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Volumn 42, Issue 8, 2014, Pages 4791-4799

Transcript level and sequence determinants of protein abundance and noise in Escherichia coli

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA;

EID: 84899881726     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gku126     Document Type: Article
Times cited : (68)

References (73)
  • 1
    • 33746265259 scopus 로고    scopus 로고
    • Natural selection on gene expression
    • Gilad, Y., Oshlack, A. and Rifkin, S.A. (2006) Natural selection on gene expression. Trends Genet., 22, 456-461.
    • (2006) Trends Genet. , vol.22 , pp. 456-461
    • Gilad, Y.1    Oshlack, A.2    Rifkin, S.A.3
  • 2
    • 79954456859 scopus 로고    scopus 로고
    • Determinants of translation efficiency and accuracy
    • Gingold, H. and Pilpel, Y. (2011) Determinants of translation efficiency and accuracy. Mol. Syst. Biol., 7, 481.
    • (2011) Mol. Syst. Biol. , vol.7 , pp. 481
    • Gingold, H.1    Pilpel, Y.2
  • 3
    • 84858439862 scopus 로고    scopus 로고
    • Insights into the regulation of protein abundance from proteomic and transcriptomic analyses
    • Vogel, C. and Marcotte, E.M. (2012) Insights into the regulation of protein abundance from proteomic and transcriptomic analyses. Nat. Rev. Genet., 13, 227-232.
    • (2012) Nat. Rev. Genet. , vol.13 , pp. 227-232
    • Vogel, C.1    Marcotte, E.M.2
  • 5
    • 33846165487 scopus 로고    scopus 로고
    • Absolute protein expression profiling estimates the relative contributions of transcriptional and translational regulation
    • Lu, P., Vogel, C., Wang, R., Yao, X. and Marcotte, E.M. (2007) Absolute protein expression profiling estimates the relative contributions of transcriptional and translational regulation. Nat. Biotechnol., 25, 117-124.
    • (2007) Nat. Biotechnol. , vol.25 , pp. 117-124
    • Lu, P.1    Vogel, C.2    Wang, R.3    Yao, X.4    Marcotte, E.M.5
  • 7
    • 75149180460 scopus 로고    scopus 로고
    • Unbiased quantitation of Escherichia coli membrane proteome using phase transfer surfactants
    • Masuda, T., Saito, N., Tomita, M. and Ishihama, Y. (2009) Unbiased quantitation of Escherichia coli membrane proteome using phase transfer surfactants. Mol. Cell Proteomics, 8, 2770-2777.
    • (2009) Mol. Cell Proteomics , vol.8 , pp. 2770-2777
    • Masuda, T.1    Saito, N.2    Tomita, M.3    Ishihama, Y.4
  • 8
    • 33845790070 scopus 로고    scopus 로고
    • Correlation of mRNA expression and protein abundance affected by multiple sequence features related to translational efficiency in Desulfovibrio vulgaris: A quantitative analysis
    • Nie, L., Wu, G. and Zhang, W. (2006) Correlation of mRNA expression and protein abundance affected by multiple sequence features related to translational efficiency in Desulfovibrio vulgaris: a quantitative analysis. Genetics, 174, 2229-2243.
    • (2006) Genetics , vol.174 , pp. 2229-2243
    • Nie, L.1    Wu, G.2    Zhang, W.3
  • 9
    • 0141920354 scopus 로고    scopus 로고
    • Comparing protein abundance and mRNA expression levels on a genomic scale
    • Greenbaum, D., Colangelo, C., Williams, K. and Gerstein, M. (2003) Comparing protein abundance and mRNA expression levels on a genomic scale. Genome Biol., 4, 117.
    • (2003) Genome Biol. , vol.4 , pp. 117
    • Greenbaum, D.1    Colangelo, C.2    Williams, K.3    Gerstein, M.4
  • 10
    • 27644482393 scopus 로고    scopus 로고
    • Lost in translation: The influence of ribosomes on bacterial mRNA decay
    • Deana, A. and Belasco, J.G. (2005) Lost in translation: the influence of ribosomes on bacterial mRNA decay. Genes Dev., 19, 2526-2533.
