Synthesis and antitumor activity of 1,2,4-triazoles having 1,4-benzodioxan fragment as a novel class of potent methionine aminopeptidase type II inhibitors

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 20, 2011, Pages 5948-5954

  Hou, Ya Ping ^a,b   Sun, Juan ^a,b   Pang, Zhong Hua ^a,b   Lv, Peng Cheng ^a,b   Li, Dong Dong ^a,b   Yan, Li ^a,b   Zhang, Hong Jia ^a,b   Zheng, Emily Xi ^a,b   Zhao, Jing ^a,b   Zhu, Hai Liang ^a,b  

^a NANJING UNIVERSITY   (China)

^b NASSAU UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Antitumor activity; Auto Dock; Benzodioxan; MetAP2; Triazole

Indexed keywords

1,2,4 TRIAZOLE DERIVATIVE; 1,4 BENZODIOXAN; 2 (2,3 DIHYDROBENZO[B][1,4]DIOXINE 6 CARBONYL) N PHENYLHYDRAZINECARBOTHIOAMIDE; 2,3 DIHYDROBENZO[B][1,4]DIOXINE 6 CARBOHYDRAZIDE; 3 (2 BROMOBENZYLTHIO) 5 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL) 4 PHENYL 4H 1,2,4 TRIAZOLE; 3 (2 CHLOROBENZYLTHIO) 5 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL) 5 (4 NITROBENZYLTHIO) 4 PHENYL 4H 1,2,4 TRIAZOLE; 3 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL) 5 (2 FLOUROBENZYLTHIO) 4 PHENYL 4H 1,2,4 TRIAZOLE; 3 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL) 5 (2 NITROBENZYLTHIO) 4 PHENYL 4H 1,2,4 TRAZOLE; 3 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL) 5 (3 METHYLOXYBENZYLTHIO) 4 PHENYL 4H 1,2,4 TRIAZOLE; 3 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL) 5 (3 NITROBENZYLTHIO) 4 PHENYL 4H 1,2,4 TRIAZOLE; 3 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL) 5 (4 FLOUROBENZYLTHIO) 4 PHENYL 4H 1,2,4 TRIAZOLE; 3 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL) 5 (4 METHYLBENZYLTHIO) 4 PHENYL 4H 1,2,4 TRIAZOLE; 3 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL) 5 (4 NITROBENZYLTHIO) 4 PHENYL 4H 1,2,4 TRIAZOLE; 3 (2,4 DIFLUOROBENZYLTHIO) 5 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL) 4 PHENYL 4H 1,2,4 TRIAZOLE; 3 (2,6 DIFLUOROBENZYLTHIO) 5 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL) 4 PHENYL 4H 1,2,4 TRIAZOLE; 3 (3 BROMOBENZYLTHIO) 5 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL) 4 PHENYL 4H 1,2,4 TRIAZOLE; 3 (3 CHLOROBENZYLTHIO) 5 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL) 5 (4 NITROBENZYLTHIO) 4 PHENYL 4H 1,2,4 TRIAZOLE; 3 (4 BROMOBENZYLTHIO) 5 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL) 4 PHENYL 4H 1,2,4 TRIAZOLE; 3 (4 CHLOROBENZYLTHIO) 5 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL) 5 (4 NITROBENZYLTHIO) 4 PHENYL 4H 1,2,4 TRIAZOLE; 3 (BENZYLTHIO) 5 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL) 4 PHENYL 4H 1,2,4 TRIAZOLE; 3 (BENZYLTHIO) 5 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL) 4 PHENYL 4H 1,2,4 TRIAZOLE SUBSTITUTED BENZYL BROMIDE; 5 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL) 4 PHENYL 4H 1,2,4 TRIAZOLE 3 THIOL; ANTINEOPLASTIC AGENT; METHIONYL AMINOPEPTIDASE 2; METHYL 2,3 DIHYDROBENZO[B][1,4]DIOXINE 6 CARBOXYLATE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CONTROLLED STUDY; DRUG DESIGN; DRUG INHIBITION; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MOLECULAR DOCKING; NEOPLASM;

AMINOPEPTIDASES; ANIMALS; ANTINEOPLASTIC AGENTS; CELL GROWTH PROCESSES; CELL LINE, TUMOR; DIOXANES; HELA CELLS; HEP G2 CELLS; HUMANS; METALLOENDOPEPTIDASES; MICE; MODELS, MOLECULAR; PROTEASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

RUMEX;

EID: 80053220304     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.08.063     Document Type: Article

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