Toll-like receptor 2 promotes invasion by SGC-7901 human gastric carcinoma cells and is associated with gastric carcinoma metastasis

Annals of Clinical and Laboratory Science

Volumn 44, Issue 2, 2014, Pages 158-166

  Yang, Huan ^a   Wang, Bo ^a   Yan, Jie ^a   Wang, Tao ^a   Zhou, Xiao Ni ^a   Wen, Hui Yan ^a   Zhu, Xue Ming ^a  

^a THE SECOND AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

Author keywords

Gastric carcinoma; Invasion; Metastasis; SGC 7901 cells; Toll like receptor 2

Indexed keywords

GELATINASE B; INTERLEUKIN 6; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 10; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 5; TOLL LIKE RECEPTOR 6; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; TOLL LIKE RECEPTOR 9; VASCULOTROPIN C; LIPOPEPTIDE; MESSENGER RNA; PAM(3)CSK(4) PEPTIDE; TLR2 PROTEIN, HUMAN;

ADULT; AGE; ARTICLE; CANCER MORTALITY; CARCINOMA CELL; CELL DIFFERENTIATION; CLINICAL ARTICLE; CONTROLLED STUDY; DISTANT METASTASIS; FEMALE; FLOW CYTOMETRY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LYMPH NODE METASTASIS; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH CARCINOMA; TISSUE DISTRIBUTION; TUMOR INVASION; TUMOR LOCALIZATION; UPREGULATION; AGED; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MIDDLE AGED; PATHOLOGY; STOMACH TUMOR; TUMOR CELL LINE; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; CELL LINE, TUMOR; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; LIPOPEPTIDES; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS; RNA, MESSENGER; STOMACH NEOPLASMS; TOLL-LIKE RECEPTOR 2; UP-REGULATION;

