An integrated top-down and bottom-up proteomic approach to characterize the antigen-binding fragment of antibodies

Proteomics

Volumn 14, Issue 10, 2014, Pages 1239-1248

  Dekker, Lennard ^a   Wu, Si ^b   Vanduijn, Martijn ^a   Tolić, Nikolai ^b   Stingl, Christoph ^a   Zhao, Rui ^b   Luider, Theo ^a   Paša Tolić, Ljiljana ^b  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b PACIFIC NORTHWEST NATIONAL LABORATORY   (United States)

Author keywords

Antibodies; Bottom up; MS; Sequencing; Technology; Top down

Indexed keywords

ADALIMUMAB; ALEMTUZUMAB; AMINO ACID; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN FC FRAGMENT; MONOCLONAL ANTIBODY; IMMUNOGLOBULIN G;

AMINO ACID SEQUENCE; ARTICLE; CHROMATOFOCUSING; CHROMATOGRAPHY; COLLISIONALLY ACTIVATED DISSOCIATION; COMPLEMENTARITY DETERMINING REGION; FOURIER TRANSFORM MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY MASS SPECTROMETRY; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEOMICS; ANTIGEN BINDING; CONTROLLED STUDY; HUMAN; LIGHT CHAIN; LIQUID CHROMATOGRAPHY; MEASUREMENT ACCURACY; PROTEIN ANALYSIS; REVERSED PHASE LIQUID CHROMATOGRAPHY; SEQUENCE ANALYSIS; ANTIBODY COMBINING SITE; CHEMISTRY; MOLECULAR GENETICS; PROCEDURES; SEQUENCE ALIGNMENT;

AMINO ACID SEQUENCE; BINDING SITES, ANTIBODY; CHROMATOGRAPHY, LIQUID; IMMUNOGLOBULIN FAB FRAGMENTS; IMMUNOGLOBULIN G; MASS SPECTROMETRY; MOLECULAR SEQUENCE DATA; PROTEOMICS; SEQUENCE ALIGNMENT;

EID: 84899873223     PISSN: 16159853     EISSN: 16159861     Source Type: Journal    
DOI: 10.1002/pmic.201300366     Document Type: Article

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