Conversion of channelrhodopsin into a light-gated chloride channel

Science

Volumn 344, Issue 6182, 2014, Pages 409-412

  Wietek, Jonas ^a   Wiegert, J Simon ^b   Adeishvili, Nona ^a   Schneider, Franziska ^a   Watanabe, Hiroshi ^c   Tsunoda, Satoshi P ^a   Vogt, Arend ^a   Elstner, Marcus ^c   Oertner, Thomas G ^b   Hegemann, Peter ^a  

^a HUMBOLDT UNIVERSITY   (Germany)

^b UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^c KARLSRUHE INSTITUTE OF TECHNOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ANION CHANNEL; CHANNELRHODOPSIN; CHLORIDE CHANNEL; GLASS FIBER; GUANIDINE; ION CHANNEL; RHODOPSIN; UNCLASSIFIED DRUG; CHLORIDE; HYBRID PROTEIN;

ANION; BRAIN; CATION; CHLORIDE; GENE EXPRESSION; INHIBITION; NEUROLOGY; PROTEIN;

ACTION POTENTIAL; ARTICLE; BINDING SITE; CELLULAR DISTRIBUTION; CHROMATOPHORE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; HUMAN; HUMAN CELL; HYDROGEN BOND; HYPERPOLARIZATION; LIGHT INTENSITY; MOLECULAR DYNAMICS; OPTOGENETICS; PHOTOACTIVATION; PRIORITY JOURNAL; PROTEIN STABILITY; PROTON TRANSPORT; PYRAMIDAL NERVE CELL; STATIC ELECTRICITY; WATER SUPPLY; ANIMAL; CHANNEL GATING; CHEMICAL STRUCTURE; CHEMISTRY; CYTOLOGY; GENETIC TRANSFECTION; GENETICS; HEK293 CELL LINE; HIPPOCAMPAL CA1 REGION; LIGHT; METABOLISM; MUTATION; PATCH CLAMP TECHNIQUE; PROTEIN CONFORMATION; PROTEIN ENGINEERING; RAT;

ACTION POTENTIALS; ANIMALS; BINDING SITES; CA1 REGION, HIPPOCAMPAL; CHLORIDE CHANNELS; CHLORIDES; HEK293 CELLS; HUMANS; HYDROGEN BONDING; ION CHANNEL GATING; LIGHT; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MUTATION; PATCH-CLAMP TECHNIQUES; PROTEIN CONFORMATION; PROTEIN ENGINEERING; PYRAMIDAL CELLS; RATS; RECOMBINANT FUSION PROTEINS; RHODOPSIN; TRANSFECTION;

EID: 84899629429     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1249375     Document Type: Article

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