The free radical scavenger Trolox dampens neuronal hyperexcitability, reinstates synaptic plasticity, and improves hypoxia tolerance in a mouse model of Rett syndrome

Frontiers in Cellular Neuroscience

Volumn 8, Issue FEB, 2014, Pages

  Janc, Oliwia A ^a,b   Müller, Michael ^a,b  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

Author keywords

Free radical scavenger; Mitochondrial metabolism; Neurodevelopmental disorder; Oxidative stress; Reactive oxygen species (ROS); Redox signaling; Synaptic dysfunction; Vitamin E

Indexed keywords

SCAVENGER; TROLOX C;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOFLUORESCENCE; CONTROLLED STUDY; ELECTROPHYSIOLOGICAL PROCEDURES; EPIFLUORESCENCE MICROSCOPY; GENOTYPE; HIPPOCAMPUS; HYPOXIA; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; MOUSE; NERVE CELL PLASTICITY; NERVE EXCITABILITY; NONHUMAN; OXIDATIVE STRESS; PHENOTYPE; POSTSYNAPTIC POTENTIAL; RETT SYNDROME; SEIZURE;

EID: 84899915490     PISSN: 16625102     EISSN: None     Source Type: Journal    
DOI: 10.3389/fncel.2014.00056     Document Type: Article

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