Enhanced topical delivery and ex vivo anti-inflammatory activity from a betamethasone dipropionate formulation containing fish oil

Inflammation Research

Volumn 59, Issue 1, 2010, Pages 23-30

  Zulfakar, Mohd Hanif ^a   Abdelouahab, Nassima ^a   Heard, Charles M ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

COX; Fatty acids; Models; PGs; Skin inflammation

Indexed keywords

BETAMETHASONE DIPROPIONATE; CYCLOOXYGENASE 2; FISH OIL; PROSTAGLANDIN E2; SALICYLIC ACID;

ADD ON THERAPY; ANIMAL CELL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG POTENTIATION; DRUG SOLUBILITY; ENZYME LINKED IMMUNOSORBENT ASSAY; EPIDERMIS; EX VIVO STUDY; IMMUNOHISTOCHEMISTRY; NONHUMAN; PROTEIN EXPRESSION;

ADMINISTRATION, TOPICAL; ANIMALS; ANTI-INFLAMMATORY AGENTS; BETAMETHASONE; CYCLOOXYGENASE 2; DINOPROSTONE; DRUG THERAPY, COMBINATION; FISH OILS; MODELS, ANIMAL; SALICYLIC ACID; SKIN; SKIN ABSORPTION; SWINE;

EID: 77949274548     PISSN: 10233830     EISSN: 1420908X     Source Type: Journal    
DOI: 10.1007/s00011-009-0065-z     Document Type: Article

References (37)

