Impaired vascular function in physically active premenopausal women with functional hypothalamic amenorrhea is associated with low shear stress and increased vascular tone

Journal of Clinical Endocrinology and Metabolism

Volumn 99, Issue 5, 2014, Pages 1798-1806

  O'Donnell, Emma ^a   Goodman, Jack M ^a,b   Mak, Susanna ^b   Harvey, Paula J ^c  

^a UNIVERSITY OF TORONTO   (Canada)

^b MOUNT SINAI HOSPITAL   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ESTRADIOL; GLYCERYL TRINITRATE; LIOTHYRONINE;

ADULT; AREA UNDER THE CURVE; ARTERY BLOOD FLOW; ARTICLE; BLOOD VESSEL TONE; BODY MASS; BRACHIAL ARTERY; CLINICAL EVALUATION; DIASTOLIC BLOOD PRESSURE; DISEASE ASSOCIATION; ESTRADIOL BLOOD LEVEL; EXERCISE INTENSITY; FEMALE; HUMAN; HYPOTHALAMIC AMENORRHEA; LIOTHYRONINE BLOOD LEVEL; MEAN ARTERIAL PRESSURE; MENSTRUATION; PHYSICAL ACTIVITY; PREMENOPAUSE; PRIORITY JOURNAL; RECREATION; SEDENTARY LIFESTYLE; SHEAR RATE; SHEAR STRESS; SYSTOLIC BLOOD PRESSURE; VASCULAR DISEASE; VASCULAR ENDOTHELIUM; VASCULAR RESISTANCE; YOUNG ADULT;

ADULT; AMENORRHEA; BRACHIAL ARTERY; ENDOTHELIUM, VASCULAR; EXERCISE; FEMALE; HUMANS; HYPOTHALAMIC DISEASES; REGIONAL BLOOD FLOW; STRESS, MECHANICAL;

EID: 84899902508     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2013-3398     Document Type: Article

References (41)

