MicroRNA-93 inhibits inflammatory cytokine production in LPS-stimulated murine macrophages by targeting IRAK4

FEBS Letters

Volumn 588, Issue 9, 2014, Pages 1692-1698

  Xu, Yan ^a,b   Jin, Huiyi ^a,b   Yang, Xiaolu ^a,b   Wang, Lili ^a,b   Su, Li ^a,b   Liu, Kun ^a,b   Gu, Qing ^a,b   Xu, Xun ^a,b  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b Shanghai Key Laboratory of Fundus Disease   (China)

Author keywords

IRAK4; LPS; MicroRNA 93

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 4; INTERLEUKIN 1BETA; INTERLEUKIN 6; MICRORNA; MICRORNA 93; MONOCYTE CHEMOTACTIC PROTEIN 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING SITE; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE ACTIVITY; DOWN REGULATION; ENDOTOXIN-INDUCED UVEITIS; GENE EXPRESSION; GENE FUNCTION; GENE IDENTIFICATION; GENE LOCATION; IMMUNE RESPONSE; MACROPHAGE; MALE; MOLECULAR DYNAMICS; MOLECULAR PATHOLOGY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN RNA BINDING; PROTEIN TARGETING; SIGNAL TRANSDUCTION;

ANIMALIA; MURINAE; RATTUS;

IRAK4; LPS; MICRORNA-93;

3' UNTRANSLATED REGIONS; ANIMALS; BASE SEQUENCE; BINDING SITES; CYTOKINES; DOWN-REGULATION; EYE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEK293 CELLS; HUMANS; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES; LIPOPOLYSACCHARIDES; MACROPHAGES; MALE; MICE; MICRORNAS; NF-KAPPA B; RATS; RATS, WISTAR; RNA INTERFERENCE; SIGNAL TRANSDUCTION; UVEITIS;

EID: 84899627188     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2014.03.013     Document Type: Article

References (25)

1. J.T. Rosenbaum, H.O. McDevitt, R.B. Guss, and P.R. Egbert Endotoxin-induced uveitis in rats as a model for human disease Nature 286 1980 611 613
2. R. Hoekzema, C. Verhagen, M. van Haren, and A. Kijlstra Endotoxin-induced uveitis in the rat. The significance of intraocular interleukin-6 Invest. Ophthalmol. Vis. Sci. 33 1992 532 539
3. N. Nagai et al. Suppression of ocular inflammation in endotoxin-induced uveitis by blocking the angiotensin II type 1 receptor Invest. Ophthalmol. Vis. Sci. 46 2005 2925 2931
4. Q. Li, and I.M. Verma NF-kappaB regulation in the immune system Nat. Rev. Immunol. 2 2002 725 734
5. T. Kawai, and S. Akira TLR signaling Semin. Immunol. 19 2007 24 32
6. M. Koziczak-Holbro, A. Gluck, C. Tschopp, J.C. Mathison, and H. Gram IRAK-4 kinase activity-dependent and -independent regulation of lipopolysaccharide-inducible genes Eur. J. Immunol. 38 2008 788 796
7. D.P. Bartel MicroRNAs: genomics, biogenesis, mechanism, and function Cell 116 2004 281 297
8. M.A. Valencia-Sanchez, J. Liu, G.J. Hannon, and R. Parker Control of translation and mRNA degradation by miRNAs and siRNAs Genes Dev. 20 2006 515 524
9. P.D. Zamore, and B. Haley Ribo-gnome: the big world of small RNAs Science 309 2005 1519 1524
10. Q. Zhou, X. Xiao, C. Wang, X. Zhang, F. Li, Y. Zhou, A. Kijlstra, and P. Yang Decreased microRNA-155 expression in ocular Behcet's disease but not in Vogt Koyanagi Harada syndrome Invest. Ophthalmol. Vis. Sci. 53 2012 5665 5674
11. M. Shi et al. TRIM30 alpha negatively regulates TLR-mediated NF-kappa B activation by targeting TAB2 and TAB3 for degradation Nat. Immunol. 9 2008 369 377
12. J. Cui et al. NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways Cell 141 2010 483 496
13. D. Betel, A. Koppal, P. Agius, C. Sander, and C. Leslie Comprehensive modeling of microRNA targets predicts functional non-conserved and non-canonical sites Genome Biol. 11 2010 R90
14. Q.Q. Wang, H. Li, T. Oliver, M. Glogauer, J. Guo, and Y.W. He Integrin beta 1 regulates phagosome maturation in macrophages through Rac expression J. Immunol. 180 2008 2419 2428
15. S.K. Biswas, and E. Lopez-Collazo Endotoxin tolerance: new mechanisms, molecules and clinical significance Trends Immunol. 30 2009 475 487
16. M.A. Nahid, M. Satoh, and E.K. Chan MicroRNA in TLR signaling and endotoxin tolerance Cell. Mol. Immunol. 8 2011 388 403
17. L.A. O'Neill, F.J. Sheedy, and C.E. McCoy MicroRNAs: the fine-tuners of Toll-like receptor signalling Nat. Rev. Immunol. 11 2011 163 175
18. K.D. Taganov, M.P. Boldin, and D. Baltimore MicroRNAs and immunity: tiny players in a big field Immunity 26 2007 133 137
19. D. Baek, J. Villen, C. Shin, F.D. Camargo, S.P. Gygi, and D.P. Bartel The impact of microRNAs on protein output Nature 455 2008 64 71
20. M. Selbach, B. Schwanhausser, N. Thierfelder, Z. Fang, R. Khanin, and N. Rajewsky Widespread changes in protein synthesis induced by microRNAs Nature 455 2008 58 63
21. M.E. Pennini, D.J. Perkins, A.M. Salazar, M. Lipsky, and S.N. Vogel Complete dependence on IRAK4 kinase activity in TLR2, but not TLR4, signaling pathways underlies decreased cytokine production and increased susceptibility to Streptococcus pneumoniae infection in IRAK4 kinase-inactive mice J. Immunol. 190 2013 307 316
22. M.A. Nahid, B. Yao, P.R. Dominguez-Gutierrez, L. Kesavalu, M. Satoh, and E.K. Chan Regulation of TLR2-mediated tolerance and cross-tolerance through IRAK4 modulation by miR-132 and miR-212 J. Immunol. 190 2013 1250 1263
23. Y. Wu, J. Zuo, Y. Zhang, Y. Xie, F. Hu, L. Chen, B. Liu, and F. Liu Identification of miR-106b-93 as a negative regulator of brown adipocyte differentiation Biochem. Biophys. Res. Commun. 438 2013 575 580
24. A. Lattanzi, B. Gentner, D. Corno, T. Di Tomaso, P. Mestdagh, F. Speleman, L. Naldini, and A. Gritti Dynamic activity of miR-125b and miR-93 during murine neural stem cell differentiation and in the subventricular zone neurogenic niche PLoS ONE 8 2013 e67411
25. S. Hazarika, C.R. Farber, A.O. Dokun, A.N. Pitsillides, T. Wang, R.J. Lye, and B.H. Annex MicroRNA-93 controls perfusion recovery after hindlimb ischemia by modulating expression of multiple genes in the cell cycle pathway Circulation 127 2013 1818 1828