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Volumn 35, Issue 9, 2011, Pages 1982-1988

A novel NMDA receptor glycine-site partial agonist, GLYX-13, has therapeutic potential for the treatment of autism

Author keywords

Autism; GLYX 13; Microarray; NMDA; Rats; Rough and tumble play; Vocalizations

Indexed keywords

ANIMALS; AUTISTIC DISORDER; BRAIN CHEMISTRY; ENDORPHINS; GENE EXPRESSION; HUMANS; OLIGOPEPTIDES; PLAY AND PLAYTHINGS; RATS; RECEPTORS, GLYCINE; RECEPTORS, N-METHYL-D-ASPARTATE; VOCALIZATION, ANIMAL;

EID: 80053108650     PISSN: 01497634     EISSN: 18737528     Source Type: Journal    
DOI: 10.1016/j.neubiorev.2011.06.006     Document Type: Review
Times cited : (67)

References (63)
  • 4
    • 59249086604 scopus 로고    scopus 로고
    • Low-dose naltrexone for disease prevention and quality of life
    • Brown N., Panksepp J. Low-dose naltrexone for disease prevention and quality of life. Med. Hypotheses 2009, 72:333-337.
    • (2009) Med. Hypotheses , vol.72 , pp. 333-337
    • Brown, N.1    Panksepp, J.2
  • 5
    • 77953122243 scopus 로고    scopus 로고
    • Uncovering the molecular basis of positive affect using rough-and-tumble play in rats: a role for insulin-like growth factor I
    • Burgdorf J., Kroes R.A., Beinfeld M.C., Panksepp J., Moskal J.R. Uncovering the molecular basis of positive affect using rough-and-tumble play in rats: a role for insulin-like growth factor I. Neuroscience 2010, 168:769-777.
    • (2010) Neuroscience , vol.168 , pp. 769-777
    • Burgdorf, J.1    Kroes, R.A.2    Beinfeld, M.C.3    Panksepp, J.4    Moskal, J.R.5
  • 6
    • 56749150859 scopus 로고    scopus 로고
    • Ultrasonic vocalizations of rats (Rattus norvegicus) during mating, play, and aggression: Behavioral concomitants, relationship to reward, and self-administration of playback
    • Burgdorf J., Kroes R.A., Moskal J.R., Pfaus J.G., Brudzynski S.M., Panksepp J. Ultrasonic vocalizations of rats (Rattus norvegicus) during mating, play, and aggression: Behavioral concomitants, relationship to reward, and self-administration of playback. J. Comp. Psychol. 2008, 122:357-367.
    • (2008) J. Comp. Psychol. , vol.122 , pp. 357-367
    • Burgdorf, J.1    Kroes, R.A.2    Moskal, J.R.3    Pfaus, J.G.4    Brudzynski, S.M.5    Panksepp, J.6
  • 10
    • 80053093657 scopus 로고    scopus 로고
    • The antidepressant and anxiolytic properties of GLYX-13: a novel NMDA receptor glycine site functional partial agonist
    • Burgdorf J., Westrich L., Sprouse J., Moskal J.R. The antidepressant and anxiolytic properties of GLYX-13: a novel NMDA receptor glycine site functional partial agonist. Soc. Neurosci. Annu. Meet. 2010, 572.:523.
    • (2010) Soc. Neurosci. Annu. Meet. , pp. 523
    • Burgdorf, J.1    Westrich, L.2    Sprouse, J.3    Moskal, J.R.4
  • 11
    • 34548611424 scopus 로고    scopus 로고
    • Neurobiology of 50-kHz ultrasonic vocalizations in rats: electrode mapping, lesion, and pharmacology studies
    • Burgdorf J., Wood P.L., Kroes R.A., Moskal J.R., Panksepp J. Neurobiology of 50-kHz ultrasonic vocalizations in rats: electrode mapping, lesion, and pharmacology studies. Behav. Brain Res. 2007, 182:274-283.
    • (2007) Behav. Brain Res. , vol.182 , pp. 274-283
    • Burgdorf, J.1    Wood, P.L.2    Kroes, R.A.3    Moskal, J.R.4    Panksepp, J.5
  • 12
    • 80053101372 scopus 로고    scopus 로고
    • The N-methyl-d-aspartate receptor modulator GLYX-13 enhances learning and memory, in young adult and learning impaired aging rats
    • Burgdorf J., Zhang X.L., Weiss C., Matthews E., Disterhoft J.F., Stanton P.K., Moskal J.R. The N-methyl-d-aspartate receptor modulator GLYX-13 enhances learning and memory, in young adult and learning impaired aging rats. Neurobiol. Aging 2011, 23:3698-3706.
