In channelrhodopsin-2 Glu-90 is crucial for ion selectivity and is deprotonated during the photocycle

Journal of Biological Chemistry

Volumn 287, Issue 9, 2012, Pages 6904-6911

  Eisenhauer, Kirstin ^a   Kuhne, Jens ^a   Ritter, Eglof ^b   Berndt, André ^c   Wolf, Steffen ^d   Freier, Erik ^a   Bartl, Franz ^b   Hegemann, Peter ^c   Gerwert, Klaus ^a,d  

^a RUHR UNIVERSITY BOCHUM   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c HUMBOLDT UNIVERSITY   (Germany)

^d MAX PLANCK INSTITUTE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELLULAR PROCESS; CHANNEL PROPERTY; HOMOLOGY MODELING; ION CHANNEL; ION SELECTIVITY; MOLECULAR REACTIONS; PHOTOCYCLES; SPATIO-TEMPORAL RESOLUTION; TIME-RESOLVED FT-IR; VOLTAGE CLAMP;

EXPERIMENTS; FOURIER TRANSFORM INFRARED SPECTROSCOPY;

IONS;

CHANNELRHODOPSIN 2; GLUTAMIC ACID; GLUTAMIC ACID 90; ION CHANNEL; MONOMER; RHODOPSIN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; GENE MUTATION; INFRARED SPECTROSCOPY; ION SELECTIVE ELECTRODE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTON TRANSPORT; VOLTAGE CLAMP;

ANIMALS; CARRIER PROTEINS; CERCOPITHECUS AETHIOPS; CHLAMYDOMONAS REINHARDTII; COMPUTER SIMULATION; COS CELLS; GLUTAMIC ACID; LASERS; LIGHT; MODELS, CHEMICAL; MUTAGENESIS, SITE-DIRECTED; OOCYTES; PATCH-CLAMP TECHNIQUES; PROTEIN STRUCTURE, TERTIARY; PROTONS; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; WATER; XENOPUS;

EID: 84857478497     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.327700     Document Type: Article

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