Molecular rotors as conditionally fluorescent labels for rapid detection of biomolecular interactions

Journal of the American Chemical Society

Volumn 136, Issue 17, 2014, Pages 6159-6162

  Goh, Walter L ^b   Lee, Min Yen ^a   Joseph, Thomas L ^c   Quah, Soo Tng ^b   Brown, Christopher J ^b   Verma, Chandra ^c,d,e   Brenner, Sydney ^a   Ghadessy, Farid J ^b   Teo, Yin Nah ^a,f  

^a Agency for Science   (Singapore)

^b AGENCY FOR SCIENCE   (Singapore)

^c BIOINFORMATICS INSTITUTE   (Singapore)

^d NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^e NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^f Nanyang Technological University   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ASSAYS; PEPTIDES; PROBES;

BIOMOLECULAR INTERACTIONS; FLUORESCENT LABELS; HOMOGENEOUS ASSAYS; MOLECULAR ROTORS; PEPTIDE-PROTEIN INTERACTIONS; RAPID DETECTION; TWISTED INTRA-MOLECULAR CHARGE TRANSFERS; VERSATILE TOOLS;

FLUORESCENCE;

CARBOXYL GROUP; PROTEIN MDM2; PROTEIN P53; VINYL DERIVATIVE; 9-(2-CARBOXY-2-CYANOVINYL)JULOLIDINE; FLUORESCENT DYE; MDM2 PROTEIN, HUMAN; NITRILE; PEPTIDE; QUINOLIZINE DERIVATIVE;

ARTICLE; ASSAY; FLUORESCENCE; IRRADIATION; MOLECULAR INTERACTION; PROTEIN PROTEIN INTERACTION; VALIDATION STUDY; VISCOSITY; AMINO ACID SEQUENCE; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; DRUG SCREENING; HUMAN; METABOLISM; MOLECULAR GENETICS; PROCEDURES; PROTEIN ANALYSIS; SPECTROFLUOROMETRY;

AMINO ACID SEQUENCE; DRUG EVALUATION, PRECLINICAL; FLUORESCENT DYES; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NITRILES; PEPTIDES; PROTEIN INTERACTION MAPPING; PROTEIN INTERACTION MAPS; PROTO-ONCOGENE PROTEINS C-MDM2; QUINOLIZINES; SPECTROMETRY, FLUORESCENCE; TUMOR SUPPRESSOR PROTEIN P53; VISCOSITY;

EID: 84899707002     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja413031h     Document Type: Article

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