The effect of interstitial pressure on therapeutic agent transport: Coupling with the tumor blood and lymphatic vascular systems

Journal of Theoretical Biology

Volumn 355, Issue , 2014, Pages 194-207

  Wu, Min ^a   Frieboes, Hermann B ^b   Chaplain, Mark A J ^c   McDougall, Steven R ^d   Cristini, Vittorio ^e,f   Lowengrub, John S ^a,g  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b University of Louisville   (United States)

^c UNIVERSITY OF DUNDEE   (United Kingdom)

^d HERIOT WATT UNIVERSITY   (United Kingdom)

^e UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

^f University of New Mexico   (United States)

^g University of California at Irvine   (United States)

Author keywords

Cancer simulation; Chemotherapy; Interstitial fluid pressure; Tumor lymphatics; Tumor vasculature

Indexed keywords

ANTINEOPLASTIC AGENT;

BLOOD; BODY FLUID; CANCER; CHEMOTHERAPY; PATHOLOGY; TUMOR;

AREA UNDER THE CURVE; ARTICLE; CANCER CHEMOTHERAPY; CELL HETEROGENEITY; COMPUTATIONAL FLUID DYNAMICS; CONCENTRATION RESPONSE; CONTROLLED STUDY; CROSS COUPLING REACTION; DRUG DEGRADATION; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG PENETRATION; DRUG RESPONSE; DRUG RETENTION; DRUG TRANSPORT; HYDRAULIC CONDUCTIVITY; HYPOXIA; INTERSTITIUM; LYMPH FLOW; LYMPHATIC DRAINAGE; MATHEMATICAL MODEL; PRIORITY JOURNAL; TISSUE PRESSURE; TUMOR BLOOD FLOW; TUMOR MICROENVIRONMENT; TUMOR MODEL; TUMOR REGRESSION; TUMOR VASCULARIZATION; VASCULAR RESISTANCE; ACTIVE TRANSPORT; ANIMAL; BIOLOGICAL MODEL; BLOOD PRESSURE; HUMAN; LYMPHANGIOGENESIS; METABOLISM; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; PATHOPHYSIOLOGY; PSYCHOLOGY; THEORETICAL MODEL; VASCULARIZATION;

ANIMALS; ANTINEOPLASTIC AGENTS; BIOLOGICAL TRANSPORT, ACTIVE; BLOOD PRESSURE; HUMANS; LYMPHANGIOGENESIS; MODELS, BIOLOGICAL; MODELS, THEORETICAL; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC;

EID: 84899859337     PISSN: 00225193     EISSN: 10958541     Source Type: Journal    
DOI: 10.1016/j.jtbi.2014.04.012     Document Type: Article

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