Methylation of SFRPs and APC Genes in ovarian cancer infected with high risk human papillomaVirus

Asian Pacific Journal of Cancer Prevention

Volumn 15, Issue 6, 2014, Pages 2719-2725

  Al Shabanah, Othman Abdulla ^a   Hafez, Mohamed Mahmoud ^a   Hassan, Zeinab Korany ^b   Sayed Ahmed, Mohamed Mohamed ^a   Abozeed, Waleed Nabeel ^b   Alsheikh, Abdulmalik ^b   Al Rejaie, Salem Saleh ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b KING KHALID UNIVERSITY HOSPITAL   (Saudi Arabia)

Author keywords

DNA methylation; HPV; MSP; Ovarian cancer; SFRPs and APC genes; Wnt pathway

Indexed keywords

APC PROTEIN; FRZB PROTEIN; GLYCOPROTEIN; MEMBRANE PROTEIN; ONCOPROTEIN; SFRP1 PROTEIN, HUMAN; SFRP2 PROTEIN, HUMAN; SFRP4 PROTEIN, HUMAN; SIGNAL PEPTIDE;

ADULT; AGED; CANCER STAGING; CLASSIFICATION; DNA METHYLATION; FEMALE; FOLLOW UP; GENE EXPRESSION REGULATION; GENETICS; HUMAN; MIDDLE AGED; OVARY TUMOR; PAPILLOMA VIRUS; PAPILLOMAVIRUS INFECTION; PATHOLOGY; PROGNOSIS; PROMOTER REGION; RISK FACTOR; VERY ELDERLY; VIROLOGY; YOUNG ADULT;

ADENOMATOUS POLYPOSIS COLI PROTEIN; ADULT; AGED; AGED, 80 AND OVER; DNA METHYLATION; FEMALE; FOLLOW-UP STUDIES; GENE EXPRESSION REGULATION, NEOPLASTIC; GLYCOPROTEINS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; MIDDLE AGED; NEOPLASM STAGING; OVARIAN NEOPLASMS; PAPILLOMAVIRIDAE; PAPILLOMAVIRUS INFECTIONS; PROGNOSIS; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS; RISK FACTORS; YOUNG ADULT;

EID: 84899814269     PISSN: 15137368     EISSN: 2476762X     Source Type: Journal    
DOI: 10.7314/APJCP.2014.15.6.2719     Document Type: Article

References (68)

