Activation of platelet-derived growth factor receptor alpha contributes to liver fibrosis

PLoS ONE

Volumn 9, Issue 3, 2014, Pages

  Hayes, Brian J ^a   Riehle, Kimberly J ^a,b   Shimizu Albergine, Masami ^a,b   Bauer, Renay L ^a   Hudkins, Kelly L ^a   Johansson, Fredrik ^a   Yeh, Matthew M ^a   Mahoney Jr , William M ^a   Yeung, Raymond S ^a,b   Campbell, Jean S ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON TETRACHLORIDE; GREEN FLUORESCENT PROTEIN; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; RNA; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HETEROZYGOSITY; HISTOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; LIVER CELL CARCINOMA; LIVER FIBROSIS; LIVER INJURY; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; PROTEIN EXPRESSION; STELLATE CELL; UPREGULATION; ALLELE; ANIMAL; CELL LINE; DRUG EFFECTS; GENE DOSAGE; GENE EXPRESSION REGULATION; GENETICS; LIVER; LIVER CIRRHOSIS; LIVER TUMOR; METABOLISM; PATHOLOGY; TOXIC HEPATITIS;

ALLELES; ANIMALS; CARCINOMA, HEPATOCELLULAR; CELL LINE; DRUG-INDUCED LIVER INJURY; GENE DOSAGE; GENE EXPRESSION REGULATION, NEOPLASTIC; HEPATIC STELLATE CELLS; HUMANS; LIVER; LIVER CIRRHOSIS; LIVER NEOPLASMS; MALE; MICE; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR ALPHA; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR BETA; RNA, MESSENGER;

EID: 84899736241     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0092925     Document Type: Article

References (52)

