Basal leg blood flow in healthy women is related to age and hormone replacement therapy status

Journal of Physiology

Volumn 547, Issue 1, 2003, Pages 309-316

  Moreau, Kerrie L ^a   Donato, Anthony J ^a   Tanaka, Hirofumi ^a   Parker Jones, Pamela ^a   Gates, Phillip E ^a   Seals, Douglas R ^a,b  

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONJUGATED ESTROGEN; ESTRADIOL;

ADULT; AGED; AGING; ARTERY BLOOD FLOW; ARTERY DIAMETER; BODY FAT; CONDUCTANCE; CONTROLLED STUDY; DRUG USE; ESTROGEN DEFICIENCY; FEMALE; FEMORAL ARTERY; HEART OUTPUT; HORMONE SUBSTITUTION; HUMAN; LEG BLOOD FLOW; LONG TERM CARE; NERVE CONDUCTION; POSTMENOPAUSE; PRIORITY JOURNAL; REVIEW; SHEAR STRESS; SYMPATHETIC FUNCTION; SYMPATHETIC NERVE; VASOCONSTRICTION; AGE; ARTICLE; BLOOD VESSEL REACTIVITY; FAT FREE MASS; FEMORAL ARTERY FLOW; HUMAN EXPERIMENT; NORMAL HUMAN; SYMPATHETIC TONE; VASCULAR RESISTANCE;

ADULT; AGING; CARDIAC OUTPUT; ESTROGEN REPLACEMENT THERAPY; ESTROGENS; FEMALE; FEMORAL ARTERY; HUMANS; LEG; MIDDLE AGED; MUSCLE, SKELETAL; POSTMENOPAUSE; PREMENOPAUSE; PROGESTERONE; REGIONAL BLOOD FLOW; SYMPATHETIC NERVOUS SYSTEM; VASCULAR RESISTANCE;

EID: 0037440676     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.2002.032524     Document Type: Review

References (45)

