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Volumn 15, Issue 2, 2013, Pages

Involvement of PDGF in fibrosis and scleroderma: Recent insights from animal models and potential therapeutic opportunities

Author keywords

Animal models; Fibrosis; Imatinib; Mouse model; Neutralizing antibody; PDGF; Pericyte; Scleroderma; Therapeutic

Indexed keywords

BENZAMIDE DERIVATIVE; IMATINIB; PIPERAZINE DERIVATIVE; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN KINASE INHIBITOR; PYRIMIDINE DERIVATIVE;

EID: 84872014405     PISSN: 15233774     EISSN: 15346307     Source Type: Journal    
DOI: 10.1007/s11926-012-0304-0     Document Type: Article
Times cited : (53)

References (57)
  • 1
    • 84655175061 scopus 로고    scopus 로고
    • Understanding fibrosis in systemic sclerosis: Shifting paradigms, emerging opportunities
    • Bhattacharyya S, Wei J, Varga J. Understanding fibrosis in systemic sclerosis: shifting paradigms, emerging opportunities. Nat Rev Rheumatol. 2012;8:42-54.
    • (2012) Nat Rev Rheumatol. , vol.8 , pp. 42-54
    • Bhattacharyya, S.1    Wei, J.2    Varga, J.3
  • 3
    • 33847348491 scopus 로고    scopus 로고
    • Systemic sclerosis: A prototypic multisystem fibrotic disorder
    • DOI 10.1172/JCI31139
    • Varga J, Abraham D. Systemic sclerosis: a prototypic multisystem fibrotic disorder. J Clin Invest. 2007;117:557-67. (Pubitemid 46348510)
    • (2007) Journal of Clinical Investigation , vol.117 , Issue.3 , pp. 557-567
    • Varga, J.1    Abraham, D.2
  • 5
    • 0015359850 scopus 로고
    • Connective tissue synthesis by scleroderma skin fibroblasts in cell culture
    • Leroy EC. Connective tissue synthesis by scleroderma skin fibroblasts in cell culture. J Exp Med. 1972;135:1351-62.
    • (1972) J Exp Med. , vol.135 , pp. 1351-1362
    • Leroy, E.C.1
  • 6
    • 84859073207 scopus 로고    scopus 로고
    • Recent developments in myofibroblast biology: Paradigms for connective tissue remodeling
    • Hinz B, Phan SH, Thannickal VJ, et al. Recent developments in myofibroblast biology: paradigms for connective tissue remodeling. Am J Pathol. 2012;180:1340-55.
    • (2012) Am J Pathol. , vol.180 , pp. 1340-1355
    • Hinz, B.1    Phan, S.H.2    Thannickal, V.J.3
  • 7
    • 0016283728 scopus 로고
    • Platelets as a source of fibroblast growthpromoting activity
    • Kohler N, Lipton A. Platelets as a source of fibroblast growthpromoting activity. Exp Cell Res. 1974;87:297-301.
    • (1974) Exp Cell Res. , vol.87 , pp. 297-301
    • Kohler, N.1    Lipton, A.2
  • 8
    • 1842280753 scopus 로고
    • A platelet-dependent serum factor that stimulates the proliferation of arterial smooth muscle cells in vitro
    • Ross R, Glomset J, Kariya B, Harker L. A platelet-dependent serum factor that stimulates the proliferation of arterial smooth muscle cells in vitro. Proc Natl Acad Sci USA. 1974;71:1207-10.
    • (1974) Proc Natl Acad Sci USA , vol.71 , pp. 1207-1210
    • Ross, R.1    Glomset, J.2    Kariya, B.3    Harker, L.4
  • 9
    • 44149090296 scopus 로고    scopus 로고
    • Role of platelet-derived growth factors in physiology and medicine
    • DOI 10.1101/gad.1653708
    • Andrae J, Gallini R, Betsholtz C. Role of platelet-derived growth factors in physiology and medicine. Genes Dev. 2008;22:1276-312. (Pubitemid 351717519)
    • (2008) Genes and Development , vol.22 , Issue.10 , pp. 1276-1312
    • Andrae, J.1    Gallini, R.2    Betsholtz, C.3
  • 10
    • 84862190770 scopus 로고    scopus 로고
    • B-cell depletion therapy in patients with diffuse systemic sclerosis associates with a significant decrease in PDGFR expression and activation in spindle-like cells in the skin
    • Daoussis D, Tsamandas AC, Liossis SN, et al. B-cell depletion therapy in patients with diffuse systemic sclerosis associates with a significant decrease in PDGFR expression and activation in spindle-like cells in the skin. Arthritis Res Ther. 2012;14:R145.
