메뉴 건너뛰기




Volumn 9, Issue 3, 2014, Pages

Does dexmedetomidine as a neuraxial adjuvant facilitate better anesthesia and analgesia? A systematic review and meta-analysis

Author keywords

[No Author keywords available]

Indexed keywords

ANALGESIC AGENT; BUPIVACAINE; DEXMEDETOMIDINE; PLACEBO; ROPIVACAINE; LOCAL ANESTHETIC AGENT;

EID: 84899867664     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0093114     Document Type: Article
Times cited : (81)

References (51)
  • 1
    • 0035436713 scopus 로고    scopus 로고
    • Regional anesthesia and analgesia: Their role in postoperative outcome
    • Ekatodramis G (2001) Regional anesthesia and analgesia: their role in postoperative outcome. Current topics in medicinal chemistry 1: 183-192.
    • (2001) Current Topics in Medicinal Chemistry , vol.1 , pp. 183-192
    • Ekatodramis, G.1
  • 2
    • 33748669434 scopus 로고    scopus 로고
    • Regional anaesthesia and perioperative outcome
    • DOI 10.1097/01.aco.0000245278.22658.1e, PII 0000150320061000000010
    • Tziavrangos E, Schug SA (2006) Regional anaesthesia and perioperative outcome. Current opinion in anaesthesiology 19: 521-525. (Pubitemid 44386055)
    • (2006) Current Opinion in Anaesthesiology , vol.19 , Issue.5 , pp. 521-525
    • Tziavrangos, E.1    Schug, S.A.2
  • 3
    • 84873036991 scopus 로고    scopus 로고
    • Local anesthetics: Review of pharmacological considerations
    • quiz 102-103
    • Becker DE, Reed KL (2012) Local anesthetics: review of pharmacological considerations. Anesthesia progress 59: 90-101; quiz 102-103.
    • (2012) Anesthesia Progress , vol.59 , pp. 90-101
    • Becker, D.E.1    Reed, K.L.2
  • 4
    • 84880515883 scopus 로고    scopus 로고
    • Analgesic and sympatholytic effects of low-dose intrathecal clonidine compared with bupivacaine: A dose-response study in female volunteers
    • Ginosar Y, Riley ET, Angst MS (2013) Analgesic and sympatholytic effects of low-dose intrathecal clonidine compared with bupivacaine: a dose-response study in female volunteers. British journal of anaesthesia 111: 256-263.
    • (2013) British Journal of Anaesthesia , vol.111 , pp. 256-263
    • Ginosar, Y.1    Riley, E.T.2    Angst, M.S.3
  • 5
    • 84870990610 scopus 로고    scopus 로고
    • Hyperbaric articaine with or without fentanyl in spinal anaesthesia: Patient and observer blinded comparison
    • Kairaluoma P, Bachmann M, Kallio H, Rosenberg P, Pere P (2013) Hyperbaric articaine with or without fentanyl in spinal anaesthesia: patient and observer blinded comparison. Acta anaesthesiologica Scandinavica 57: 118-125.
    • (2013) Acta Anaesthesiologica Scandinavica , vol.57 , pp. 118-125
    • Kairaluoma, P.1    Bachmann, M.2    Kallio, H.3    Rosenberg, P.4    Pere, P.5
  • 6
    • 84880573491 scopus 로고    scopus 로고
    • Hypobaric spinal anesthesia with ropivacaine plus sufentanil for traumatic femoral neck surgery in the elderly: A dose-response study
    • Lilot M, Meuret P, Bouvet L, Caruso L, Dabouz R, et al. (2013) Hypobaric spinal anesthesia with ropivacaine plus sufentanil for traumatic femoral neck surgery in the elderly: a dose-response study. Anesthesia and analgesia 117: 259-264.
    • (2013) Anesthesia and Analgesia , vol.117 , pp. 259-264
    • Lilot, M.1    Meuret, P.2    Bouvet, L.3    Caruso, L.4    Dabouz, R.5
  • 7
    • 84885917184 scopus 로고    scopus 로고
    • Postoperative pain relief after total hip arthroplasty: A randomized, double-blind comparison between intrathecal morphine and local infiltration analgesia
    • Kuchalik J, Granath B, Ljunggren A, Magnuson A, Lundin A, et al. (2013) Postoperative pain relief after total hip arthroplasty: a randomized, double-blind comparison between intrathecal morphine and local infiltration analgesia. British journal of anaesthesia 111: 793-799.
