Dexmedetomidine as an intrathecal adjuvant for postoperative analgesia

Indian Journal of Anaesthesia

Volumn 55, Issue 4, 2011, Pages 347-351

  Gupta, Rajni ^a   Bogra, Jaishri ^a   Verma, Reetu ^a   Kohli, Monica ^a   Kushwaha, Jitendra Kumar ^a   Kumar, Sanjiv ^b  

^a KING GEORGE'S MEDICAL UNIVERSITY   (India)

^b Eras Lucknow Medical College and Hospital   (India)

Author keywords

Dexmedetomidine; Postoperative analgesia; Ropivacaine; Spinal block

Indexed keywords

DEXMEDETOMIDINE; ROPIVACAINE;

ADULT; ANALGESIA; ARTICLE; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG ERUPTION; DRUG SAFETY; HUMAN; HYPOTENSION; MAJOR CLINICAL STUDY; NAUSEA; OUTCOME ASSESSMENT; POSTOPERATIVE ANALGESIA; POSTOPERATIVE PAIN; PRURITUS; RANDOMIZED CONTROLLED TRIAL; RESPIRATION DEPRESSION; SEDATION; SHIVERING; SIDE EFFECT; SPINAL ANESTHESIA; VISUAL ANALOG SCALE; VOMITING;

EID: 80054037158     PISSN: 00195049     EISSN: None     Source Type: Journal    
DOI: 10.4103/0019-5049.84841     Document Type: Article

References (23)

1. Yamashita A, Matsumoto M, Matsumoto S, Itoh M, Kawai K, Sakabe T. A comparison of the neurotoxic effects on the spinal cord of tetracaine, lidocaine, bupivacaine, and ropivacaine administered intrathecally in rabbits. AnesthAnalg 2003;97:512-9. Back to cited text no. 1
2. McNamee DA, Convery PN, Milligan KR. Total knee replacement: A comparison of ropivacaine and bupivacaine in combined femoral and sciatic block. ActaAnaesthesiolScand 2001;45:477-81. Back to cited text no. 2
3. Martin E, Ramsay G, Mantz J, Sum-Ping ST. The role of the alpha2-adrenreceptor agonist dexmedetomidine in post-surgical sedation inthe intensive care unit. J Intensive Care Med 2003;18:29-34. Back to cited text no. 3
4. Kalso EA, Poyhia R, Rosenberg PH. Spinal antinociception by dexmedetomidine, a highly selective a2-adrenergic agonist. PharmacolToxicol 1991;68:140-3. Back to cited text no. 4
5. Eisenach JC, Shafer SL, Bucklin BA, Jackson C, Kallio A. Pharmacokinetics and pharmacodynamics of intraspinaldexmedetomidine in sheep. Anesthesiology 1994;80:1349-59. Back to cited text no. 5
6. Lo WC, Harris J, Clarke RW. Endogenous opioids support the spinal inhibitory action of an alpha 2-adrenoceptor agonist in the decerebratedspinalised rabbit. Neurosci Lett 2003;340:95-8. Back to cited text no. 6
7. Talke P, Xu M, Paloheimo M, Kalso E. Effects of intrathecally administered dexmedetomidine, MPV-2426 and tizanidine on EMG in rats. ActaAnaesthesiolScand 2003;47:347-54. Back to cited text no. 7
8. Xu M, Kontinen VK, Kalso E. Effects of radolmidine, a novel alpha2-adrenergic agonist compared with dexmedetomidine in different pain models in the rat. Anesthesiology 2000;93:473-81. Back to cited text no. 8
9. Horvath G, Joo G, Dobos I, Klimscha W, Toth G, Benedek G. The synergistic antinociceptive interactions of endomorphin-1 with dexmedetomidine and/or S (+)-ketamine in rats. AnesthAnalg 2001;93:1018-24. Back to cited text no. 9
10. Shimode N, Fukuoka T, Tanimoto M, Tashiro C, Tokunaga A, Noguchi K. The effects of dexmedetomidine and halothane on the Fos expression in the spinal dorsal horn using a rat postoperative pain model. NeurosciLett 2003;343:45-8. Back to cited text no. 10
11. Onttonen T, Pertovaara A. The mechanical antihyperalgesic effect of intrathecally administered MPV-2426, a novel alpha2-adrenoceptor agonist, in a rat model of postoperative pain. Anesthesiology 2000;92:1740-5. Back to cited text no. 11
12. Takano Y, Yaksh TL. Characterization of the pharmacology of intrathecally administered alpha 2-agonists and antagonists in rats. J PharmacolExpTher 1992;261:764-72. Back to cited text no. 12
13. Fukushima K, Nishimi Y, Mori K, Takeda J. Effect of epidurally administered dexmedetomidine on sympathetic activity and postoperative pain in man. AnesthAnalg 1996;82: S121. Back to cited text no. 13
14. Maroof M, Khan SA, Jain D, Khan RM, Maroof SM. Evaluation of effect of dexmedetomidine in reducing shivering following epidural anesthesia. Anesthesiology 2004;101: A495. Back to cited text no. 14
15. Kanazi GE, Aouad MT, Jabbour-Khoury SI, Al-Jazzar, Alameddine MM, Al-Yaman R, et al. Effect of low dose dexmedetomidine or clonidine on the characteristics of bupivacaine spinal block. ActaAnesthesiolScand 2006;50:222-7. Back to cited text no. 15
16. Al-Ghanem SM, Massad IM, Al-Mustafa MM, Al-Zaben KR, Qudaisat IY, Qatawneh AM, et al. Effect of adding dexmedetomidine versus fentanyl to intrathecal bupivacaine on spinal block characteristics in gynecological procedures. Am JApplSci2009;6:882-7. Back to cited text no. 16
17. Al-Mustafa MM, Abu-Halaweh SA, Aloweidi AS, Murshidi MM, Ammari BA, Awwad ZM, et al. Effect of Dexmedetomidineadded to spinal bupivacaine for urological procedure. Saudi Med J 2009;30:365-70. Back to cited text no. 17
18. De Kock M, Gautier P, Fanard L, Hody JL, Lavand'homme P. Intrathecal Ropivacaine and clonidine for ambulatory Knee arthroscopy. A dose response study. Anesthesiology 2001;94:574-8. Back to cited text no. 18
19. Eisanach JC, De Kock M, Klimscha W. Á2 adrenergic agonists for regional anesthesia. Anesthesiology 1996;85:655-74. Back to cited text no. 19
20. Salgado PF, Sabbag AT, Silva PC, Brienze SL, Dalto HP, Módolo NS, et al. Synergistic effect between dexmedetomidine and 0.75% ropivacaine in epidural anesthesia. Rev Assoc Med Bras 2008;54:110-5. Back to cited text no. 20
21. Harada Y, Nishioka K, Kitahata LM, Kishikawa K, Collins JG. Visceral antinociceptive effects of spinal clonidine combined with morphine, enkephalin, or U50, 488H. Anesthesiology 1995;83:344-52. Back to cited text no. 21
22. Yaksh TL, Reddy SV. Studies in primate on the analgesic effects associated with intrathecal actions of opiates, adrenergic agonists, and baclofen. Anesthesiology 1981;54:451-67. Back to cited text no. 22
23. Talke P, Tayefeh F, Sessler DI, Jeffrey R, Noursalehi M, Richardson C. Dexmedetomidine does not alter the sweating threshold, but comparably and linearly reduces the vasoconstriction and shivering thresholds. Anesthesiology 1997;87:835-41. Back to cited text no. 23