Transport rankings of non-steroidal antiinflammatory drugs across blood-brain barrier in vitro models

PLoS ONE

Volumn 9, Issue 1, 2014, Pages

  Novakova, Iveta ^a   Subileau, Eva Anne ^b   Toegel, Stefan ^c   Gruber, Daniela ^a   Lachmann, Bodo ^a   Urban, Ernst ^a   Chesne, Christophe ^b   Noe, Christian R ^a   Neuhaus, Winfried ^a,d  

^a UNIVERSITY OF VIENNA   (Austria)

^b Biopredic International   (France)

^c MEDICAL UNIVERSITY OF VIENNA   (Austria)

^d UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYFLUORESCEIN; CELECOXIB; DIAZEPAM; DICLOFENAC; IBUPROFEN; MELOXICAM; NONSTEROID ANTIINFLAMMATORY AGENT; PIROXICAM; PROBENECID; TENOXICAM; VERAPAMIL;

ANIMAL CELL; ARTICLE; BLOOD BRAIN BARRIER; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG BINDING; DRUG PENETRATION; DRUG TRANSPORT; IN VITRO STUDY; MALE; NEWBORN; NONHUMAN; RAT; SERUM; SWINE; TRANSPORT MEDIUM;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASTROCYTES; BIOLOGICAL TRANSPORT, ACTIVE; BLOOD-BRAIN BARRIER; CELL MEMBRANE PERMEABILITY; CELLS, CULTURED; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CULTURE MEDIA, CONDITIONED; DRUG DISCOVERY; ENDOTHELIUM, VASCULAR; GLIOMA; MALE; RATS; RATS, WISTAR; SWINE; TISSUE DISTRIBUTION;

EID: 84899789968     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0086806     Document Type: Article

References (51)