EID: 84899731204     PISSN: 00917370     EISSN: 15508080     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Medzhitov R, Preston-Hurlburt P, Janeway CA. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 1997;388: 394-397.
2. Goto Y, Arigami T, Kitago M, Nguyen SL, Narita N, Ferrone S, Morton DL, Irie RF, Hoon DS. Activation of Toll-like receptors 2, 3, and 4 on human melanoma cells induces inflammatory factors. Mol Cancer Ther 2008;7:3642-3653.
3. Lee JW, Choi JJ, Seo ES, Kim MJ, Kim WY, Choi CH, Kim TJ, Kim BG, Song SY, Bae DS. Increased toll-like receptor 9 expression in cervical neoplasia. Mol Carcinog 2007;46:941-947.
4. Väisänen MR, Väisänen T, Jukkola-Vuorinen A, Vuopala KS Desmond R, Selander KS, Vaarala MH. Expression of tolllike receptor-9 is increased in poorly differentiated prostate tumors. Prostate 2010;70:817-824.
5. Cherfils-Vicini J, Platonova S, Gillard M, Laurans L, Validire P, Caliandro R, Magdeleinat P, Mami-Chouaib F, Dieu-Nosjean MC, Fridman WH, Damotte D, Sautès-Fridman C Cremer I. Triggering of TLR7 and TLR8 expressed by human lung cancer cells induces cell survival and chemoresistance. J Clin Invest 2010;120:1285-1297.
6. Kelly MG, Alvero AB, Chen R, Silasi DA, Abrahams VM Chan S, Visintin I, Rutherford T, Mor G. TLR-4 Signaling Promotes Tumor Growth and Paclitaxel Chemoresistance in Ovarian Cancer. Cancer Res 2006;66: 3859-3868.
7. Huang B, Zhao J, Li H, He KL, Chen Y, Chen SH, Mayer L Unkeless JC, Xiong H. Toll-like receptors on tumor cells facilitate evasion of immune surveillance. Cancer Res 2005;65:5009-5014.
8. Hua D, Liu MY, Cheng ZD, Qin XJ, Zhang HM, Chen Y, Qin GJ, Liang G, Li JN, Han XF, Liu DX. Small interfering RNAdirected targeting of Toll-like receptor 4 inhibits human prostate cancer cell invasion, survival, and tumorigenicity. Mol Immunol 2009;46:2876-2884.
9. Killeen SD, Wang JH, Andrews EJ, Redmond HP. Bacterial endotoxin enhances colorectal cancer cell adhesion and invasion through TLR-4 and NF-kappaB-dependent activation of the urokinase plasminogen activator system. Br J Cancer 2009;100: 1589-1602.
10. Sun Q, Liu Q, Zheng Y, Cao X. Rapamycin suppresses TLR4-triggered IL-6 and PGE(2) production of colon cancer cells by inhibiting TLR4 expression and NF-kappaB activation. Mol Immunol 2008;45: 2929-2936.
11. Schmausser B, Andrulis M, Endrich S, Muller-Hermelink HK Eck M. Toll-like receptors TLR4, TLR5, TLR9 on gastric carcinoma cells: an implication for interaction with Helicobacter pylori. Int J Med Microbiol 2005;295:179-185.
12. Ohara T, Morishita T, Suzuki H. Heterozygous Thr 135 Ala polymorphism at leucine-rich repeat (LRR) in genomic DNA of toll-like receptor 4 in patients with poorly-differentiated gastric adenocarcinomas. Int J Mol Med 2006 ;18: 59-63.
13. Chang YJ. Wu MS. Lin JT. Chen CC. Helicobacter pylori-induced invasion and angiogenesis of gastric cells is mediated by cyclooxygenase-2 induction through TLR2/TLR9 and promoter regulation. J Immunol 2005;175: 8242-8252.
14. Smith MF, Mitchell A, Li G, Ding S, Fitzmaurice AM, Ryan K, Crowe S, Goldberg JB. Toll-like receptor (TLR)2 and TLR5 but not TLR4, are eequired for Helicobacter pylori-induced NF-κB activation and chemokine expression by epithelial cells. J Biol Chem 2003;278: 32552-32560.
15. Pimentel-Nunes P, Afonso L, Lopes P, Roncon-Albuquerque R, Gonçalves N, Henrique R, Moreira-Dias L, Leite-Moreira AF, Dinis-Ribeiro M. Increased expression of Toll-like Receptors (TLR) 2, 4 and 5 in gastric dysplasia. Pathol Oncol Res 2011;17: 677-683.
16. Rydberg C, Månsson A, Uddman R. Toll-like receptor agonists induce inflammation and cell death in a model of head and neck squamous cell carcinomas. Immunology 2009;128: e600-611.
17. Huang B, Zhao J, Shen S, Li H, He KL, Shen GX, Mayer L Unkeless J, Li D, Yuan Y, Zhang GM, Xiong H, Feng ZH. Listeria monocytogenes promotes tumor growth via tumor cell Toll-like receptor 2 signaling. Cancer Res 2007 ;67:4346-4352.
18. Xie W, Wang Y, Huang Y, Yang H. Wang J. Hu Z. Toll-like receptor 2 mediates invasion via activating NF-kappaB in MDA-MB-231 breast cancer cells. Biochem Biophys Res Commun 2009;379: 1027-1032.
19. Lival KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001;25:402-408.
20. Tye H, Kennedy CL, Najdovska M, McLeod L, McCormack W, Hughes N, Dev A, Sievert W, Ooi CH, Ishikawa TO Oshima H, Bhathal PS, Parker AE, Oshima M, Tan P, Jenkins BJ. STAT3-driven upregulation of TLR2 promotes gastric tumorigenesis independent of tumor inflammation. Cancer Cell 2012; 22: 466-478.
21. De Luca K, Frances-Duvert V, Asensio MJ, Ihsani R, Debien E, Taillardet M, Verhoeyen E, Bella C, Lantheaume S Genestier L, Defrance T. The TLR1/2 agonist Pam3CSK4 instructs commitment of human hematopoietic stem cells to a myeloid cell fate. Leukemia 2009; 23: 2063-2074.
22. Huynh AS, Chung WJ, Cho HI, Moberg VE, Celis E, Morse DL, Vagner J. Novel Toll-like Receptor 2 Ligands for Targeted Pancreatic Cancer Imaging and Immunotherapy. J Med Chem 2012;55:9751-9762.
23. Beaulieu LM, Lin E, Morin KM, Tanriverdi K, Freedman JE. Regulatory effects of TLR2 on megakaryocytic cell function. Blood 2011; 117: 5963-5974.
24. Lu C, Liu L, Chen Y, Ha T, Kelley J, Schweitzer J, Kalbfleisch JH, Kao RL, Williams DL, Li C. TLR2 ligand induces protection against cerebral ischemia/reperfusion injury via activation of phosphoinositide 3-kinase/Akt signaling. J Immunol 2011;187: 1458-1466.
25. Park BK, Zhang H, Zeng Q, Dai J, Keller ET, Giordano T, Gu K, Shah V, Pei L, Zarbo RJ, McCauley L, Shi S, Chen S, Wang CY. NF-κB in breast cancer cells promotes osteolytic bone metastasis by inducing osteoclastogenesis via GM-CSF. Nat Med 2007;13:62-69.
26. Karin M, Cao Y, Greten FR, Li ZW. NF-κB in cancer: from innocent bystander to major culprit, Nat Rev Cancer 2002;2:301-310.
27. Kim SH, Cho NH, Kim K, Lee JS, Koo BS, Kim JH, Chang JH, Choi EC. Correlations of oral tongue cancer invasion with matrix metalloproteinases (MMPs) and vascular endothelial growth factor (VEGF) expression. J Surg Oncol 2006; 93:330-337.