    • (2012) Arthritis Res Ther. , vol.14
    • Daoussis, D.1    Tsamandas, A.C.2    Liossis, S.N.3
  • 11
    • 0024539072 scopus 로고
    • Immunohistologic demonstration of platelet-derived growth factor (PDGF) and sis-oncogene expression in scleroderma
    • Gay S, Jones Jr RE, Huang GQ, Gay RE. Immunohistologic demonstration of platelet-derived growth factor (PDGF) and sisoncogene expression in scleroderma. J Invest Dermatol. 1989;92:301-3. (Pubitemid 19061278)
    • (1989) Journal of Investigative Dermatology , vol.92 , Issue.2 , pp. 301-303
    • Gay, S.1    Jones Jr., R.E.2    Huang, G.-Q.3    Gay, R.E.4
  • 12
    • 0025014021 scopus 로고
    • Increased expression of platelet-derived growth factor type B receptors in the skin of patients with systemic sclerosis
    • Klareskog L, Gustafsson R, Scheynius A, Hallgren R. Increased expression of platelet-derived growth factor type B receptors in the skin of patients with systemic sclerosis. Arthritis Rheum. 1990;33:1534-41. (Pubitemid 20362097)
    • (1990) Arthritis and Rheumatism , vol.33 , Issue.10 , pp. 1534-1541
    • Klareskog, L.1    Gustafsson, R.2    Scheynius, A.3    Hallgren, R.4
  • 13
    • 0032929924 scopus 로고    scopus 로고
    • Activation of microvascular pericytes in autoimmune Raynaud's phenomenon and systemic sclerosis
    • DOI 10.1002/1529-0131(199905)42:5<930::AID-ANR11>3.0.CO;2-1
    • Rajkumar VS, Sundberg C, Abraham DJ, et al. Activation of microvascular pericytes in autoimmune Raynaud's phenomenon and systemic sclerosis. Arthritis Rheum. 1999;42:930-41. (Pubitemid 29215003)
    • (1999) Arthritis and Rheumatism , vol.42 , Issue.5 , pp. 930-941
    • Rajkumar, V.S.1    Sundberg, C.2    Abraham, D.J.3    Rubin, K.4    Black, C.M.5
  • 15
    • 0028973641 scopus 로고
    • Elevated levels of platelet derived growth factor and transforming growth factor-beta 1 in bronchoalveolar lavage fluid from patients with scleroderma
    • Ludwicka A, Ohba T, Trojanowska M, et al. Elevated levels of platelet derived growth factor and transforming growth factor-beta 1 in bronchoalveolar lavage fluid from patients with scleroderma. J Rheumatol. 1995;22:1876-83.
    • (1995) J Rheumatol. , vol.22 , pp. 1876-1883
    • Ludwicka, A.1    Ohba, T.2    Trojanowska, M.3
  • 17
    • 59649093844 scopus 로고    scopus 로고
    • Increased PDGFRalpha activation disrupts connective tissue development and drives systemic fibrosis
    • Olson LE, Soriano P. Increased PDGFRalpha activation disrupts connective tissue development and drives systemic fibrosis. Dev Cell. 2009;16:303-13.
    • (2009) Dev Cell. , vol.16 , pp. 303-313
    • Olson, L.E.1    Soriano, P.2
  • 19
    • 0032875460 scopus 로고    scopus 로고
    • Mechanism of action and in vivo role of platelet-derived growth factor
    • Heldin CH, Westermark B. Mechanism of action and in vivo role of platelet-derived growth factor. Physiol Rev. 1999;79:1283-316. (Pubitemid 29473317)
    • (1999) Physiological Reviews , vol.79 , Issue.4 , pp. 1283-1316
    • Heldin, C.-H.1    Westermark, B.2
  • 20
    • 2942682928 scopus 로고    scopus 로고
    • Regulation of PDGF and its receptors in fibrotic diseases
    • DOI 10.1016/j.cytogfr.2004.03.006, PII S1359610104000164
    • Bonner JC. Regulation of PDGF and its receptors in fibrotic diseases. Cytokine Growth Factor Rev. 2004;15:255-73. (Pubitemid 38781050)
    • (2004) Cytokine and Growth Factor Reviews , vol.15 , Issue.4 , pp. 255-273
    • Bonner, J.C.1
  • 21
    • 33745277147 scopus 로고    scopus 로고
    • Stimulatory autoantibodies to the PDGF receptor in systemic sclerosis
    • Baroni SS, Santillo M, Bevilacqua F, et al. Stimulatory autoantibodies to the PDGF receptor in systemic sclerosis. N Engl J Med. 2006;354:2667-76.
