Transfer function analysis for the assessment of cerebral autoregulation using spontaneous oscillations in blood pressure and cerebral blood flow

Medical Engineering and Physics

Volumn 36, Issue 5, 2014, Pages 563-575

  Meel van den Abeelen, Aisha S S ^a   van Beek, Arenda H E A ^a   Slump, Cornelis H ^d   Panerai, Ronney B ^c   Claassen, Jurgen A H R ^a,b  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b RADBOUD UNIVERSITY   (Netherlands)

^c GLENFIELD HOSPITAL   (United Kingdom)

^d UNIVERSITY OF TWENTE   (Netherlands)

Author keywords

Cerebral autoregulation; Method comparison; Review; Transfer function analysis

Indexed keywords

BLOOD PRESSURE; REVIEWS; TISSUE;

CEREBRAL AUTOREGULATION; CEREBRAL BLOOD FLOW; CEREBRAL BLOOD FLOW VELOCITIES; IMPLEMENTATION TECHNIQUES; METHOD COMPARISON; SCIENTIFIC RESEARCHES; SPONTANEOUS OSCILLATIONS; TRANSFER FUNCTION ANALYSIS;

TRANSFER FUNCTIONS;

AUTOREGULATION; BLOOD PRESSURE; BRAIN BLOOD FLOW; BRAIN PROTECTION; CAROTID ARTERY OBSTRUCTION; CEREBRAL AUTOREGULATION; EXERCISE; HOMEOSTASIS; HUMAN; HYPERCAPNIA; HYPERTENSION; OSCILLATION; PATHOPHYSIOLOGY; PHYSIOLOGY; PRIORITY JOURNAL; REFERENCE VALUE; REVIEW; VASODILATATION; ANIMAL; BRAIN; BRAIN CIRCULATION; VASCULARIZATION;

ANIMALS; BLOOD PRESSURE; BRAIN; CEREBROVASCULAR CIRCULATION; HOMEOSTASIS; HUMANS;

EID: 84899631371     PISSN: 13504533     EISSN: 18734030     Source Type: Journal    
DOI: 10.1016/j.medengphy.2014.02.001     Document Type: Review

References (140)