1. Amrani M, Goodwin AT, Gray CC & Yacoub MH (1996). Ageing is associated with reduced basal and stimulated release of nitric oxide by the coronary endothelium. Acta Physiol Scand 157, 79-84.
2. Baron AD, Laakso M, Brechtel G, Hoit B, Watt C & Edelman SV (1990). Reduced postprandial skeletal muscle blood flow contributes to glucose intolerance in human obesity. J Clin Endocrinol Metab 70, 1525-1533.
3. Binko J, Murphy TV & Majewski H (1998). 17Beta-oestradiol enhances nitric oxide synthase activity in endothelium-denuded rat aorta. Clin Exp Pharmacol Physiol 25, 120-127.
4. Brooks EM, Morgan AL, Pierzga JM, Wladkowski SL, O'Gorman JT, Derr JA & Kenney WL (1997). Chronic hormone replacement therapy alters thermoregulatory and vasomotor function in postmenopausal women. J Appl Physiol 83, 477-484.
5. Carallo C, Concetta I, Pujia A, De Franceschi MS, Crescenzo A, Motti C, Cortese C, Mattioli PL & Gnasso A (1999). Evaluation of common carotid hemodynamic forces: Relations with wall thickening. Hypertension 34, 217-221.
6. Davies PF (1995). Flow-mediated endothelial mechanotransduction. Physiol Rev 75, 519-560.
7. Del Rio G, Velardo A, Menozzi R, Zizzo G, Tavernari V, Venneri MG, Marrama P & Petraglia F (1998). Acute estradiol and progesterone administration reduced cardiovascular and catecholamine responses to mental stress in menopausal women. Neuroendocrinology 67, 269-274.
8. Dinenno FA, Jones PP, Seals DR & Tanaka H (1999). Limb blood flow and vascular conductance are reduced with age in healthy humans: relation to elevations in sympathetic nerve activity and declines in oxygen demand. Circulation 100, 164-170.
9. Dinenno FA, Seals DR, Desouza CA & Tanaka H (2001a). Age-related decreases in basal limb blood flow in humans: time course, determinants and habitual exercise effects. J Physiol 531, 573-579.
10. Dinenno FA, Tanaka H, Monahan KD, Clevenger CM, Eskurza I, Desouza CA & Seals DR (2001b). Regular endurance exercise induces expansive arterial remodelling in the trained limbs of healthy men. J Physiol 534, 287-295.
11. Dinenno FA, Tanaka H, Stauffer BL & Seals DR (2001c). Reductions in basal limb blood flow and vascular conductance with human ageing: role for augmented alpha-adrenergic vasoconstriction. J Physiol 536, 977-983.
12. Dubey RK & Jackson EK (2001). Estrogen-induced cardiorenal protection: potential cellular, biochemical, and molecular mechanisms. Am J Physiol Renal Physiol 280, F365-388.
13. Dunbar SL & Kenney WL (2000). Effects of hormone replacement therapy on hemodynamic responses of postmenopausal women to passive heating. J Appl Physiol 89, 97-103.
14. Friedewald WT, Levey RI & Frederickson DS (1972). Estimation of the concentration of LDL-C in plasma without the use of the preparative ultracentrifuge. Clin Chem 18, 499-502.
15. Gilligan DM, Badar DM, Panza JA, Quyyumi AA & Cannon RO (1994). Acute vascular effects of estrogen in postmenopausal women. Circulation 90, 786-791.
16. Hjermann I (1992). The metabolic cardiovascular syndrome: syndrome X, Reaven's syndrome, insulin resistance syndrome, atherothrombogenic syndrome. J Cardiovasc Pharmacol 20, S5-10.
17. Hunt BE, Taylor JA, Hamner JW, Gagnon M & Lipsitz LA (2001). Estrogen replacement therapy improves baroreflex regulation of vascular sympathetic outflow in postmenopausal women. Circulation 103, 2909-2914.
18. Jones PP, Davy KP, Alexander S & Seals DR (1997). Age-related increase in muscle sympathetic nerve activity is associated with abdominal adiposity. Am J Physiol 272, E976-980.
19. Kenney WL (1997). Thermoregulation at rest and during exercise in healthy older adults. Exerc Sport Sci Rev 25, 41-76.
20. Kenney WL, Morgan AL, Farquhar WB, Brooks EM, Pierzga JM & Derr JA ( 1997). Decreased active vasodilator sensitivity in aged skin. Am J Physiol 272, H1609-1614.
21. Lieberman EH, Gerhard MD, Uehata A, Walsh BW, Selwyn AP, Ganz P, Yeung AC & Creager MA (1994). Estrogen improves endothelium-dependent, flow-mediated vasodilation in postmenopausal women. Ann Intern Med 121, 936-941.
22. Lind L & Lithell H (1993). Decreased peripheral blood flow in the pathogenesis of the metabolic syndrome comprising hypertension, hyperlipidemia, and hyperinsulinemia. Am Heart J 125, 1494-1497.