    • (2006) N Engl J Med. , vol.354 , pp. 2667-2676
    • Baroni, S.S.1    Santillo, M.2    Bevilacqua, F.3
  • 22
    • 65249139405 scopus 로고    scopus 로고
    • Lack of evidence of stimulatory autoantibodies to platelet-derived growth factor receptor in patients with systemic sclerosis
    • Classen JF, Henrohn D, Rorsman F, et al. Lack of evidence of stimulatory autoantibodies to platelet-derived growth factor receptor in patients with systemic sclerosis. Arthritis Rheum. 2009;60:1137-44.
    • (2009) Arthritis Rheum. , vol.60 , pp. 1137-1144
    • Classen, J.F.1    Henrohn, D.2    Rorsman, F.3
  • 23
    • 65249190778 scopus 로고    scopus 로고
    • Lack of detection of agonist activity by antibodies to platelet-derived growth factor receptor alpha in a subset of normal and systemic sclerosis patient sera
    • Loizos N, Lariccia L, Weiner J, et al. Lack of detection of agonist activity by antibodies to platelet-derived growth factor receptor alpha in a subset of normal and systemic sclerosis patient sera. Arthritis Rheum. 2009;60:1145-51.
    • (2009) Arthritis Rheum. , vol.60 , pp. 1145-1151
    • Loizos, N.1    Lariccia, L.2    Weiner, J.3
  • 24
    • 0142243109 scopus 로고    scopus 로고
    • Roles of PDGF in animal development
    • DOI 10.1242/dev.00721
    • Hoch RV, Soriano P. Roles of PDGF in animal development. Development. 2003;130:4769-84. (Pubitemid 37321862)
    • (2003) Development , vol.130 , Issue.20 , pp. 4769-4784
    • Hoch, R.V.1    Soriano, P.2
  • 25
    • 0032774661 scopus 로고    scopus 로고
    • Roles for PDGF-A and sonic hedgehog in development of mesenchymal components of the hair follicle
    • Karlsson L, Bondjers C, Betsholtz C. Roles for PDGF-A and sonic hedgehog in development of mesenchymal components of the hair follicle. Development. 1999;126:2611-21. (Pubitemid 29338623)
    • (1999) Development , vol.126 , Issue.12 , pp. 2611-2621
    • Karlsson, L.1    Bondjers, C.2    Betsholtz, C.3
  • 27
    • 0030808324 scopus 로고    scopus 로고
    • The PDGFα receptor is required for neural crest cell development and for normal patterning of the somites
    • Soriano P. The PDGF alpha receptor is required for neural crest cell development and for normal patterning of the somites. Development. 1997;124:2691-700. (Pubitemid 27354815)
    • (1997) Development , vol.124 , Issue.14 , pp. 2691-2700
    • Soriano, P.1
  • 29
    • 0033832891 scopus 로고    scopus 로고
    • Abnormal gastrointestinal development in PDGF-A and PDGFR-(alpha) deficient mice implicates a novel mesenchymal structure with putative instructive properties in villus morphogenesis
    • Karlsson L, Lindahl P, Heath JK, Betsholtz C. Abnormal gastrointestinal development in PDGF-A and PDGFR-(alpha) deficient mice implicates a novel mesenchymal structure with putative instructive properties in villus morphogenesis. Development. 2000;127:3457-66.