    • (2011) Neurobiol. Aging , vol.23 , pp. 3698-3706
    • Burgdorf, J.1    Zhang, X.L.2    Weiss, C.3    Matthews, E.4    Disterhoft, J.F.5    Stanton, P.K.6    Moskal, J.R.7
  • 13
    • 0031880046 scopus 로고    scopus 로고
    • Hypothesis: is infantile autism a hypoglutamatergic disorder? Relevance of glutamate - serotonin interactions for pharmacotherapy
    • Carlsson M.L. Hypothesis: is infantile autism a hypoglutamatergic disorder? Relevance of glutamate - serotonin interactions for pharmacotherapy. J. Neural Transm. 1998, 105:525-535.
    • (1998) J. Neural Transm. , vol.105 , pp. 525-535
    • Carlsson, M.L.1
  • 14
    • 0033153241 scopus 로고    scopus 로고
    • Beta-endorphin levels in peripheral blood mononuclear cells and long-term naltrexone treatment in autistic children
    • Cazzullo A.G., Musetti M.C., Musetti L., Bajo S., Sacerdote P., Panerai A. Beta-endorphin levels in peripheral blood mononuclear cells and long-term naltrexone treatment in autistic children. Eur. Neuropsychopharmacol. 1999, 9:361-366.
    • (1999) Eur. Neuropsychopharmacol. , vol.9 , pp. 361-366
    • Cazzullo, A.G.1    Musetti, M.C.2    Musetti, L.3    Bajo, S.4    Sacerdote, P.5    Panerai, A.6
  • 15
    • 73149102059 scopus 로고    scopus 로고
    • CDC Prevalence of autism spectrum disorders - Autism and Developmental Disabilities Monitoring Network, United States, 2006
    • CDC Prevalence of autism spectrum disorders - Autism and Developmental Disabilities Monitoring Network, United States, 2006. MMWR Surveill Summ. 2009, 58:1-20.
    • (2009) MMWR Surveill Summ. , vol.58 , pp. 1-20
  • 16
    • 34250731835 scopus 로고    scopus 로고
    • Memantine as adjunctive therapy in children diagnosed with autistic spectrum disorders: an observation of initial clinical response and maintenance tolerability
    • Chez M.G., Burton Q., Dowling T., Chang M., Khanna P., Kramer C. Memantine as adjunctive therapy in children diagnosed with autistic spectrum disorders: an observation of initial clinical response and maintenance tolerability. J. Child Neurol. 2007, 22:574-579.
    • (2007) J. Child Neurol. , vol.22 , pp. 574-579
    • Chez, M.G.1    Burton, Q.2    Dowling, T.3    Chang, M.4    Khanna, P.5    Kramer, C.6
  • 18
    • 33745115657 scopus 로고    scopus 로고
    • Efficacy and safety of naltrexone use in pediatric patients with autistic disorder
    • Elchaar G.M., Maisch N.M., Augusto L.M., Wehring H.J. Efficacy and safety of naltrexone use in pediatric patients with autistic disorder. Ann. Pharmacother. 2006, 40:1086-1095.
    • (2006) Ann. Pharmacother. , vol.40 , pp. 1086-1095
    • Elchaar, G.M.1    Maisch, N.M.2    Augusto, L.M.3    Wehring, H.J.4
  • 19
    • 0021970857 scopus 로고
    • Endorphin activity in childhood psychosis. Spinal fluid levels in 24 cases
    • Gillberg C., Terenius L., Lonnerholm G. Endorphin activity in childhood psychosis. Spinal fluid levels in 24 cases. Arch. Gen. Psychiatry 1985, 42:780-783.
    • (1985) Arch. Gen. Psychiatry , vol.42 , pp. 780-783
    • Gillberg, C.1    Terenius, L.2    Lonnerholm, G.3
  • 20
    • 77954944264 scopus 로고    scopus 로고
    • Autism and oxytocin: new developments in translational approaches to therapeutics
    • Green J.J., Hollander E. Autism and oxytocin: new developments in translational approaches to therapeutics. Neurotherapeutics 2010, 7:250-257.
