Piperine: A valuable alkaloid from piper species

International Journal of Pharmacy and Pharmaceutical Sciences

Volumn 6, Issue 4, 2014, Pages 34-38

  Vasavirama, K ^a   Upender, Mahesh ^b  

^a GITAM UNIVERSITY   (India)

^b UNIVERSITY OF HYDERABAD   (India)

Author keywords

Alkaloid; Medicinal value; Piper longum; Piper nigrum; Piperine

Indexed keywords

BETA CAROTENE; BIOPERINE; CURCUMIN; CYTOCHROME P450 3A4; MULTIDRUG RESISTANCE PROTEIN; OXYPHENBUTAZONE; PIPERINE; PROTECTIVE AGENT; RESVERATROL; SELENIUM; TRACE ELEMENT; UNCLASSIFIED DRUG; VITAMIN B GROUP;

ANALGESIC ACTIVITY; ANTIDEPRESSANT ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIPYRETIC ACTIVITY; BIOAVAILABILITY; CELL PROTECTION; COGNITIVE DEFECT; CONTRACEPTION; DENSITOMETRY; DRUG FORMULATION; DRUG METABOLISM; EXTRACTION; FRUIT; GROWTH STIMULATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH PERFORMANCE THIN LAYER CHROMATOGRAPHY; INSECTICIDAL ACTIVITY; LIPID PEROXIDATION; LIVER PROTECTION; MOOD; NONHUMAN; PATENT; PIPER (PLANT); RADIATION; REVIEW; SKIN PIGMENTATION; SOLVENT EXTRACTION; SPECIES CONSERVATION; THERMOGENESIS; ULTRAVIOLET SPECTROPHOTOMETRY; VEGETATIVE PROPAGATION;

EID: 84899806552     PISSN: None     EISSN: 09751491     Source Type: Journal    
DOI: None     Document Type: Review

References (68)