1. Lassen N.A. Cerebral blood flow and oxygen consumption in man. Physiological Reviews 1959, 39:183-238.
2. Blaber A.P., Bondar R.L., Stein F., Dunphy P.T., Moradshahi P., Kassam M.S., et al. Transfer function analysis of cerebral autoregulation dynamics in autonomic failure patients. Stroke: A Journal of Cerebral Circulation 1997, 28:1686-1692.
3. Soehle M., Czosnyka M., Pickard J.D., Kirkpatrick P.J. Continuous assessment of cerebral autoregulation in subarachnoid hemorrhage. Anesthesia and Analgesia 2004, 98:1133-1139. table of contents.
4. Piechnik S.K., Yang X., Czosnyka M., Smielewski P., Fletcher S.H., Jones A.L., et al. The continuous assessment of cerebrovascular reactivity: a validation of the method in healthy volunteers. Anesthesia and Analgesia 1999, 89:944-949.
5. Reinhard M., Gerds T.A., Grabiak D., Zimmermann P.R., Roth M., Guschlbauer B., et al. Cerebral dysautoregulation and the risk of ischemic events in occlusive carotid artery disease. Journal of Neurology 2008, 255:1182-1189.
6. Czosnyka M., Smielewski P., Kirkpatrick P., Menon D.K., Pickard J.D. Monitoring of cerebral autoregulation in head-injured patients. Stroke: A Journal of Cerebral Circulation 1996, 27:1829-1834.
7. Eames P.J., Blake M.J., Dawson S.L., Panerai R.B., Potter J.F. Dynamic cerebral autoregulation and beat to beat blood pressure control are impaired in acute ischaemic stroke. Journal of Neurology, Neurosurgery, and Psychiatry 2002, 72:467-472.
8. Eames P.J., Blake M.J., Panerai R.B., Potter J.F. Cerebral autoregulation indices are unimpaired by hypertension in middle aged and older people. American Journal of Hypertension 2003, 16:746-753.
9. Vokatch N., Grotzsch H., Mermillod B., Burkhard P.R., Sztajzel R. Is cerebral autoregulation impaired in Parkinson's disease? A transcranial Doppler study. Journal of the Neurological Sciences 2007, 254:49-53.
10. Urbano F., Roux F., Schindler J., Mohsenin V. Impaired cerebral autoregulation in obstructive sleep apnea. Journal of Applied Physiology (Bethesda, MD: 1985) 2008, 105:1852-1857.
11. Hu K., Peng C.K., Czosnyka M., Zhao P., Novak V. Nonlinear assessment of cerebral autoregulation from spontaneous blood pressure and cerebral blood flow fluctuations. Cardiovascular Engineering 2008, 8:60-71.
12. Noack F., Christ M., May S.A., Steinmeier R., Morgenstern U. Assessment of dynamic changes in cerebral autoregulation. Biomedizinische Technik (Berlin) 2007, 52:31-36.
13. Tiecks F.P., Lam A.M., Aaslid R., Newell D.W. Comparison of static and dynamic cerebral autoregulation measurements. Stroke: A Journal of Cerebral Circulation 1995, 26:1014-1019.
14. Reinhard M., Roth M., Muller T., Czosnyka M., Timmer J., Hetzel A. Cerebral autoregulation in carotid artery occlusive disease assessed from spontaneous blood pressure fluctuations by the correlation coefficient index. Stroke: A Journal of Cerebral Circulation 2003, 34:2138-2144.
15. Panerai R.B., Rennie J.M., Kelsall A.W., Evans D.H. Frequency-domain analysis of cerebral autoregulation from spontaneous fluctuations in arterial blood pressure. Medical & Biological Engineering & Computing 1998, 36:315-322.
16. van Beek A.H., Claassen J.A., Rikkert M.G., Jansen R.W. Cerebral autoregulation: an overview of current concepts and methodology with special focus on the elderly. Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism 2008, 28:1071-1085.
17. Panerai R.B. Assessment of cerebral pressure autoregulation in humans - a review of measurement methods. Physiological Measurement 1998, 19:305-338.
18. Claassen J., Levine B.D., Zhang R. Dynamic cerebral autoregulation during repeated squat-stand maneuvers. Journal of Applied Physiology (Bethesda, MD: 1985) 2009, 106:153-160.
19. Giller C.A. The frequency-dependent behavior of cerebral autoregulation. Neurosurgery 1990, 27:362-368.
20. Saul J.P., Berger R.D., Albrecht P., Stein S.P., Chen M.H., Cohen R.J. Transfer function analysis of the circulation: unique insights into cardiovascular regulation. The American Journal of Physiology 1991, 261:H1231-H1245.
21. Saul J.P., Berger R.D., Chen M.H., Cohen R.J. Transfer function analysis of autonomic regulation. II. Respiratory sinus arrhythmia. The American Journal of Physiology 1989, 256:H153-H161.
22. Holstein-Rathlou N.H., Wagner A.J., Marsh D.J. Tubuloglomerular feedback dynamics and renal blood flow autoregulation in rats. The American Journal of Physiology 1991, 260:F53-F68.