    • (2000) Development. , vol.127 , pp. 3457-3466
    • Karlsson, L.1    Lindahl, P.2    Heath, J.K.3    Betsholtz, C.4
  • 30
    • 0030756325 scopus 로고    scopus 로고
    • Pericyte loss and microaneurysm formation in PDGF-B-deficient mice
    • DOI 10.1126/science.277.5323.242
    • Lindahl P, Johansson BR, Leveen P, Betsholtz C. Pericyte loss and microaneurysm formation in PDGF-B-deficient mice. Science. 1997;277:242-5. (Pubitemid 27446080)
    • (1997) Science , vol.277 , Issue.5323 , pp. 242-245
    • Lindahl, P.1    Johansson, B.R.2    Leveen, P.3    Betsholtz, C.4
  • 31
    • 79958799319 scopus 로고    scopus 로고
    • Epicardial-derived cell epithelial-to-mesenchymal transition and fate specification require PDGF receptor signaling
    • Smith CL, Baek ST, Sung CY, Tallquist MD. Epicardial-derived cell epithelial-to-mesenchymal transition and fate specification require PDGF receptor signaling. Circ Res. 2011;108:e15-26.
    • (2011) Circ Res. , vol.108
    • Smith, C.L.1    Baek, S.T.2    Sung, C.Y.3    Tallquist, M.D.4
  • 32
    • 0032768156 scopus 로고    scopus 로고
    • Role of PDGF-B and PDGFR-β in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse
    • Hellstrom M, Kalen M, Lindahl P, et al. Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse. Development. 1999;126:3047-55. (Pubitemid 29378170)
    • (1999) Development , vol.126 , Issue.14 , pp. 3047-3055
    • Hellstrom, M.1    Kalen, M.2    Lindahl, P.3    Abramsson, A.4    Betsholtz, C.5
  • 33
    • 84859465056 scopus 로고    scopus 로고
    • In vivo identification of bipotential adipocyte progenitors recruited by beta3- adrenoceptor activation and high-fat feeding
    • Lee YH, Petkova AP, Mottillo EP, Granneman JG. In vivo identification of bipotential adipocyte progenitors recruited by beta3- adrenoceptor activation and high-fat feeding. Cell Metab. 2012;15:480-91.
    • (2012) Cell Metab. , vol.15 , pp. 480-491
    • Lee, Y.H.1    Petkova, A.P.2    Mottillo, E.P.3    Granneman, J.G.4
  • 34
    • 53549130485 scopus 로고    scopus 로고
    • White fat progenitor cells reside in the adipose vasculature
    • Tang W, Zeve D, Suh JM, et al. White fat progenitor cells reside in the adipose vasculature. Science. 2008;322:583-6.
    • (2008) Science , vol.322 , pp. 583-586
    • Tang, W.1    Zeve, D.2    Suh, J.M.3
  • 35
    • 75949096894 scopus 로고    scopus 로고
    • Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis
    • Joe AW, Yi L, Natarajan A, et al. Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis. Nat Cell Biol. 2010;12:153-63.
    • (2010) Nat Cell Biol. , vol.12 , pp. 153-163
    • Joe, A.W.1    Yi, L.2    Natarajan, A.3
  • 36
    • 75949130333 scopus 로고    scopus 로고
    • Mesenchymal progenitors distinct from satellite cells contribute to ectopic fat cell formation in skeletal muscle
    • Uezumi A, Fukada S, Yamamoto N, et al. Mesenchymal progenitors distinct from satellite cells contribute to ectopic fat cell formation in skeletal muscle. Nat Cell Biol. 2010;12:143-52.
    • (2010) Nat Cell Biol. , vol.12 , pp. 143-152
    • Uezumi, A.1    Fukada, S.2    Yamamoto, N.3
  • 37
    • 84864722077 scopus 로고    scopus 로고
    • Lineage tracing and genetic ablation of ADAM12(+) perivascular cells identify a major source of profibrotic cells during acute tissue injury
    • Dulauroy S, Di Carlo SE, Langa F, et al. Lineage tracing and genetic ablation of ADAM12(+) perivascular cells identify a major source of profibrotic cells during acute tissue injury. Nat Med. 2012;18:1262-70.
    • (2012) Nat Med. , vol.18 , pp. 1262-1270
    • Dulauroy, S.1    Di Carlo, S.E.2    Langa, F.3
  • 38
    • 77951732927 scopus 로고    scopus 로고
    • Decreased lymphatic vessel counts in patients with systemic sclerosis: Association with fingertip ulcers
    • Akhmetshina A, Beer J, Zwerina K, et al. Decreased lymphatic vessel counts in patients with systemic sclerosis: association with fingertip ulcers. Arthritis Rheum. 2010;62:1513-22.