1. L Stein 2005 Clinical studies of a new vehicle formulation for topical corticosteroids in the treatment of psoriasis J Am Acad Derm 53 S39 S49 10.1016/j.jaad.2005.04.029 15968263 (Pubitemid 40828180)
2. Valencia IC, Kerdel FA. Topical glucocorticoids. In: Freeberg IM, Eisen AZ, Wolff K, Austen KF, Goldsmith LA, Katz SI, editors. Fitzpatrick's dermatology in general medicine. New York: McGraw-Hill; 2003. p. 2324-8.
3. IJ Elenkov GP Chrousos 2002 Stress hormones, proinflammatory and antiinflammatory cytokines and autoimmunity Ann N Y Acad Sci 966 290 303 10.1111/j.1749-6632.2002.tb04229.x 1:CAS:528:DC%2BD38XlvVWmur0%3D 12114286
4. Callis KP, Krueger GG. Topical agents in the treatment of moderate to severe psoriasis. In: Freeberg IM, Eisen AZ, Wolff K, Austen KF, Goldsmith LA, Katz SI, editors. Fitzpatrick's dermatology in general medicine. New York: McGraw-Hill; 2003. p. 29-51.
5. SR Feldman AB Fleischer Jr JZ Cooper 2000 New topical treatment changes the pattern of treatment of psoriasis: dermatologists remain the primary providers of this care Int J Dermatol 39 41 44 10.1046/j.1365-4362.2000.00878.x 1:STN:280:DC%2BD3c7hslylsg%3D%3D 10651966 (Pubitemid 30113540)
6. Williams AC. Transdermal and topical drug delivery: from theory to clinical practice. London: Pharmaceutical Press; 2003.
7. Loden M. Keratolytics. In: Gabard B, Elsner P, Surber C, Treffel P, editors. Dermatopharmacology of topical preparations. Berlin: Springer, 2000. pp. 255-280.
8. SJ Bashir F Dreher AL Chew H Zhai C Levina R Stern HI Maibach 2005 Cutaneous bioassay of salicylic acid as a keratolytic Int J Pharm 292 187 194 10.1016/j.ijpharm.2004.11.032 1:CAS:528:DC%2BD2MXhs1GgsLc%3D 15725565 (Pubitemid 40255800)
9. M Lebwohl 1999 The role of salicylic acid in the treatment of psoriasis Int J Dermatol 38 16 24 10.1046/j.1365-4362.1999.00500.x 1:STN:280: DyaK1M7mtlCrtQ%3D%3D 10065604 (Pubitemid 29066854)
10. L Krochmal JCT Wang B Patel J Rodgers 1989 Topical corticosteroid compounding: effects on physicochemical stability and skin penetration rate J Am Acad Dermatol 21 979 984 10.1016/S0190-9622(89)70286-3 1:STN:280: DyaK3c%2FjslOqsA%3D%3D 2808834
11. A Gil 2002 Polyunsaturated fatty acids and inflammatory diseases Biomed Pharmacother 56 388 396 10.1016/S0753-3322(02)00256-1 1:CAS:528: DC%2BD38XotVKrur4%3D 12442911 (Pubitemid 35232741)
12. PC Calder 2001 N-3 polyunsaturated fatty acids, inflammation and immunity: pouring oil on troubled waters or another fishy tale? Nutr Res 21 309 341 10.1016/S0271-5317(00)00287-6 1:CAS:528:DC%2BD3MXitFajs7w%3D (Pubitemid 32222278)
13. DH Nugteren E Christ-Hazelhof A van der Beek UMT Houtsmuller 1995 Metabolism of linoleic acid and other essential fatty acids in the epidermis of the rat Biochim Biophys Acta 834 429 436
14. SO Escobar R Achenbach R Iannantuono V Torem 1992 Topical fish oil in psoriasis-a controlled and blind study Clin Exp Dermatol 17 159 162 10.1111/j.1365-2230.1992.tb00194.x 1:STN:280:DyaK3s%2Fot1yqtw%3D%3D 1451289
15. R Riku S Nakatani N Okada K Yoshikawa 1993 Growth inhibitory effect of eicosapentaenoic acid on cultured human epidermal keratinocytes J Dermatol Sci 5 14 18 10.1016/0923-1811(93)90100-4 1:CAS:528:DyaK3sXks12js7k%3D 8387329
16. T Kojima T Terano E Tanabe S Okamoto Y Tamura S Yoshida 1991 Long term administration of highly purified eicosapentaenoic acid provides improvement of psoriasis Dermatologica 182 225 230 10.1159/000247800 1:STN:280: DyaK3Mzlslaiuw%3D%3D 1884857
17. MH Zulfakar M Edwards CM Heard 2007 Is there a role for topically delivered eicosapentaenoic acid in the treatment of psoriasis? Eur J Dermatol 17 284 291 1:CAS:528:DC%2BD2sXpslOnsLo%3D 17540633
18. CP Thomas CM Heard 2005 In vitro transcutaneous delivery of ketoprofen and polyunsaturated fatty acids from a fish oil vehicle incorporating 1,8-cineole Drug Deliv 12 7 14 10.1080/10717540590889565 1:CAS:528: DC%2BD2cXhtFChsLrJ 15801715 (Pubitemid 40066255)
19. C Puglia S Tropea L Rizza NA Santagati F Bonina 2005 In vitro percutaneous absorption studies and in vivo evaluation of anti-inflammatory activity of essential fatty acids (EFA) from fish oil extracts Int J Pharm 299 41 48 10.1016/j.ijpharm.2005.04.031 1:CAS:528:DC%2BD2MXmtFSgs7g%3D 15979259 (Pubitemid 40962404)