1. Oersted. "Über das Piperin, einneuesPflanzenalkaloid" [On piperine, a new plant alkaloid]. (Schweigger's) Journal fürChemie und Physik, 29(1): 80-82, (1820).
2. Pharmacographia (London: Macmillan & Co.), p. 584, (1879).
3. Stenhouse in Pharm. J, 14: 363, (1855).
4. McNamara FN, Randall A, Gunthorpe MJ. Effects of piperine, the pungent component of black pepper, at the human vanilloid receptor (TRPV1). Br. J. Pharmacol, 144(6): 781-90 (2005).
5. Annalen. 75, 82; 84, 345, (1850)cf. Wertheim and Rochleder, Br. J. Pharmacol., 54, 255, (1845).
6. Babo& Keller. Journ. pr. Chem, 72: 53, (1857).
7. Rugheimer. Ber., 15, 1390 (1882).
8. Srinivasan K. Black pepper and its pungent principle-piperine. A review of diverse physiological effects. Crit. Rev. Food Sci. Nutr, 47: 735-748 (2007).
9. Dhanya K, Kizhakkayil J, Syamkumar S, Sasikumar B. Isolation and Amplification of Genomic DNA from Recalcitrant Dried Berries of Black Pepper (Piper nigrumL.). A Medicinal Spice. Mol. Biotechnol, 7: 165-168 (2007).
10. Parganiha R, Verma S, Chandrakar S, Pal S, Sawarkar HA, Kashyap P. In vitro anti-asthmatic activity of fruit extract of Piper nigrum(Piperaceae). Inter. J Herbal Drug Res, 1: 15-18 (2011).
11. Sujatha R, Luckin CB, Nazeem PA. Histology of organogenesis from callus cultures of black pepper (Piper nigrumL). J. Trop. Agric, 41: 16-19 (2003).
12. Fan LS, Muhmad R, Omar D, Rahimani M. Insecticidal Properties of Piper nigrumFruit Extracts and Essential Oils against Spodopteralitura. Inter. J. Agric. Biol, 13: 517-52 (2011).
13. Parmar VS, Jain SC, Bisht KS, Jain R, Taneja P, Jha A, Tyagi OD. Phytochemistry of the genus Piper. Phytochemistry, 46: 597-673 (1997).
14. Govindrajan VS. Critical resviews in food science and nutrition, 9: 115-225 (1977).
15. Kanta K. Morphology and embryology of Piper. nigrum L. Phytomorphology, 12: 207-221 (1962).
16. Nair RR, Gupta SD. High-frequency plant regeneration through cyclic secondary somatic embryogenesis in black pepper (Piper nigrum L.). Plant Cell Rep 24: 699-707 (2006).
17. Sarasan V, Thomas E, Lawrence B, Nair GM. Plant regeneration in Piper longumL. (Piperaceae) through direct and indirect shoot development. J. Spices Arom. Crops 2: 34-40 (1993).
18. Sharma YR, Kallo G. Status of current research towards increased production and productivity in black pepper in India. Focus on Pepper, 1: 69-86 (2004).
19. Zhang Z, Zhao L, Chen X, Zheng X. Successful micropropagation protocol of piper methysticum. BiologiaPlantarum, 52: 110-112 (2008).
20. Marion L. The Pyrrolidine Alkaloids. In The Alkaloids Chemistry and Physiology; Manske R. H. F., Holmes H. L., Eds.; Academic Press: London, 1, p 168 (1960).
21. Rastogi N K, Niranjan K. Enhanced Mass Transfer during Osmotic Dehydration of High-Pressure Treated Pineapple. J. Food Sci, 63: 508-511 (1998).
22. Raman G and Gaikar VG. Extraction of Piperine from Piper nigrum(Black Pepper) by Hydrotropic Solubilization. Merck Index, 11th Edition: 7442 (2002).
23. LupinaT and Cripps H. J Assoc Off Anal Chem, 70: 112-113 (1987).
24. Jansz E R, Pathirana I C and Packiyasothy E V. J NatrlSciCounc, 11: 129-138 (1983).
25. Kulkarni D, Apte S P, Francis M and Sane R T. Indian Drugs, 38: 323-326 (2001).
26. Suthar AC, Sohoni DP, Banavalikar MM and Biyani MK. HPTLC method for identification of different piper species and their mixtures. Indian Drugs, 40: 692-694 (2003).
27. Verzele M, Mussche P, Qureshi SA. High performance liquid chromatographic analysis of the pungent principles of pepper and pepper extracts. J. Chromatogr, 172: 493-497 (1979).
28. Rathnawathie M and Buckle KA. Determination of piperine in pepper (Piper nigrum) using high-performance liquid chromatography. J. Chromatogr, 264: 316-320 (1998).