    • (2013) British Journal of Anaesthesia , vol.111 , pp. 793-799
    • Kuchalik, J.1    Granath, B.2    Ljunggren, A.3    Magnuson, A.4    Lundin, A.5
  • 9
    • 84888215215 scopus 로고    scopus 로고
    • Effect of ketamine as an adjunct to intravenous patient-controlled analgesia, in patients at high risk of postoperative nausea and vomiting undergoing lumbar spinal surgery
    • Song JW, Shim JK, Song Y, Yang SY, Park SJ, et al. (2013) Effect of ketamine as an adjunct to intravenous patient-controlled analgesia, in patients at high risk of postoperative nausea and vomiting undergoing lumbar spinal surgery. British journal of anaesthesia 111: 630-635.
    • (2013) British Journal of Anaesthesia , vol.111 , pp. 630-635
    • Song, J.W.1    Shim, J.K.2    Song, Y.3    Yang, S.Y.4    Park, S.J.5
  • 10
    • 84355166671 scopus 로고    scopus 로고
    • Effects of adjunct intrathecal magnesium sulfate to bupivacaine for spinal anesthesia: A randomized, double-blind trial in patients undergoing lower extremity surgery
    • Khalili G, Janghorbani M, Sajedi P, Ahmadi G (2011) Effects of adjunct intrathecal magnesium sulfate to bupivacaine for spinal anesthesia: a randomized, double-blind trial in patients undergoing lower extremity surgery. Journal of anesthesia 25: 892-897.
    • (2011) Journal of Anesthesia , vol.25 , pp. 892-897
    • Khalili, G.1    Janghorbani, M.2    Sajedi, P.3    Ahmadi, G.4
  • 11
    • 80052867144 scopus 로고    scopus 로고
    • Intrathecal midazolam as supplementary analgesia for chronic lumbar pain-15 years' experience
    • Prochazka J, Hejcl A, Prochazkova L (2011) Intrathecal midazolam as supplementary analgesia for chronic lumbar pain-15 years' experience. Pain medicine 12: 1309-1315.
    • (2011) Pain Medicine , vol.12 , pp. 1309-1315
    • Prochazka, J.1    Hejcl, A.2    Prochazkova, L.3
  • 12
    • 84885915113 scopus 로고    scopus 로고
    • Efficacy of dexmedetomidine compared with midazolam for sedation in adult intensive care patients: A systematic review
    • Adams R, Brown GT, Davidson M, Fisher E, Mathisen J, et al. (2013) Efficacy of dexmedetomidine compared with midazolam for sedation in adult intensive care patients: a systematic review. British journal of anaesthesia 111: 703-710.
    • (2013) British Journal of Anaesthesia , vol.111 , pp. 703-710
    • Adams, R.1    Brown, G.T.2    Davidson, M.3    Fisher, E.4    Mathisen, J.5
  • 13
    • 84880572383 scopus 로고    scopus 로고
    • The facilitatory effects of intravenous dexmedetomidine on the duration of spinal anesthesia: A systematic review and meta-analysis
    • Abdallah FW, Abrishami A, Brull R (2013) The facilitatory effects of intravenous dexmedetomidine on the duration of spinal anesthesia: a systematic review and meta-analysis. Anesthesia and analgesia 117: 271-278.
    • (2013) Anesthesia and Analgesia , vol.117 , pp. 271-278
    • Abdallah, F.W.1    Abrishami, A.2    Brull, R.3
  • 14
    • 84899851428 scopus 로고    scopus 로고
    • Involvement of spinal microglia and interleukin-18 in the anti-nociceptive effect of dexmedetomidine in rats subjected to CCI
    • Li SS, Zhang WS, Ji D, Zhou YL, Li H, et al. (2013) Involvement of spinal microglia and interleukin-18 in the anti-nociceptive effect of dexmedetomidine in rats subjected to CCI. Neuroscience letters.
    • (2013) Neuroscience Letters
    • Li, S.S.1    Zhang, W.S.2    Ji, D.3    Zhou, Y.L.4    Li, H.5
  • 15
    • 84877578542 scopus 로고    scopus 로고
    • Neuroprotective effects of dexmedetomidine against glutamate agonist-induced neuronal cell death are related to increased astrocyte brain-derived neurotrophic factor expression
    • Degos V, Charpentier TL, Chhor V, Brissaud O, Lebon S, et al. (2013) Neuroprotective effects of dexmedetomidine against glutamate agonist-induced neuronal cell death are related to increased astrocyte brain-derived neurotrophic factor expression. Anesthesiology 118: 1123-1132.
