New 2H-chromene-3-carboxamide derivatives: Design, synthesis and use as inhibitors of hMAO

European Journal of Medicinal Chemistry

Volumn 80, Issue , 2014, Pages 278-284

  Pan, Zhi Xiang ^a   He, Xu ^a   Chen, Yan Yan ^a   Tang, Wen Jian ^a   Shi, Jing Bo ^a   Tang, Yu Lan ^a   Song, Bao An ^b   Li, Jun ^a   Liu, Xin Hua ^a,b,c  

^a ANHUI MEDICAL UNIVERSITY   (China)

^b GUIZHOU UNIVERSITY   (China)

^c NANJING UNIVERSITY   (China)

Author keywords

Coumarin; Design; hMAO B; Inhibitors; Synthesis

Indexed keywords

2 OXO N M TOLYL CHROMENE 3 CARBOXAMIDE; 2 OXO N O TOLYL CHROMENE 3 CARBOXAMIDE; 2 OXO N [3 (TRI FLUOROMETHYL)PHENYL] CHROMENE 3 CARBOXAMIDE; 2 OXO N,N DIPHENYL CHROMENE 3 CARBOXAMIDE; 6 NITRO 2 OXO N M TOLYL CHROMENE 3 CARBOXAMIDE; 6 NITRO 2 OXO N O TOLYL CHROMENE 3 CARBOXAMIDE; 6 NITRO 2 OXO N [3 (TRIFLUOROMETHYL)PHENYL] CHROMENE 3 CARBOXAMIDE; 6,8 DIBROMO 2 OXO N M TOLYL CHROMENE 3 CARBOXAMIDE; 6,8 DIBROMO 2 OXO N O TOLYL CHROMENE 3 CARBOXAMIDE; 6,8 DIBROMO 2 OXO N [3 (TRIFLUOROMETHYL)PHENYL] CHROMENE 3 CARBOXAMIDE; 6,8 DIBROMO 2 OXO N,N DIPHENYL CHROMENE 3 CARBOXAMIDE; 6,8 DIBROMO N (3 MORPHOLINOPROPYL) 2 OXO CHROMENE 3 CARBOXAMIDE; 6,8 DIBROMO N TERT BUTYL 2 OXO CHROMENE 3 CARBOXAMIDE; 6,8-DIBROMO N (2 METHOXYPHENYL) 2 OXO CHROMENE 3 CARBOXAMIDE; AMIDE; CHROMENE 3 CARBOXAMIDE DERIVATIVE; CHROMENE DERIVATIVE; IPRONIAZID; MONOAMINE OXIDASE A INHIBITOR; MONOAMINE OXIDASE B INHIBITOR; N (2 METHOXYPHENYL) 2 OXO CHROMENE 3 CARBOXAMIDE; N (2 METHOXYPHENYL) 6 NITRO 2 OXO CHROMENE 3 CARBOXAMIDE; N (3 MORPHOLINOPROPYL) 2 OXO CHROMENE 3 CARBOXAMIDE; N (3 MORPHOLINOPROPYL) 6 NITRO 2 OXO CHROMENE 3 CARBOXAMIDE; N SEC BUTYL 6 NITRO 2 OXO CHROMENE 3 CARBOXAMIDE; N,N DIHEXYL 2 OXO CHROMENE 3 CARBOXAMIDE; UNCLASSIFIED DRUG; AMINE OXIDASE (FLAVIN CONTAINING); BENZOPYRAN DERIVATIVE; MONOAMINE OXIDASE INHIBITOR;

ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG MECHANISM; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROGEN BOND; IC 50; LIGAND BINDING; MOLECULAR DOCKING; PROTEIN FOLDING; CHEMISTRY; HUMAN; IC50; METABOLISM; SYNTHESIS;

BENZOPYRANS; CHEMISTRY TECHNIQUES, SYNTHETIC; DRUG DESIGN; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR DOCKING SIMULATION; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS;

EID: 84899845395     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.04.060     Document Type: Article

References (18)

1. D.E. Edmondson, A. Mattevi, C. Binda, M. Li, and F. Hubálek Current Medicinal Chemistry 11 2007 1983 1993
2. C. Binda, J. Wang, L. Pisani, C. Caccia, A. Carotti, P. Salvati, D.E. Edmondson, and A. Mattevi Journal of Medicinal Chemistry 50 2007 5848 5852
3. L.D. Colibus, M. Li, C. Binda, A. Lustig, D.E. Edmondson, and A. Mattevi Proceedings of the National Academy of Sciences of the United States of America 102 2005 12684 12689
4. C. Binda, F. Hubálek, D.E. Edmonson, and A. Mattevi Nature Structural Biology 9 2002 22 26
5. J. Ma, M. Yoshimura, E. Yamashita, A. Nakagawa, A. Ito, and T. Tsukihara Journal of Molecular Biology 338 2004 103 114
6. W. Weyler, Y.P. Hsu, and X.O. Breakefield Pharmacology & Therapeutics 47 1990 391 417
7. J.L. Saura, J.M. Cesure, A.M. Da Prada, M. Chan-Palay, V. Huber, G. Loffler, and J.G. Richard Neuroscience 62 1994 15 30
8. M.B.H. Youdim, O.B. Am, M. Yogev-Falach, O. Weinreb, W. Maruyama, M. Naoi, and T. Amit Journal of Neuroscience Research 79 2005 172 179
9. Y.R. Prasad, A.L. Rao, L. Prasoona, K. Murali, and P.R. Kumar Bioorganic & Medicinal Chemistry Letters 15 2005 5030 5034
10. N. Gökhan-Kelekçi, S. Yabanoǧlu, E. Küpeli, U. Salgin, Ö. Özgen, G. Uçar, E. Yeşilada, E. Kendi, A. Yeşilada, and A.A. Bilgin Bioorganic & Medicinal Chemistry 15 2007 5775 5786
11. J. Venkatesan, B.N. Sinha, G. Ucar, and A. Ercan Bioorganic & Medicinal Chemistry Letters 18 2008 6362 6368
12. M.J. Matos, D. Viña, E. Quezada, C. Picciau, G. Delogu, F. Orallo, L. Santana, and E. Uriarte Bioorganic & Medicinal Chemistry Letters 19 2009 3268 3270
13. M.J. Matos, D. Viña, C. Picciau, F. Orallo, L. Santana, and E. Uriarte Bioorganic & Medicinal Chemistry Letters 19 2009 5053 5055
14. D. Viña, M.J. Matos, M. Yañeez, L. Santana, and E. Uriarte Medicinal Chemistry Communications 3 2012 213 218
15. L. Santana, H. Gonzáalez-Díaz, E. Quezada, E. Uriarte, M. Yáñez, D. Viñna, and F. Orallo Journal of Medicinal Chemistry 51 2008 6740 6751
16. E.M. Milczek, D. Bonivento, C. Binda, A. Mattevi, I. McDonald, and D.E. Edmondson Journal of Medicinal Chemistry 51 2008 8019 8026
17. R. Satguru, J. Mcmahon, and J.C. Padget Journal of Coatings Technology 66 1994 47 55
18. G.M. Sheldrick SHELXTL-97, Program for Crystal Structure Solution and Refinement 1997 University of Göttingen Göttingen, Germany