    • (2005) Genes Dev. , vol.19 , pp. 2526-2533
    • Deana, A.1    Belasco, J.G.2
  • 12
    • 0025297285 scopus 로고
    • Codon preferences in free-living microorganisms
    • Andersson, S.G. and Kurland, C.G. (1990) Codon preferences in free-living microorganisms. Microbiol. Rev., 54, 198-210.
    • (1990) Microbiol. Rev. , vol.54 , pp. 198-210
    • Andersson, S.G.1    Kurland, C.G.2
  • 13
    • 0025941139 scopus 로고
    • The selection-mutation-drift theory of synonymous codon usage
    • Bulmer, M. (1991) The selection-mutation-drift theory of synonymous codon usage. Genetics, 129, 897-907.
    • (1991) Genetics , vol.129 , pp. 897-907
    • Bulmer, M.1
  • 14
    • 62549134121 scopus 로고    scopus 로고
    • Genome-wide analysis in vivo of translation with nucleotide resolution using ribosome profiling
    • Ingolia, N.T., Ghaemmaghami, S., Newman, J.R. and Weissman, J.S. (2009) Genome-wide analysis in vivo of translation with nucleotide resolution using ribosome profiling. Science, 324, 218-223.
    • (2009) Science , vol.324 , pp. 218-223
    • Ingolia, N.T.1    Ghaemmaghami, S.2    Newman, J.R.3    Weissman, J.S.4
  • 16
    • 10944232800 scopus 로고    scopus 로고
    • Post-transcriptional expression regulation in the yeast Saccharomyces cerevisiae on a genomic scale
    • Beyer, A., Hollunder, J., Nasheuer, H.P. and Wilhelm, T. (2004) Post-transcriptional expression regulation in the yeast Saccharomyces cerevisiae on a genomic scale. Mol. Cell Proteomics, 3, 1083-1092.
    • (2004) Mol. Cell Proteomics , vol.3 , pp. 1083-1092
    • Beyer, A.1    Hollunder, J.2    Nasheuer, H.P.3    Wilhelm, T.4
  • 17
    • 34047223024 scopus 로고    scopus 로고
    • Posttranscriptional expression regulation: What determines translation rates? PLoS Comput
    • Brockmann, R., Beyer, A., Heinisch, J.J. and Wilhelm, T. (2007) Posttranscriptional expression regulation: what determines translation rates? PLoS Comput. Biol., 3, e57.
    • (2007) Biol. , vol.3
    • Brockmann, R.1    Beyer, A.2    Heinisch, J.J.3    Wilhelm, T.4
  • 18
    • 78650304100 scopus 로고    scopus 로고
    • Synonymous but not the same: The causes and consequences of codon bias
    • Plotkin, J.B. and Kudla, G. (2011) Synonymous but not the same: the causes and consequences of codon bias. Nat. Rev. Genet., 12, 32-42.
    • (2011) Nat. Rev. Genet. , vol.12 , pp. 32-42
    • Plotkin, J.B.1    Kudla, G.2
  • 19
    • 0028220048 scopus 로고
    • Synonymous codon usage in Drosophila melanogaster: Natural selection and translational accuracy
    • Akashi, H. (1994) Synonymous codon usage in Drosophila melanogaster: natural selection and translational accuracy. Genetics, 136, 927-935.
    • (1994) Genetics , vol.136 , pp. 927-935
    • Akashi, H.1
  • 20
    • 0021958933 scopus 로고
    • Codon usage and tRNA content in unicellular and multicellular organisms
    • Ikemura, T. (1985) Codon usage and tRNA content in unicellular and multicellular organisms. Mol. Biol. Evol., 2, 13-34.
    • (1985) Mol. Biol. Evol. , vol.2 , pp. 13-34
    • Ikemura, T.1
  • 21
    • 0021764898 scopus 로고
    • Translation is a non-uniform process effect of tRNA availability on the rate of elongation of nascent polypeptide chains
    • Varenne, S., Buc, J., Lloubes, R. and Lazdunski, C. (1984) Translation is a non-uniform process. effect of tRNA availability on the rate of elongation of nascent polypeptide chains. J. Mol. Biol., 180, 549-576.
    • (1984) J. Mol. Biol. , vol.180 , pp. 549-576
    • Varenne, S.1    Buc, J.2    Lloubes, R.3    Lazdunski, C.4
  • 22
    • 37849033856 scopus 로고    scopus 로고
    • Determinants of protein abundance and translation efficiency in S cerevisiae
    • Tuller, T., Kupiec, M. and Ruppin, E. (2007) Determinants of protein abundance and translation efficiency in S. cerevisiae. PLoS Comput. Biol., 3, e248.