23. 2. Brain Research 2008, 1230:115-124.
24. Panerai R.B., Dawson S.L., Potter J.F. Linear and nonlinear analysis of human dynamic cerebral autoregulation. The American Journal of Physiology 1999, 277:H1089-H1099.
25. Kay S.M., Marple S.L. Spectrum analysis - a modern perspective. Proceedings of the IEEE 1981, 69:1380-1419.
26. Sreekanth S., Khanna P.D., Rao P.U.M. An efficient noise reduction by using diagonal and nondiagonal estimation techniques. International Conference on Communication and Computational Intelligence (INCOCCI) 2010, 393-398. IEEE.
27. Aaslid R., Lindegaard K.F., Sorteberg W., Nornes H. Cerebral autoregulation dynamics in humans. Stroke: A Journal of Cerebral Circulation 1989, 20:45-52.
28. Muller M., Bianchi O., Erulku S., Stock C., Schwerdtfeger K., HOTBIG Brain lesion size and phase shift as an index of cerebral autoregulation in patients with severe head injury. Acta Neurochirurgica 2003, 145:643-648.
29. Deegan B.M., Serrador J.M., Nakagawa K., Jones E., Sorond F.A., Olaighin G. The effect of blood pressure calibrations and transcranial Doppler signal loss on transfer function estimates of cerebral autoregulation. Medical Engineering & Physics 2011, 33:553-562.
30. Nakagawa K., Serrador J.M., LaRose S.L., Sorond F.A. Dynamic cerebral autoregulation after intracerebral hemorrhage: a case-control study. BMC Neurology 2011, 11:108.
31. Zhu Y.S., Tseng B.Y., Shibata S., Levine B.D., Zhang R. Increases in cerebrovascular impedance in older adults. Journal of Applied Physiology (Bethesda, MD: 1985) 2011, 111:376-381.
32. van Beek A.H., Olde Rikkert M.G., Pasman J.W., Hopman M.T., Claassen J.A. Dynamic cerebral autoregulation in the old using a repeated sit-stand maneuver. Ultrasound in Medicine & Biology 2010, 36:192-201.
33. Fisher J.P., Ogoh S., Young C.N., Raven P.B., Fadel P.J. Regulation of middle cerebral artery blood velocity during dynamic exercise in humans: influence of aging. Journal of Applied Physiology (Bethesda, MD: 1985) 2008, 105:266-273.
34. Gelinas J.C., Marsden K.R., Tzeng Y.C., Smirl J.D., Smith K.J., Willie C.K., et al. Influence of posture on the regulation of cerebral perfusion. Aviation, Space, and Environmental Medicine 2012, 83:751-757.
35. Kety S.S., Schmidt C.F. The effects of altered arterial tensions of carbon dioxide and oxygen on cerebral blood flow and cerebral oxygen consumption of normal young men. The Journal of Clinical Investigation 1948, 27:484-492.
36. 2 on dynamic cerebral autoregulation measurement. Physiological Measurement 1999, 20:265-275.
37. Zhang R., Zuckerman J.H., Giller C.A., Levine B.D. Transfer function analysis of dynamic cerebral autoregulation in humans. The American Journal of Physiology 1998, 274:H233-H241.
38. 2. American Journal of Physiology - Regulatory Integrative and Comparative Physiology 2002, 283:R653-R662.
39. Fritzsch C., Rosengarten B., Guschlbauer B., Weiller C., Hetzel A., Reinhard M. Neurovascular coupling and cerebral autoregulation in patients with stenosis of the posterior cerebral artery. Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging 2010, 20:368-372.
40. Hu H.H., Kuo T.B., Wong W.J., Luk Y.O., Chern C.M., Hsu L.C., et al. Transfer function analysis of cerebral hemodynamics in patients with carotid stenosis. Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism 1999, 19:460-465.
41. Reinhard M., Muller T., Guschlbauer B., Timmer J., Hetzel A. Transfer function analysis for clinical evaluation of dynamic cerebral autoregulation - a comparison between spontaneous and respiratory-induced oscillations. Physiological Measurement 2003, 24:27-43.
42. Reinhard M., Muller T., Roth M., Guschlbauer B., Timmer J., Hetzel A. Bilateral severe carotid artery stenosis or occlusion - cerebral autoregulation dynamics and collateral flow patterns. Acta Neurochirurgica 2003, 145:1053-1059. discussion 9-60.
43. Reinhard M., Roth M., Muller T., Guschlbauer B., Timmer J., Czosnyka M., et al. Effect of carotid endarterectomy or stenting on impairment of dynamic cerebral autoregulation. Stroke: A Journal of Cerebral Circulation 2004, 35:1381-1387.
44. Gommer E.D., Shijaku E., Mess W.H., Reulen J.P.H. Dynamic cerebral autoregulation: different signal processing methods without influence on results and reproducibility. Medical & Biological Engineering & Computing 2010, 48:1243-1250.
45. 2. Acta Physiologica Scandinavica 1987, 129:157-163.