1. Joo F (1996) Endothelial cells of the brain and other organ systems: some similarities and differences. Prog Neurobiol 48: 255-273.
2. Neuhaus W, Noe CR (2009) Transport at the Blood-Brain Barrier. In: Ecker G, Chiba P, editors. Transporters as Drug Carriers: Structure, Function, Substrates: 44 (Methods and Principles in Medicinal Chemistry). Weinheim, Germany: Wiley- VCH Verlag GmbH & Co. KGaA; 2009. pp. 263-298.
3. Abbott NJ, Rönnbäck L, Hansson E (2006) Astrocyte-endothelial interactions at the blood-brain barrier. Nat Rev Neurosci 7: 41-53. (Pubitemid 41828930)
4. Cucullo L, Hossain M, Tierney W, Janigro D (2013) A new dynamic in vitro modular capillaries-venules modular system: cerebrovascular physiology in a box. BMC Neurosci 6: 14-18.
5. Bell R, Zlokovic B (2009) Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease. Acta Neuropathol 118: 103-113.
6. Kortekaas R, Leenders KL, van Oostrom JC, Vaalburg W, Bart J, et al. (2005) Blood-brain barrier dysfunction in parkinsonian midbrain in vivo. Ann Neurol 57: 176-179. (Pubitemid 40179854)
7. Minagar A, Alexander JS (2003) Blood-brain barrier disruption in multiple sclerosis. Mult Scler 9: 540-549. (Pubitemid 37479401)
8. Kleinschnitz C, Blecharz K, Kahles T, Schwarz T, Kraft P, et al. (2011) Glucocorticoid insensitivity at the hypoxic blood-brain barrier can be reversed by inhibition of the proteasome. Stroke 42: 1081-1089.
9. Thal SC, Schaible EV, Neuhaus W, Scheffer D, Brandstetter M, et al. (2013) Inhibition of proteasomal glucocorticoid receptor degradation restores dexa-methasone-mediated stabilization of the blood-brain barrier after traumatic brain injury. Crit Care Med 41: 1305-1315.
10. Zlokovic BV (2011) Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders. Nat Rev Neurosci 12: 723-738.
11. Dokmeci D (2004) Ibuprofen and Alzheimer's disease. Folia Med (Plovdiv) 46: 5-10.
12. Mutschler E, Geisslinger G, Kroemer HK, Menzel S, Ruth P (2012) Mutschler Arzneimittelwirkungen: Pharmakologie - Klinische Pharmakologie - Toxikologie. Stuttgart: Wissenschaftliche Verlagsgesellschaft Stuttgart.
13. Smolinske SC, Hall AH, Vandenberg SA, Spoerke DG, McBride PV (1990) Toxic effects of nonsteroidal anti-inflammatory drugs in overdose. An overview of recent evidence on clinical effects and dose-response relationships. Drug Saf 5: 252-274. (Pubitemid 20294970)
14. Aygün D, Kaplan S, Odaci E, Onger ME, Altunkaynak ME (2012) Toxicity of non-steroidal anti-inflammatory drugs: a review of melatonin and diclofenac sodium association. Histol Histopathol 27: 417-436.
15. Parepally JM, Mandula H, Smith QR (2006) Brain uptake of nonsteroidal antiinflammatory drugs: ibuprofen, flurbiprofen, and indomethacin. Pharm Res 23: 873-881. (Pubitemid 43781395)
16. Dembo G, Park SB, Kharasch ED (2005) Central nervous system concentrations of cyclooxygenase-2 inhibitors in humans. Anesthesiology 102: 409-415. (Pubitemid 40189092)
17. Jolliet P, Simon N, Brée F, Urien S, Pagliara A, et al., (1997) Blood-to-brain transfer of various oxicams: effects of plasma binding on their brain delivery. Pharm Res 14: 650-656. (Pubitemid 27220285)
18. Hakan T, Toklu HZ, Biber N, Ozevren H, Solakoglu S, et al. (2010) Effect of COX-2 inhibitor meloxicam against traumatic brain injury-induced biochemical, histopathological changes and blood-brain barrier permeability. Neurol Res 32: 629-635.
19. Foster KA, Weiss M, Roberts MS (2002) Distribution kinetics of solutes in the isolated in-situ perfused rat head using the multiple indicator dilution technique and a physiological two-barrier model. J Pharm Pharmacol 54: 373-382. (Pubitemid 34232337)
20. Farooq F, Abadía-Molina F, Mackenzie D, Hadwen J, Shamim F, et al. (2013) Celecoxib increases SMN and survival in a severe spinal muscular atrophy mouse model via p38 pathway activation. Hum Mol Genet 22: 3415-3424.
21. Teifel M, Friedl P (1996) Establishment of the permanent microvascular endothelial cell line PBMEC/C1-2 from porcine brains. Exp Cell Res 228: 50-57. (Pubitemid 26349712)
22. Neuhaus W, Bogner E, Wirth M, Trzeciak J, Lachmann B, et al. (2006) A novel tool to characterize paracellular transport: the APTS-dextran ladder. Pharm Res 23: 1491-1501. (Pubitemid 43993812)
23. Neuhaus W, Plattner VE, Wirth M, Germann B, Lachmann B, et al. (2008) Validation of in vitro cell culture models of the blood-brain barrier: tightness characterization of two promising cell lines. J Pharm Sci 97: 5158-5175.
24. Neuhaus W, Stessl M, Strizsik E, Bennani-Baiti B, Wirth M, et al., (2010) Bloodbrain barrier cell line PBMEC/C1-2 possesses functionally active P-glycoprotein. Neurosci Lett 469: 224-228.
25. Poetsch V, Neuhaus W, Noe CR (2010) Serum-derived immunoglobulins neutralize adverse effects of amyloid-beta peptide on the integrity of a bloodbrain barrier in vitro model. J Alzheimers Dis 21: 303-314.
26. Neuhaus W, Lauer R, Oelzant S, Fringeli UP, Ecker GF, et al. (2006) A novel flow based hollow-fiber blood-brain barrier in vitro model with immortalised cell line PBMEC/C1-2. J Biotechnol 125: 127-141. (Pubitemid 44066610)
27. Neuhaus W, Trauner G, Gruber D, Oelzant S, Klepal W, et al. (2008) Transport of a GABAA receptor modulator and its derivatives from Valeriana officinalis L. s. l. across an in vitro cell culture model of the blood-brain barrier. Planta Med 74: 1338-1344.
28. Alvarez JI, Dodelet-Devillers A, Kebir H, Ifergan I, Fabre PJ, et al. (2011) The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence. Science 334: 1727-1731.