    • (2007) PLoS Comput. Biol. , vol.3
    • Tuller, T.1    Kupiec, M.2    Ruppin, E.3
  • 23
    • 77649245858 scopus 로고    scopus 로고
    • Translation efficiency is determined by both codon bias and folding energy
    • Tuller, T., Waldman, Y.Y., Kupiec, M. and Ruppin, E. (2010) Translation efficiency is determined by both codon bias and folding energy. Proc. Natl Acad. Sci. USA, 107, 3645-3650.
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 3645-3650
    • Tuller, T.1    Waldman, Y.Y.2    Kupiec, M.3    Ruppin, E.4
  • 24
    • 64849114915 scopus 로고    scopus 로고
    • Coding-sequence determinants of gene expression in Escherichia coli
    • Kudla, G., Murray, A.W., Tollervey, D. and Plotkin, J.B. (2009) Coding-sequence determinants of gene expression in Escherichia coli. Science, 324, 255-258.
    • (2009) Science , vol.324 , pp. 255-258
    • Kudla, G.1    Murray, A.W.2    Tollervey, D.3    Plotkin, J.B.4
  • 25
    • 19544379881 scopus 로고    scopus 로고
    • Stochasticity in gene expression: From theories to phenotypes
    • Kaern, M., Elston, T.C., Blake, W.J. and Collins, J.J. (2005) Stochasticity in gene expression: from theories to phenotypes. Nat. Rev. Genet., 6, 451-464.
    • (2005) Nat. Rev. Genet. , vol.6 , pp. 451-464
    • Kaern, M.1    Elston, T.C.2    Blake, W.J.3    Collins, J.J.4
  • 26
    • 0037078982 scopus 로고    scopus 로고
    • Control, exploitation and tolerance of intracellular noise
    • Rao, C.V., Wolf, D.M. and Arkin, A.P. (2002) Control, exploitation and tolerance of intracellular noise. Nature, 420, 231-237.
    • (2002) Nature , vol.420 , pp. 231-237
    • Rao, C.V.1    Wolf, D.M.2    Arkin, A.P.3
  • 27
    • 33645027986 scopus 로고    scopus 로고
    • Stochastic protein expression in individual cells at the single molecule level
    • Cai, L., Friedman, N. and Xie, X.S. (2006) Stochastic protein expression in individual cells at the single molecule level. Nature, 440, 358-362.
    • (2006) Nature , vol.440 , pp. 358-362
    • Cai, L.1    Friedman, N.2    Xie, X.S.3
  • 31
  • 34
    • 84866082847 scopus 로고    scopus 로고
    • Teasing apart translational and transcriptional components of stochastic variations in eukaryotic gene expression
    • Salari, R., Wojtowicz, D., Zheng, J., Levens, D., Pilpel, Y. and Przytycka, T.M. (2012) Teasing apart translational and transcriptional components of stochastic variations in eukaryotic gene expression. PLoS Comput. Biol., 8, e1002644.
    • (2012) PLoS Comput. Biol. , vol.8
    • Salari, R.1    Wojtowicz, D.2    Zheng, J.3    Levens, D.4    Pilpel, Y.5    Przytycka, T.M.6
  • 35
    • 77955102352 scopus 로고    scopus 로고
    • Quantifying E coli proteome and transcriptome with single-molecule sensitivity in single cells
    • Taniguchi, Y., Choi, P.J., Li, G.W., Chen, H., Babu, M., Hearn, J., Emili, A. and Xie, X.S. (2010) Quantifying E. coli proteome and transcriptome with single-molecule sensitivity in single cells. Science, 329, 533-538.
    • (2010) Science , vol.329 , pp. 533-538
    • Taniguchi, Y.1    Choi, P.J.2    Li, G.W.3    Chen, H.4    Babu, M.5    Hearn, J.6    Emili, A.7    Xie, X.S.8
  • 36
    • 0026544545 scopus 로고
    • The influence of ribosome-binding-site elements on translational efficiency in Bacillus subtilis and Escherichia coli in vivo
    • Vellanoweth, R.L. and Rabinowitz, J.C. (1992) The influence of ribosome-binding-site elements on translational efficiency in Bacillus subtilis and Escherichia coli in vivo. Mol. Microbiol., 6, 1105-1114.