29. Mukherjee P K. Quality Control of Herbal Drugs. Business Horizons, 1st Ed: 205-209 (2002).
30. Santosh MK, Shaila D, Rajyalakshmi I and Sanjeevarao I. RPHPLC method for determination of piperine from Piper longum L. and Piper nigrum L. E-journal of chemistry 2: 131-135 (2005).
31. Hu S, Ao P and Liu D. Pharmacognostical studies on the roots of Piper nigrum L. III: Determination of essential oil and piperine. Acta Hort. (ISHS), 426: 179-182 (1996).
32. Hamrapurkar PD, Jadhav K and Zine S. Quantitative estimation of piperine in Piper nigrum and Piper longum using high performance thin layer chromatography. Journal of Applied Pharmaceutical Science, 01: 117-120 (2011).
33. Dussel S, Heuertz RM, Ezeklel UR. Growth inhibition of colon cancer cells by plant compounds. Clin Lab Sci Summer, 21: 151-7 (2008).
34. Wattanathorn J, Chonpathompikunlert P, Muchimapura S, Priprem A, Tankamnerdthai O. Piperine, the potential functional food for mood and cognitive disorders. Food ChemTechnol, 46: 3106-3110 (2008).
35. Kumar A, Khan IA, Koul S, Koul JL, Taneja SC, Ali I, Ali F, Sharma S, Mirza ZM, Kumar M, Sangwan PL, Gupta P, Thota N, Qazi GN. Novel structural analogues of piperine as inhibitors of the Nor A efflux pump of Staphylococcus aureus. J. AntimicrobChemother, 61: 1270-1276 (2008).
36. Bhardwaj RK, Glaeser H, Becquemont L, Klotz U, Gupta SK, Fromm MF. Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4. J PharmacolExpTherapeut, 302: 645-650 (2007).
37. Tiwari P, Singh D. Antitrichomonas activity of sapindussaponins, a candidate for development as microbicidalcontraceptive. J. AntimicrobChemother, 62: 526-534 (2008).
38. Reshmi SK, Satya E, Devi PS. Isolation of piperidine from Piper nigrum and its antiproliferative activity. African. J PharmaPharmacol, 4: 5622-573 (2010).
39. Panda S, Kar A. Piperine lowers the serum concentrations of thyroid harmones, glucose and hepatic 5D activity in adult male mice. HormMetab Res, 35: 523 (2003).
40. Singh NK, Kumar P, Gupta DK, Singh S, Singh VK. UVspectrometric method development for estimation of piperine in chitrakadiVati. Der PharmaLettre, 3: 178-182 (2011).
41. Kumar S, Singhal V, Roshan R, Sharma A, Rembhotkar GW, Ghosh B. Piperine inhibits TNF-α induced adhesion on neutrophils to endothelial monolayer through suppression of NF-κ and IκB kinase activation. Eur J Pharmacol, 575: 177-186 (2007).
42. Sunila ES, Kuttan G. Immunomodulatory and Antitumor activity of Piper longum Linn. and Piperine. J. Ethnopharmacol, 90: 339-346 (2004).
43. Li S, Wang C, Li W, Koike K, Nikaido T, Wang MW. Antidepressant-like effects of piperine and its derivative antiepilepsirine. J Asian Nat Prod Res, 9: 421-430 (2007).
44. Pathak N, Khandelwal S. Immunomodulatory role of Piperine in cadium induced thymic atrophy and splenomegaly in mice. Environ ToxicolPharma, 28: 52-60 (2009).
45. Bhat BG, Chandrasekhara N. Effect of black pepper and piperine on bile secretion and composition in rats. Nahrung, 3: 913-916 (1987).
46. Mujumdar AM, Dhuley JN, Deshmukh VK, Raman PH, Thorat SL, Naik SR. Effect of piperine on pentobarbitore induced hypnosis in rats. Indian J ExpBiol, 28: 486-487 (1990a).
47. Mujumdar AM, Dhuley JN, Deshmukh VK, Naik SR. Effect of piperine bioavailability of oxyphenylbutazone in rats. Indian Drugs, 36: 123-126 (1999).
48. Desai SK, Gawali VS, Naik AS, D'souza LL. Potentiating effect of piperine on hepatoprotective activity of Boerhaaviadiffusa to combat oxidative stress. Int J Pharmacogn, 4: 393-397 (2008).
49. Dhuley JN, Raman PH, Mujumdar AM, Naik SR. Inhibition of lipid peroxidation by piperine during experimental inflammation in rats. Indian J ExpBiol 31: 443-445 (1993).