46. Kouchakpour H., Allen R., Simpson D.M. Nonlinear, multiple-input modeling of cerebral autoregulation using Volterra Kernel estimation. Conference Proceedings of the IEEE Engineering in Medicine and Biology Society 2010, 2010:2375-2378.
47. Panerai R.B., Moody M., Eames P.J., Potter J.F. Dynamic cerebral autoregulation during brain activation paradigms. American Journal of Physiology Heart and Circulatory Physiology 2005, 289:H1202-H1208.
48. Giller C.A., Bowman G., Dyer H., Mootz L., Krippner W. Cerebral arterial diameters during changes in blood pressure and carbon dioxide during craniotomy. Neurosurgery 1993, 32:737-741. discussion 41-2.
49. Schreiber S.J., Gottschalk S., Weih M., Villringer A., Valdueza J.M. Assessment of blood flow velocity and diameter of the middle cerebral artery during the acetazolamide provocation test by use of transcranial Doppler sonography and MR imaging. American Journal of Neuroradiology 2000, 21:1207-1211.
50. Serrador J.M., Picot P.A., Rutt B.K., Shoemaker J.K., Bondar R.L. MRI measures of middle cerebral artery diameter in conscious humans during simulated orthostasis. Stroke: A Journal of Cerebral Circulation 2000, 31:1672-1678.
51. Lorenz M.W., Loesel N., Thoelen N., Gonzalez M., Lienerth C., Dvorak F., et al. Effects of poor bone window on the assessment of cerebral autoregulation with transcranial Doppler sonography - a source of systematic bias and strategies to avoid it. Journal of the Neurological Sciences 2009, 283:49-56.
52. Meel-van den Abeelen A.S.S., Simpson D.M., Wang L.J.Y., Zhang R., Tarumi T., Rickards C.A., et al. Between-centre variability in transfer function analysis, a widely used method for linear quantification of the dynamic pressure-flow relation: the CARNet study. Medical Engineering & Physics 2014, 36:620-627.
53. Ainslie P.N., Barach A., Murrell C., Hamlin M., Hellemans J., Ogoh S. Alterations in cerebral autoregulation and cerebral blood flow velocity during acute hypoxia: rest and exercise. American Journal of Physiology Heart and Circulatory Physiology 2007, 292:H976-H983.
54. Hilz M.J., Kolodny E.H., Brys M., Stemper B., Haendl T., Marthol H. Reduced cerebral blood flow velocity and impaired cerebral autoregulation in patients with Fabry disease. Journal of Neurology 2004, 251:564-570.
55. Ogoh S., Fisher J.P., Purkayastha S., Dawson E.A., Fadel P.J., White M.J., et al. Regulation of middle cerebral artery blood velocity during recovery from dynamic exercise in humans. Journal of Applied Physiology (Bethesda, MD: 1985) 2007, 102:713-721.
56. Ainslie P.N., Burgess K., Subedi P., Burgess K.R. Alterations in cerebral dynamics at high altitude following partial acclimatization in humans: wakefulness and sleep. Journal of Applied Physiology (Bethesda, MD: 1985) 2007, 102:658-664.
57. Immink R.V., van Montfrans G.A., Stam J., Karemaker J.M., Diamant M., van Lieshout J.J. Dynamic cerebral autoregulation in acute lacunar and middle cerebral artery territory ischemic stroke. Stroke: A Journal of Cerebral Circulation 2005, 36:2595-2600.
58. Ainslie P.N., Hamlin M., Hellemans J., Rasmussen P., Ogoh S. Cerebral hypoperfusion during hypoxic exercise following two different hypoxic exposures: independence from changes in dynamic autoregulation and reactivity. American Journal of Physiology Regulatory, Integrative and Comparative Physiology 2008, 295:R1613-R1622.
59. Iwasaki K., Levine B.D., Zhang R., Zuckerman J.H., Pawelczyk J.A., Diedrich A., et al. Human cerebral autoregulation before, during and after spaceflight. The Journal of Physiology 2007, 579:799-810.
60. Panerai R.B., Hudson V., Fan L., Mahony P., Yeoman P.M., Hope T., et al. Assessment of dynamic cerebral autoregulation based on spontaneous fluctuations in arterial blood pressure and intracranial pressure. Physiological Measurement 2002, 23:59-72.
61. Ainslie P.N., Lucas S.J., Fan J.L., Thomas K.N., Cotter J.D., Tzeng Y.C., et al. Influence of sympathoexcitation at high altitude on cerebrovascular function and ventilatory control in humans. Journal of Applied Physiology (Bethesda, MD: 1985) 2012, 113:1058-1067.
62. Iwasaki K., Ogawa Y., Aoki K., Yanagida R. Cerebral circulation during mild +Gz hypergravity by short-arm human centrifuge. Journal of Applied Physiology (Bethesda, MD: 1985) 2012, 112:266-271.
