Human cerebral autoregulation before, during and after spaceflight

Journal of Physiology

Volumn 579, Issue 3, 2007, Pages 799-810

  Iwasaki, Ken Ichi ^a,b   Levine, Benjamin D ^a   Zhang, Rong ^a   Zuckerman, Julie H ^a   Pawelczyk, James A ^c   Diedrich, André ^d   Ertl, Andrew C ^d   Cox, James F ^e   Cooke, William H ^f   Giller, Cole A ^g   Ray, Chester A ^c   Lane, Lynda D ^d   Buckey Jr , Jay C ^h   Baisch, Friedhelm J ⁱ   Eckberg, Dwain L ^e   Robertson, David ^d   Biaggioni, Italo ^d   Blomqvist, C Gunnar ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b NIHON UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c PENN STATE COLLEGE OF MEDICINE   (United States)

^d VANDERBILT UNIVERSITY   (United States)

^e VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF TEXAS AT SAN ANTONIO   (United States)

^g BAYLOR UNIVERSITY MEDICAL CENTER   (United States)

^h DARTMOUTH HITCHCOCK MEDICAL CENTER   (United States)

ⁱ GERMAN AEROSPACE CENTER DLR   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ANALYSIS OF VARIANCE; ARTICLE; AUTOREGULATION; BLOOD FLOW VELOCITY; BRAIN BLOOD FLOW; DOPPLER ECHOGRAPHY; HUMAN; HUMAN EXPERIMENT; MALE; MEAN ARTERIAL PRESSURE; MICROGRAVITY; MIDDLE CEREBRAL ARTERY; NORMAL HUMAN; ORTHOSTATIC HYPOTENSION; ORTHOSTATIC STRESS; PHOTOELECTRIC PLETHYSMOGRAPHY; PRIORITY JOURNAL; SPACE FLIGHT; STANDING; STATISTICAL SIGNIFICANCE; TILTING; WEIGHTLESSNESS; BRAIN FUNCTION; BREATHING; CEREBRAL AUTOREGULATION; COSMONAUT;

ADAPTATION, PHYSIOLOGICAL; ADULT; ASTRONAUTS; BLOOD FLOW VELOCITY; BLOOD PRESSURE; BRAIN; CEREBROVASCULAR CIRCULATION; HOMEOSTASIS; HUMANS; HYPOTENSION, ORTHOSTATIC; MALE; SPACE FLIGHT; STRESS; WEIGHTLESSNESS;

EID: 33947102068     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2006.119636     Document Type: Article

References (56)

