Anti-N-Methyl-D-Aspartate (NMDA) receptor encephalitis: An unusual cause of autistic regression in a toddler

Journal of Child Neurology

Volumn 29, Issue 5, 2014, Pages 691-694

  Scott, Ori ^a   Richer, Lawrence ^a   Forbes, Karen ^a   Sonnenberg, Lyn ^b   Currie, Angela ^b   Eliyashevska, Myroslava ^a   Goez, Helly R ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b GLENROSE REHABILITATION HOSPITAL   (Canada)

Author keywords

anti NMDA receptor encephalitis; Autistic spectrum disorder; autoimmune autistic regression

Indexed keywords

ANTIBODY; IMMUNOGLOBULIN; IMMUNOGLOBULIN G; N METHYL DEXTRO ASPARTIC ACID ANTIBODY; STEROID; UNCLASSIFIED DRUG;

ANGER; ANTI N METHYL D ASPARTATE RECEPTOR ENCEPHALITIS; ANTIBIOTIC THERAPY; ANTIBODY DETECTION; ARTICLE; AUTISM; AUTISTIC REGRESSION; BEHAVIOR CHANGE; CASE REPORT; CEREBROSPINAL FLUID ANALYSIS; CHILD; DECREASED APPETITE; DEVELOPMENTAL DISORDER; DSM-IV; HAND MOVEMENT; HUMAN; INSOMNIA; IRRITABILITY; LANGUAGE ABILITY; MALE; MOTOR DYSFUNCTION; PRESCHOOL CHILD; PRIORITY JOURNAL; SOCIAL INTERACTION; STEROID THERAPY; UPPER RESPIRATORY TRACT INFECTION; AUTISTIC DISORDER; COMPLICATION;

ANTI-N-METHYL-D-ASPARTATE RECEPTOR ENCEPHALITIS; AUTISTIC DISORDER; CHILD, PRESCHOOL; HUMANS; MALE;

EID: 84899671093     PISSN: 08830738     EISSN: 17088283     Source Type: Journal    
DOI: 10.1177/0883073813501875     Document Type: Article

References (40)