63. Panerai R.B., Kerins V., Fan L., Yeoman P.M., Hope T., Evans D.H. Association between dynamic cerebral autoregulation and mortality in severe head injury. British Journal of Neurosurgery 2004, 18:471-479.
64. Ainslie P.N., Ogoh S., Burgess K., Celi L., McGrattan K., Peebles K., et al. Differential effects of acute hypoxia and high altitude on cerebral blood flow velocity and dynamic cerebral autoregulation: alterations with hyperoxia. Journal of Applied Physiology (Bethesda, MD: 1985) 2008, 104:490-498.
65. Iwasaki K., Ogawa Y., Shibata S., Aoki K. Acute exposure to normobaric mild hypoxia alters dynamic relationships between blood pressure and cerebral blood flow at very low frequency. Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism 2007, 27:776-784.
66. Bailey D.M., Evans K.A., James P.E., McEneny J., Young I.S., Fall L., et al. Altered free radical metabolism in acute mountain sickness: implications for dynamic cerebral autoregulation and blood-brain barrier function. The Journal of Physiology 2009, 587:73-85.
67. Iwasaki K., Zhang R., Zuckerman J.H., Ogawa Y., Hansen L.H., Levine B.D. Impaired dynamic cerebral autoregulation at extreme high altitude even after acclimatization. Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism 2011, 31:283-292.
68. Bailey D.M., Jones D.W., Sinnott A., Brugniaux J.V., New K.J., Hodson D., et al. Impaired cerebral haemodynamic function associated with chronic traumatic brain injury in professional boxers. Clinical Science (London, England: 1979) 2012.
69. Jachan M., Reinhard M., Spindeler L., Hetzel A., Schelter B., Timmer J. Parametric versus nonparametric transfer function estimation of cerebral autoregulation from spontaneous blood-pressure oscillations. Cardiovascular Engineering (Dordrecht, Netherlands) 2009, 9:72-82.
70. Peng T., Rowley A.B., Ainslie P.N., Poulin M.J., Payne S.J. Multivariate system identification for cerebral autoregulation. Annals of Biomedical Engineering 2008, 36:308-320.
71. Bellapart J., Chan G.S., Tzeng Y.C., Ainslie P., Barnett A.G., Dunster K.R., et al. The effect of ventricular assist devices on cerebral autoregulation: a preliminary study. BMC Anesthesiology 2011, 11:4.
72. Jochum T., Reinhard M., Boettger M.K., Piater M., Bar K.J. Impaired cerebral autoregulation during acute alcohol withdrawal. Drug and Alcohol Dependence 2010, 110:240-246.
73. Peng T., Rowley A.B., Ainslie P.N., Poulin M.J., Payne S.J. Wavelet phase synchronization analysis of cerebral blood flow autoregulation. IEEE Transactions on Bio-Medical Engineering 2010, 57:960-968.
74. Kim Y.S., Immink R.V., Stok W.J., Karemaker J.M., Secher N.H., van Lieshout J.J. Dynamic cerebral autoregulatory capacity is affected early in Type 2 diabetes. Clinical Science (London, England: 1979) 2008, 115:255-262.
75. Porta C., Casucci G., Castoldi S., Rinaldi A., Bernardi L. Influence of respiratory instability during neurocardiogenic presyncope on cerebrovascular and cardiovascular dynamics. Heart 2008, 94:1433-1439.
76. Brassard P., Kim Y.S., van Lieshout J., Secher N.H., Rosenmeier J.B. Endotoxemia reduces cerebral perfusion but enhances dynamic cerebrovascular autoregulation at reduced arterial carbon dioxide tension. Critical Care Medicine 2012, 40:1873-1878.
77. Kim Y.S., Krogh-Madsen R., Rasmussen P., Plomgaard P., Ogoh S., Secher N.H., et al. Effects of hyperglycemia on the cerebrovascular response to rhythmic handgrip exercise. American Journal of Physiology Heart and Circulatory Physiology 2007, 293:H467-H473.
78. Purkayastha S., Saxena A., Eubank W.L., Hoxha B., Raven P.B. Alpha-1 adrenergic receptor control of the cerebral vasculature in humans at rest and during exercise. Experimental Physiology 2013, 98:451-461. 10.1113/expphysiol.2012.066118.
79. Brodie F.G., Panerai R.B., Foster S., Evans D.H., Robinson T.G. Long-term changes in dynamic cerebral autoregulation: a 10 years follow up study. Clinical Physiology and Functional Imaging 2009, 29:366-371.
80. Kim Y.S., Nur E., van Beers E.J., Truijen J., Davis S.C., Biemond B.J., et al. Dynamic cerebral autoregulation in homozygous Sickle cell disease. Stroke: A Journal of Cerebral Circulation 2009, 40:808-814.
81. Ramos E.G., Simpson D.M., Panerai R.B., Nadal J., Lopes J.M., Evans D.H. Objective selection of signals for assessment of cerebral blood flow autoregulation in neonates. Physiological Measurement 2006, 27:35-49.
82. Carrera E., Lee L.K., Giannopoulos S., Marshall R.S. Cerebrovascular reactivity and cerebral autoregulation in normal subjects. Journal of the Neurological Sciences 2009, 285:191-194.