    • (1992) Mol. Microbiol. , vol.6 , pp. 1105-1114
    • Vellanoweth, R.L.1    Rabinowitz, J.C.2
  • 37
    • 0028584414 scopus 로고
    • Determination of the optimal aligned spacing between the Shine-Dalgarno sequence and the translation initiation codon of Escherichia coli mRNAs
    • Chen, H., Bjerknes, M., Kumar, R. and Jay, E. (1994) Determination of the optimal aligned spacing between the Shine-Dalgarno sequence and the translation initiation codon of Escherichia coli mRNAs. Nucleic Acids Res., 22, 4953-4957.
    • (1994) Nucleic Acids Res. , vol.22 , pp. 4953-4957
    • Chen, H.1    Bjerknes, M.2    Kumar, R.3    Jay, E.4
  • 38
    • 0028036559 scopus 로고
    • Control of translation by mRNA secondary structure in Escherichia coli. A quantitative analysis of literature data
    • de Smit, M.H. and van Duin, J. (1994) Control of translation by mRNA secondary structure in Escherichia coli. A quantitative analysis of literature data. J. Mol. Biol., 244, 144-150.
    • (1994) J. Mol. Biol. , vol.244 , pp. 144-150
    • De Smit, M.H.1    Van Duin, J.2
  • 39
    • 0020486135 scopus 로고
    • A role for mRNA secondary structure in the control of translation initiation
    • Hall, M.N., Gabay, J., Debarbouille, M. and Schwartz, M. (1982) A role for mRNA secondary structure in the control of translation initiation. Nature, 295, 616-618.
    • (1982) Nature , vol.295 , pp. 616-618
    • Hall, M.N.1    Gabay, J.2    Debarbouille, M.3    Schwartz, M.4
  • 40
    • 0029905958 scopus 로고    scopus 로고
    • Genetic analysis of the Shine-Dalgarno interaction: Selection of alternative functional mRNA-rRNA combinations
    • Lee, K., Holland-Staley, C.A. and Cunningham, P.R. (1996) Genetic analysis of the Shine-Dalgarno interaction: selection of alternative functional mRNA-rRNA combinations. RNA, 2, 1270-1285.
    • (1996) RNA , vol.2 , pp. 1270-1285
    • Lee, K.1    Holland-Staley, C.A.2    Cunningham, P.R.3
  • 41
    • 70349964350 scopus 로고    scopus 로고
    • Automated design of synthetic ribosome binding sites to control protein expression
    • Salis, H.M., Mirsky, E.A. and Voigt, C.A. (2009) Automated design of synthetic ribosome binding sites to control protein expression. Nat. Biotechnol., 27, 946-950.
    • (2009) Nat. Biotechnol. , vol.27 , pp. 946-950
    • Salis, H.M.1    Mirsky, E.A.2    Voigt, C.A.3
  • 42
    • 0016610995 scopus 로고
    • Determinant of cistron specificity in bacterial ribosomes
    • Shine, J. and Dalgarno, L. (1975) Determinant of cistron specificity in bacterial ribosomes. Nature, 254, 34-38.
    • (1975) Nature , vol.254 , pp. 34-38
    • Shine, J.1    Dalgarno, L.2
  • 43
    • 33645965566 scopus 로고    scopus 로고
    • Unfolding of mRNA secondary structure by the bacterial translation initiation complex
    • Studer, S.M. and Joseph, S. (2006) Unfolding of mRNA secondary structure by the bacterial translation initiation complex. Mol. Cell, 22, 105-115.
    • (2006) Mol. Cell , vol.22 , pp. 105-115
    • Studer, S.M.1    Joseph, S.2
  • 44
    • 77957240693 scopus 로고    scopus 로고
    • Multifactorial determinants of protein expression in prokaryotic open reading frames
    • Allert, M., Cox, J.C. and Hellinga, H.W. (2010) Multifactorial determinants of protein expression in prokaryotic open reading frames. J. Mol. Biol., 402, 905-918.
    • (2010) J. Mol. Biol. , vol.402 , pp. 905-918
    • Allert, M.1    Cox, J.C.2    Hellinga, H.W.3
  • 45
    • 0023650543 scopus 로고
    • The codon Adaptation Index- a measure of directional synonymous codon usage bias, and its potential applications
    • Sharp, P.M. and Li, W.H. (1987) The codon Adaptation Index- a measure of directional synonymous codon usage bias, and its potential applications. Nucleic Acids Res., 15, 1281-1295.
