Alternatively spliced, truncated GCSF receptor promotes leukemogenic properties and sensitivity to JAK inhibition

Leukemia

Volumn 28, Issue 5, 2014, Pages 1041-1051

  Mehta, H M ^a   Futami, M ^a,b   Glaubach, T ^a   Lee, D W ^c   Andolina, J R ^a,d   Yang, Q ^a   Whichard, Z ^a   Quinn, M ^a   Lu, H F ^a   Kao, W M ^e   Przychodzen, B ^e   Sarkar, C A ^f   Minella, A ^a   Maciejewski, J P ^e   Corey, S J ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY OF TOKYO   (Japan)

^c NATIONAL CANCER INSTITUTE   (United States)

^d UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^e TAUSSIG CANCER INSTITUTE   (United States)

^f UNIVERSITY OF MINNESOTA   (United States)

Author keywords

acute myeloid leukemia: JAK2; GCSF; GCSFR; myelodysplastic syndromes

Indexed keywords

GRANULOCYTE COLONY STIMULATING FACTOR RECEPTOR; JANUS KINASE; PHOSPHOPROTEIN; RUXOLITINIB; SIGNAL PEPTIDE; STAT3 PROTEIN; STAT5 PROTEIN;

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; ANIMAL CELL; APOPTOSIS; ARTICLE; BINDING AFFINITY; CELL DIFFERENTIATION; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME INHIBITION; FEMALE; GENE EXPRESSION; GENE MUTATION; HUMAN; HUMAN CELL; LEUKEMIA RELAPSE; MALE; MONOSOMY 7; MYELODYSPLASTIC SYNDROME; NONHUMAN; NONSENSE MUTATION; PRIORITY JOURNAL; STEM CELL;

ADULT; ALTERNATIVE SPLICING; ANIMALS; CELL LINE; CHILD; FEMALE; FLOW CYTOMETRY; HUMANS; JANUS KINASES; LEUKEMIA, MYELOID, ACUTE; MALE; MICE; RECEPTORS, GRANULOCYTE COLONY-STIMULATING FACTOR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 84899910696     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2013.321     Document Type: Article

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