83. Kuo T.B., Chern C.M., Sheng W.Y., Wong W.J., Hu H.H. Frequency domain analysis of cerebral blood flow velocity and its correlation with arterial blood pressure. Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism 1998, 18:311-318.
84. Reinhard M., Muller T., Guschlbauer B., Timmer J., Hetzel A. Dynamic cerebral autoregulation and collateral flow patterns in patients with severe carotid stenosis or occlusion. Ultrasound in Medicine & Biology 2003, 29:1105-1113.
85. Chen Z., Hu K., Stanley H.E., Novak V., Ivanov P. Cross-correlation of instantaneous phase increments in pressure-flow fluctuations: applications to cerebral autoregulation. Physical Review E: Statistical, Nonlinear, and Soft Matter Physics 2006, 73:031915.
86. Lind-Holst M., Cotter J.D., Helge J.W., Boushel R., Augustesen H., Van Lieshout J.J., et al. Cerebral autoregulation dynamics in endurance-trained individuals. Journal of Applied Physiology (Bethesda, MD: 1985) 2011, 110:1327-1333.
87. Claassen J.A., Diaz-Arrastia R., Martin-Cook K., Levine B.D., Zhang R. Altered cerebral hemodynamics in early Alzheimer disease: a pilot study using transcranial Doppler. Journal of Alzheimer's Disease 2009, 17:621-629.
88. Low D.A., Wingo J.E., Keller D.M., Davis S.L., Cui J., Zhang R., et al. Dynamic cerebral autoregulation during passive heat stress in humans. American Journal of Physiology Regulatory, Integrative and Comparative Physiology 2009, 296:R1598-R1605.
89. Reinhard M., Roth M., Guschlbauer B., Harloff A., Timmer J., Czosnyka M., et al. Dynamic cerebral autoregulation in acute ischemic stroke assessed from spontaneous blood pressure fluctuations. Stroke: A Journal of Cerebral Circulation 2005, 36:1684-1689.
90. Cooke W.H., Carter J.R., Kuusela T.A. Human cerebrovascular and autonomic rhythms during vestibular activation. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2004, 286:R838-R843.
91. Marmarelis V., Shin D., Zhang R. Linear and nonlinear modeling of cerebral flow autoregulation using principal dynamic modes. Open Biomedical Engineering Journal 2012, 6:42-55.
92. Cooke W.H., Lurie K.G., Rohrer M.J., Convertino V.A. Human autonomic and cerebrovascular responses to inspiratory impedance. The Journal of Trauma 2006, 60:1275-1283.
93. Marthol H., Werner D., Brown C.M., Hecht M., Daniel W.G., Hilz M.J. Enhanced external counterpulsation does not compromise cerebral autoregulation. Acta Neurologica Scandinavica 2005, 111:34-41.
94. Cooke W.H., Pellegrini G.L., Kovalenko O.A. Dynamic cerebral autoregulation is preserved during acute head-down tilt. Journal of Applied Physiology 2003, 95:1439-1445.
95. Marthol H., Zikeli U., Brown C.M., Tutaj M., Hilz M.J. Cardiovascular and cerebrovascular responses to lower body negative pressure in type 2 diabetic patients. Journal of the Neurological Sciences 2007, 252:99-105.
96. Reinhard M., Wehrle-Wieland E., Roth M., Niesen W.D., Timmer J., Weiller C., et al. Preserved dynamic cerebral autoregulation in the middle cerebral artery among persons with migraine. Experimental Brain Research. Experimentelle Hirnforschung. Experimentation Cerebrale 2007, 180:517-523.
97. Muller M., Bianchi O., Erulku S., Stock C., Schwerdtfeger K., Homburg Traumatic Brain Injury G. Changes in linear dynamics of cerebrovascular system after severe traumatic brain injury. Stroke: A Journal of Cerebral Circulation 2003, 34:1197-1202.
98. Sakagami J., Ono T., Hasegawa Y., Hori K., Zhang M., Maeda Y. Transfer function analysis of cerebral autoregulation dynamics during jaw movements. Journal of Dental Research 2011, 90:71-76.
99. Deegan B.M., Sorond F.A., Galica A., Lipsitz L.A., O'Laighin G., Serrador J.M. Elderly women regulate brain blood flow better than men do. Stroke: A Journal of Cerebral Circulation 2011, 42:1988-1993.
100. Sammons E.L., Samani N.J., Smith S.M., Rathbone W.E., Bentley S., Potter J.F., et al. Influence of noninvasive peripheral arterial blood pressure measurements on assessment of dynamic cerebral autoregulation. Journal of Applied Physiology (Bethesda, MD: 1985). 2007, 103:369-375.
101. Dutsch M., Devinsky O., Doyle W., Marthol H., Hilz M.J. Cerebral autoregulation improves in epilepsy patients after temporal lobe surgery. Journal of Neurology 2004, 251:1190-1197.