20. R Rajakariar MM Yaqoob DW Gilroy 2006 COX-2 in Inflammation and Resolution Mol Interv 6 199 207 10.1124/mi.6.4.6 1:CAS:528:DC%2BD28XhtVyqurbN 16960142 (Pubitemid 44455202)
21. DM Reilly R Parslew GR Sharpe 2000 Inflammatory mediators in normal, sensitive, and diseased skin types Acta Derm Venereol 80 171 174 10.1080/000155500750042907 1:CAS:528:DC%2BD3MXjvFCrtLk%3D 10954205
22. T Ruzicka T Simmet BA Peskar J Ring 1986 Skin levels of AA-derived inflammatory mediators and histamine in atopic dermatitis and psoriasis J Invest Dermatol 86 105 108 10.1111/1523-1747.ep12284061 1:STN:280:DyaL28zgsF2msg%3D%3D 3018086
23. N Oyama K Iwatsuki Y Homma KF Kane 1999 Induction of transcription factor AP-2 by inflammatory cytokines in human keratinocytes J Invest Dermatol 113 600 606 10.1046/j.1523-1747.1999.00734.x 1:CAS:528:DyaK1MXmslamsbs%3D 10504447 (Pubitemid 29489623)
24. Siewert M, Dressman J, Brown CK, Shah VP. FIP/AAPS guidelines to dissolution/in vitro release testing of novel/special dosage forms. AAPS PharmSciTech. 2003; 4(1):E7.
25. SW Collier NM Sheikh A Sakr JL Lichtin RF Stewart RL Bronaugh 1989 Maintenance of skin viability during in vitro percutaneous absorption/metabolism studies Toxicol Appl Pharmacol 99 522 533 10.1016/0041-008X(89)90159-2 1:CAS:528:DyaL1MXltlSitLY%3D 2749737 (Pubitemid 19189764)
26. Kiernan J. Histological and histochemical methods: theory and practice. Oxford: Butterworth Heinemann; 1999.
27. CP Thomas Z Davison CM Heard 2007 Probing the skin permeation of fish oil/EPA and ketoprofen-3. Effects on epidermal COX-2 and LOX Prostaglandins Leukot Essent Fatty Acids 76 357 362 10.1016/j.plefa.2007.05.002 1:CAS:528:DC%2BD2sXotlSntL0%3D 17588732 (Pubitemid 47095276)
28. Sefton B. Labelling cultured cells with 32Pi and preparing cell lysates for immunoprecipitation. In: Ausubel F, Brent R, Kingston R, Moore D, Seidman J, Smith J, et al., editors. Current protocols in molecular biology. New York: Wiley; 2005.
29. CP Thomas CM Heard 2007 Probing the skin permeation of eicosapentaenoic acid and ketoprofen: 2. Comparative depth profiling and metabolism of eicosapentaenoic acid Eur J Pharm Biopharm 67 156 165 10.1016/j.ejpb.2006.11.024 1:CAS:528:DC%2BD2sXntF2mur4%3D 17270404 (Pubitemid 46991313)
30. K Vang VA Ziboh 2005 15-lipoxygenase metabolites of [gamma]-linolenic acid/eicosapentaenoic acid suppress growth and AA metabolism in human prostatic adenocarcinoma cells: Possible implications of dietary fatty acids Prostaglandin Leukot Essent Fatty Acids 72 363 372 10.1016/j.plefa.2005.02.002 1:CAS:528:DC%2BD2MXjs1KntrY%3D (Pubitemid 40585791)
31. SN Stehr AR Heller 2006 Omega 3 fatty acids effects on biochemical indices following cancer surgery Clin Chim Acta 373 1 8 10.1016/j.cca.2006.04. 024 1:CAS:528:DC%2BD28XptFSrurg%3D 16796997 (Pubitemid 44292172)
32. D Bagga L Wang R Farias-Eisner JA Glaspy ST Reddy 2003 Differential effects of prostaglandin derived from omega-6 and omega-3 polyunsaturated fatty acids on COX-2 expression and IL-6 secretion Proc Natl Acad Sci USA 100 1751 1756 10.1073/pnas.0334211100 1:CAS:528:DC%2BD3sXhsFGkurs%3D 12578976 (Pubitemid 36254520)
33. J Belch A Hill 2000 Evening primrose oil and borage oil in rheumatologic conditions Am J Clin Nutr 71 Supplement 1 352 356
34. F Grimminger P Mayser 1995 Lipid mediators, free fatty acids and psoriasis Prostaglandin Leukot Essent Fatty Acids 52 1 15 10.1016/0952-3278(95) 90090-X 1:CAS:528:DyaK2MXks12gsr0%3D
35. Haraldsson GG, Hjaltason B. Fish oils as sources of polyunsaturated fatty acids. In: Gunstone FD, editor. Structured and modified lipids. New York: Marcel Dekker; 2001. p. 313-50.
36. AP DeFilippis LS Sperling 2006 Understanding omega-3s Am Heart J 151 564 570 10.1016/j.ahj.2005.03.051 1:CAS:528:DC%2BD28XhvVWmsb8%3D 16504616 (Pubitemid 43290245)
37. JM Schwab CN Serhan 2006 Lipoxins and new lipid mediators in the resolution of inflammation Curr Opin Pharmacol 6 414 420 10.1016/j.coph.2006.02. 006 1:CAS:528:DC%2BD28XmslGjs7c%3D 16750421