1. Åaslid R, Markwalder TM & Nornes H (1982). Noninvasive transcranial Doppler ultrasound recording of flow velocity in basal cerebral arteries. J Neurosurg 57, 769-774.
2. Alfrey CP, Udden MM, Leach-Huntoon C, Driscoll T & Pickett MH (1996). Control of red blood cell mass in spaceflight. J Appl Physiol 81, 98-104.
3. Arbeille P, Fomina G, Roumy J, Alferova I, Tobal N & Herault S (2001). Adaptation of the left heart, cerebral and femoral arteries, and jugular and femoral veins during short- and long-term head-down tilt and spaceflights. Eur J Appl Physiol 86, 157-168.
4. Bagian JP & Hackett P (1991). Cerebral blood flow: Comparison of ground-based and spaceflight data and correlation with space adaptation syndrome. J Clin Pharmacol 31, 1036-1040.
5. Blaber AP, Bondar RL, Stein F, Dunphy PT, Moradshahi P et al. (1997). Transfer function analysis of cerebral autoregulation dynamics in autonomic failure patients. Stroke 28, 1686-1692.
6. Blomqvist CG & Stone HL (1983). Cardiovascular adjustments to gravitational stress. In Handbook of Physiology, section 2, The Cardiovascular System, vol. III, Peripheral Circulation and Organ Blood Flow, ed. Shepherd JT & Abboud FM, pp. 1025-1063. American Physiological Society, Bethesda, MD, USA.
7. Bondar RL, Kassam MS, Stein F, Dunphy PT, Fortney S & Riedesel ML (1995). Simultaneous cerebrovascular and cardiovascular responses during presyncope. Stroke 26, 1794-1800.
8. Buckey JC, Lane LD, Levine BD, Watenpaugh DE, Wright SJ, Moore WE et al. (1996). Orthostatic intolerance after spaceflight. J Appl Physiol 81, 7-18.
9. Bungo MW, Charles JB & Johnson PC Jr (1985). Cardiovascular deconditioning during space flight and the use of saline as a countermeasure to orthostatic intolerance. Aviat Space Environ Med 56, 985-990.
10. Carey BJ, Manktelow BN, Panerai RB & Potter JF (2001). Cerebral autoregulatory responses to head-up tilt in normal subjects and patients with recurrent vasovagal syncope. Circulation 104, 898-902.
11. Cox JF, Tahvanainen KU, Kuusela TA, Levine BD, Cooke WH, Mano T et al. (2002). Influence of microgravity on astronauts' sympathetic and vagal responses to Valsalva's manoeuvre. J Physiol 538, 309-320.
12. Ertl AC, Diedrich A, Biaggioni I, Levine BD, Robertson RM, Cox JF et al. (2002). Human muscle sympathetic nerve activity and plasma noradrenaline kinetics in space. J Physiol 538, 321-329.
13. Foldager N & Blomqvist CG (1991). Repeated plasma volume determination with the Evans Blue dye dilution technique: The method and a computer program. Comput Biol Med 21, 35-41.
14. Fritsch-Yelle JM, Charles JB, Jones MM, Beightol LA & Eckberg DL (1994). Spaceflight alters autonomic regulation of arterial pressure in humans. J Appl Physiol 77, 1776-1783.
15. Fritsch-Yelle JM, Whitson PA, Bondar RL & Brown TE (1996). Subnormal norepinephrine release relates to presyncope in astronauts after spaceflight. J Appl Physiol 81, 2134-2141.
16. Fu Q, Levine BD, Pawelczyk JA, Ertl AC, Diedrich A, Cox JF et al. (2002). Cardiovascular and sympathetic neural responses to handgrip and cold pressor stimuli in humans before, during and after spaceflight. J Physiol 544, 653-664.
17. Giller CA (1990). The frequency-dependent behavior of cerebral autoregulation. Neurosurgery 27, 363-368.
18. Giller CA, Bowman G, Dyer H, Mootz L & Krippner W (1993). Cerebral arterial diameters during changes in blood pressure and carbon dioxide during craniotomy. Neurosurgery 32, 737-742.
19. Giller CA & Giller AM (1997). A new method for fixation of probes for transcranial Doppler ultrasound. J Neuroimaging 7, 103-115.
20. Herault S, Fomina G, Alferova I, Kotovskaya A, Poliakov V & Arbeille P (2000). Cardiac, arterial and venous adaptation to weightlessness during 6-month MIR spaceflights with and without thigh cuffs (bracelets). Eur J Appl Physiol 81, 384-390.
21. Hoffler GW, Wolthuis RA & Johnson PL (1974). Apollo space crew cardiovascular evaluations. Aerospace Med 45, 807-820.
22. Hopkins WG (2000). Reliability from consecutive pairs of trials. In A New View of Statistics. sportsci.org: Internet Society for Sport Science, http://sportsci.org/resource/stats/xrely.xls
23. Huber P & Handa J (1967). Effect of contrast material, hypercapnia, hyperventilation, hypertonic glucose and papaverine on the diameter of the cerebral arteries. Angiographic determination in man. Invest Radiol 2, 17-32.
24. Iwasaki K, Zhang R, Perhonen MA, Zuckerman JH & Levine BD (2004). Reduced baroreflex control of heart period after bed rest is normalized by acute plasma volume restoration. Am J Physiol Regul Integr Comp Physiol 287, R1256-R1262.
25. Iwasaki K, Zhang R, Zuckerman JH, Pawelczyk JA & Levine BD (2000). Effect of head-down-tilt bed rest and hypovolemia on dynamic regulation of heart rate and blood pressure. Am J Physiol Regul Integr Comp Physiol 279, R2189-R2199.
26. Jacob G, Atkinson D, Jordan J, Shannon JR, Furlan R et al. (1999). Effects of standing on cerebrovascular resistance in patients with idiopathic orthostatic intolerance. Am J Med 106, 59-64.
27. Kamiya A, Iwase S, Michikami D, Fu Q, Mano T et al. (2000). Increased vasomotor sympathetic nerve activity and decreased plasma nitric oxide release after head-down bed rest in humans: Disappearance of correlation between vasoconstrictor and vasodilator. Neurosci Lett 281, 21-24.