102. Muller M., Marziniak M. The linear behavior of the system middle cerebral artery flow velocity and blood pressure in patients with migraine: lack of autonomic control?. Stroke: A Journal of Cerebral Circulation 2005, 36:1886-1890.
103. Serrador J.M., Sorond F.A., Vyas M., Gagnon M., Iloputaife I.D., Lipsitz L.A. Cerebral pressure-flow relations in hypertensive elderly humans: transfer gain in different frequency domains. Journal of Applied Physiology (Bethesda, MD: 1985) 2005, 98:151-159.
104. Eames P.J., Potter J.F., Panerai R.B. Influence of controlled breathing patterns on cerebrovascular autoregulation and cardiac baroreceptor sensitivity. Clinical Science (London, England: 1979) 2004, 106:155-162.
105. Murrell C., Wilson L., Cotter J.D., Lucas S., Ogoh S., George K., et al. Alterations in autonomic function and cerebral hemodynamics to orthostatic challenge following a mountain marathon. Journal of Applied Physiology (Bethesda, MD: 1985) 2007, 103:88-96.
106. Subudhi A.W., Dimmen A.C., Julian C.G., Wilson M.J., Panerai R.B., Roach R.C. Effects of acetazolamide and dexamethasone on cerebral hemodynamics in hypoxia. Journal of Applied Physiology (Bethesda, MD: 1985) 2011, 110:1219-1225.
107. Eames P.J., Potter J.F., Panerai R.B. Assessment of cerebral autoregulation from ectopic heartbeats. Clinical Science (London, England: 1979) 2005, 109:109-115.
108. Nakagawa K., Serrador J.M., LaRose S.L., Moslehi F., Lipsitz L.A., Sorond F.A. Autoregulation in the posterior circulation is altered by the metabolic state of the visual cortex. Stroke: A Journal of Cerebral Circulation 2009, 40:2062-2067.
109. Subudhi A.W., Panerai R.B., Roach R.C. Acute hypoxia impairs dynamic cerebral autoregulation: results from two independent techniques. Journal of Applied Physiology (Bethesda, MD: 1985) 2009, 107:1165-1171.
110. Subudhi A.W., Panerai R.B., Roach R.C. Effects of hypobaric hypoxia on cerebral autoregulation. Stroke: A Journal of Cerebral Circulation 2010, 41:641-646.
111. Narayanan K., Collins J.J., Hamner J., Mukai S., Lipsitz L.A. Predicting cerebral blood flow response to orthostatic stress from resting dynamics: effects of healthy aging. American Journal of Physiology Regulatory, Integrative and Comparative Physiology 2001, 281:R716-R722.
112. Ter Laan M., van Dijk J.M.C., Staal M.J., Elting J.W.J. Electrical modulation of the sympathetic nervous system in order to augment cerebral blood flow: a protocol for an experimental study. BMJ Open 2011, 2011.
113. Formes K., Zhang P., Tierney N., Schaller F., Shi X. Chronic physical activity mitigates cerebral hypoperfusion during central hypovolemia in elderly humans. American Journal of Physiology Heart and Circulatory Physiology 2010, 298:H1029-H1037.
114. 2 hypoxia. Journal of Applied Physiology (Bethesda, MD: 1985) 2010, 108:1154-1161.
115. Tzeng Y.C., Ainslie P.N., Cooke W.H., Peebles K.C., Willie C.K., Macrae B.A., et al. Assessment of cerebral autoregulation: the quandary of quantification. American Journal of Physiology Heart and Circulatory Physiology 2012, 303:H658-H671.
116. Nishimura N., Iwasaki K., Ogawa Y., Shibata S. Oxygen administration, cerebral blood flow velocity, and dynamic cerebral autoregulation. Aviation, Space, and Environmental Medicine 2007, 78:1121-1127.
117. Tzeng Y.C., Lucas S.J., Atkinson G., Willie C.K., Ainslie P.N. Fundamental relationships between arterial baroreflex sensitivity and dynamic cerebral autoregulation in humans. Journal of Applied Physiology (Bethesda, MD: 1985) 2010, 108:1162-1168.
118. Fu C.H., Yang C.C.H., Kuo T.B.J. Effects of different classes of antihypertensive drugs on cerebral hemodynamics in elderly hypertensive patients. American Journal of Hypertension 2005, 18:1621-1625.
119. Ocon A.J., Medow M.S., Taneja I., Clarke D., Stewart J.M. Decreased upright cerebral blood flow and cerebral autoregulation in normocapnic postural tachycardia syndrome. American Journal of Physiology Heart and Circulatory Physiology 2009, 297:H664-H673.
120. Ogawa Y., Iwasaki K., Aoki K., Gokan D., Hirose N., Kato J., et al. The different effects of midazolam and propofol sedation on dynamic cerebral autoregulation. Anesthesia and Analgesia 2010, 111:1279-1284.
121. Wang X., Krishnamurthy S., Evans J., Bhakta D., Justice L., Bruce E., et al. Transfer function analysis of gender-related differences in cerebral autoregulation. Biomedical Sciences Instrumentation 2005, 41:48-53.