    • (2013) Anesthesiology , vol.118 , pp. 1123-1132
    • Degos, V.1    Charpentier, T.L.2    Chhor, V.3    Brissaud, O.4    Lebon, S.5
  • 16
    • 33846874140 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha induces long-term potentiation of C-fiber evoked field potentials in spinal dorsal horn in rats with nerve injury: The role of NF-kappa B, JNK and p38 MAPK
    • Liu YL, Zhou LJ, Hu NW, Xu JT, Wu CY, et al. (2007) Tumor necrosis factor-alpha induces long-term potentiation of C-fiber evoked field potentials in spinal dorsal horn in rats with nerve injury: the role of NF-kappa B, JNK and p38 MAPK. Neuropharmacology 52: 708-715.
    • (2007) Neuropharmacology , vol.52 , pp. 708-715
    • Liu, Y.L.1    Zhou, L.J.2    Hu, N.W.3    Xu, J.T.4    Wu, C.Y.5
  • 17
    • 82955162529 scopus 로고    scopus 로고
    • Inhibition by dexmedetomidine of the activation of spinal dorsal horn glias and the intracellular ERK signaling pathway induced by nerve injury
    • Liu L, Ji F, Liang J, He H, Fu Y, et al. (2012) Inhibition by dexmedetomidine of the activation of spinal dorsal horn glias and the intracellular ERK signaling pathway induced by nerve injury. Brain Res 1427: 129.
    • (2012) Brain Res , vol.1427 , pp. 129
    • Liu, L.1    Ji, F.2    Liang, J.3    He, H.4    Fu, Y.5
  • 18
    • 84878344524 scopus 로고    scopus 로고
    • Facilitatory effects of perineural dexmedetomidine on neuraxial and peripheral nerve block: A systematic review and meta-analysis
    • Abdallah FW, Brull R (2013) Facilitatory effects of perineural dexmedetomidine on neuraxial and peripheral nerve block: a systematic review and meta-analysis. British journal of anaesthesia 110: 915-925.
    • (2013) British Journal of Anaesthesia , vol.110 , pp. 915-925
    • Abdallah, F.W.1    Brull, R.2
  • 19
    • 84885937171 scopus 로고    scopus 로고
    • Effects of intravenous and intrathecal dexmedetomidine in spinal anesthesia: A meta-analysis
    • Niu XY, Ding XB, Guo T, Chen MH, Fu SK, et al. (2013) Effects of intravenous and intrathecal dexmedetomidine in spinal anesthesia: a meta-analysis. CNS neuroscience & therapeutics 19: 897-904.
    • (2013) CNS Neuroscience & Therapeutics , vol.19 , pp. 897-904
    • Niu, X.Y.1    Ding, X.B.2    Guo, T.3    Chen, M.H.4    Fu, S.K.5
  • 20
    • 0033610734 scopus 로고    scopus 로고
    • Improving the quality of reports of meta-analyses of randomised controlled trials: The QUOROM statement. Quality of Reporting of Meta-analyses
    • Moher D, Cook DJ, Eastwood S, Olkin I, Rennie D, et al. (1999) Improving the quality of reports of meta-analyses of randomised controlled trials: the QUOROM statement. Quality of Reporting of Meta-analyses. Lancet 354: 1896-1900.
    • (1999) Lancet , vol.354 , pp. 1896-1900
    • Moher, D.1    Cook, D.J.2    Eastwood, S.3    Olkin, I.4    Rennie, D.5
  • 21
    • 84942475903 scopus 로고
    • The Cochrane Collaboration. Preparing, maintaining, and disseminating systematic reviews of the effects of health care
    • Bero L, Rennie D (1995) The Cochrane Collaboration. Preparing, maintaining, and disseminating systematic reviews of the effects of health care. JAMA : the journal of the American Medical Association 274: 1935-1938.
    • (1995) JAMA: The Journal of the American Medical Association , vol.274 , pp. 1935-1938
    • Bero, L.1    Rennie, D.2
  • 22
    • 0029914622 scopus 로고    scopus 로고
    • Assessing the quality of reports of randomized clinical trials: Is blinding necessary?
    • Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, et al. (1996) Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 17: 1212.
    • (1996) Control Clin Trials , vol.17 , pp. 1212
    • Jadad, A.R.1    Moore, R.A.2    Carroll, D.3    Jenkinson, C.4    Reynolds, D.J.5
  • 25
    • 0028659004 scopus 로고
    • Operating characteristics of a rank correlation test for publication bias
    • Begg CB, Mazumdar M (1994) Operating characteristics of a rank correlation test for publication bias. Biometrics 50: 1088-1101.