1. Anitha P, Priyadarsini RV, Kavitha K, Thiyagarajan P, Nagini S (2013). Ellagic acid coordinately attenuates Wnt/betacatenin and NF-kappaB signaling pathways to induce intrinsic apoptosis in an animal model of oral oncogenesis. Eur J Nutr, 52, 75-84.
2. Al-Shabanah OA, Hafez MM, Hassan ZK, et al (2013). Human papillomavirus genotyping and integration in ovarian cancer Saudi patients. Virol J, 20, 10-343.
3. Basu M, Roy SS (2013). Wnt/beta-catenin pathway is regulated by PITX2 homeodomain protein and thus contributes to the proliferation of human ovarian adenocarcinoma cell, SKOV- 3. J Biol Chem, 288, 4355-67.
4. Behrens J (2005). The role of the Wnt signalling pathway in colorectal tumorigenesis. Biochem Soc Trans, 33, 672-5.
5. Bernard P, Ryan J, Sim H, et al (2012). Wnt signaling in ovarian development inhibits Sf1 activation of Sox9 via the Tesco enhancer. Endocrinology, 153, 901-12.
6. Bovolenta P, Esteve P, Ruiz JM, Cisneros E, Lopez-Rios J (2008). Beyond Wnt inhibition: new functions of secreted Frizzled-related proteins in development and disease. J Cell Sci, 121, 737-46.
7. Boyer A, Goff AK, Boerboom D (2010). WNT signaling in ovarian follicle biology and tumorigenesis. Trends Endocrinol Metab, 21, 25-32.
8. Chen J, Rocken C, Lofton-Day C, et al (2005). Molecular analysis of APC promoter methylation and protein expression in colorectal cancer metastasis. Carcinogenesis 26, 37-43.
9. Chen S, Zhou J, Zhang X, et al (2011). Mutation analysis of the APC gene in a Chinese FAP pedigree with unusual phenotype. ISRN Gastroenterol, 2011, 2011: 909121.
10. Cheng YY, Yu J, Wong YP, et al (2007). Frequent epigenetic inactivation of secreted frizzled-related protein 2 (SFRP2) by promoter methylation in human gastric cancer. Br J Cancer, 97, 895-901.
11. Chien AJ, Conrad WH, Moon RT (2009). A Wnt survival guide: from flies to human disease. J Invest Dermatol, 129, 1614-27.
12. Chung MT, Lai HC, Sytwu HK, et al (2009). SFRP1 and SFRP2 suppress the transformation and invasion abilities of cervical cancer cells through Wnt signal pathway. Gynecol Oncol, 112, 646-53.
13. De A (2011). Wnt/Ca2+signaling pathway: a brief overview. Acta Biochim Biophys Sin, 43, 745-56.
14. Ding DC, Chiang MH, Lai HC, et al (2009). Methylation of the long control region of HPV16 is related to the severity of cervical neoplasia. Eur J Obstet Gynecol Reprod Biol, 147, 215-20.
15. Doi T, Puri P, Bannigan J, Thompson J (2010). Disruption of noncanonical Wnt/CA2+pathway in the cadmium-induced omphalocele in the chick model. J Pediatr Surg, 45, 1645-9.
16. Eads CA, Danenberg KD, Kawakami K, et al (1999). CpG island hypermethylation in human colorectal tumors is not associated with DNA methyltransferase overexpression. Cancer Res, 59, 2302-6.
17. Esteller M, Sparks A, Toyota M, et al (2000). Analysis of adenomatous polyposis coli promoter hypermethylation in human cancer. Cancer Res, 60, 4366-71.
18. Fang J, Jasperson K (2011). Germline APC Mutation and Familial Barrett Esophagus: Causal or Coincidence? Gastroenterol Hepatol, 7, 342-4.
19. Fonar Y, Frank D (2011). FAK and WNT signaling: the meeting of two pathways in cancer and development. Anticancer Agents Med Chem, 11, 600-6.
20. Gregory MA, Phang TL, Neviani P, et al (2010). Wnt/Ca2+/ NFAT signaling maintains survival of Ph+leukemia cells upon inhibition of Bcr-Abl. Cancer Cell, 18, 74-87.
21. Haya S Al-Eid MSM, Shouki Bazarbashi, Ali Al-Zahrani (2007). Cancer Incidence and Survival Report Saudi Arabia.
22. Hiltunen MO, Alhonen L, Koistinaho J, et al (1997). Hypermethylation of the APC (adenomatous polyposis coli) gene promoter region in human colorectal carcinoma. International journal of cancer. Int J Cancer, 70, 644-8.
23. Huang J, Zhang YL, Teng XM, et al (2007). Down-regulation of SFRP1 as a putative tumor suppressor gene can contribute to human hepatocellular carcinoma. BMC cancer, 7, 126.
24. Hughes LA, Khalid-de Bakker CA, Smits KM, et al (2012). The CpG island methylator phenotype in colorectal cancer: progress and problems. Biochim Biophys Acta, 1825, 77-85.
