5 NITRO 1H IMIDAZOL 1 YL]ETHYL 2,3 DIHYDROBENZO[B][1,4]DIOXINE 5 CARBOXYLATE;
2 [2 (3 FLUOROSTYRYL) 5 NITRO 1H IMIDAZOL 1 YL]ETHYL 2,3 DIHYDROBENZO[B][1,4]DIOXINE 5 CARBOXYLATE;
2 [2 (3 METHOXYSTYRYL) 5 NITRO 1H IMIDAZOL 1 YL]ETHYL 2,3 DIHYDROBENZO[B][1,4]DIOXINE 5 CARBOXYLATE;
2 [2 (3 METHYLSTYRYL) 5 NITRO 1H IMIDAZOL 1 YL]ETHYL 2,3 DIHYDROBENZO[B][1,4]DIOXINE 5 CARBOXYLATE;
2 [2 (4 BROMOSTYRYL) 5 NITRO 1H IMIDAZOL 1 YL]ETHYL 2,3 DIHYDROBENZO[B][1,4]DIOXINE 5 CARBOXYLATE;
2 [2 (4 CHLOROSTYRYL) 5 NITRO 1H IMIDAZOL 1 YL]ETHYL 2,3 DIHYDROBENZO[B][1,4]DIOXINE 5 CARBOXYLATE;
2 [2 (4 FLUOROSTYRYL) 5 NITRO 1H IMIDAZOL 1 YL]ETHYL 2,3 DIHYDROBENZO[B][1,4]DIOXINE 5 CARBOXYLATE;
2 [2 (4 METHOXYSTYRYL) 5 NITRO 1H IMIDAZOL 1 YL]ETHYL 2,3 DIHYDROBENZO[B][1,4]DIOXINE 5 CARBOXYLATE;
2 [2 (4 METHYLSTYRYL) 5 NITRO 1H IMIDAZOL 1 YL]ETHYL 2,3 DIHYDROBENZO[B][1,4]DIOXINE 5 CARBOXYLATE;
2 [2 [2 (NAPHTHALEN 1 YL)VINYL] 5 NITRO 1H IMIDAZOL 1 YL]ETHYL 2,3 DIHYDROBENZO[B][1,4]DIOXINE 5 CARBOXYLATE;
ANTINEOPLASTIC AGENT;
FOCAL ADHESION KINASE INHIBITOR;
STAUROSPORINE;
UNCLASSIFIED DRUG;
1,4-BENZODIOXAN;
2-STYRYL-5-NITROIMIDAZOLE;
DIOXANE DERIVATIVE;
FOCAL ADHESION KINASE;
NITROIMIDAZOLE DERIVATIVE;
PROTEIN KINASE INHIBITOR;
ANTINEOPLASTIC ACTIVITY;
ANTIPROLIFERATIVE ACTIVITY;
APOPTOSIS;
ARTICLE;
BINDING AFFINITY;
BIOLOGICAL ACTIVITY;
CONCENTRATION RESPONSE;
CONFORMATION;
CONTROLLED STUDY;
DRUG DESIGN;
DRUG SCREENING;
DRUG SYNTHESIS;
ENZYME ACTIVE SITE;
ENZYME ACTIVITY;
ENZYME INHIBITION;
FLUORESCENCE ACTIVATED CELL SORTING;
HUMAN;
HUMAN CELL;
MOLECULAR DOCKING;
STRUCTURE ACTIVITY RELATION;
ANTAGONISTS AND INHIBITORS;
CELL PROLIFERATION;
CELL SURVIVAL;
CHEMICAL STRUCTURE;
CHEMISTRY;
DOSE RESPONSE;
DRUG EFFECTS;
HELA CELL LINE;
METABOLISM;
SYNTHESIS;
TUMOR CELL LINE;
ANTINEOPLASTIC AGENTS;
CELL LINE, TUMOR;
CELL PROLIFERATION;
CELL SURVIVAL;
DIOXANES;
DOSE-RESPONSE RELATIONSHIP, DRUG;
DRUG SCREENING ASSAYS, ANTITUMOR;
FOCAL ADHESION PROTEIN-TYROSINE KINASES;
HELA CELLS;
HUMANS;
MOLECULAR DOCKING SIMULATION;
MOLECULAR STRUCTURE;
NITROIMIDAZOLES;
PROTEIN KINASE INHIBITORS;
STRUCTURE-ACTIVITY RELATIONSHIP;
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EID: 84899916466
PISSN: 09680896
EISSN: 14643391
Source Type: Journal
DOI: 10.1016/j.bmc.2014.04.005 Document Type: Article |
Times cited : (23)
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References (27)
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