    • (1994) Biometrics , vol.50 , pp. 1088-1101
    • Begg, C.B.1    Mazumdar, M.2
  • 26
    • 0030922816 scopus 로고    scopus 로고
    • Bias in meta-analysis detected by a simple, graphical test
    • Egger M, Davey Smith G, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315: 629-634. (Pubitemid 27387172)
    • (1997) British Medical Journal , vol.315 , Issue.7109 , pp. 629-634
    • Egger, M.1    Smith, G.D.2    Schneider, M.3    Minder, C.4
  • 27
    • 21544449115 scopus 로고    scopus 로고
    • Estimating the mean and variance from the median, range, and the size of a sample
    • Hozo SP, Djulbegovic B, Hozo I (2005) Estimating the mean and variance from the median, range, and the size of a sample. BMC Med Res Methodol 5: 13.
    • (2005) BMC Med Res Methodol , vol.5 , pp. 13
    • Hozo, S.P.1    Djulbegovic, B.2    Hozo, I.3
  • 29
    • 80054023805 scopus 로고    scopus 로고
    • Effects of dexmedetomidine added to caudal ropivacaine in paediatric lower abdominal surgeries
    • Anand VG, Kannan M, Thavamani A, Bridgit MJ (2011) Effects of dexmedetomidine added to caudal ropivacaine in paediatric lower abdominal surgeries. Indian J Anaesth 55: 340-346.
    • (2011) Indian J Anaesth , vol.55 , pp. 340-346
    • Anand, V.G.1    Kannan, M.2    Thavamani, A.3    Bridgit, M.J.4
  • 30
    • 77953162855 scopus 로고    scopus 로고
    • Effect of epidural dexmedetomidine on intraoperative awareness and postoperative pain after one-lung ventilation
    • Elhakim M, Abdelhamid D, Abdelfattach H, Magdy H, Elsayed A, et al. (2010) Effect of epidural dexmedetomidine on intraoperative awareness and postoperative pain after one-lung ventilation. Acta anaesthesiologica Scandinavica 54: 703-709.
    • (2010) Acta Anaesthesiologica Scandinavica , vol.54 , pp. 703-709
    • Elhakim, M.1    Abdelhamid, D.2    Abdelfattach, H.3    Magdy, H.4    Elsayed, A.5
  • 34
    • 84864461911 scopus 로고    scopus 로고
    • Efficacy of intrathecally administered dexmedetomidine versus dexmedetomidine with fentanyl in patients undergoing major abdominal cancer surgery
    • Mohamed AA, Fares KM, Mohamed SA (2012) Efficacy of intrathecally administered dexmedetomidine versus dexmedetomidine with fentanyl in patients undergoing major abdominal cancer surgery. Pain physician 15: 339-348.
    • (2012) Pain Physician , vol.15 , pp. 339-348
    • Mohamed, A.A.1    Fares, K.M.2    Mohamed, S.A.3
  • 36
    • 45849096058 scopus 로고    scopus 로고
    • Synergistic effect between dexmedetomidine and 0.75% ropivacaine in epidural anesthesia
    • Salgado PF, Sabbag AT, Silva PC, Brienze SL, Dalto HP, et al. (2008) [Synergistic effect between dexmedetomidine and 0.75% ropivacaine in epidural anesthesia]. Rev Assoc Med Bras 54: 110-115.
    • (2008) Rev Assoc Med Bras , vol.54 , pp. 110-115
    • Salgado, P.F.1    Sabbag, A.T.2    Silva, P.C.3    Brienze, S.L.4    Dalto, H.P.5
  • 37
    • 25444453226 scopus 로고    scopus 로고
    • Intraoperative analgesic effect of epidural ketamine, clonidine or dexmedetomidine for upper abdominal surgery
    • Schnaider TB, Vieira AM, Brandao AC, Lobo MV (2005) [Intraoperative analgesic effect of epidural ketamine, clonidine or dexmedetomidine for upper abdominal surgery.]. Revista brasileira de anestesiologia 55: 525-531.
    • (2005) Revista Brasileira de Anestesiologia , vol.55 , pp. 525-531
    • Schnaider, T.B.1    Vieira, A.M.2    Brandao, A.C.3    Lobo, M.V.4
  • 38
    • 84886249104 scopus 로고    scopus 로고
    • Comparative evaluation of epidural bupivacaine - Dexmedetomidine and bupivacaine -fentanyl on Doppler velocimetry of uterine and umbilical arteries during labor
    • Selim MF, Elnabtity AM, Hasan AM (2012) Comparative evaluation of epidural bupivacaine - dexmedetomidine and bupivacaine -fentanyl on Doppler velocimetry of uterine and umbilical arteries during labor. J Prenat Med 6: 47-54.