25. Jacob F, Ukegjini K, Nixdorf S, et al (2012). Loss of secreted frizzled-related protein 4 correlates with an aggressive phenotype and predicts poor outcome in ovarian cancer patients. PloS one, 7, 31885.
26. Jin Z, Tamura G, Tsuchiya T, et al (2001). Adenomatous polyposis coli (APC) gene promoter hypermethylation in primary breast cancers. Br J Cancer, 85, 69-73.
27. Kawano Y, Kypta R (2003). Secreted antagonists of the Wnt signalling pathway. J Cell Sci, 116, 2627-34.
28. Keita M, Wang ZQ, Pelletier JF, et al (2013). Global methylation profiling in serous ovarian cancer is indicative for distinct aberrant DNA methylation signatures associated with tumor aggressiveness and disease progression.Gynecol Oncol, 128, 356-63.
29. Kikuchi A, Yamamoto H, Sato A, Matsumoto S (2012). Wnt5a: its signalling, functions and implication in diseases. Acta Physiol, 204, 17-33.
30. Kim J, Kim DW, Chang W, et al (2012). Wnt5a is secreted by follicular dendritic cells to protect germinal center B cells via Wnt/Ca2+/NFAT/NF-kappaB-B cell lymphoma 6 signaling. J Immunol, 188, 182-9.
31. Kurman RJ, Shih Ie M (2010). The origin and pathogenesis of epithelial ovarian cancer: a proposed unifying theory. The American journal of surgical pathology. Am J Surg Pathol. 34, 433-43.
32. Lengyel E (2010). Ovarian cancer development and metastasis. Am J Pathol, 177, 1053-64.
33. Lo PK, Mehrotra J, D'Costa A, et al (2006). Epigenetic suppression of secreted frizzled related protein 1 (SFRP1) expression in human breast cancer. Cancer Biol Ther, 5, 281-6.
34. Lu D, Carson DA (2011). Inhibition of Wnt signaling and cancer stem cells. Oncotarget, 2, 587.
35. Malisic E, Jankovic R, Jakovljevic K (2012). Detection and genotyping of human papillomaviruses and their role in the development of ovarian carcinomas. Arch Gynecol Obstet, 286, 723-28.
36. Marsit CJ, McClean MD, Furniss CS, Kelsey KT (2006). Epigenetic inactivation of the SFRP genes is associated with drinking, smoking and HPV in head and neck squamous cell carcinoma. International journal of cancer. Int J Cancer, 119, 1761-6.
37. Miller DL, Puricelli MD, Stack MS (2012). Virology and molecular pathogenesis of HPV (human papillomavirus)- associated oropharyngeal squamous cell carcinoma. Biochem J, 443, 339-53.
38. Montavon C, Gloss BS, Warton K, et al (2012). Prognostic and diagnostic significance of DNA methylation patterns in high grade serous ovarian cancer. Gynecol Oncol, 124, 582-8.
39. Munger K, Baldwin A, Edwards KM, et al (2004). Mechanisms of human papillomavirus-induced oncogenesis. J Virol, 78 11451-60.
40. Ozdemir F, Altinisik J, Karateke A, Coksuer H, Buyru N (2012). Methylation of tumor suppressor genes in ovarian cancer. Exp Ther Med, 4, 1092-6.
41. Pacheco-Pinedo EC, Morrisey EE (2011). Wnt and Kras signaling-dark siblings in lung cancer. Oncotarget, 2, 569-74.
42. Perri F, Cotugno R, Piepoli A, et al (2007). Aberrant DNA methylation in non-neoplastic gastric mucosa of H. Pylori infected patients and effect of eradication. Kelly CP. Am J Gastroenterol, 102, 1361-71.
43. Qu W, Jiang G, Cruz Y, et al (1997). PCR detection of human papillomavirus: comparison between MY09/MY11 and GP5+/GP6+primer systems. J Clin Microbiol, 35, 1304-10.
44. Rampias T, Boutati E, Pectasides E, et al (2010). Activation of Wnt signaling pathway by human papillomavirus E6 and E7 oncogenes in HPV16-positive oropharyngeal squamous carcinoma cells. Mol Cancer Res, 8, 433-43.
45. Rigi-Ladiz MA, Kordi-Tamandani DM, Torkamanzehi A (2011). Analysis of hypermethylation and expression profiles of APC and ATM genes in patients with oral squamous cell carcinoma. Clin Epigenetics, 3, 6.
46. Samudio-Ruiz SL, Hudson LG (2012). Increased DNA methyltransferase activity and DNA methylation following Epidermal Growth Factor stimulation in ovarian cancer cells. Epigenetics, 7, 216-24.
47. Shanmughapriya S, Senthilkumar G, Vinodhini K, et al (2012). Viral and bacterial aetiologies of epithelial ovarian cancer. Eur J Clin Microbiol Infect Dis, 31, 2311-7.