    • (1987) Nucleic Acids Res. , vol.15 , pp. 1281-1295
    • Sharp, P.M.1    Li, W.H.2
  • 46
    • 0029931535 scopus 로고    scopus 로고
    • Synonymous codon bias is related to gene length in Escherichia coli: Selection for translational accuracy?
    • Eyre-Walker, A. (1996) Synonymous codon bias is related to gene length in Escherichia coli: selection for translational accuracy? Mol. Biol. Evol., 13, 864-872.
    • (1996) Mol. Biol. Evol. , vol.13 , pp. 864-872
    • Eyre-Walker, A.1
  • 47
    • 0041817645 scopus 로고    scopus 로고
    • Translational selection and yeast proteome evolution
    • Akashi, H. (2003) Translational selection and yeast proteome evolution. Genetics, 164, 1291-1303.
    • (2003) Genetics , vol.164 , pp. 1291-1303
    • Akashi, H.1
  • 49
    • 84934438960 scopus 로고    scopus 로고
    • UNAFold: Software for nucleic acid folding and hybridization
    • Markham, N.R. and Zuker, M. (2008) UNAFold: software for nucleic acid folding and hybridization. Methods Mol. Biol., 453, 3-31.
    • (2008) Methods Mol. Biol. , vol.453 , pp. 3-31
    • Markham, N.R.1    Zuker, M.2
  • 50
    • 0032826179 scopus 로고    scopus 로고
    • Identifying DNA and protein patterns with statistically significant alignments of multiple sequences
    • Hertz, G.Z. and Stormo, G.D. (1999) Identifying DNA and protein patterns with statistically significant alignments of multiple sequences. Bioinformatics, 15, 563-577.
    • (1999) Bioinformatics , vol.15 , pp. 563-577
    • Hertz, G.Z.1    Stormo, G.D.2
  • 52
    • 33846829987 scopus 로고    scopus 로고
    • The pls Package: Principal component and partial least squares regression in R
    • Mevik, B.-H. and Wehrens, R. (2007) The pls Package: principal component and partial least squares regression in R. J. Stat. Softw., 18, 1-24.
    • (2007) J. Stat. Softw. , vol.18 , pp. 1-24
    • Mevik, B.-H.1    Wehrens, R.2
  • 53
  • 54
    • 84899892485 scopus 로고    scopus 로고
    • A handbook of statistical analyses using stata
    • Berry, D. (2008) A handbook of statistical analyses using stata. J. R. Stat. Soc. Stat., 171, 760-760.
    • (2008) J. R. Stat. Soc. Stat. , vol.171 , pp. 760-760
    • Berry, D.1
  • 56
    • 0001677717 scopus 로고
    • Controlling the false discovery rate: A practical and powerful approach to multiple testing
    • Benjamini, Y. and Hochberg, Y. (1995) Controlling the false discovery rate: a practical and powerful approach to multiple testing. J. R. Stat. Soc. B Methodol., 57, 289-300.
    • (1995) J. R. Stat. Soc. B Methodol. , vol.57 , pp. 289-300
    • Benjamini, Y.1    Hochberg, Y.2
  • 57
    • 0025166089 scopus 로고
    • Secondary structure of the ribosome binding site determines translational efficiency: A quantitative analysis
    • de Smit, M.H. and van Duin, J. (1990) Secondary structure of the ribosome binding site determines translational efficiency: a quantitative analysis. Proc. Natl Acad. Sci. USA, 87, 7668-7672.
    • (1990) Proc. Natl Acad. Sci. USA , vol.87 , pp. 7668-7672
    • De Smit, M.H.1    Van Duin, J.2
  • 60
    • 0035999672 scopus 로고    scopus 로고
    • Analysis of mRNA expression and protein abundance data: An approach for the comparison of the enrichment of features in the cellular population of proteins and transcripts
    • Greenbaum, D., Jansen, R. and Gerstein, M. (2002) Analysis of mRNA expression and protein abundance data: an approach for the comparison of the enrichment of features in the cellular population of proteins and transcripts. Bioinformatics, 18, 585-596.