1. Vitaliani R, Mason W, Ances B, et al. Paraneoplastic encephalitis, psychiatric symptoms, and hypoventilation in ovarian teratoma. Ann Neurol. 2005 ; 58: 594-604
2. Dalmau J, Tüzün E, Wu HY, et al. Paraneoplastic anti-N-methyl-d-aspartate receptor encephalitis associated with ovarian teratoma. Ann Neurol. 2007 ; 61: 25
3. Shimazaki H, Ando Y, Nakano I, Dalmau J. Reversible limbic encephalitis with antibodies against the membranes of neurones of the hippocampus. J Neurol Neurosurg Psychiatry. 2007 ; 78: 324
4. Iizuka T, Sakai F, Ide T, et al. Anti-NMDA receptor encephalitis in Japan: long-term outcome without tumor removal. Neurology. 2008 ; 70: 504
5. Seki M, Suzuki S, Iizuka T, et al. Neurological response to early removal of ovarian teratoma in anti-NMDAR encephalitis. J Neurol Neurosurg Psychiatry. 2008 ; 79: 324
6. Dalmau J, Gleichman AJ, Hughes EG, et al. Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies. Lancet Neurol. 2008 ; 7: 1091
7. Dalmau J, Lancaster E, Martinez-Hernandez E, et al. Clinical experience and laboratory investigations in patients with anti-NMDAR encephalitis. Lancet Neurol. 2011 ; 10: 63
8. Florance NR, Davis RL, Lam C, et al. Anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis in children and adolescents. Ann Neurol. 2009 ; 66: 11
9. Florance-Ryan N, Dalmau J. Update on anti-N-methyl-d-aspartate receptor encephalitis in children and adolescents. Curr Opin Pediatr. 2010 ; 22: 739
10. Perini P, Calabrese M, Ranzato F, Tiberio M, Gallo P. Cerebrospinal fluid examination in the differential diagnosis of inflammatory myelopathies. Neurol Sci. 2001 ; 22 (suppl 2). S65 - S68
11. Lourenco P, Shirani A, Saeedi J, Oger J, Schreiber WE, Tremlett H. Oligoclonal bands and cerebrospinal fluid markers in multiple sclerosis: associations with disease course and progression. Mult Scler. 2013 ; 19: 577-584
12. Wei YC, Liu CH, Lin JJ, et al. Rapid progression and brain atrophy in anti-AMPA receptor encephalitis. J Neuroimmunol. 2013 ; 261: 129-133
13. Sansing LH, Tüzün E, Ko MW, Baccon J, Lynch DR, Dalmau J. A patient with encephalitis associated with NMDA receptor antibodies. Nat Clin Pract Neurol. 2007 ; 3: 291-296
14. Hughes RA, Raphael JC, Swan AV, van Doorn PA. Intravenous immunoglobulin for Guillain-Barré syndrome. Cochrane Database Syst Rev. 2010 ;: CD002063
15. Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision. Washington, DC: American Psychiatric Association ; 2000 :
16. Ozonoff S, Iosif AM, Young GS, et al. Onset patterns in autism: correspondence between home video and parent report. J Am Acad Child Adolesc Psychiatry. 2011 ; 50: 796
17. Tuchman RF, Rapin I. Regression in pervasive developmental disorders: seizures and epileptiform electroencephalogram correlates. Pediatrics. 1997 ; 99: 560
18. Werner E, Dawson G. Validation of the phenomenon of autistic regression using home videotapes. Arch Gen Psychiatry. 2005 ; 62: 889
19. Singh VK. Phenotypic expression of autoimmune autistic disorder (AAD): a major subset of autism. Ann Clin Psychiatry. 2009 ; 21: 148-161
20. Keil A, Daniels JL, Forssen U, et al. Parental autoimmune diseases associated with autism spectrum disorders in offspring. Epidemiology. 2010 ; 21: 805-808
21. Jung JY, Kohane IS, Wall DP. Identification of autoimmune gene signatures in autism. Transl Psychiatry. 2011 ; 1: e63
22. Molloy CA, Morrow AL, Meinzen-Derr J, et al. Familial autoimmune thyroid disease as a risk factor for regression in children with autism spectrum disorder: a CPEA Study. J Autism Dev Disord. 2006 ; 36: 317-324
23. Comi AM, Zimmerman AW, Frye VH, Law PA, Peeden JN. Familial clustering of autoimmune disorders and evaluation of medical risk factors in autism. J Child Neurol. 1999 ; 14: 388-394
24. van Gent T, Heijnen CJ, Treffers PD. Autism and the immune system. J Child Psychol Psychiatry. 1997 ; 38: 337-349
25. Cook EH, Perry BD, Dawson G, Wainwright MS, Leventhal BL. Receptor inhibition by immunoglobulins: specific inhibition by autistic children, their relatives, and control subjects. J Autism Dev Disord. 1993 ; 23: 67-78
26. Singh VK, Warren R, Averett R, Ghaziuddin M. Circulating autoantibodies to neuronal and glial filament proteins in autism. Pediatr Neurol. 1997 ; 17: 88-90
27. Todd RD, Hickok JM, Anderson GM, Cohen DJ. Antibrain antibodies in infantile autism. Biol Psychiatry. 1988 ; 23: 644-647
28. Connolly AM, Chez MG, Pestronk A, et al. Serum autoantibodies to brain in Landau-Kleffner variant, autism, and other neurologic disorders. J Pediatr. 1999 ; 134: 607-613
29. Singh VK, Rivas WH. Prevalence of serum antibodies to caudate nucleus in autistic children. Neurosci Lett. 2004 ; 355: 53-56
30. Plioplys AV, Greaves A, Yoshida W. Anti-CNS antibodies in childhood neurologic diseases. Neuropediatrics. 1989 ; 20: 93-102
31. Burgdorf J, Moskal JR, Brudzynski SM, Panksepp J. Rats selectively bred for low levels of play-induced 50 kHz vocalizations as a model for autism spectrum disorders: a role for NMDA receptors. Behav Brain Res. 2013 ; 251: 18-24
32. Burket JA, Herndon AL, Winebarger EE, Jacome LF, Deutsch SI. Complex effects of mGluR5 antagonism on sociability and stereotypic behaviors in mice: possible implications for the pharmacotherapy of autism spectrum disorders. Brain Res Bull. 2011 ; 86: 152-158
33. Deutsch SI, Pepe GJ, Burket JA, et al. d-Cycloserine improves sociability and spontaneous stereotypic behaviors in 4-week old mice. Brain Res. 2012 ; 1439: 96-107
34. Arons MH, Thynne CJ, Grabrucker AM, et al. Autism-associated mutations in ProSAP2/Shank3 impair synaptic transmission and neurexin-neuroligin-mediated transsynaptic signaling. J Neurosci. 2012 ; 32: 14966-14978
35. Blundell J, Blaiss CA, Etherton MR, et al. Neuroligin-1 deletion results in impaired spatial memory and increased repetitive behavior. J Neurosci. 2010 ; 30: 2115-2129
36. Won H, Lee HR, Gee HY, et al. Autistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor function. Nature. 2012 ; 486: 261-265
37. Etherton M, Földy C, Sharma M, et al. Autism-linked neuroligin-3 R451C mutation differentially alters hippocampal and cortical synaptic function. Proc Natl Acad Sci U S A. 2011 ; 108: 13764-13769
38. Moskal JR, Burgdorf J, Kroes RA, Brudzynski SM, Panksepp J.. A novel NMDA receptor glycine-site partial agonist, GLYX-13, has therapeutic potential for the treatment of autism. Neurosci Biobehav Rev. 2011 ; 35: 1982-1988
39. Ninan I. Oxytocin suppresses basal glutamatergic transmission but facilitates activity-dependent synaptic potentiation in the medial prefrontal cortex. J Neurochem. 2011 ; 119: 324-331
40. Anagnostou E, Soorya L, Chaplin W, et al. Intranasal oxytocin versus placebo in the treatment of adults with autism spectrum disorders: a randomized controlled trial. Mol Autism. 2012 ; 3: 16