48. Shen JZ, Xu CB, Fu HY, et al (2011). Methylation of secreted frizzled related protein gene in acute leukemia patients in China. Asian Pac J Cancer Prev, 12, 2617-21.
49. Shin H, Kim JH, Lee YS, Lee YC (2012). Change in gene expression profiles of secreted frizzled-related proteins (SFRPs) by sodium butyrate in gastric cancers: induction of promoter demethylation and histone modification causing inhibition of Wnt signaling. Int J Oncol, 40, 1533-42.
50. Siegel R, Naishadham D, Jemal A (2012). Cancer statistics, 2012. CA Cancer J Clin, 62, 10-29.
51. Skinner MK, Manikkam M, Guerrero-Bosagna C (2010). Epigenetic transgenerational actions of environmental factors in disease etiology. Trends Endocrinol Metab, 21, 214-22.
52. Smith IM, Mithani SK, Mydlarz WK, Chang SS, Califano JA (2010). Inactivation of the tumor suppressor genes causing the hereditary syndromes predisposing to head and neck cancer via promoter hypermethylation in sporadic head and neck cancers. ORL J Otorhinolaryngol Relat Spec, 72, 44-50.
53. Sonoda K, Miyamoto S, Yamazaki A, et al (2007). Biologic significance of receptor-binding cancer antigen expressed on SiSo cells (RCAS1) as a pivotal regulator of tumor growth through angiogenesis in human uterine cancer. Cancer, 110, 1979-90.
54. Su HY, Lai HC, Lin YW, et al (2009). An epigenetic marker panel for screening and prognostic prediction of ovarian cancer. International journal of cancer. Int J Cancer, 124, 387-93.
55. Su HY, Lai HC, Lin YW, et al (2010). Epigenetic silencing of SFRP5 is related to malignant phenotype and chemoresistance of ovarian cancer through Wnt signaling pathway. International journal of cancer. Int J Cancer, 127, 555-67.
56. Urakami S, Shiina H, Enokida H, et al (2006). Combination analysis of hypermethylated Wnt-antagonist family genes as a novel epigenetic biomarker panel for bladder cancer detection. Clin Cancer Res, 12, 2109-16.
57. Usongo M, Li X, Farookhi R (2013). Activation of the canonical WNT signaling pathway promotes ovarian surface epithelial proliferation without inducing beta-catenin/Tcf-mediated reporter expression. Dev Dyn, 242, 291-300.
58. Veeck J, Dahl E (2012). Targeting the Wnt pathway in cancer: the emerging role of Dickkopf-3. Biochim Biophys Acta 1825, 18-28.
59. Veeck J, Noetzel E, Bektas N, et al (2008). Promoter hypermethylation of the SFRP2 gene is a high-frequent alteration and tumor-specific epigenetic marker in human breast cancer. Molecular Cancer, 7, 83.
60. Vinokurova S, von Knebel Doeberitz M (2011). Differential methylation of the HPV 16 upstream regulatory region during epithelial differentiation and neoplastic transformation. PloS One, 6, 24451.
61. Wang Q, Symes AJ, Kane CA, et al (2010). A novel role for Wnt/Ca2+signaling in actin cytoskeleton remodeling and cell motility in prostate cancer. PloS one, 5, 10456.
62. Wang ZK, Liu J, Liu C, et al (2012). Hypermethylation of adenomatous polyposis coli gene promoter is associated with novel Wnt signaling pathway in gastric adenomas. J Gastroenterol Hepatol, 27, 1629-34.
63. Wong EW, Lee WM, Cheng CY (2013). Secreted Frizzled-related protein 1 (sFRP1) regulates spermatid adhesion in the testis via dephosphorylation of focal adhesion kinase and the nectin-3 adhesion protein complex. FASEB J, 27, 464-77.
64. Wong NC, Novakovic B, Weinrich B, et al (2008). Methylation of the adenomatous polyposis coli (APC) gene in human placenta and hypermethylation in choriocarcinoma cells. Cancer Letters, 268, 56-62.
65. Yao H, Ashihara E, Maekawa T (2011). Targeting the Wnt/betacatenin signaling pathway in human cancers. Expert Opin Ther Targets, 15, 873-87.
66. Zeller C, Dai W, Steele NL, et al (2012). Candidate DNA methylation drivers of acquired cisplatin resistance in ovarian cancer identified by methylome and expression profiling. Oncogene, 31, 4567-76.
67. Zhang Z, Huettner PC, Nguyen L, et al (2006). Aberrant promoter methylation and silencing of the POU2F3 gene in cervical cancer. Oncogene, 25, 5436-45.
68. Zhao C, Ma H, Bu X, Wang W, Zhang N (2013). SFRP5 inhibits gastric epithelial cell migration induced by macrophagederived Wnt5a. Carcinogenesis, 34, 146-52.