Paracrine activation of hepatic stellate cells in platelet-derived growth factor C transgenic mice: Evidence for stromal induction of hepatocellular carcinoma

International Journal of Cancer

Volumn 134, Issue 4, 2014, Pages 778-788

  Wright, Jocelyn H ^a   Johnson, Melissa M ^a   Shimizu Albergine, Masami ^a,b   Bauer, Renay L ^a   Hayes, Brian J ^a   Surapisitchat, James ^a,b   Hudkins, Kelly L ^a   Riehle, Kimberly J ^a,b   Johnson, Simon C ^a   Yeh, Matthew M ^a   Bammler, Theodor K ^a   Beyer, Richard P ^b   Gilbertson, Debra G ^c   Alpers, Charles E ^a   Fausto, Nelson ^a   Campbell, Jean S ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c BRISTOL MYERS SQUIBB   (United States)

Author keywords

hepatocellular carcinoma; microenvironment; PDGF; stromal cell

Indexed keywords

EPIDERMAL GROWTH FACTOR; HEPARIN BINDING EPIDERMAL GROWTH FACTOR; INTERLEUKIN 6; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PLATELET DERIVED GROWTH FACTOR C; SCATTER FACTOR; SOMATOMEDIN B; SOMATOMEDIN C; TRANSFORMING GROWTH FACTOR ALPHA; VASCULOTROPIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER STAGING; CELL ACTIVATION; CELL ISOLATION; CELL PROLIFERATION; CELL TRANSFORMATION; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOKINE PRODUCTION; EXTRACELLULAR MATRIX; GENE INDUCTION; HEPATITIS; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; LIVER CARCINOGENESIS; LIVER CELL; LIVER CELL CARCINOMA; LIVER FIBROSIS; LIVER SINUSOID; LUNG CONGESTION; MALE; MOUSE; MYOFIBROBLAST; NONALCOHOLIC FATTY LIVER; NONHUMAN; PARACRINE SIGNALING; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS; STELLATE CELL; TRANSGENIC MOUSE; TUMOR MICROENVIRONMENT; TUMOR VASCULARIZATION;

EID: 84890115892     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.28421     Document Type: Article

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