    • (2010) Arthritis Rheum. , vol.62 , pp. 1513-1522
    • Akhmetshina, A.1    Beer, J.2    Zwerina, K.3
  • 39
    • 84862491030 scopus 로고    scopus 로고
    • Aberrant mural cell recruitment to lymphatic vessels and impaired lymphatic drainage in a murine model of pulmonary fibrosis
    • Meinecke AK, Nagy N, Lago GD, et al. Aberrant mural cell recruitment to lymphatic vessels and impaired lymphatic drainage in a murine model of pulmonary fibrosis. Blood. 2012;119:5931-42.
    • (2012) Blood. , vol.119 , pp. 5931-5942
    • Meinecke, A.K.1    Nagy, N.2    Lago, G.D.3
  • 40
    • 84863632660 scopus 로고    scopus 로고
    • Follicular dendritic cells emerge from ubiquitous perivascular precursors
    • Krautler NJ, Kana V, Kranich J, et al. Follicular dendritic cells emerge from ubiquitous perivascular precursors. Cell. 2012;150:194-206.
    • (2012) Cell. , vol.150 , pp. 194-206
    • Krautler, N.J.1    Kana, V.2    Kranich, J.3
  • 41
    • 0042845995 scopus 로고    scopus 로고
    • Transgenic overexpression of platelet-derived growth factor-C in the mouse heart induces cardiac fibrosis, hypertrophy, and dilated cardiomyopathy
    • Ponten A, Li X, Thoren P, et al. Transgenic overexpression of platelet-derived growth factor-C in the mouse heart induces cardiac fibrosis, hypertrophy, and dilated cardiomyopathy. Am J Pathol. 2003;163:673-82. (Pubitemid 36909428)
    • (2003) American Journal of Pathology , vol.163 , Issue.2 , pp. 673-682
    • Ponten, A.1    Li, X.2    Thoren, P.3    Aase, K.4    Sjoblom, T.5    Ostman, A.6    Eriksson, U.7
  • 42
    • 27944503433 scopus 로고    scopus 로고
    • Platelet-derived growth factor D induces cardiac fibrosis and proliferation of vascular smooth muscle cells in heart-specific transgenic mice
    • DOI 10.1161/01.RES.0000190590.31545.d4
    • Ponten A, Folestad EB, Pietras K, Eriksson U. Platelet-derived growth factor D induces cardiac fibrosis and proliferation of vascular smooth muscle cells in heart-specific transgenic mice. Circ Res. 2005;97:1036-45. (Pubitemid 41668917)
    • (2005) Circulation Research , vol.97 , Issue.10 , pp. 1036-1045
    • Ponten, A.1    Folestad, E.B.2    Pietras, K.3    Eriksson, U.4
  • 44
    • 79958239247 scopus 로고    scopus 로고
    • PDGFRbeta signaling regulates mural cell plasticity and inhibits fat development
    • Olson LE, Soriano P. PDGFRbeta Signaling Regulates Mural Cell Plasticity and Inhibits Fat Development. Dev Cell. 2011;20:815-26.
    • (2011) Dev Cell. , vol.20 , pp. 815-826
    • Olson, L.E.1    Soriano, P.2
  • 45
    • 1642297200 scopus 로고    scopus 로고
    • Myocardin and ternary complex factors compete for SRF to control smooth muscle gene expression
    • DOI 10.1038/nature02382
    • Wang Z, Wang DZ, Hockemeyer D, et al. Myocardin and ternary complex factors compete for SRF to control smooth muscle gene expression. Nature. 2004;428:185-9. (Pubitemid 38374315)
    • (2004) Nature , vol.428 , Issue.6979 , pp. 185-189
    • Wang, Z.1    Wang, D.-Z.2    Hockemeyer, D.3    McAnally, J.4    Nordheim, A.5    Olson, E.N.6
  • 47
    • 0036007120 scopus 로고    scopus 로고
    • An allelic series at the PDGFαR locus indicates unequal contributions of distinct signaling pathways during development
    • DOI 10.1016/S1534-5807(01)00103-4
    • Klinghoffer RA, Hamilton TG, Hoch R, Soriano P. An allelic series at the PDGFalphaR locus indicates unequal contributions of distinct signaling pathways during development. Dev Cell. 2002;2:103-13. (Pubitemid 34065910)
    • (2002) Developmental Cell , vol.2 , Issue.1 , pp. 103-113
    • Klinghoffer, R.A.1    Hamilton, T.G.2    Hoch, R.3    Soriano, P.4
  • 48
    • 2342419356 scopus 로고    scopus 로고
    • Additive effects of PDGF receptor beta signaling pathways in vascular smooth muscle cell development
    • Tallquist MD, French WJ, Soriano P. Additive effects of PDGF receptor beta signaling pathways in vascular smooth muscle cell development. PLoS Biol. 2003;1:E52.