122. Ogawa Y., Iwasaki K., Aoki K., Kojima W., Kato J., Ogawa S. Dexmedetomidine weakens dynamic cerebral autoregulation as assessed by transfer function analysis and the thigh cuff method. Anesthesiology 2008, 109:642-650.
123. Wilson L.C., Cotter J.D., Fan J.L., Lucas R.A., Thomas K.N., Ainslie P.N. Cerebrovascular reactivity and dynamic autoregulation in tetraplegia. American Journal of Physiology Regulatory, Integrative and Comparative Physiology 2010, 298:R1035-R1042.
124. Gisolf J., Stok W.J., Oei S.I., Immink R.V., vanLieshout J.J., Karemaker J.M. Dynamic cerebral autoregulation under sinusoidal gravitational loading. Journal of Gravitational Physiology: A Journal of the International Society for Gravitational Physiology 2002, 9:P85-P86.
125. Ogawa Y., Iwasaki K., Aoki K., Saitoh T., Kato J., Ogawa S. Dynamic cerebral autoregulation after mild dehydration to simulate microgravity effects. Aviation, Space, and Environmental Medicine 2009, 80:443-447.
126. Zhang R., Behbehani K., Levine B.D. Dynamic pressure-flow relationship of the cerebral circulation during acute increase in arterial pressure. The Journal of Physiology 2009, 587:2567-2577.
127. Gommer E.D., Martens E.G., Aalten P., Shijaku E., Verhey F.R., Mess W.H., et al. Dynamic cerebral autoregulation in subjects with Alzheimer's disease, mild cognitive impairment, and controls: evidence for increased peripheral vascular resistance with possible predictive value. Journal of Alzheimer's Disease 2012, 30:805-813.
128. Ogawa Y., Iwasaki K., Aoki K., Shibata S., Kato J., Ogawa S. Central hypervolemia with hemodilution impairs dynamic cerebral autoregulation. Anesthesia and Analgesia 2007, 105:1389-1396. table of contents.
129. Zhang R., Wilson T.E., Witkowski S., Cui J., Crandall G.G., Levine B.D. Inhibition of nitric oxide synthase does not alter dynamic cerebral autoregulation in humans. American Journal of Physiology Heart and Circulatory Physiology 2004, 286:H863-H869.
130. Ogawa Y., Iwasaki K., Shibata S., Kato J., Ogawa S., Oi Y. The effect of sevoflurane on dynamic cerebral blood flow autoregulation assessed by spectral and transfer function analysis. Anesthesia and Analgesia 2006, 102:552-559.
131. Zhang R., Witkowski S., Fu Q., Claassen J.A., Levine B.D. Cerebral hemodynamics after short- and long-term reduction in blood pressure in mild and moderate hypertension. Hypertension 2007, 49:1149-1155.
132. Gommer E.D., Staals J., van Oostenbrugge R.J., Lodder J., Mess W.H., Reulen J.P. Dynamic cerebral autoregulation and cerebrovascular reactivity: a comparative study in lacunar infarct patients. Physiological Measurement 2008, 29:1293-1303.
133. Ogoh S., Brothers R.M., Barnes Q., Eubank W.L., Hawkins M.N., Purkayastha S., et al. The effect of changes in cardiac output on middle cerebral artery mean blood velocity at rest and during exercise. The Journal of Physiology 2005, 569:697-704.
134. Hamner J.W., Cohen M.A., Mukai S., Lipsitz L.A., Taylor J.A. Spectral indices of human cerebral blood flow control: responses to augmented blood pressure oscillations. The Journal of Physiology 2004, 559:965-973.
135. Ogoh S., Dalsgaard M.K., Secher N.H., Raven P.B. Dynamic blood pressure control and middle cerebral artery mean blood velocity variability at rest and during exercise in humans. Acta Physiologica 2007, 191:3-14.
136. Zhang R., Zuckerman J.H., Iwasaki K., Wilson T.E., Crandall C.G., Levine B.D. Autonomic neural control of dynamic cerebral autoregulation in humans. Circulation 2002, 106:1814-1820.
137. Haubrich C., Pies K., Dafotakis M., Block F., Kloetzsch C., Diehl R.R. Transcranial Doppler monitoring in Parkinson's disease: cerebrovascular compensation of orthostatic hypotension. Ultrasound in Medicine and Biology 2010, 36:1581-1587.
138. Ogoh S., Dalsgaard M.K., Yoshiga C.C., Dawson E.A., Keller D.M., Raven P.B., et al. Dynamic cerebral autoregulation during exhaustive exercise in humans. American Journal of Physiology Heart and Circulatory Physiology 2005, 288:H1461-H1467.
139. Haubrich C., Wendt A., Diehl R.R., Klotzsch C. Dynamic autoregulation testing in the posterior cerebral artery. Stroke: A Journal of Cerebral Circulation 2004, 35:848-852.
140. Ogoh S., Fadel P.J., Zhang R., Selmer C., Jans O., Secher N.H., et al. Middle cerebral artery flow velocity and pulse pressure during dynamic exercise in humans. American Journal of Physiology Heart and Circulatory Physiology 2005, 288:H1526-H1531.