28. Larsen FS, Olsen KS, Hansen BA, Paulson OB & Knudsen GM (1994). Transcranial Doppler is valid for determination of the lower limit of cerebral blood flow autoregulation. Stroke 25, 1985-1988.
29. Levine BD, Giller CA, Lane LD, Buckey JC & Blomqvist CG (1994). Cerebral versus systemic hemodynamics during graded orthostatic stress in humans. Circulation 90, 298-306.
30. Levine BD, Pawelczyk JA, Ertl AC, Cox JF, Zuckerman JH, Diedrich A et al. (2002). Human muscle sympathetic neural and haemodynamic responses to tilt following spaceflight. J Physiol 538, 331-340.
31. Levine BD, Zuckerman JH & Pawelczyk JA (1997). Cardiac atrophy after bed-rest deconditioning: A nonneural mechanism for orthostatic intolerance. Circulation 96, 517-525.
32. Lipsitz LA, Mukai S, Hamner J, Gagnon M & Babikian V (2000). Dynamic regulation of middle cerebral artery blood flow velocity in aging and hypertension. Stroke 31, 1897-1903.
33. Newell DW, Åaslid R, Lam A, Mayberg TS & Winn HR (1994). Comparison of flow and velocity during dynamic autoregulation testing in humans. Stroke 25, 793-797.
34. Novak V, Novak P, Spies JM & Low PA (1998). Autoregulation of cerebral blood flow in orthostatic hypotension. Stroke 29, 104-111.
35. Ogawa Y, Iwasaki K, Shibata S, Kato J, Ogawa S & Oi Y (2006). The effect of sevoflurane on dynamic cerebral blood flow autoregulation assessed by spectral and transfer function analysis. Anesth Analg 102, 552-559.
36. Ogoh S, Dalsgaard MK, Yoshiga CC, Dawson EA, Keller DM et al. (2005). Dynamic cerebral autoregulation during exhaustive exercise in humans. Am J Physiol Heart Circ Physiol 288, H1461-H1467.
37. Panerai RB, Dawson SL & Potter JF (1999). Linear and nonlinear analysis of human dynamic cerebral autoregulation. Am J Physiol Heart Circ Physiol 277, H1089-H1099.
38. Paulson OB, Strandgaard S & Edvinsson L (1990). Cerebral autoregulation. Cerebrovasc Brain Metab Rev 2, 161-192.
39. Pavy-Le Traon A, Costes-Salon MC, Vasseur-Clausen P, Bareille MP, Maillet A & Parant M (2002). Changes in kinetics of cerebral auto-regulation with head-down bed rest. Clin Physiol Func Im 22, 108-114.
40. Pavy-Le Traon A, Vasseur P, Arbeille P, Guell A, Bes A & Gharib C (1995). Effects of 28-day head-down tilt with and without countermeasures on lower body negative pressure responses. Aviat Space Environ Med 66, 982-991.
41. Pawelczyk JA, Zuckerman JH, Blomqvist CG & Levine BD (2001). Regulation of muscle sympathetic nerve activity after bed rest deconditioning. Am J Physiol Heart Circ Physiol 280, H2230-H2239.
42. Rucker J, Tester J, Fedorko L, Takeuchi A, Mascia L, Vesely A et al. (2002). Normocapnia improves cerebral oxygen delivery during conventional oxygen therapy in carbon monoxide-exposed research subjects. Ann Emerg Med 40, 611-618.
43. Schondorf R, Benoit J & Wein T (1997). Cerebrovascular and cardiovascular measurements during neurally mediated syncope induced by head-up tilt. Stroke 28, 1564-1568.
44. Serrador JM, Picot PA, Rutt BK, Shoemaker JK & Bondar RL (2000 a). MRI measures of middle cerebral artery diameter in conscious humans during simulated orthostasis. Stroke 31, 1672-1678.
45. Serrador JM, Shoemaker JK, Brown TE, Kassam MS, Bondar RL & Schlegel TT (2000 b). Cerebral vasoconstriction precedes orthostatic intolerance after parabolic flight. Brain Res Bull 53, 113-120.
46. Shortt TL & Ray CA (1997). Sympathetic and vascular responses to head-down neck flexion in humans. Am J Physiol Heart Circ Physiol 272, H1780-H1784.
47. Töyry JP, Kuikka JT & Lansimies EA (1997). Regional cerebral perfusion in cardiovascular reflex syncope. Eur J Nucl Med 24, 215-218.
48. Triebwasser JH, Johnson RL Jr, Burpo RP, Campbell JC, Reardon WC & Blomqvist CG (1977). Noninvasive determination of cardiac output by a modified acetylene rebreathing procedure utilizing mass spectrometer measurements. Aviat Space Environ Med 48, 203-209.
49. Watenpaugh DE & Hargens AR (1996). The cardiovascular system in microgravity. In Handbook of Physiology, section 4, Environmental Physiology, ed. Fregly MJ & Blatteis CM, pp. 631-674. American Physiological Society, Bethesda, MD, USA.
50. Wilkerson MK, Muller-Delp J, Colleran PN & Delp MD (1999). Effects of hindlimb unloading on rat cerebral, splenic, and mesenteric resistance artery morphology. J Appl Physiol 87, 2115-2121.
51. Young LR, Mendoza JC, Groleau N & Wojcik PW (1996). Tactile influences on astronaut visual spatial orientation: Human neurovestibular studies on SLS-2. J Appl Physiol 81, 44-49.
52. Zhang R, Zuckerman JH, Giller CA & Levine BD (1998 a). Transfer function analysis of dynamic cerebral autoregulation in humans. Am J Physiol Heart Circ Physiol 274, H233-H241.
53. Zhang R, Zuckerman JH, Iwasaki K, Wilson TE, Crandall CG & Levine BD (2002). Autonomic neural control of dynamic cerebral autoregulation in humans. Circulation 106, 1814-1820.
54. Zhang R, Zuckerman JH & Levine BD (1998 b). Deterioration of cerebral autoregulation during orthostatic stress: Insights from the frequency domain. J Appl Physiol 85, 1113-1122.
55. Zhang R, Zuckerman JH & Levine BD (2000). Spontaneous fluctuations in cerebral blood flow: Insights from extended-duration recordings in humans. Am J Physiol Heart Circ Physiol 278, H1848-H1855.
56. Zhang R, Zuckerman JH, Pawelczyk JA & Levine BD (1997). Effects of head-down-tilt bed rest on cerebral hemodynamics during orthostatic stress. J Appl Physiol 83, 2139-2145.