    • (2010) Neurotherapeutics , vol.7 , pp. 250-257
    • Green, J.J.1    Hollander, E.2
  • 21
    • 0025950425 scopus 로고
    • Glycine-like modulation of N-methyl-d-aspartate receptors by a monoclonal antibody that enhances long-term potentiation
    • Haring R., Stanton P.K., Scheideler M.A., Moskal J.R. Glycine-like modulation of N-methyl-d-aspartate receptors by a monoclonal antibody that enhances long-term potentiation. J. Neurochem. 1991, 57:323-332.
    • (1991) J. Neurochem. , vol.57 , pp. 323-332
    • Haring, R.1    Stanton, P.K.2    Scheideler, M.A.3    Moskal, J.R.4
  • 22
    • 34548011214 scopus 로고    scopus 로고
    • Can neuroscience be integrated into the DSM-V?
    • Hyman S.E. Can neuroscience be integrated into the DSM-V?. Nat. Rev. Neurosci. 2007, 8:725-732.
    • (2007) Nat. Rev. Neurosci. , vol.8 , pp. 725-732
    • Hyman, S.E.1
  • 24
    • 0024521902 scopus 로고
    • Beta-endorphin concentrations in cerebrospinal fluid of monkeys are influenced by grooming relationships
    • Keverne E.B., Martensz N.D., Tuite B. Beta-endorphin concentrations in cerebrospinal fluid of monkeys are influenced by grooming relationships. Psychoneuroendocrinology 1989, 14:155-161.
    • (1989) Psychoneuroendocrinology , vol.14 , pp. 155-161
    • Keverne, E.B.1    Martensz, N.D.2    Tuite, B.3
  • 27
    • 29744451802 scopus 로고    scopus 로고
    • Modeling depression: social dominance-submission gene expression patterns in rat neocortex
    • Kroes R.A., Panksepp J., Burgdorf J., Otto N.J., Moskal J.R. Modeling depression: social dominance-submission gene expression patterns in rat neocortex. Neuroscience 2006, 137:37-49.
    • (2006) Neuroscience , vol.137 , pp. 37-49
    • Kroes, R.A.1    Panksepp, J.2    Burgdorf, J.3    Otto, N.J.4    Moskal, J.R.5
  • 30
    • 0023508704 scopus 로고
    • Behavioral treatment and normal educational and intellectual functioning in young autistic children
    • Lovaas O.I. Behavioral treatment and normal educational and intellectual functioning in young autistic children. J. Consult. Clin. Psychol. 1987, 55:3-9.
    • (1987) J. Consult. Clin. Psychol. , vol.55 , pp. 3-9
    • Lovaas, O.I.1
  • 31
    • 84979183288 scopus 로고
    • Manipulation of self-destruction in three retarded children
    • Lovaas O.I., Simmons J.Q. Manipulation of self-destruction in three retarded children. J. Appl. Behav. Anal. 1969, 2:143-157.
    • (1969) J. Appl. Behav. Anal. , vol.2 , pp. 143-157
    • Lovaas, O.I.1    Simmons, J.Q.2
  • 32
    • 33748924655 scopus 로고    scopus 로고
    • Intermediate phenotypes and genetic mechanisms of psychiatric disorders
    • Meyer-Lindenberg A., Weinberger D.R. Intermediate phenotypes and genetic mechanisms of psychiatric disorders. Nat. Rev. Neurosci. 2006, 7:818-827.
    • (2006) Nat. Rev. Neurosci. , vol.7 , pp. 818-827
    • Meyer-Lindenberg, A.1    Weinberger, D.R.2
  • 33
    • 3042616101 scopus 로고    scopus 로고
    • Deficit in attachment behavior in mice lacking the mu-opioid receptor gene
    • Moles A., Kieffer B.L., D'Amato F.R. Deficit in attachment behavior in mice lacking the mu-opioid receptor gene. Science 2004, 304:1983-1986.
    • (2004) Science , vol.304 , pp. 1983-1986
    • Moles, A.1    Kieffer, B.L.2    D'Amato, F.R.3
  • 37
    • 0018614713 scopus 로고
    • A neurochemical theory of autism
    • Panksepp J. A neurochemical theory of autism. Trends Neurosci. 1979, 2:174-177.
    • (1979) Trends Neurosci. , vol.2 , pp. 174-177
    • Panksepp, J.1
  • 38
    • 0002565093 scopus 로고
    • Brain opioids: a neurochemical substrate for narcotic and social dependence
    • Academic Press, London, Cooper (Ed.)
    • Panksepp J. Brain opioids: a neurochemical substrate for narcotic and social dependence. Progress in Theory in Psychopharmacology 1981, 149-175. Academic Press, London. Cooper (Ed.).