1. Starr SP, Raines D (2011) Cirrhosis: diagnosis, management, and prevention. Am Fam Physician 84: 1353-1359.
2. Bataller R, Brenner DA (2005) Liver fibrosis. J Clin Invest 115: 209-218. (Pubitemid 40385459)
3. Hernandez-Gea V, Friedman SL (2011) Pathogenesis of liver fibrosis. Annu Rev Pathol 6: 425-456.
4. Pierce GF, Tarpley JE, Tseng J, Bready J, Chang D, et al. (1995) Detection of platelet-derived growth factor (PDGF)-AA in actively healing human wounds treated with recombinant PDGF-BB and absence of PDGF in chronic nonhealing wounds. J Clin Invest 96: 1336-1350.
5. Olson LE, Soriano P (2009) Increased PDGFRalpha activation disrupts connective tissue development and drives systemic fibrosis. Dev Cell 16: 303-313.
6. Chong JJ, Reinecke H, Iwata M, Torok-Storb B, Stempien-Otero A, et al. (2013) Progenitor cells identified by PDGFR-alpha expression in the developing and diseased human heart. Stem Cells Dev 22: 1932-1943.
7. Antoniades HN, Bravo MA, Avila RE, Galanopoulos T, Neville-Golden J, et al. (1990) Platelet-derived growth factor in idiopathic pulmonary fibrosis. J Clin Invest 86: 1055-1064. (Pubitemid 20370408)
8. Floege J, Eitner F, Alpers CE (2008) A new look at platelet-derived growth factor in renal disease. J Am Soc Nephrol 19: 12-23.
9. Zymek P, Bujak M, Chatila K, Cieslak A, Thakker G, et al. (2006) The role of platelet-derived growth factor signaling in healing myocardial infarcts. J Am Coll Cardiol 48: 2315-2323. (Pubitemid 44855440)
10. Abdollahi A, Li M, Ping G, Plathow C, Domhan S, et al. (2005) Inhibition of platelet-derived growth factor signaling attenuates pulmonary fibrosis. J Exp Med 201: 925-935. (Pubitemid 40524462)
11. Chen YT, Chang FC, Wu CF, Chou YH, Hsu HL, et al. (2011) Platelet-derived growth factor receptor signaling activates pericyte-myofibroblast transition in obstructive and post-ischemic kidney fibrosis. Kidney Int 80: 1170-1181.
12. Andrae J, Gallini R, Betsholtz C (2008) Role of platelet-derived growth factors in physiology and medicine. Genes Dev 22: 1276-1312. (Pubitemid 351717519)
13. Hoch RV, Soriano P (2003) Roles of PDGF in animal development. Development 130: 4769-4784. (Pubitemid 37321862)
14. Soriano P (1994) Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice. Genes Dev 8: 1888-1896.
15. Soriano P (1997) The PDGF alpha receptor is required for neural crest cell development and for normal patterning of the somites. Development 124: 2691-2700.
16. Mellgren AM, Smith CL, Olsen GS, Eskiocak B, Zhou B, et al. (2008) Platelet-derived growth factor receptor beta signaling is required for efficient epicardial cell migration and development of two distinct coronary vascular smooth muscle cell populations. Circ Res 103: 1393-1401.
17. Olson LE, Soriano P (2011) PDGFR b signaling regulates mural cell plasticity and inhibits fat development. Dev Cell 20: 815-826.
18. Chen H, Gu X, Liu Y, Wang J, Wirt SE, et al. (2011) PDGF signalling controls age-dependent proliferation in pancreatic β-cells. Nature 478: 349-355.
19. Tallquist MD, Soriano P (2003) Cell autonomous requirement for PDGFRalpha in populations of cranial and cardiac neural crest cells. Development 130: 507-518. (Pubitemid 36231270)
20. Hamilton TG, Klinghoffer RA, Corrin PD, Soriano P (2003) Evolutionary divergence of platelet-derived growth factor alpha receptor signaling mechanisms. Mol Cell Biol 23: 4013-4025. (Pubitemid 36597478)
21. Bonner JC (2004) Regulation of PDGF and its receptors in fibrotic diseases. Cytokine Growth Factor Rev 15: 255-273.
22. Iwayama T, Olson LE (2013) Involvement of PDGF in fibrosis and scleroderma: recent insights from animal models and potential therapeutic opportunities. Curr Rheumatol Rep 15: 304.
23. Yeh MM, Larson AM, Campbell JS, Fausto N, Rulyak SJ, et al. (2007) The expression of transforming growth factor-alpha in cirrhosis, dysplastic nodules, and hepatocellular carcinoma: an immunohistochemical study of 70 cases. Am J Surg Pathol 31: 681-689. (Pubitemid 46684206)
24. Campbell JS, Johnson MM, Bauer RL, Hudkins KL, Gilbertson DG, et al. (2007) Targeting stromal cells for the treatment of platelet-derived growth factor C-induced hepatocellular carcinogenesis. Differentiation 75: 843-852. (Pubitemid 350086173)
25. Junqueira LC, Bignolas G, Brentani RR (1979) Picrosirius staining plus polarization microscopy, a specific method for collagen detection in tissue sections. Histochem J 11: 447-455. (Pubitemid 9238595)
26. Campbell JS, Riehle KJ, Brooling JT, Bauer RL, Mitchell C, et al. (2006) Proinflammatory cytokine production in liver regeneration is Myd88-dependent, but independent of Cd14, Tlr2, and Tlr4. J Immunol 176: 2522-2528. (Pubitemid 43201703)
27. Wright JH, Johnson MM, Shimizu-Albergine M, Bauer RL, Hayes BJ, et al. (2013) Paracrine activation of hepatic stellate cells in platelet-derived growth factor C transgenic mice: Evidence for stromal induction of hepatocellular carcinoma. Int J Cancer.
