Soluble CEACAM8 interacts with CEACAM1 inhibiting TLR2-triggered immune responses

PLoS ONE

Volumn 9, Issue 4, 2014, Pages

  Singer, Bernhard B ^a   Opp, Lena ^b   Heinrich, Annina ^b   Schreiber, Frauke ^b   Binding Liermann, Ramona ^b   Berrocal Almanza, Luis Carlos ^b   Heyl, Kerstin A ^c   Müller, Mario M ^c   Weimann, Andreas ^b   Zweigner, Janine ^b   Slevogt, Hortense ^c  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c JENA UNIVERSITY HOSPITAL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL DNA; CARCINOEMBRYONIC ANTIGEN RELATED CELL ADHESION MOLECULE 1; CARCINOEMBRYONIC ANTIGEN RELATED CELL ADHESION MOLECULE 8; MEMBRANE PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN TYROSINE PHOSPHATASE SHP 1; TOLL LIKE RECEPTOR 2; TYROSINE; UNCLASSIFIED DRUG; CD66 ANTIGENS; CEACAM8 PROTEIN, HUMAN; CELL ADHESION MOLECULE; CYTOCHALASIN D; GLYCOSYLPHOSPHATIDYLINOSITOL ANCHORED PROTEIN; LEUKOCYTE ANTIGEN; PROTEIN BINDING; TLR2 PROTEIN, HUMAN; TOLL LIKE RECEPTOR 9;

ARTICLE; BRONCHIAL LAVAGE FLUID GRANULOCYTE; CELL COUNT; CONTROLLED STUDY; GRANULOCYTE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; LUNG ALVEOLUS EPITHELIUM; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; RESPIRATORY EPITHELIUM; SIGNAL TRANSDUCTION; ANIMAL; BRONCHUS; CELL LINE; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; EPITHELIUM CELL; IMMUNOLOGY; LUNG LAVAGE; METABOLISM; RAT; SOLUBILITY;

ANIMALS; ANTIGENS, CD; BRONCHI; BRONCHOALVEOLAR LAVAGE FLUID; CELL ADHESION MOLECULES; CELL COUNT; CELL LINE; CYTOCHALASIN D; EPITHELIAL CELLS; GPI-LINKED PROTEINS; GRANULOCYTES; HUMANS; PROTEIN BINDING; RATS; SIGNAL TRANSDUCTION; SOLUBILITY; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 9;

EID: 84899715513     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0094106     Document Type: Article

References (30)