    • (1981) Progress in Theory in Psychopharmacology , pp. 149-175
    • Panksepp, J.1
  • 39
    • 0026785985 scopus 로고
    • Oxytocin effects on emotional processes: separation distress, social bonding, and relationships to psychiatric disorders
    • Panksepp J. Oxytocin effects on emotional processes: separation distress, social bonding, and relationships to psychiatric disorders. Ann. N. Y. Acad. Sci. 1992, 652:243-252.
    • (1992) Ann. N. Y. Acad. Sci. , vol.652 , pp. 243-252
    • Panksepp, J.1
  • 43
    • 0026386809 scopus 로고
    • Naltrexone and other potential new pharmacological treatments of autism
    • Panksepp J., Lensing P., Leboyer M., Bouvard M.P. Naltrexone and other potential new pharmacological treatments of autism. Brain Dysfunction 1991, 4:281-300.
    • (1991) Brain Dysfunction , vol.4 , pp. 281-300
    • Panksepp, J.1    Lensing, P.2    Leboyer, M.3    Bouvard, M.P.4
  • 44
    • 0001771162 scopus 로고
    • Possible brain opioid involvement in disrupted social intent and language development of autism
    • Plenum Press, New York, E. Schopler, G. Mesibov (Eds.)
    • Panksepp J., Sahley T. Possible brain opioid involvement in disrupted social intent and language development of autism. Neurobiological Issues in Autism 1987, Plenum Press, New York. E. Schopler, G. Mesibov (Eds.).
    • (1987) Neurobiological Issues in Autism
    • Panksepp, J.1    Sahley, T.2
  • 45
    • 35148850474 scopus 로고    scopus 로고
    • Affiliative behavior, ultrasonic communication and social reward are influenced by genetic variation in adolescent mice
    • Panksepp J.B., Jochman K.A., Kim J.U., Koy J.J., Wilson E.D., Chen Q., Wilson C.R., Lahvis G.P. Affiliative behavior, ultrasonic communication and social reward are influenced by genetic variation in adolescent mice. PLoS One 2007, 2:e351.
    • (2007) PLoS One , vol.2
    • Panksepp, J.B.1    Jochman, K.A.2    Kim, J.U.3    Koy, J.J.4    Wilson, E.D.5    Chen, Q.6    Wilson, C.R.7    Lahvis, G.P.8
  • 47
    • 42549141631 scopus 로고    scopus 로고
    • Psychopharmacology of aggression in children and adolescents with autism: a critical review of efficacy and tolerability
    • Parikh M.S., Kolevzon A., Hollander E. Psychopharmacology of aggression in children and adolescents with autism: a critical review of efficacy and tolerability. J. Child Adolesc. Psychopharmacol. 2008, 18:157-178.
    • (2008) J. Child Adolesc. Psychopharmacol. , vol.18 , pp. 157-178
    • Parikh, M.S.1    Kolevzon, A.2    Hollander, E.3
  • 49
    • 0035856428 scopus 로고    scopus 로고
    • Postmortem brain abnormalities of the glutamate neurotransmitter system in autism
    • Purcell A.E., Jeon O.H., Zimmerman A.W., Blue M.E., Pevsner J. Postmortem brain abnormalities of the glutamate neurotransmitter system in autism. Neurology 2001, 57:1618-1628.
    • (2001) Neurology , vol.57 , pp. 1618-1628
    • Purcell, A.E.1    Jeon, O.H.2    Zimmerman, A.W.3    Blue, M.E.4    Pevsner, J.5
  • 52
    • 75649107225 scopus 로고    scopus 로고
    • Novel and emerging treatments for autism spectrum disorders: a systematic review
    • Rossignol D.A. Novel and emerging treatments for autism spectrum disorders: a systematic review. Ann. Clin. Psychiatry 2009, 21:213-236.
    • (2009) Ann. Clin. Psychiatry , vol.21 , pp. 213-236
    • Rossignol, D.A.1
  • 53
    • 0033843726 scopus 로고    scopus 로고
    • Uncoupling of proopiomelanocortin (POMC) fragments is related to self-injury
    • Sandman C.A., Hetrick W., Talyor D., Marion S., Chicz-DeMet A. Uncoupling of proopiomelanocortin (POMC) fragments is related to self-injury. Peptides 2000, 21:785-791.