50. Daware MB, Mujumdar AM, Ghaskadbi S. Reproductive toxicity of piperine in Swiss albino mice. Planta Med, 66: 231-236 (2000).
51. Aggarwal M, Kaul BL. The radioprotective effect of piperine in plants. Indian Drugs 29, 447-449 (1992).
52. D'Hooge R, Pei YQ, Raes A, Lebrun P, Bogaert PP, De Deyn PP. Anticonvulsant activity of piperine on seizures by excitatory amino acid receptor agonists. Arzneimittelforschung 46: 557-560 (1996).
53. Bai YF, Xu H. Protective action of piperine against experimental gastric ulcer. ActaPharmacolSin 21: 357-359 (2000).
54. Gupta SK, Bansal P, Bhardwaj RK, Velpandian T. Comparative anti-nociceptive, anti-inflammatory and toxicity profile of nimesulides vs nimesulide and piperine combination. Pharmacol Res 41: 657-662 (2000).
55. Selven-diran K, Singh JP, Krishnan KB, Saktisekaran D. Cytoprotective effect of piperine against benzole [a]pyrene induced lung cancer with reference to lipid peroxidation and antioxidant system in Swiss albino mice. Fitoterapia 74: 109-115 (2003).
56. Lee SA, Hong SS, Han XB, Hwang JS, Oh GJ, Lee KS, Lee MK, Hwang BY, Ro JS. Piperine from the fruits of Piper nigrum with inhibitory effect on monoamine oxidase and antidepressant like activity. Chem Pharm Bull, 53: 832-835 (2005).
57. Bang JS, Oh DH, Choi HM, Sur BJ, Lim SJ, Kim JY, Yang HI, Yoo MC, Hahm DH, Kim KS. Anti-inflammatory and antiarthritic effects of piperine in human interleukin 1β-stimulated fibroblast-likesynoviocytes and in rat arthritis models. Arthritis Res Ther, 11(2): R49 (2009).
58. Kapoor IPS, Singh B, Singh G, De Heluani CS, De Lampasona MP, Catalan CAN. Chemistry and in vitro antioxidant activity of volatile oil and oleoresins of Black pepper (Piper nigrum). J Agric Food Chem, 57: 5358-5364 (2009).
59. Timmers, L. Herbal Medicines Used against Epilepsy in Developing Countries; Publication Number PUG/94-4; PublicatiesWetenschapswinkelGeneesmiddelen: Vrouwen, The Netherlands (1994).
60. Karan RS, Bhargava VK, Garg SK. Effect of piperine on the pharmacokinetic profile of isoniazid in rabbits. Indian J. Pharmacol 30: 254-256 (1988).
61. Sharma A, Gautam S, Jadhav SS. Spice extracts as dose modifying factors in radiation inactivation of bacteria. J Agric Food Chem, 48: 1340-1344 (2000).
62. Bhardwaj RK, Glaeser H, Becquemont L, Klotz U, Gupta SK and Fromm MF. Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4. J PharmacolExpTher, 302: 645-650 (2002).
63. Atal CK, Dubey RK and Singh J. "Biochemical basis of enhanced drug bioavailability by piperine: evidence that piperine is a potent inhibitor of drug metabolism". J PharmacolExpTher, 232 (1): 258-62 (1985).
64. Reen RK, Jamwal DS, Taneja SC, Koul JL, Dubey RK, Wiebel FJ, Singh J. Impairment of UDP-glucose dehydrogenase and glucuronidation activities in liver and small intestine of rat and guinea pig in vitro by piperine. Biochem. Pharmacol, 46: 229-38 (1993).
65. Shoba G, Joy D, Joseph T, Majeed M, Rajendran R, Srinivas PS. "Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers". Planta Med, 64: 353-6 (1998).
66. Manoharan S, Balakrishnan S, Menon VP, Alias LM. Chemopreventive efficacy of curcumin and piperine during 7, 12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis. Singapore Med J, 50: 139-46 (2009).
67. Johnson JJ, NIHAL M, Siddiqui IA, Scarlett CO, Bailey HH, Mukhtar H & Ahmad N. Enhancing the bioavailability of resveratrol by combining it with piperine. Molecular Nutrition & Food Research, 55: 1169-1176 (2011).
68. Faas L, Venkatasamy R, Hider RC, Young AR and Soumyanath A. "In vivo evaluation of piperine and synthetic analogues as potential treatments for vitiligo using a sparsely pigmented mouse model". British Journal of Dermatology, 158: 941-50 (2008).