1. Förstermann U, Münzel T. Endothelial nitric oxide synthase in vascular disease: from marvel to menace. Circulation. 2006;113:1708-1714.
2. Bairey Merz CN, Johnson BD, Sharaf BL, et al. Hypoestrogenemia of hypothalamic origin and coronary artery disease in premenopausal women: a report from the NHLBI-sp onsored WISE study. J Am Coll Cardiol. 2003;41:413-419.
3. Kaplan JR, Manuck SB. Ovarian dysfunction, stress, and disease: a primate continuum. ILAR J. 2004;45:89-115.
4. Otis CL, Drinkwater B, Johnson M, Loucks A, Wilmore J. 1997 American College of Sports Medicine position stand. The Female Athlete Triad. Med Sci Sports Exerc. 29:i-ix
5. Williams NI, Helmreich DL, Parfitt DB, Caston-Balderrama A, Cameron JL. Evidence for a causal role of low energy availability in the induction of menstrual cycle disturbances during strenuous exercise training. J Clin Endocrinol Metab. 2001;86:5184-5193.
6. Hoch AZ, Jurva JW, Staton MA, et al. Athletic amenorrhea and endothelial dysfunction. WMJ. 2007;106:301-306.
7. Rickenlund A, Eriksson MJ , Schenck-Gustafsson K, Hirschberg AL. Amenorrhea in female athletes is associated with endothelial dysfunction and unfavorable lipid profile. J Clin Endocrinol Metab. 2005;90:1354-1359.
8. Yoshida N , Ikeda H, Sugi K, Imaizumi T. Impaired endotheliumdependent and-independent vasodilation in young female athletes with exercise-associated amenorrhea. Arterioscler Thromb Vasc Biol. 2006;26:231-232.
9. Zeni Hoch A, Dempsey RL, Carrera GF, et al. Is there an association between athletic amenorrhea and endothelial cell dysfunction Med Sci Sports Exerc. 2003;35:377-383.
10. O'Donnell E, Harvey PJ, Goodman JM, De Souza MJ. Long-term estrogen deficiency lowers regional blood flow, resting systolic blood pressure, and heart rate in exercising premenopausal women. Am J Physiol Endocrinol Metab. 2007; 292:E1401-E1409.
11. O'Donnell E, Harvey PJ, De Souza MJ. Relationships between vascular resistance and energy deficiency, nutritional status and oxidative stress in oestrogen deficient physically active women. Clin Endocrinol (Oxf). 2009;70:294-302.
12. Halliwill JR. Mechanisms and clinical implications of post-exercise hypotension in humans. Exerc Sport Sci Rev. 2001;29:65-70.
13. Harvey PJ, Picton PE, Su WS, Morris BL, Notarius CF, Floras JS. Exercise as an alternative to oral estrogen for amelioration of endothelial dysfunction in postmenopausal women.AmHeart J. 2005; 149:291-297.
14. Traub O, Berk BC. Laminar shear stress: mechanisms by which endothelial cells transduce an atheroprotective force. Arterioscler Thromb Vasc Biol. 1998;18:677-685.
15. Vanhoutte PM. Endothelial dysfunction: The first step toward coronary arteriosclerosis. Circ J. 2009;73:595-601.
16. Schaal K, Van Loan MD, Casazza GA. Reduced catecholamine response to exercise in amenorrheic athletes. Med Sci Sports Exerc. 2011;43:34-43.
17. Pyke K, Green DJ, Weisbrod C, et al. Nitric oxide is not obligatory for radial artery flow-mediated dilation following release of 5 or 1 0 min distal occlusion. Am J Physiol Heart Circ Physiol. 2010;298: H119-H126.
18. Harris RA, Nishiyama SK, Wray DW, Richardson RS. Ultrasound assessment of flow-mediated dilation. Hypertension. 2010;55: 1075-1085.
19. Bartoli G, Menegaz G, Dragoni S, Gori T. 2007 SpLiNeS: automatic analysis of ecographic movies of flow-mediated dilation. In: Emelianov SY, McAleavey SA, eds. Proc SP IE. Vol 6513, 65131G. The International Society for Optical Engineering; 2007.
20. Reading JL, Goodman JM, Plyley MJ, et al. Vascular conductance and aerobic power in sedentary and active subjects and hea rt failure patients. J Appl Physiol. 1993;74:567-573.
21. Friedewald WT Halperin M. Clofibrate in ischemic heart disease Ann Intern Med.1972 76 821-823.
22. Loucks AB, Heath EM. Induction of low-T3 syndrome in exercising women occurs at a threshold of energy availability. Am J Physiol. 1994;266:R817-R823.
23. Thijssen DH, Dawson EA, Tinken TM, Cable NT, Green DJ. Retrograde flow and shear rate acutely impair endothelial function in humans. Hypertension. 2009;53:986-992.
24. Moreau KL, Donato AJ, Tanaka H, Jones PP, Gates PE, Seals DR. Basal leg blood flow in healthy women is related to age and hormone replacement therapy status. J Physiol. 2003;547:309-316.
25. Gerhard M, Walsh BW, Tawakol A, et al. Estradiol therapy combined with progesterone and endothelium-dependent vasodilation in postmenopausal women. Circulation. 1998;98:1158-1163.
26. Orshal JM, Khalil RA. Gender, sex hormones, and vascular tone. Am J Physiol Regul Integr Comp Physiol. 2004;286:R233-R249.
27. Pyke KE, Dwyer EM, Tschakovsky ME. Impact of controlling shear rate on flow-mediated dilation responses in the brachial artery of humans. J Appl Physiol. 2004;97:499-508.
28. Lepori M, Sartori C, Duplain H, Nicod P, Scherrer U. Sympathectomy potentiates the vasoconstrictor response to nitric oxide synthase inhibition in humans. Cardiovasc Res. 1999;43:739-743.
29. Momen A, Gao Z, Cohen A, Khan T, Leuenberger UA, Sinoway LI. Coronary vasoconstrictor responses are attenuated in youngwomen as compared with age-matched men. J Physiol. 2010;588:4007-4016.
30. Sudhir K, Elser MD, Jennings GL, Komesaroff PA. Estrogen supp lementation decreases norepinephrine-induced vasoconstriction and total body norepinephrine spillover in perimenopausal women. Hypertension. 1997;30:1538-1543.
31. Drexler H, Hayoz D, M ünzel T, et al. Endothelial function in chronic congestive heart failure. Am J Cardiol. 1992;69:1596-1601.
32. Jacobsen TN, Morgan BJ, Scherrer U, et al. Relative contributions of cardiopulmonary and sinoa ortic baroreflexes in causing sympathetic activation in the human skeletal muscle circulation during orthostatic stress. Circ Res. 1993;73:367-378.
33. DeSouza MJ, Leidy HJ, O'Donnell E, Lasley B, Williams NI. Fasting ghrelin levels in physically active women: relationship with menstrual disturbances and metabolic hormones. J Clin Endocrinol Metab. 2004;89:3536-3542.
34. O'Donnell E, De Souza MJ. Increased serum adiponectin concentrations in amenorrheic physically active women are associated with impaired bone health but not with estrogen exposure. Bone. 2011; 48:760-767.
35. Tesauro M, Schinza ri F, Iantorno M, et al. Ghrelin improves endothelial function in patients with metabolic syndrome. Circulation. 2005;112:2986-2992.
36. Cao Y, Tao L, Yuan Y, et al. Endothelial dysfunction in adiponectin deficiency and its mechanisms involved. J Mol Cell Cardiol. 2009; 46:413-419.
37. Grossini E, Molinari C, Mary DA, Ghigo E, Bona G, Vacca G. Intracoronary ghrelin infusion decreases coronary blood flow in anesthetized pigs. Endocrinology. 2007;148:806-812.
38. Laughlin MH, Davis MJ, Secher NH, et al. Peripheral circulation. Compr Physiol. 2012;2:321-447.
39. SalehTM,Connell BJ. Centrally mediated effect of 17beta-estradiol on parasympathetic tone in male rats. Am J Physiol. 1999;276: R474-R481.
40. Vongpatanasin W, Tuncel M, Mansour Y, Arbique D, Victor RG. Transdermal estrogen replacement therapy decreases sympat hetic activity in postmenopausal women. Circulation. 2001;103:2903-2908.
41. Thijssen DH, Black MA, Pyke KE, et al. Assessment of flow-mediated dilation in humans: a methodological and physiologi cal guideline. Am J Physiol Heart Circ Physiol. 2011;300:H2-H12.