    • (2003) PLoS Biol. , vol.1
    • Tallquist, M.D.1    French, W.J.2    Soriano, P.3
  • 50
    • 58249120518 scopus 로고    scopus 로고
    • Treatment with imatinib prevents fibrosis in different preclinical models of systemic sclerosis and induces regression of established fibrosis
    • Akhmetshina A, Venalis P, Dees C, et al. Treatment with imatinib prevents fibrosis in different preclinical models of systemic sclerosis and induces regression of established fibrosis. Arthritis Rheum. 2009;60:219-24.
    • (2009) Arthritis Rheum. , vol.60 , pp. 219-224
    • Akhmetshina, A.1    Venalis, P.2    Dees, C.3
  • 51
    • 80155204477 scopus 로고    scopus 로고
    • A one-year, phase I/IIa, open-label pilot trial of imatinib mesylate in the treatment of systemic sclerosis-associated active interstitial lung disease
    • Khanna D, Saggar R, Mayes MD, et al. A one-year, phase I/IIa, open-label pilot trial of imatinib mesylate in the treatment of systemic sclerosis-associated active interstitial lung disease. Arthritis Rheum. 2011;63:3540-6.
    • (2011) Arthritis Rheum. , vol.63 , pp. 3540-3546
    • Khanna, D.1    Saggar, R.2    Mayes, M.D.3
  • 52
    • 80155206225 scopus 로고    scopus 로고
    • Imatinib in active diffuse cutaneous systemic sclerosis: Results of a six-month, randomized, double-blind, placebo-controlled, proof-of-concept pilot study at a single center
    • Pope J, McBain D, Petrlich L, et al. Imatinib in active diffuse cutaneous systemic sclerosis: results of a six-month, randomized, double-blind, placebo-controlled, proof-of-concept pilot study at a single center. Arthritis Rheum. 2011;63:3547-51.
    • (2011) Arthritis Rheum. , vol.63 , pp. 3547-3551
    • Pope, J.1    McBain, D.2    Petrlich, L.3
  • 53
    • 79955860261 scopus 로고    scopus 로고
    • Imatinib mesylate (Gleevec) in the treatment of diffuse cutaneous systemic sclerosis: Results of a 1-year, phase IIa, single-arm, open-label clinical trial
    • Spiera RF, Gordon JK, Mersten JN, et al. Imatinib mesylate (Gleevec) in the treatment of diffuse cutaneous systemic sclerosis: results of a 1-year, phase IIa, single-arm, open-label clinical trial. Ann Rheum Dis. 2011;70:1003-9.
    • (2011) Ann Rheum Dis. , vol.70 , pp. 1003-1009
    • Spiera, R.F.1    Gordon, J.K.2    Mersten, J.N.3
  • 54
    • 84861824342 scopus 로고    scopus 로고
    • Sunitinib inhibits the phosphorylation of platelet-derived growth factor receptor beta in the skin of mice with scleroderma-like features and prevents the development of the disease
    • Kavian N, Servettaz A, Marut W, et al. Sunitinib inhibits the phosphorylation of platelet-derived growth factor receptor beta in the skin of mice with scleroderma-like features and prevents the development of the disease. Arthritis Rheum. 2012;64:1990-2000.
    • (2012) Arthritis Rheum. , vol.64 , pp. 1990-2000
    • Kavian, N.1    Servettaz, A.2    Marut, W.3
  • 55
    • 74949085470 scopus 로고    scopus 로고
    • Cardiac mast cells cause atrial fibrillation through PDGF-A-mediated fibrosis in pressure-overloaded mouse hearts
    • Liao CH, Akazawa H, Tamagawa M, et al. Cardiac mast cells cause atrial fibrillation through PDGF-A-mediated fibrosis in pressure-overloaded mouse hearts. J Clin Invest. 2010;120:242-53.
    • (2010) J Clin Invest. , vol.120 , pp. 242-253
    • Liao, C.H.1    Akazawa, H.2    Tamagawa, M.3


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