28. Argast GM, Campbell JS, Brooling JT, Fausto N (2004) Epidermal growth factor receptor transactivation mediates tumor necrosis factor-induced hepatocyte replication. J Biol Chem 279: 34530-34536. (Pubitemid 39318081)
29. Thieringer F, Maass T, Czochra P, Klopcic B, Conrad I, et al. (2008) Spontaneous hepatic fibrosis in transgenic mice overexpressing PDGF-A. Gene 423: 23-28.
30. Czochra P, Klopcic B, Meyer E, Herkel J, Garcia-Lazaro JF, et al. (2006) Liver fibrosis induced by hepatic overexpression of PDGF-B in transgenic mice. J Hepatol 45: 419-428. (Pubitemid 44142114)
31. Campbell JS, Hughes SD, Gilbertson DG, Palmer TE, Holdren MS, et al. (2005) Platelet-derived growth factor C induces liver fibrosis, steatosis, and hepatocellular carcinoma. Proc Natl Acad Sci U S A 102: 3389-3394. (Pubitemid 40328055)
32. Ikura Y, Morimoto H, Ogami M, Jomura H, Ikeoka N, et al. (1997) Expression of platelet-derived growth factor and its receptor in livers of patients with chronic liver disease. J Gastroenterol 32: 496-501. (Pubitemid 27367980)
33. Wong L, Yamasaki G, Johnson RJ, Friedman SL (1994) Induction of beta-platelet-derived growth factor receptor in rat hepatic lipocytes during cellular activation in vivo and in culture. J Clin Invest 94: 1563-1569.
34. Pinzani M, Milani S, Herbst H, DeFranco R, Grappone C, et al. (1996) Expression of platelet-derived growth factor and its receptors in normal human liver and during active hepatic fibrogenesis. Am J Pathol 148: 785-800. (Pubitemid 126660671)
35. Tiribelli C, Melato M, Crocè LS, Giarelli L, Okuda K, et al. (1989) Prevalence of hepatocellular carcinoma and relation to cirrhosis: comparison of two different cities of the world-Trieste, Italy, and Chiba, Japan. Hepatology 10: 998-1002. (Pubitemid 20341090)
36. Weber LW, Boll M, Stampfl A (2003) Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model. Crit Rev Toxicol 33: 105-136. (Pubitemid 36432872)
37. Borkham-Kamphorst E, Kovalenko E, van Roeyen CR, Gassler N, Bomble M, et al. (2008) Platelet-derived growth factor isoform expression in carbon tetrachloride-induced chronic liver injury. Lab Invest 88: 1090-1100.
38. Breitkopf K, Roeyen C, Sawitza I, Wickert L, Floege J, et al. (2005) Expression patterns of PDGF-A, -B, -C and -D and the PDGF-receptors alpha and beta in activated rat hepatic stellate cells (HSC). Cytokine 31: 349-357. (Pubitemid 41188056)
39. Johnson S, Rabinovitch P (2012) Ex vivo imaging of excised tissue using vital dyes and confocal microscopy. Curr Protoc Cytom Chapter 9: Unit 9.39.
40. Rockey DC, Boyles JK, Gabbiani G, Friedman SL (1992) Rat hepatic lipocytes express smooth muscle actin upon activation in vivo and in culture. J Submicrosc Cytol Pathol 24: 193-203.
41. Yamaoka K, Nouchi T, Marumo F, Sato C (1993) Alpha-smooth-muscle actin expression in normal and fibrotic human livers. Dig Dis Sci 38: 1473-1479. (Pubitemid 23266628)
42. Heldin CH, Westermark B (1999) Mechanism of action and in vivo role of platelet-derived growth factor. Physiol Rev 79: 1283-1316. (Pubitemid 29473317)
43. Friedman SL, Arthur MJ (1989) Activation of cultured rat hepatic lipocytes by Kupffer cell conditioned medium. Direct enhancement of matrix synthesis and stimulation of cell proliferation via induction of platelet-derived growth factor receptors. J Clin Invest 84: 1780-1785. (Pubitemid 20016181)
44. Krampert M, Heldin CH, Heuchel RL (2008) A gain-of-function mutation in the PDGFR-beta alters the kinetics of injury response in liver and skin. Lab Invest 88: 1204-1214.
45. Crosby JR, Seifert RA, Soriano P, Bowen-Pope DF (1998) Chimaeric analysis reveals role of Pdgf receptors in all muscle lineages. Nat Genet 18: 385-388. (Pubitemid 28158171)
46. McKinnon RD, Waldron S, Kiel ME (2005) PDGF alpha-receptor signal strength controls an RTK rheostat that integrates phosphoinositol 3′-kinase and phospholipase Cgamma pathways during oligodendrocyte maturation. J Neurosci 25: 3499-3508.
47. Bell RD, Winkler EA, Sagare AP, Singh I, LaRue B, et al. (2010) Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging. Neuron 68: 409-427.
48. Andrae J, Ehrencrona H, Gallini R, Lal M, Ding H, et al. (2013) Analysis of mice lacking the heparin-binding splice isoform of PDGF-A. Mol Cell Biol.
49. Schmahl J, Raymond C, Soriano P (2007) PDGF signaling specificity is mediated through multiple immediate early genes. Nat Genet 39: 52-60. (Pubitemid 46026501)
50. Uhlen M, Oksvold P, Fagerberg L, Lundberg E, Jonasson K, et al. (2010) Towards a knowledge-based Human Protein Atlas. Nat Biotechnol 28: 1248-1250.
51. Teo YL, Ho HK, Chan A (2013) Risk of tyrosine kinase inhibitors-induced hepatotoxicity in cancer patients: A meta-analysis. Cancer Treat Rev 39: 199-206.
52. Hasinoff BB, Patel D (2010) The lack of target specificity of small molecule anticancer kinase inhibitors is correlated with their ability to damage myocytes in vitro. Toxicol Appl Pharmacol 249: 132-139.