29. Kröll S, El-Gindi J, Thanabalasundaram G, Panpumthong P, Schrot S, et al. (2009) Control of the blood-brain barrier by glucocorticoids and the cells of the neurovascular unit. Ann N Y Acad Sci 1165: 228-239.
30. Deli MA, Abrahám CS, Kataoka Y, Niwa M (2005) Permeability studies on in vitro blood-brain barrier models: physiology, pathology, and pharmacology. Cell Mol Neurobiol 25: 59-127. (Pubitemid 40558585)
31. Neuhaus W, Wirth M, Plattner VE, Germann B, Gabor F, et al. (2008) Expression of Claudin-1, Claudin-3 and Claudin-5 in human blood-brain barrier mimicking cell line ECV304 is inducible by glioma-conditioned media. Neurosci Lett 446: 59-64.
32. Schlichtiger J, Pekcec A, Bartmann H, Winter P, Fuest C, et al. (2010) Celecoxib treatment restores pharmacosensitivity in a rat model of pharmacoresistant epilepsy. Br J Pharmacol 160: 1062-1071.
33. Neuhaus W, Mandikova J, Pawlowitsch R, Linz B, Bennani-Baiti B, et al. (2012) Blood-brain barrier in vitro models as tools in drug discovery: assessment of the transport ranking of antihistaminic drugs. Pharmazie 67: 432-439.
34. Pagliarulo V, Ancona P, Niso M, Colabufo NA, Contino M, et al. (2013) The interaction of celecoxib with MDR transporters enhances the activity of mitomycin C in a bladder cancer cell line. Mol Cancer 12: 47.
35. Lagas JS, van der Kruijssen CM, van de Wetering K, Beijnen JH, Schinkel AH (2009) Transport of diclofenac by breast cancer resistance protein (ABCG2) and stimulation of multidrug resistance protein 2 (ABCC2)-mediated drug transport by diclofenac and benzbromarone. Drug Metab Dispos 37: 129-136.
36. Uchida Y, Kamiie J, Ohtsuki S, Terasaki T (2007) Multichannel liquid chromatography-tandem mass spectrometry cocktail method for comprehensive substrate characterization of multidrug resistance-associated protein 4 transporter. Pharm Res 24: 2281-2296. (Pubitemid 350064251)
37. Tian Q, Zhang J, Chan SY, Tan TM, Duan W, et al. (2006) Topotecan is a substrate for multidrug resistance associated protein 4. Curr Drug Metab 7: 105-118.
38. El-Sheikh AA, van den Heuvel JJ, Koenderink JB, Russel FG (2007) Interaction of nonsteroidal anti-inflammatory drugs with multidrug resistance protein (MRP) 2/ABCC2- and MRP4/ABCC4-mediated methotrexate transport. J Pharmacol Exp Ther 320: 229-235. (Pubitemid 46025738)
39. Yazdanian M, Briggs K, Jankovsky C, Hawi A (2004) The "High Solubility" Definitio of the Current FDA Guidance on Biopharmaceutical Classification System May Be Too Strict for Acidic Drugs. Pharm Res 21: 293-299. (Pubitemid 38221975)
40. Hakala KS, Laitinen L, Kaukonen AM, Hirvonen J, Kostiainen R, et al. (2003) Development of LC/MS/MS methods for cocktail dosed Caco-2 samples using atmospheric pressure photoionization and electrosprayionization. Anal Chem 75: 5969-5977. (Pubitemid 37356480)
41. Koljonen M, Hakala KS, Ahtola-Satila T, Laitinen L, Kostiainen R, et al. (2006) Evaluation of cocktail approach to standardise Caco-2 permeability experiments. Eur J Pharm Biopharm 64: 379-387. (Pubitemid 44585212)
42. Smalley J, Kadiyala P, Xin B, Balimane P, Olah T (2006) Development of an on-line extraction turbulent flow chromatography tandem mass spectrometry method for cassette analysis of Caco-2 cell based bi-directional assay samples. J Chromatography B 830: 270-277. (Pubitemid 43075462)
43. Lee G, Piquette-Miller M (2003) Cytokines alter the expression and activity of the multidrug resistance transporters in human hepatoma cell lines; analysis using RT-PCR and cDNA microarrays. J Pharm Sci 92: 2152-2163. (Pubitemid 37356689)
44. Nagle MA, Wu W, Eraly SA, Nigam SK (2013) Organic anion transport pathways in antiviral handling in choroid plexus in Oat1 (Slc22a6) and Oat3 (Slc22a8) deficient tissue. Neurosci Lett 534: 133-138.
45. Baehr C, Reichel V, Fricker G (2006) Choroid plexus epithelial monolayers - a cell culture model from porcine brain. Cerebrospinal Fluid Res 3: 1-14.
46. Nozaki Y, Kusuhara H, Kondo T, Iwaki M, Shiroyanagi Y, et al. (2007) Species difference in the inhibitory effect of nonsteroidal anti-inflammatory drugs on the uptake of methotrexate by human kidney slices. J Pharmacol Exp Ther 322: 1162-1170.
47. Sauer SW, Opp S, Mahringer A, Kamiński MM, Thiel C, et al. (2010) Glutaric aciduria type I and methylmalonic aciduria: simulation of cerebral import and export of accumulating neurotoxic dicarboxylic acids in in vitro models of the blood-brain barrier and the choroid plexus. Biochim Biophys Acta 1802: 552-560.
48. Römermann K, Wanek T, Bankstahl M, Bankstahl JP, Fedrowitz M, et al. (2013) (R)-[11C]verapamil is selectively transported by murine and human P-glycoprotein at the blood-brain barrier, and not by MRP1 and BCRP. Nucl Med Biol S0969-8051(13)00116-9.
49. Angelini A, Iezzi M, Di Febbo C, Di Ilio C, Cuccurullo F, et al. (2008) Reversal of P-glycoprotein-mediated multidrug resistance in human sarcoma MES-SA/Dx-5 cells by nonsteroidal anti-inflammatory drugs. Oncol Rep 20: 731-735.
50. Awara WM, El-Sisi AE, El-Sayad ME, Goda AE (2004) The potential role of cyclooxygenase-2 inhibitors in the treatment of experimentally-induced mammary tumour: does celecoxib enhance the anti-tumour activity of doxorubicin? Pharmacol Res 50: 487-498. (Pubitemid 39349050)
51. Verma N, Rettenmeier AW, Schmitz-Spanke S (2011) Recent advances in the use of Sus scrofa (pig) as a model system for proteomic studies. Proteomics 11: 776-793.