Biphasic role of chondroitin sulfate in cardiac differentiation of embryonic stem cells through inhibition of Wnt/β-catenin signaling

PLoS ONE

Volumn 9, Issue 3, 2014, Pages

  Prinz, Robert D ^a,d   Willis, Catherine M ^a,b,e   Van Kuppevelt, Toin H ^c   Klüppel, Michael ^a,b  

^a CHILDREN'S MEMORIAL HOSPITAL   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^d UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

^e ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA FETOPROTEIN; BETA CATENIN; CHONDROITIN ABC LYASE; CHONDROITIN SULFATE; FIBROBLAST GROWTH FACTOR 5; MYOSIN LIGHT CHAIN 2; MYOSIN LIGHT CHAIN 2 VENTRICLE; OCTAMER TRANSCRIPTION FACTOR 4; TRANSCRIPTION FACTOR GATA 4; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR NKX2.5; UNCLASSIFIED DRUG; WNT PROTEIN; BIOLOGICAL MARKER; MESSENGER RNA;

ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL LINEAGE; CELL PROLIFERATION; CONTROLLED STUDY; EMBRYOID BODY; EMBRYONIC STEM CELL; HEART MUSCLE CELL; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM; SULFATION; WNT SIGNALING PATHWAY; ANIMAL; ANTAGONISTS AND INHIBITORS; CYTOLOGY; DRUG EFFECTS; EMBRYOLOGY; ENZYME IMMUNOASSAY; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; HEART; METABOLISM; MOUSE; ORGANOGENESIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALS; BETA CATENIN; BIOMARKERS; BLOTTING, WESTERN; CELL DIFFERENTIATION; CELL LINEAGE; CELLS, CULTURED; CHONDROITIN SULFATES; EMBRYONIC STEM CELLS; FLUORESCENT ANTIBODY TECHNIQUE; HEART; HUMANS; IMMUNOENZYME TECHNIQUES; MICE; ORGANOGENESIS; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; WNT PROTEINS;

EID: 84899844060     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0092381     Document Type: Article

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