    • (2000) Peptides , vol.21 , pp. 785-791
    • Sandman, C.A.1    Hetrick, W.2    Talyor, D.3    Marion, S.4    Chicz-DeMet, A.5
  • 55
    • 69549111246 scopus 로고    scopus 로고
    • Neuroprotection by a novel NMDAR functional glycine site partial agonist, GLYX-13
    • Stanton P.K., Potter P.E., Aguilar J., Decandia M., Moskal J.R. Neuroprotection by a novel NMDAR functional glycine site partial agonist, GLYX-13. Neuroreport 2009, 20:1193-1197.
    • (2009) Neuroreport , vol.20 , pp. 1193-1197
    • Stanton, P.K.1    Potter, P.E.2    Aguilar, J.3    Decandia, M.4    Moskal, J.R.5
  • 56
    • 11844270409 scopus 로고    scopus 로고
    • Self-injurious behavior and the efficacy of naltrexone treatment: a quantitative synthesis
    • Symons F.J., Thompson A., Rodriguez M.C. Self-injurious behavior and the efficacy of naltrexone treatment: a quantitative synthesis. Ment. Retard. Dev. Disabil. Res. Rev. 2004, 10:193-200.
    • (2004) Ment. Retard. Dev. Disabil. Res. Rev. , vol.10 , pp. 193-200
    • Symons, F.J.1    Thompson, A.2    Rodriguez, M.C.3
  • 57
    • 0026671647 scopus 로고
    • Hippocampus-dependent learning facilitated by a monoclonal antibody or d-cycloserine
    • Thompson L.T., Moskal J.R., Disterhoft J.F. Hippocampus-dependent learning facilitated by a monoclonal antibody or d-cycloserine. Nature 1992, 359:638-641.
    • (1992) Nature , vol.359 , pp. 638-641
    • Thompson, L.T.1    Moskal, J.R.2    Disterhoft, J.F.3
  • 59
    • 0018740511 scopus 로고
    • Severe impairments of social interaction and associated abnormalities in children: epidemiology and classification
    • Wing L., Gould J. Severe impairments of social interaction and associated abnormalities in children: epidemiology and classification. J. Autism Dev. Disord. 1979, 9:11-29.
    • (1979) J. Autism Dev. Disord. , vol.9 , pp. 11-29
    • Wing, L.1    Gould, J.2
  • 60
    • 79551717822 scopus 로고    scopus 로고
    • Lack of social exploratory activation in male mu-opioid receptor KO mice in response to playback of female ultrasonic vocalizations
    • Wohr M., Moles A., Schwarting R.K., DAmato F.R. Lack of social exploratory activation in male mu-opioid receptor KO mice in response to playback of female ultrasonic vocalizations. Soc. Neurosci. 2011, 6:76-87.
    • (2011) Soc. Neurosci. , vol.6 , pp. 76-87
    • Wohr, M.1    Moles, A.2    Schwarting, R.K.3    Damato, F.R.4
  • 61
    • 67249089972 scopus 로고    scopus 로고
    • Antinociceptive action of GLYX-13: an N-methyl-d-aspartate receptor glycine site partial agonist
    • Wood P.L., Mahmood S.A., Moskal J.R. Antinociceptive action of GLYX-13: an N-methyl-d-aspartate receptor glycine site partial agonist. Neuroreport 2008, 19:1059-1061.
    • (2008) Neuroreport , vol.19 , pp. 1059-1061
    • Wood, P.L.1    Mahmood, S.A.2    Moskal, J.R.3
  • 62
    • 33847219669 scopus 로고    scopus 로고
    • A review of gene linkage, association and expression studies in autism and an assessment of convergent evidence
    • Yang M.S., Gill M. A review of gene linkage, association and expression studies in autism and an assessment of convergent evidence. Int. J. Dev. Neurosci. 2007, 25:69-85.
    • (2007) Int. J. Dev. Neurosci. , vol.25 , pp. 69-85
    • Yang, M.S.1    Gill, M.2
  • 63
    • 54049113747 scopus 로고    scopus 로고
    • A NMDA receptor glycine site partial agonist GLYX-13, simultaneously enhances LTP and reduces LTD at Schaffer collateral-CA1 synapses in hippocampus
    • Zhang X.L., Sullivan J.A., Moskal J.R., Stanton P.K. A NMDA receptor glycine site partial agonist GLYX-13, simultaneously enhances LTP and reduces LTD at Schaffer collateral-CA1 synapses in hippocampus. Neuropharmacology 2008, 55:1238-1250.
    • (2008) Neuropharmacology , vol.55 , pp. 1238-1250
    • Zhang, X.L.1    Sullivan, J.A.2    Moskal, J.R.3    Stanton, P.K.4


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