    • (2002) Bioinformatics , vol.18 , pp. 585-596
    • Greenbaum, D.1    Jansen, R.2    Gerstein, M.3
  • 61
    • 0037133671 scopus 로고    scopus 로고
    • Metabolic efficiency and amino acid composition in the proteomes of Escherichia coli and Bacillus subtilis
    • Akashi, H. and Gojobori, T. (2002) Metabolic efficiency and amino acid composition in the proteomes of Escherichia coli and Bacillus subtilis. Proc. Natl Acad. Sci. USA, 99, 3695-3700.
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 3695-3700
    • Akashi, H.1    Gojobori, T.2
  • 62
    • 0030564828 scopus 로고    scopus 로고
    • Co-variation of tRNA abundance and codon usage in Escherichia coli at different growth rates
    • Dong, H., Nilsson, L. and Kurland, C.G. (1996) Co-variation of tRNA abundance and codon usage in Escherichia coli at different growth rates. J. Mol. Biol., 260, 649-663.
    • (1996) J. Mol. Biol. , vol.260 , pp. 649-663
    • Dong, H.1    Nilsson, L.2    Kurland, C.G.3
  • 63
    • 0026048796 scopus 로고
    • Levels of tRNAs in bacterial cells as affected by amino acid usage in proteins
    • Yamao, F., Andachi, Y., Muto, A., Ikemura, T. and Osawa, S. (1991) Levels of tRNAs in bacterial cells as affected by amino acid usage in proteins. Nucleic Acids Res., 19, 6119-6122.
    • (1991) Nucleic Acids Res. , vol.19 , pp. 6119-6122
    • Yamao, F.1    Andachi, Y.2    Muto, A.3    Ikemura, T.4    Osawa, S.5
  • 64
    • 84879345901 scopus 로고    scopus 로고
    • Rate-limiting steps in yeast protein translation
    • Shah, P., Ding, Y., Niemczyk, M., Kudla, G. and Plotkin, J.B. (2013) Rate-limiting steps in yeast protein translation. Cell, 153, 1589-1601.
    • (2013) Cell , vol.153 , pp. 1589-1601
    • Shah, P.1    Ding, Y.2    Niemczyk, M.3    Kudla, G.4    Plotkin, J.B.5
  • 65
    • 0023813828 scopus 로고
    • Codon usage and intragenic position
    • Bulmer, M. (1988) Codon usage and intragenic position. J. Theor. Biol., 133, 67-71.
    • (1988) J. Theor. Biol. , vol.133 , pp. 67-71
    • Bulmer, M.1
  • 66
    • 0023134450 scopus 로고
    • Translation rate modification by preferential codon usage: Intragenic position effects
    • Liljenstrom, H. and von Heijne, G. (1987) Translation rate modification by preferential codon usage: intragenic position effects. J. Theor. Biol., 124, 43-55.
    • (1987) J. Theor. Biol. , vol.124 , pp. 43-55
    • Liljenstrom, H.1    Von Heijne, G.2
  • 70
    • 33749060045 scopus 로고    scopus 로고
    • Diverse molecular mechanisms for translation initiation in prokaryotes
    • Boni, I.V. (2006) Diverse molecular mechanisms for translation initiation in prokaryotes. Mol. Biol., 40, 658-668.
    • (2006) Mol. Biol. , vol.40 , pp. 658-668
    • Boni, I.V.1
  • 71
    • 37849046403 scopus 로고    scopus 로고
    • Translation initiation region sequence preferences in Escherichia coli
    • Vimberg, V., Tats, A., Remm, M. and Tenson, T. (2007) Translation initiation region sequence preferences in Escherichia coli. BMC Mol. Biol., 8, 100.
    • (2007) BMC Mol. Biol. , vol.8 , pp. 100
    • Vimberg, V.1    Tats, A.2    Remm, M.3    Tenson, T.4
  • 72
    • 54149105223 scopus 로고    scopus 로고
    • Coevolution of codon usage and tRNA genes leads to alternative stable states of biased codon usage
    • Higgs, P.G. and Ran, W. (2008) Coevolution of codon usage and tRNA genes leads to alternative stable states of biased codon usage. Mol. Biol. Evol., 25, 2279-2291.
    • (2008) Mol. Biol. Evol. , vol.25 , pp. 2279-2291
    • Higgs, P.G.1    Ran, W.2


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