1. Craig A, Mai J, Cai S, Jeyaseelan S (2009) Neutrophil recruitment to the lungs during bacterial pneumonia. Infect Immun 77: 568-575.
2. Parker D, Prince A (2011) Innate immunity in the respiratory epithelium. Am J Respir Cell Mol Biol 45: 189-201.
3. Mantovani A, Cassatella MA, Costantini C, Jaillon S (2011) Neutrophils in the activation and regulation of innate and adaptive immunity. Nat Rev Immunol 11: 519-531.
4. Schmidt T, Zundorf J, Gruger T, Brandenburg K, Reiners AL, et al. (2012) CD66b overexpression and homotypic aggregation of human peripheral blood neutrophils after activation by a gram-positive stimulus. J Leukoc Biol 91: 791-802.
5. Singer BB, Scheffrahn I, Heymann R, Sigmundsson K, Kammerer R, et al. (2002) Carcinoembryonic antigen-related cell adhesion molecule 1 expression and signaling in human, mouse, and rat leukocytes: evidence for replacement of the short cytoplasmic domain isoform by glycosylphosphatidylinositol-linked proteins in human leukocytes. J Immunol 168: 5139-5146. (Pubitemid 34495979)
6. Singer BB, Scheffrahn I, Kammerer R, Suttorp N, Ergun S, et al. (2010) Deregulation of the CEACAM expression pattern causes undifferentiated cell growth in human lung adenocarcinoma cells. PLoS One 5: e8747.
7. Gray-Owen SD, Blumberg RS (2006) CEACAM1: contact-dependent control of immunity. Nat Rev Immunol 6: 433-446.
8. Jog NR, Rane MJ, Lominadze G, Luerman GC, Ward RA, et al. (2007) The actin cytoskeleton regulates exocytosis of all neutrophil granule subsets. American Journal of Physiology-Cell Physiology 292: C1690-C1700. (Pubitemid 47080571)
9. Kuroki M, Matsuo Y, Kinugasa T, Matsuoka Y (1992) Augmented expression and release of nonspecific cross-reacting antigens (NCAs), members of the CEA family, by human neutrophils during cell activation. J Leukoc Biol 52: 551-557.
10. Kuroki M, Yamanaka T, Matsuo Y, Oikawa S, Nakazato H, et al. (1995) Immunochemical analysis of carcinoembryonic antigen (CEA)-related antigens differentially localized in intracellular granules of human neutrophils. Immunol Invest 24: 829-843.
11. Yoon J, Terada A, Kita H (2007) CD66b Regulates Adhesion and Activation of Human Eosinophils. The Journal of Immunology 179: 8454-8462.
12. Jiang L, Barclay AN (2010) Identification of leucocyte surface protein interactions by high-throughput screening with multivalent reagents. Immunology 129: 55-61.
13. Schaar V, de Vries SP, Perez Vidakovics ML, Bootsma HJ, Larsson L, et al. (2011) Multicomponent Moraxella catarrhalis outer membrane vesicles induce an inflammatory response and are internalized by human epithelial cells. Cell Microbiol 13: 432-449.
14. Slevogt H, Seybold J, Tiwari KN, Hocke AC, Jonatat C, et al. (2007) Moraxella catarrhalis is internalized in respiratory epithelial cells by a trigger-like mechanism and initiates a TLR2-and partly NOD1-dependent inflammatory immune response. Cellular microbiology 9: 694-707. (Pubitemid 46231975)
15. Slevogt H, Zabel S, Opitz B, Hocke A, Eitel J, et al. (2008) CEACAM1 inhibits Toll-like receptor 2-triggered antibacterial responses of human pulmonary epithelial cells. Nature immunology 9: 1270-1278.
16. Hartl D, Krauss-Etschmann S, Koller B, Hordijk PL, Kuijpers TW, et al. (2008) Infiltrated neutrophils acquire novel chemokine receptor expression and chemokine responsiveness in chronic inflammatory lung diseases. J Immunol 181: 8053-8067.
17. Meyer KC, Raghu G, Baughman RP, Brown KK, Costabel U, et al. (2012) An official American Thoracic Society clinical practice guideline: the clinical utility of bronchoalveolar lavage cellular analysis in interstitial lung disease. Am J Respir Crit Care Med 185: 1004-1014.
18. Meyer KC (2007) Bronchoalveolar Lavage as a Diagnostic Tool. Semin Respir Crit Care Med 28: 546-560. (Pubitemid 350036965)
19. Slevogt H, Schmeck B, Jonatat C, Zahlten J, Beermann W, et al. (2006) Moraxella catarrhalis induces inflammatory response of bronchial epithelial cells via MAPK and NF-kappaB activation and histone deacetylase activity reduction. Am J Physiol Lung Cell Mol Physiol 290: L818-826. (Pubitemid 43725042)
20. Zhao L, Furebring M, Xu S, Venge P (2004) Subcellular localization and mobilization of carcinoembryonic antigen-related cell adhesion molecule 8 in human neutrophils. Br J Haematol 125: 666-673. (Pubitemid 38747970)
21. Kammerer R, Popp T, Hartle S, Singer BB, Zimmermann W (2007) Species-specific evolution of immune receptor tyrosine based activation motif-containing CEACAM1-related immune receptors in the dog. BMC Evol Biol 7: 196.
22. El Kebir D, József L, Pan W, Wang L, Filep JG (2009) Bacterial DNA Activates Endothelial Cells and Promotes Neutrophil Adherence through TLR9 Signaling. The Journal of Immunology 182: 4386-4394.
23. Radsak MP, Salih HR, Rammensee HG, Schild H (2004) Triggering receptor expressed on myeloid cells-1 in neutrophil inflammatory responses: differential regulation of activation and survival. J Immunol 172: 4956-4963. (Pubitemid 38456421)
24. Schwartz DA, Quinn TJ, Thorne PS, Sayeed S, Yi AK, et al. (1997) CPG-ODN motifs in bacterial DNA cause inflammation in the lower respiratory tract. J Clin Invest 100: 68-73. (Pubitemid 27311244)
25. Shields AM, Panayi GS, Corrigall VM (2011) Resolution-associated molecular patterns (RAMP): RAMParts defending immunological homeostasis? Clin Exp Immunol 165: 292-300.
26. Lobo EO, Zhang Z, Shively JE (2009) Pivotal Advance: CEACAM1 is a negative coreceptor for the B cell receptor and promotes CD19-mediated adhesion of B cells in a PI3K-dependent manner. J Leukoc Biol 86: 205-218.
27. Pan H, Shively JE (2010) Carcinoembryonic Antigen-Related Cell Adhesion Molecule-1 Regulates Granulopoiesis by Inhibition of Granulocyte Colony-Stimulating Factor Receptor. Immunity 33: 620-631.
28. Lu R, Pan H, Shively JE (2012) CEACAM1 Negatively Regulates IL-1b Production in LPS Activated Neutrophils by Recruiting SHP-1 to a SYK-TLR4-CEACAM1 Complex. PLoS Pathog 8: e1002597.
29. Greicius G, Severinson E, Beauchemin N, Obrink B, Singer BB (2003) CEACAM1 is a potent regulator of B cell receptor complex-induced activation. J Leukoc Biol 74: 126-134. (Pubitemid 38040445)
30. Kammerer R, Hahn S, Singer BB, Jian S, Luo, et al. (1998) Biliary glycoprotein (CD66a), a cell adhesion molecule of the immunoglobulin superfamily, on human lymphocytes: structure, expression and involvement in T cell activation. Eur J Immunol 28: 3664-3674. (Pubitemid 28510777)