23. Majmudar NG, Robson SC & Ford GA (2000). Effects of the menopause, gender, and estrogen replacement therapy on vascular nitric oxide activity. J Clin Endocrinol Metab 85, 1577-1583.
24. Meneilly GS, Elliot T, Bryer-Ash M & Floras JS (1995). Insulin-mediated increase in blood flow is impaired in the elderly. J Clin Endocrinol Metab 80, 1899-1903.
25. Meyer MC, Cummings K & Osol G (1997). Estrogen replacement attenuates resistance artery adrenergic sensitivity via endothelial vasodilators. Am J Physiol 272, H2264-2270.
26. Mikkola TS & Clarkson TB (2002). Estrogen replacement therapy, atherosclerosis, and vascular function. Cardiovasc Res 53, 605-619.
27. Ng AV, Callister R, Johnson DG & Seals DR (1993). Age and gender influence muscle sympathetic nerve activity at rest in healthy humans. Hypertension 21, 498-503.
28. Nomura K, Seto H, Kamisaki Y, Kageyama M, Nagayoshi T & Kakishita M (1996). Doppler spectral analysis of blood flow velocities in common femoral artery: age-related changes in healthy subjects and characteristics of abnormal hemodynamics in obstructive arterial disease. Radiat Med 14, 13-17.
29. 2 relationships during submaximal cycle ergometry. J Appl Physiol 84, 599-605.
30. Seals DR, Hagberg JM, Spina RJ, Rogers MA, Schechtman KB & Ehsani AA (1994). Enhanced left ventricular performance in endurance trained older men. Circulation 89, 198-205.
31. Spina RJ, Miller TR, Bogenhagen WH, Schechtman KB & Ehsani AA (1996). Gender-related differences in left ventricular filling dynamics in older subjects after endurance exercise training. J Gerontol A Biol Sci Med Sci 51, B232-237.
32. Spina RJ, Ogawa T, Kohrt WM, Martin WH III, Holloszy JO & Ehsani AA (1993a). Differences in cardiovascular adaptations to endurance exercise training between older men and women. J Appl Physiol 75, 849-855.
33. Spina RJ, Ogawa T, Miller TR, Kohrt WM & Ehsani AA (1993b). Effect of exercise training on left ventricular performance in older women free of cardiopulmonary disease. Am J Cardiol 71, 99-104.
34. Stevenson ET, Davy KP & Seals DR (1995). Hemostatic, metabolic, and androgenic risk factors for coronary heart disease in physically active and less active postmenopausal women. Arterioscler Thromb Vasc Biol 15, 669-677.
35. Sudhir K, Elser MD, Jennings GL & Komesaroff PA (1997). Estrogen supplementation decreases norepinephrine-induced vasoconstriction and total body norepinephrine spillover in perimenopausal women. Hypertension 30, 1538-1543.
36. Taddei S, Virdis A, Ghiadoni L, Salvetti G, Bernini G, Magagna A & Salvetti A (2001). Age-related reduction of NO availability and oxidative stress in humans. Hypertension 38, 274-279.
37. Tankersley CG, Nicholas WC, Deaver DR, Mikita D & Kenney WL (1992). Estrogen replacement in middle-aged women: thermoregulatory responses to exercise in the heat. J Appl Physiol 73, 1238-1245.
38. Vehkavaara S, Hakala-Ala-Pietila T, Virkamaki A, Bergholm. R, Ehnholm C, Hovatta O, Taskinen MR & Yki-Jarvinen H (2000). Differential effects of oral and transdermal estrogen replacement therapy on endothelial function in postmenopausal women. Circulation 102, 2687-2693.
39. Virdis A, Ghiadoni L, Pinto S, Lombardo M, Petraglia F, Gennazzani A, Buralli S, Taddei S & Salvetti A (2000). Mechanisms responsible for endothelial dysfunction associated with acute estrogen deprivation in normotensive women. Circulation 101, 2258-2263.
40. Volterrani M, Rosano G, Coats A, Beale C & Collins P (1995). Estrogen acutely increases peripheral blood flow in postmenopausal women. Am J Med 99, 119-122.
41. Vongpatanasin W, Tuncel M, Mansour Y, Arbique D & Victor RG (2001). Transdermal estrogen replacement therapy decreases sympathetic activity in postmenopausal women. Circulation 103, 2903-2908.
42. Wahren J, Saltin B, Jorfeldt L & Pernow B (1974). Influence of age on the local circulatory adaptation to leg exercise. Scand J Clin Lab Invest 33, 79-86.
43. Weitz G, Elam M, Born J, Fehm HL & Dodt C (2001). Postmenopausal estrogen administration suppresses muscle sympathetic nerve activity. J Clin Endocrinol Metab 86, 344-348.
44. Zanzinger J (1999). Role of nitric oxide in the neural control of cardiovascular function. Cardiovasc Res 43, 639-649.
45. Zanzinger J, Czachurski J & Seller H (1994). Inhibition of sympathetic vasoconstriction is a major principle of vasodilation by nitric oxide in vivo. Circ Res 75, 1073-1077.