    • (2012) J Prenat Med , vol.6 , pp. 47-54
    • Selim, M.F.1    Elnabtity, A.M.2    Hasan, A.M.3
  • 39
  • 40
    • 84874417866 scopus 로고    scopus 로고
    • The analgesic effect of intrathecal dexmedetomidine or clonidine, with bupivacaine, in trauma patients undergoing lower limb surgery: A randomised, double-blind study
    • Solanki SL, Bharti N, Batra YK, Jain A, Kumar P, et al. (2013) The analgesic effect of intrathecal dexmedetomidine or clonidine, with bupivacaine, in trauma patients undergoing lower limb surgery: a randomised, double-blind study. Anaesthesia and intensive care 41: 51-56.
    • (2013) Anaesthesia and Intensive Care , vol.41 , pp. 51-56
    • Solanki, S.L.1    Bharti, N.2    Batra, Y.K.3    Jain, A.4    Kumar, P.5
  • 41
    • 84874372782 scopus 로고    scopus 로고
    • Caudal dexmedetomidine combined with bupivacaine inhibit the response to hernial sac traction in children undergoing inguinal hernia repair
    • Xiang Q, Huang DY, Zhao YL, Wang GH, Liu YX, et al. (2013) Caudal dexmedetomidine combined with bupivacaine inhibit the response to hernial sac traction in children undergoing inguinal hernia repair. British journal of anaesthesia 110: 420-424.
    • (2013) British Journal of Anaesthesia , vol.110 , pp. 420-424
    • Xiang, Q.1    Huang, D.Y.2    Zhao, Y.L.3    Wang, G.H.4    Liu, Y.X.5
  • 42
    • 84878856005 scopus 로고    scopus 로고
    • Effects of intrathecal dexmedetomidine on low-dose bupivacaine spinal anesthesia in elderly patients undergoing transurethral prostatectomy
    • Kim JE, Kim NY, Lee HS, Kil HK (2013) Effects of intrathecal dexmedetomidine on low-dose bupivacaine spinal anesthesia in elderly patients undergoing transurethral prostatectomy. Biological & pharmaceutical bulletin 36: 959-965.
    • (2013) Biological & Pharmaceutical Bulletin , vol.36 , pp. 959-965
    • Kim, J.E.1    Kim, N.Y.2    Lee, H.S.3    Kil, H.K.4
  • 43
    • 80054011589 scopus 로고    scopus 로고
    • Dose-related prolongation of hyperbaric bupivacaine spinal anesthesia by dexmedetomidine
    • Hala E A Eid MAS, Hend Youssef (2011) Dose-related prolongation of hyperbaric bupivacaine spinal anesthesia by dexmedetomidine. Ain Shams Journal of Anesthesiology 4: 83-95.
    • (2011) Ain Shams Journal of Anesthesiology , vol.4 , pp. 83-95
    • Eid, H.E.A.1    S, M.A.2    Youssef, H.3
  • 44
    • 84861645082 scopus 로고    scopus 로고
    • Effect of perioperative systemic alpha2 agonists on postoperative morphine consumption and pain intensity: Systematic review and meta-analysis of randomized controlled trials
    • Blaudszun G, Lysakowski C, Elia N, Tramer MR (2012) Effect of perioperative systemic alpha2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials. Anesthesiology 116: 1312-1322.
    • (2012) Anesthesiology , vol.116 , pp. 1312-1322
    • Blaudszun, G.1    Lysakowski, C.2    Elia, N.3    Tramer, M.R.4
  • 49
    • 0031049845 scopus 로고    scopus 로고
    • Epidural clonidine used as the sole analgesic agent during and after abdominal surgery: A dose-response study
    • DOI 10.1097/00000542-199702000-00003
    • De Kock M, Wiederkher P, Laghmiche A, Scholtes JL (1997) Epidural clonidine used as the sole analgesic agent during and after abdominal surgery. A dose-response study. Anesthesiology 86: 285-292. (Pubitemid 27093372)
    • (1997) Anesthesiology , vol.86 , Issue.2 , pp. 285-292
    • De Kock, M.1    Wiederkher, P.2    Laghmiche, A.3    Scholtes, J.-L.4
  • 50
    • 67449095826 scopus 로고    scopus 로고
    • Pharmacological profiles of alpha 2 adrenergic receptor agonists identified using genetically altered mice and isobolographic analysis
    • Fairbanks CA, Stone LS, Wilcox GL (2009) Pharmacological profiles of alpha 2 adrenergic receptor agonists identified using genetically altered mice and isobolographic analysis. Pharmacology & therapeutics 123: 224-238.
    • (2009) Pharmacology & Therapeutics , vol.123 , pp. 224-238
    • Fairbanks, C.A.1    Stone, L.S.2    Wilcox, G.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.